Compile Data Set for Download or QSAR

Found 174 hits of kd data for polymerid = 50004844   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289495 (1-(4-(6-amino-5-(tri- fluoromethyl)pyridin-3- yl)-...) Show SMILES CC(C)C(O)c1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C22H28F3N5O3/c1-13(2)17(31)19-28-15(14-7-16(18(26)27-8-14)33-22(23,24)25)9-30(19)21-10-20(11-21,12-21)29-3-5-32-6-4-29/h7-9,13,17,31H,3-6,10-12H2,1-2H3,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	0.110	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM590003 ((S)-1-(4-(6-amino-5- (trifluoromethyl)pyridin-3-yl...) Show SMILES CC(C)[C@H](O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589995 ((R)-1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)...) Show SMILES CC(C)[C@@H](O)c1nc(cn1C12CC(C1)(C2)N1CCC(F)(F)CC1)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.210	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589991 (US11560366, Example 3b) Show SMILES CC(C)[C@H](O)c1nc(cn1C12CC(F)(C1)C2)-c1cnc(N)c(OC(F)(F)F)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.240	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289483 (1-(4-(6-amino-5- (trifluoromethyl)- pyridin-3-yl)-...) Show SMILES CC(C)C(O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C18H21F3N4O/c1-9(2)14(26)16-24-13(8-25(16)17-4-10(5-17)6-17)11-3-12(18(19,20)21)15(22)23-7-11/h3,7-10,14,26H,4-6H2,1-2H3,(H2,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM590004 ((S)-1-(4-(6-amino-5- (trifluoromethoxy)pyridin-3-y...) Show SMILES CC(C)[C@H](O)c1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(OC(F)(F)F)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589992 ((S)-1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)...) Show SMILES CC(C)[C@H](O)c1nc(cn1C12CC(F)(C1)C2)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289483 (1-(4-(6-amino-5- (trifluoromethyl)- pyridin-3-yl)-...) Show SMILES CC(C)C(O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C18H21F3N4O/c1-9(2)14(26)16-24-13(8-25(16)17-4-10(5-17)6-17)11-3-12(18(19,20)21)15(22)23-7-11/h3,7-10,14,26H,4-6H2,1-2H3,(H2,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289429 ((S)-1-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl...) Show SMILES CCCN1CCN(CC1)C12CC(C1)(C2)n1cc(nc1[C@@H](O)C(C)C)-c1cnc(N)c(OC(F)(F)F)c1 |r| Show InChI InChI=1S/C25H35F3N6O2/c1-4-5-32-6-8-33(9-7-32)23-13-24(14-23,15-23)34-12-18(31-22(34)20(35)16(2)3)17-10-19(21(29)30-11-17)36-25(26,27)28/h10-12,16,20,35H,4-9,13-15H2,1-3H3,(H2,29,30)/t20-,23?,24?/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289505 (1-(4-(6-amino-5-(tri- fluoromethyl)pyridin-3- yl)-...) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)C(O)C(F)(F)F)C12CC(C1)(C2)N1CCOCC1 Show InChI InChI=1S/C20H21F6N5O2/c21-19(22,23)12-5-11(6-28-15(12)27)13-7-31(16(29-13)14(32)20(24,25)26)18-8-17(9-18,10-18)30-1-3-33-4-2-30/h5-7,14,32H,1-4,8-10H2,(H2,27,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289428 ((S)-1-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)[C@@H](O)C(F)(F)F)C12CC(C1)(C2)N1CCOCC1 |r| Show InChI InChI=1S/C20H21F6N5O3/c21-19(22,23)14(32)16-29-12(11-5-13(15(27)28-6-11)34-20(24,25)26)7-31(16)18-8-17(9-18,10-18)30-1-3-33-4-2-30/h5-7,14,32H,1-4,8-10H2,(H2,27,28)/t14-,17?,18?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289428 ((S)-1-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)[C@@H](O)C(F)(F)F)C12CC(C1)(C2)N1CCOCC1 |r| Show InChI InChI=1S/C20H21F6N5O3/c21-19(22,23)14(32)16-29-12(11-5-13(15(27)28-6-11)34-20(24,25)26)7-31(16)18-8-17(9-18,10-18)30-1-3-33-4-2-30/h5-7,14,32H,1-4,8-10H2,(H2,27,28)/t14-,17?,18?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.360	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589996 ((R)-1-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl...) Show SMILES CC(C)[C@@H](O)c1nc(cn1C12CC(C1)(C2)N1CCC(F)(F)CC1)-c1cnc(N)c(OC(F)(F)F)c1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289481 (1-(4-(6-amino-5-(tri- fluoromethoxy)pyridin- 3-yl)...) Show SMILES CC(C)C(O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C18H21F3N4O2/c1-9(2)14(26)16-24-12(8-25(16)17-4-10(5-17)6-17)11-3-13(15(22)23-7-11)27-18(19,20)21/h3,7-10,14,26H,4-6H2,1-2H3,(H2,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589998 (US11560366, Example 10a) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)[C@@H](O)C(F)(F)F)C12CC(C1)(C2)N1CCC(F)(F)CC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289426 ( (R)-1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl...) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)[C@H](O)C(F)(F)F)C12CC(C1)C2 |r| Show InChI InChI=1S/C16H14F6N4O/c17-15(18,19)9-1-8(5-24-12(9)23)10-6-26(14-2-7(3-14)4-14)13(25-10)11(27)16(20,21)22/h1,5-7,11,27H,2-4H2,(H2,23,24)/t7?,11-,14?/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.740	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589997 (US11560366, Example 9b) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)[C@H](O)C(F)(F)F)C12CC(C1)(C2)N1CCC(F)(F)CC1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289481 (1-(4-(6-amino-5-(tri- fluoromethoxy)pyridin- 3-yl)...) Show SMILES CC(C)C(O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C18H21F3N4O2/c1-9(2)14(26)16-24-12(8-25(16)17-4-10(5-17)6-17)11-3-13(15(22)23-7-11)27-18(19,20)21/h3,7-10,14,26H,4-6H2,1-2H3,(H2,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM590001 ((R)-1-(4-(6-amino-5-(trifluoromethoxy)- pyridin-3-...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)[C@@H](O)C(F)(F)F)C12CC(C1)C2 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289491 (1-(4-(6-amino-5- (trifluoromethoxy)- pyridin-3-yl)...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C(O)C(F)(F)F)C12CC(C1)C2 Show InChI InChI=1S/C16H14F6N4O2/c17-15(18,19)11(27)13-25-9(6-26(13)14-2-7(3-14)4-14)8-1-10(12(23)24-5-8)28-16(20,21)22/h1,5-7,11,27H,2-4H2,(H2,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289437 (4-(3-(2-cyclopropyl-4-(3-(trifluoromethyl)-1H-pyrr...) Show SMILES FC(F)(F)c1c[nH]c2ncc(cc12)-c1cn(c(n1)C1CC1)C12CC(C1)(C2)N1CCOCC1 Show InChI InChI=1S/C23H24F3N5O/c24-23(25,26)17-9-28-19-16(17)7-15(8-27-19)18-10-31(20(29-18)14-1-2-14)22-11-21(12-22,13-22)30-3-5-32-6-4-30/h7-10,14H,1-6,11-13H2,(H,27,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289489 (1-(4-(6-amino-5-(tri- fluoromethyl)pyridin-3- yl)-...) Show SMILES CCC(O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C17H19F3N4O/c1-2-13(25)15-23-12(8-24(15)16-4-9(5-16)6-16)10-3-11(17(18,19)20)14(21)22-7-10/h3,7-9,13,25H,2,4-6H2,1H3,(H2,21,22)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589988 ((R)-1-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)[C@@H](O)C(F)(F)F)C12CC(F)(C1)C2 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MCE PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289425 ((R)-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1...) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)[C@H](O)C1CC1)C12CC(C1)C2 |r| Show InChI InChI=1S/C18H19F3N4O/c19-18(20,21)12-3-11(7-23-15(12)22)13-8-25(17-4-9(5-17)6-17)16(24-13)14(26)10-1-2-10/h3,7-10,14,26H,1-2,4-6H2,(H2,22,23)/t9?,14-,17?/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289484 ((4-(6-amino-5-(trifluoro- methyl)pyridin-3- yl)-1-...) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)C(O)C1CC1)C12CC(C1)C2 Show InChI InChI=1S/C18H19F3N4O/c19-18(20,21)12-3-11(7-23-15(12)22)13-8-25(17-4-9(5-17)6-17)16(24-13)14(26)10-1-2-10/h3,7-10,14,26H,1-2,4-6H2,(H2,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM590000 ((4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)-1-(3-...) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)C(O)C1CC1)C12CC(C1)(C2)N1CCC(F)(F)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289447 (4-(3-(2-isopropyl-4-(1-(1-(pyridin-2-yl)ethyl)-1H-...) Show SMILES CC(C)c1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc2ccn(C(C)c3ccccn3)c2c1 Show InChI InChI=1S/C29H34N6O/c1-20(2)27-32-25(16-35(27)29-17-28(18-29,19-29)33-10-12-36-13-11-33)22-14-26-24(31-15-22)7-9-34(26)21(3)23-6-4-5-8-30-23/h4-9,14-16,20-21H,10-13,17-19H2,1-3H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589999 ((4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl)-1-(3...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C(O)C1CC1)C12CC(C1)(C2)N1CCC(F)(F)CC1 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289466 (5-(2-(cyclopropyl- methyl)-1-(3-(4- methylpiperazi...) Show SMILES CN1CCN(CC1)C12CC(C1)(C2)n1cc(nc1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C23H29F3N6/c1-30-4-6-31(7-5-30)21-12-22(13-21,14-21)32-11-18(29-19(32)8-15-2-3-15)16-9-17(23(24,25)26)20(27)28-10-16/h9-11,15H,2-8,12-14H2,1H3,(H2,27,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589990 ((R)-1-(4-(6-amino-5-(trifluoromethyl)pyridin-3-yl)...) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)[C@@H](O)C(F)(F)F)C12CC(F)(C1)C2 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289509 (5-(2-isopropyl-1-(3-(4- methylpiperazin-1-yl)- bic...) Show SMILES CC(C)c1nc(cn1C12CC(C1)(C2)N1CCN(C)CC1)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C22H29F3N6O/c1-14(2)19-28-16(15-8-17(18(26)27-9-15)32-22(23,24)25)10-31(19)21-11-20(12-21,13-21)30-6-4-29(3)5-7-30/h8-10,14H,4-7,11-13H2,1-3H3,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289480 ((4-(6-amino-5-(tri- fluoromethoxy)pyridin- 3-yl)-1...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C(O)C1CC1)C12CC(C1)C2 Show InChI InChI=1S/C18H19F3N4O2/c19-18(20,21)27-13-3-11(7-23-15(13)22)12-8-25(17-4-9(5-17)6-17)16(24-12)14(26)10-1-2-10/h3,7-10,14,26H,1-2,4-6H2,(H2,22,23)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM50271212 (CHEMBL3715238) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1CC1CC1)-c1cnc(N)c(c1)C(F)(F)F)C1COC1 |r| Show InChI InChI=1S/C21H24F3N5O/c22-21(23,24)16-3-12(5-26-20(16)25)17-4-18(29(27-17)6-11-1-2-11)19-14-7-28(8-15(14)19)13-9-30-10-13/h3-5,11,13-15,19H,1-2,6-10H2,(H2,25,26)/t14-,15+,19+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a
WuXi AppTec Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity to full length wild type human DLK (M1 to P859 residues) expressed in mammalian cells by KINOMEscan assay				J Med Chem 60: 8083-8102 (2017) Article DOI: 10.1021/acs.jmedchem.7b00843 BindingDB Entry DOI: 10.7270/Q2639S7K
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589993 (US11560366, Example 5) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C(O)C1CC1)C12CC(F)(C1)C2 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	5.20	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289471 (5-(2-isobutyl-1-(3- morpholinobicyclo- [1.1.1]pent...) Show SMILES CC(C)Cc1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C22H28F3N5O/c1-14(2)7-18-28-17(15-8-16(22(23,24)25)19(26)27-9-15)10-30(18)21-11-20(12-21,13-21)29-3-5-31-6-4-29/h8-10,14H,3-7,11-13H2,1-2H3,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289444 (5-(1-(3-(bis(2-methoxyethyl)amino)bicyclo[1.1.1]pe...) Show SMILES COCCN(CCOC)C12CC(C1)(C2)n1cc(nc1C1CC1)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C23H30F3N5O3/c1-32-7-5-30(6-8-33-2)21-12-22(13-21,14-21)31-11-17(29-20(31)15-3-4-15)16-9-18(19(27)28-10-16)34-23(24,25)26/h9-11,15H,3-8,12-14H2,1-2H3,(H2,27,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289455 (5-(1-(3-morpholino- bicyclo[1.1.1]pentan-1- yl)-2-...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C1CCCO1)C12CC(C1)(C2)N1CCOCC1 Show InChI InChI=1S/C22H26F3N5O3/c23-22(24,25)33-17-8-14(9-27-18(17)26)15-10-30(19(28-15)16-2-1-5-32-16)21-11-20(12-21,13-21)29-3-6-31-7-4-29/h8-10,16H,1-7,11-13H2,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289443 (5-(2-cyclopropyl-1-(3-((2-methoxyethyl)(methyl)ami...) Show SMILES COCCN(C)C12CC(C1)(C2)n1cc(nc1C1CC1)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C21H26F3N5O2/c1-28(5-6-30-2)19-10-20(11-19,12-19)29-9-15(27-18(29)13-3-4-13)14-7-16(17(25)26-8-14)31-21(22,23)24/h7-9,13H,3-6,10-12H2,1-2H3,(H2,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289436 (5-(2-cyclopropyl-1-(3-(4-(2-fluoroethyl)piperazin-...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C1CC1)C12CC(C1)(C2)N1CCN(CCF)CC1 Show InChI InChI=1S/C23H28F4N6O/c24-3-4-31-5-7-32(8-6-31)21-12-22(13-21,14-21)33-11-17(30-20(33)15-1-2-15)16-9-18(19(28)29-10-16)34-23(25,26)27/h9-11,15H,1-8,12-14H2,(H2,28,29)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289445 (1-(3-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl)...) Show SMILES Nc1ncc(cc1OC(F)(F)F)-c1cn(c(n1)C1CC1)C12CC(C1)(C2)N1CCC(O)CC1 Show InChI InChI=1S/C22H26F3N5O2/c23-22(24,25)32-17-7-14(8-27-18(17)26)16-9-30(19(28-16)13-1-2-13)21-10-20(11-21,12-21)29-5-3-15(31)4-6-29/h7-9,13,15,31H,1-6,10-12H2,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289458 (5-(2-(cyclopropyl- methyl)-1-(3-morpho- linobicycl...) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(CC2CC2)n1)C12CC(C1)(C2)N1CCOCC1 Show InChI InChI=1S/C22H26F3N5O/c23-22(24,25)16-8-15(9-27-19(16)26)17-10-30(18(28-17)7-14-1-2-14)21-11-20(12-21,13-21)29-3-5-31-6-4-29/h8-10,14H,1-7,11-13H2,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289511 (5-(2-cyclopropyl-1-(3- (4-methylpiperazin-1- yl)bi...) Show SMILES CN1CCN(CC1)C12CC(C1)(C2)n1cc(nc1C1CC1)-c1cnc(N)c(OC(F)F)c1 Show InChI InChI=1S/C22H28F2N6O/c1-28-4-6-29(7-5-28)21-11-22(12-21,13-21)30-10-16(27-19(30)14-2-3-14)15-8-17(31-20(23)24)18(25)26-9-15/h8-10,14,20H,2-7,11-13H2,1H3,(H2,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289510 (5-(2-cyclopropyl-1-(3- (4-methylpiperazin-1- yl)bi...) Show SMILES CN1CCN(CC1)C12CC(C1)(C2)n1cc(nc1C1CC1)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C22H27F3N6/c1-29-4-6-30(7-5-29)20-11-21(12-20,13-20)31-10-17(28-19(31)14-2-3-14)15-8-16(22(23,24)25)18(26)27-9-15/h8-10,14H,2-7,11-13H2,1H3,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM589994 (US11560366, Example 6) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)C(O)C1CC1)C12CC(F)(C1)C2 Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description A fusion protein of full length of human DLK (amino acids 1-859) and the DNA binding domain of NFkB was expressed in transiently transfected HEK293 c...				Citation and Details BindingDB Entry DOI: 10.7270/Q21C21S6
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289424 (US10093664, Example 4) Show SMILES Nc1ncc(cc1C(F)(F)F)-c1cn(c(n1)C1CC1)C12CC(C1)(C2)N1CCOCC1 Show InChI InChI=1S/C21H24F3N5O/c22-21(23,24)15-7-14(8-26-17(15)25)16-9-29(18(27-16)13-1-2-13)20-10-19(11-20,12-20)28-3-5-30-6-4-28/h7-9,13H,1-6,10-12H2,(H2,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289473 (5-(2-(sec-butyl)-1-(3- morpholinobicyclo- [1.1.1]p...) Show SMILES CCC(C)c1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C22H28F3N5O2/c1-3-14(2)19-28-16(15-8-17(18(26)27-9-15)32-22(23,24)25)10-30(19)21-11-20(12-21,13-21)29-4-6-31-7-5-29/h8-10,14H,3-7,11-13H2,1-2H3,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289474 (5-(2-(sec-butyl)-1-(3- morpholinobicyclo- [1.1.1]p...) Show SMILES CCC(C)c1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(c1)C(F)(F)F Show InChI InChI=1S/C22H28F3N5O/c1-3-14(2)19-28-17(15-8-16(22(23,24)25)18(26)27-9-15)10-30(19)21-11-20(12-21,13-21)29-4-6-31-7-5-29/h8-10,14H,3-7,11-13H2,1-2H3,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289441 (4-(3-(4-(6-amino-5-(trifluoromethoxy)pyridin-3-yl)...) Show SMILES CN1CCN(CC1=O)C12CC(C1)(C2)n1cc(nc1C1CC1)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C22H25F3N6O2/c1-29-4-5-30(9-17(29)32)20-10-21(11-20,12-20)31-8-15(28-19(31)13-2-3-13)14-6-16(18(26)27-7-14)33-22(23,24)25/h6-8,13H,2-5,9-12H2,1H3,(H2,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289456 ((S)-1-(4-(6-amino-5- (trifluoromethyl)- pyridin-3-...) Show SMILES C[C@H](O)c1nc(cn1C12CC(C1)C2)-c1cnc(N)c(c1)C(F)(F)F |r| Show InChI InChI=1S/C16H17F3N4O/c1-8(24)14-22-12(7-23(14)15-3-9(4-15)5-15)10-2-11(16(17,18)19)13(20)21-6-10/h2,6-9,24H,3-5H2,1H3,(H2,20,21)/t8-,9?,15?/m0/s1	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	9.70	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 12 (Homo sapiens (Human))	BDBM289423 (5-(2-isopropyl-1-(3-morpholinobicyclo[1.1.1]pentan...) Show SMILES CC(C)c1nc(cn1C12CC(C1)(C2)N1CCOCC1)-c1cnc(N)c(OC(F)(F)F)c1 Show InChI InChI=1S/C21H26F3N5O2/c1-13(2)18-27-15(14-7-16(17(25)26-8-14)31-21(22,23)24)9-29(18)20-10-19(11-20,12-20)28-3-5-30-6-4-28/h7-9,13H,3-6,10-12H2,1-2H3,(H2,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a
Board of Regents, The University of Texas System US Patent					Assay Description The DLK dissociation constants (Kd) have been determined in the KINOMEscan KdELECT Service at DiscoveRx. A fusion protein of full length of human DLK...				US Patent US10093664 (2018) BindingDB Entry DOI: 10.7270/Q28P62KQ
					More data for this Ligand-Target Pair				3D Structure (crystal)

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