Compile Data Set for Download or QSAR

Found 658 hits Enz. Inhib. hit(s) with Target = 'Prostanoid IP receptor'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostacyclin receptor (Homo sapiens (Human))	BDBM23953 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6a | 5-{[...) Show SMILES CC(CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1 Show InChI InChI=1S/C28H27N3O3/c1-19(22-7-4-3-5-8-22)17-29-28(33)27-26(34-18-30-27)15-21-11-13-23(14-12-21)24-9-6-10-25(16-24)31-20(2)32/h3-14,16,18-19H,15,17H2,1-2H3,(H,29,33)(H,31,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM240747 (US9422273, 12e) Show SMILES CCCCCCCCNC(=O)c1coc(n1)[C@@H]1CCCN1Cc1cc(F)ccc1CCC(=O)NS(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C27H36F4N4O5S/c1-2-3-4-5-6-7-14-32-25(37)22-18-40-26(33-22)23-9-8-15-35(23)17-20-16-21(28)12-10-19(20)11-13-24(36)34-41(38,39)27(29,30)31/h10,12,16,18,23H,2-9,11,13-15,17H2,1H3,(H,32,37)(H,34,36)/t23-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	290	n/a	n/a	7.4	37
ALLERGAN, INC. US Patent					Assay Description Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...				US Patent US9422273 (2016) BindingDB Entry DOI: 10.7270/Q2DZ076K
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23956 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c | 5-{[...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2ccccc2)cc1 Show InChI InChI=1S/C27H25N3O3/c1-19(31)30-24-9-5-8-23(17-24)22-12-10-21(11-13-22)16-25-26(29-18-33-25)27(32)28-15-14-20-6-3-2-4-7-20/h2-13,17-18H,14-16H2,1H3,(H,28,32)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	721	n/a	138	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23957 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d | 5-{[...) Show SMILES CC(NC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1 Show InChI InChI=1S/C27H25N3O3/c1-18(21-7-4-3-5-8-21)29-27(32)26-25(33-17-28-26)15-20-11-13-22(14-12-20)23-9-6-10-24(16-23)30-19(2)31/h3-14,16-18H,15H2,1-2H3,(H,29,32)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.23E+3	n/a	278	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23958 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6e | 5-{[...) Show SMILES CN(CCc1ccccc1)C(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1 Show InChI InChI=1S/C28H27N3O3/c1-20(32)30-25-10-6-9-24(18-25)23-13-11-22(12-14-23)17-26-27(29-19-34-26)28(33)31(2)16-15-21-7-4-3-5-8-21/h3-14,18-19H,15-17H2,1-2H3,(H,30,32)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.16E+3	n/a	2.13E+3	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23959 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f | 5-{[...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@H]2C[C@@H]2c2ccccc2)cc1 |r| Show InChI InChI=1S/C28H25N3O3/c1-18(32)30-23-9-5-8-22(15-23)20-12-10-19(11-13-20)14-26-27(29-17-34-26)28(33)31-25-16-24(25)21-6-3-2-4-7-21/h2-13,15,17,24-25H,14,16H2,1H3,(H,30,32)(H,31,33)/t24-,25+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	331	n/a	358	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23960 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g | 5-{[...) Show SMILES C[C@@H](CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1 |r| Show InChI InChI=1S/C28H27N3O3/c1-19(22-7-4-3-5-8-22)17-29-28(33)27-26(34-18-30-27)15-21-11-13-23(14-12-21)24-9-6-10-25(16-24)31-20(2)32/h3-14,16,18-19H,15,17H2,1-2H3,(H,29,33)(H,31,32)/t19-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	53	n/a	51	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23961 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h | 5-{[...) Show SMILES C[C@H](CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1)c1ccccc1 |r| Show InChI InChI=1S/C28H27N3O3/c1-19(22-7-4-3-5-8-22)17-29-28(33)27-26(34-18-30-27)15-21-11-13-23(14-12-21)24-9-6-10-25(16-24)31-20(2)32/h3-14,16,18-19H,15,17H2,1-2H3,(H,29,33)(H,31,32)/t19-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	916	n/a	296	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23962 ((2R)-2-[(5-{[4-(3-acetamidophenyl)phenyl]methyl}-1...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@H](Cc2ccccc2)C(O)=O)cc1 |r| Show InChI InChI=1S/C28H25N3O5/c1-18(32)30-23-9-5-8-22(16-23)21-12-10-20(11-13-21)15-25-26(29-17-36-25)27(33)31-24(28(34)35)14-19-6-3-2-4-7-19/h2-13,16-17,24H,14-15H2,1H3,(H,30,32)(H,31,33)(H,34,35)/t24-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	831	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23963 ((2S)-2-[(5-{[4-(3-acetamidophenyl)phenyl]methyl}-1...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)N[C@@H](Cc2ccccc2)C(O)=O)cc1 |r| Show InChI InChI=1S/C28H25N3O5/c1-18(32)30-23-9-5-8-22(16-23)21-12-10-20(11-13-21)15-25-26(29-17-36-25)27(33)31-24(28(34)35)14-19-6-3-2-4-7-19/h2-13,16-17,24H,14-15H2,1H3,(H,30,32)(H,31,33)(H,34,35)/t24-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	476	n/a	16	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23964 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6k | 5-{[...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2ccccn2)cc1 Show InChI InChI=1S/C26H24N4O3/c1-18(31)30-23-7-4-5-21(16-23)20-10-8-19(9-11-20)15-24-25(29-17-33-24)26(32)28-14-12-22-6-2-3-13-27-22/h2-11,13,16-17H,12,14-15H2,1H3,(H,28,32)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	1.01E+3	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23965 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l | 5-{[...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2cccnc2)cc1 Show InChI InChI=1S/C26H24N4O3/c1-18(31)30-23-6-2-5-22(15-23)21-9-7-19(8-10-21)14-24-25(29-17-33-24)26(32)28-13-11-20-4-3-12-27-16-20/h2-10,12,15-17H,11,13-14H2,1H3,(H,28,32)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.95E+3	n/a	741	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23966 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m | 5-{[...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCCc2ccncc2)cc1 Show InChI InChI=1S/C26H24N4O3/c1-18(31)30-23-4-2-3-22(16-23)21-7-5-20(6-8-21)15-24-25(29-17-33-24)26(32)28-14-11-19-9-12-27-13-10-19/h2-10,12-13,16-17H,11,14-15H2,1H3,(H,28,32)(H,30,31)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.71E+3	n/a	476	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23967 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n | 5-{[...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C25H21N3O3/c1-17(29)27-22-9-5-6-20(15-22)19-12-10-18(11-13-19)14-23-24(26-16-31-23)25(30)28-21-7-3-2-4-8-21/h2-13,15-16H,14H2,1H3,(H,27,29)(H,28,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.48E+3	n/a	828	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23968 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6o | 5-{[...) Show SMILES CNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1 Show InChI InChI=1S/C20H19N3O3/c1-13(24)23-17-5-3-4-16(11-17)15-8-6-14(7-9-15)10-18-19(20(25)21-2)22-12-26-18/h3-9,11-12H,10H2,1-2H3,(H,21,25)(H,23,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.22E+4	n/a	3.31E+3	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23969 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6p | 5-{[...) Show SMILES CC(C)NC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1 Show InChI InChI=1S/C22H23N3O3/c1-14(2)24-22(27)21-20(28-13-23-21)11-16-7-9-17(10-8-16)18-5-4-6-19(12-18)25-15(3)26/h4-10,12-14H,11H2,1-3H3,(H,24,27)(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.24E+4	n/a	3.58E+3	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23970 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6q | N-[2...) Show SMILES CN(C)CCNC(=O)c1ncoc1Cc1ccc(cc1)-c1cccc(NC(C)=O)c1 Show InChI InChI=1S/C23H26N4O3/c1-16(28)26-20-6-4-5-19(14-20)18-9-7-17(8-10-18)13-21-22(25-15-30-21)23(29)24-11-12-27(2)3/h4-10,14-15H,11-13H2,1-3H3,(H,24,29)(H,26,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.41E+4	n/a	3.31E+3	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM62356 (US9422273, 12b) Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1 |r| Show InChI InChI=1S/C29H38ClF3N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	860	n/a	n/a	7.4	37
ALLERGAN, INC. US Patent					Assay Description Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...				US Patent US9422273 (2016) BindingDB Entry DOI: 10.7270/Q2DZ076K
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM240744 (US9422273, 12a) Show SMILES Fc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1 |r| Show InChI InChI=1S/C29H38F4N4O5S/c30-23-13-11-21(12-14-26(38)36-43(40,41)29(31,32)33)22(17-23)18-37-16-6-10-25(37)28-35-24(19-42-28)27(39)34-15-5-4-9-20-7-2-1-3-8-20/h11,13,17,19-20,25H,1-10,12,14-16,18H2,(H,34,39)(H,36,38)/t25-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	7.4	37
ALLERGAN, INC. US Patent					Assay Description Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...				US Patent US9422273 (2016) BindingDB Entry DOI: 10.7270/Q2DZ076K
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM240745 (US9422273, 12c) Show SMILES COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(co2)C(=O)NCCCCC2CCCCC2)c1 |r| Show InChI InChI=1S/C30H41F3N4O6S/c1-42-24-14-12-22(13-15-27(38)36-44(40,41)30(31,32)33)23(18-24)19-37-17-7-11-26(37)29-35-25(20-43-29)28(39)34-16-6-5-10-21-8-3-2-4-9-21/h12,14,18,20-21,26H,2-11,13,15-17,19H2,1H3,(H,34,39)(H,36,38)/t26-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9.50E+3	n/a	n/a	7.4	37
ALLERGAN, INC. US Patent					Assay Description Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...				US Patent US9422273 (2016) BindingDB Entry DOI: 10.7270/Q2DZ076K
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM240746 (US9422273, 12d) Show SMILES FC(F)(F)S(=O)(=O)NC(=O)CCc1cc2OCOc2cc1CN1CCC[C@H]1c1nc(co1)C(=O)NCCCCC1CCCCC1 |r| Show InChI InChI=1S/C30H39F3N4O7S/c31-30(32,33)45(40,41)36-27(38)12-11-21-15-25-26(44-19-43-25)16-22(21)17-37-14-6-10-24(37)29-35-23(18-42-29)28(39)34-13-5-4-9-20-7-2-1-3-8-20/h15-16,18,20,24H,1-14,17,19H2,(H,34,39)(H,36,38)/t24-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	7.4	37
ALLERGAN, INC. US Patent					Assay Description Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throug...				US Patent US9422273 (2016) BindingDB Entry DOI: 10.7270/Q2DZ076K
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23955 (5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b | N-be...) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(Cc2ocnc2C(=O)NCc2ccccc2)cc1 Show InChI InChI=1S/C26H23N3O3/c1-18(30)29-23-9-5-8-22(15-23)21-12-10-19(11-13-21)14-24-25(28-17-32-24)26(31)27-16-20-6-3-2-4-7-20/h2-13,15,17H,14,16H2,1H3,(H,27,31)(H,29,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	561	n/a	66	n/a	n/a	7.4	22
Pharmacopeia Drug Discovery Inc.					Assay Description IP receptor binding activity was quantified via a filter binding assay measuring displacement of [3H]-Iloprost binding to human platelet membranes. R...				Bioorg Med Chem Lett 17: 1211-5 (2007) Article DOI: 10.1016/j.bmcl.2006.12.025 BindingDB Entry DOI: 10.7270/Q2RV0M0H
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50101823 (4-(2-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1-...) Show SMILES CCCC1(CCC1)[C@@H](O)C\C=C\C1[C@H](O)CC(=O)[C@@H]1CCc1ccc(cc1)C(O)=O Show InChI InChI=1S/C25H34O5/c1-2-13-25(14-4-15-25)23(28)6-3-5-19-20(22(27)16-21(19)26)12-9-17-7-10-18(11-8-17)24(29)30/h3,5,7-8,10-11,19-21,23,26,28H,2,4,6,9,12-16H2,1H3,(H,29,30)/b5-3+/t19?,20-,21-,23+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	>0.000100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Binding affinity towards human Prostanoid IP receptor in CHO cells.				Bioorg Med Chem Lett 11: 2025-8 (2001) BindingDB Entry DOI: 10.7270/Q2CV4H1T
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50101832 ((E)-7-{(1R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4-(1...) Show SMILES CCCC1(CCC1)[C@@H](O)C\C=C\C1[C@H](O)CC(=O)[C@@H]1C\C=C\CCCC(O)=O Show InChI InChI=1S/C23H36O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h3,5,7,10,17-18,20-21,25-26H,2,4,6,8-9,11-16H2,1H3,(H,27,28)/b5-3+,10-7+/t17-,18?,20-,21+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	>0.000100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Binding affinity towards human Prostanoid IP receptor in CHO cells.				Bioorg Med Chem Lett 11: 2025-8 (2001) BindingDB Entry DOI: 10.7270/Q2CV4H1T
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50101825 ((Z)-7-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-4-hydroxy-4...) Show SMILES CCCC1(CCCCC1)[C@@H](O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O Show InChI InChI=1S/C25H40O5/c1-2-15-25(16-8-5-9-17-25)23(28)13-10-12-20-19(21(26)18-22(20)27)11-6-3-4-7-14-24(29)30/h3,6,10,12,19-20,22-23,27-28H,2,4-5,7-9,11,13-18H2,1H3,(H,29,30)/b6-3-,12-10+/t19-,20-,22-,23+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>0.000100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Binding affinity towards human Prostanoid IP receptor in CHO cells.				Bioorg Med Chem Lett 11: 2025-8 (2001) BindingDB Entry DOI: 10.7270/Q2CV4H1T
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50235385 (APD-811 | Ralinepag) Show SMILES OC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1 |r,wU:6.5,wD:9.9,(-11.29,-9.03,;-9.96,-9.8,;-9.96,-11.34,;-8.62,-9.03,;-7.29,-9.8,;-5.96,-9.03,;-4.62,-9.8,;-3.29,-9.03,;-1.96,-9.8,;-1.96,-11.34,;-.62,-12.11,;.71,-11.34,;2.04,-12.11,;2.04,-13.65,;3.38,-11.34,;3.38,-9.8,;2.04,-9.03,;2.04,-7.49,;3.38,-6.72,;4.71,-7.49,;4.71,-9.03,;4.71,-12.11,;6.05,-11.34,;7.38,-12.11,;7.38,-13.65,;8.71,-14.42,;6.05,-14.42,;4.71,-13.65,;-3.29,-12.11,;-4.62,-11.34,)| Show InChI InChI=1S/C23H26ClNO5/c24-19-10-12-21(13-11-19)25(20-4-2-1-3-5-20)23(28)30-15-18-8-6-17(7-9-18)14-29-16-22(26)27/h1-5,10-13,17-18H,6-9,14-16H2,(H,26,27)/t17-,18-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...				J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23954 (5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...) Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O Show InChI InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...				J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50101848 (6-[(1R,2S,3R)-3-Hydroxy-2-((E)-(3S,5S)-3-hydroxy-5...) Show SMILES CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(O)=O Show InChI InChI=1S/C21H36O5S/c1-3-4-8-15(2)13-16(22)10-11-17-18(23)14-19(24)21(17)27-12-7-5-6-9-20(25)26/h10-11,15-18,21-23H,3-9,12-14H2,1-2H3,(H,25,26)/b11-10+/t15-,16+,17-,18+,21+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Evaluated for its competitive binding affinity towards human Prostanoid IP receptor in CHO cells				Bioorg Med Chem Lett 11: 2029-31 (2001) BindingDB Entry DOI: 10.7270/Q2833R9D
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23954 (5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...) Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O Show InChI InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Siena Curated by ChEMBL					Assay Description Binding affinity to human PGI2 receptor by radioligand displacement assay				Eur J Med Chem 63: 85-94 (2013) Article DOI: 10.1016/j.ejmech.2013.01.044 BindingDB Entry DOI: 10.7270/Q2JH3NKC
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50168287 (CHEMBL363800 | Sodium; {3-[(1R,2S,6S)-1-(4,5-diphe...) Show SMILES [O-]C(=O)COc1cccc(C[C@@H]2CCC[C@@H]3O[C@]23c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 Show InChI InChI=1S/C30H27NO5/c32-26(33)19-34-24-15-7-9-20(18-24)17-23-14-8-16-25-30(23,36-25)29-31-27(21-10-3-1-4-11-21)28(35-29)22-12-5-2-6-13-22/h1-7,9-13,15,18,23,25H,8,14,16-17,19H2,(H,32,33)/p-1/t23-,25-,30+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptor				Bioorg Med Chem Lett 15: 3284-7 (2005) Article DOI: 10.1016/j.bmcl.2005.04.076 BindingDB Entry DOI: 10.7270/Q2C53KCV
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23954 (5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...) Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O Show InChI InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor				Bioorg Med Chem Lett 15: 3279-83 (2005) Article DOI: 10.1016/j.bmcl.2005.04.042 BindingDB Entry DOI: 10.7270/Q2J103X8
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23954 (5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...) Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O Show InChI InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co. Ltd Curated by ChEMBL					Assay Description In vitro Prostacyclin (PGI-2) receptor binding assay was determined based on displacement of [3H]-Iloprost radioligand from cloned human IP receptor				Bioorg Med Chem Lett 13: 4277-9 (2003) BindingDB Entry DOI: 10.7270/Q22R3R3D
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50235370 (CHEMBL3933704) Show SMILES OC(=O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1 |r,wU:6.5,wD:9.9,(14.03,-33.02,;15.36,-32.25,;15.36,-30.71,;16.69,-33.02,;16.69,-34.56,;18.03,-35.33,;19.36,-34.56,;19.36,-33.02,;20.7,-32.25,;22.03,-33.02,;23.36,-32.25,;24.7,-33.02,;26.03,-32.25,;26.03,-30.71,;27.36,-33.02,;27.36,-34.56,;28.7,-35.33,;28.7,-36.87,;27.36,-37.64,;26.03,-36.87,;26.03,-35.33,;28.7,-32.25,;30.03,-33.02,;31.37,-32.25,;31.37,-30.71,;30.03,-29.94,;30.03,-28.4,;28.7,-30.71,;22.03,-34.56,;20.7,-35.33,)| Show InChI InChI=1S/C23H26FNO5/c24-19-5-4-8-21(13-19)25(20-6-2-1-3-7-20)23(28)30-15-18-11-9-17(10-12-18)14-29-16-22(26)27/h1-8,13,17-18H,9-12,14-16H2,(H,26,27)/t17-,18-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Arena Pharmaceuticals Curated by ChEMBL					Assay Description Displacement of [3H]-iloprost from recombinant human IP receptor expressed in CHO-K1 cell membranes incubated for 1 hr by top count scintillation cou...				J Med Chem 60: 913-927 (2017) Article DOI: 10.1021/acs.jmedchem.6b00871 BindingDB Entry DOI: 10.7270/Q2VX0JSM
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50167887 ((R)-2-(6-((diphenylcarbamoyloxy)methyl)-6-hydroxy-...) Show SMILES OC(=O)COc1cccc2C[C@@](O)(COC(=O)N(c3ccccc3)c3ccccc3)CCc12 Show InChI InChI=1S/C26H25NO6/c28-24(29)17-32-23-13-7-8-19-16-26(31,15-14-22(19)23)18-33-25(30)27(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-13,31H,14-18H2,(H,28,29)/t26-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]iloprost from human Prostanoid IP receptor				Bioorg Med Chem Lett 15: 3091-5 (2005) Article DOI: 10.1016/j.bmcl.2005.04.047 BindingDB Entry DOI: 10.7270/Q2SF2WXV
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM23954 (5-[(2E,3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydro...) Show SMILES [H][C@]12C[C@@H](O)[C@H](\C=C\[C@@H](O)C(C)CC#CC)[C@@]1([H])C\C(C2)=C\CCCC(O)=O Show InChI InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by PDSP Ki Database									Biochim Biophys Acta 1483: 285-93 (2000) Article DOI: 10.1016/s1388-1981(99)00164-x BindingDB Entry DOI: 10.7270/Q2J964XQ
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50167890 (CHEMBL190497 | FR-193262 | Sodium; {(R)-5-[(R)-2-(...) Show SMILES [O-]C(=O)COc1cccc2[C@@H](CCCc12)N1CCC[C@@H]1c1nc(c(o1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C31H30N2O4/c34-28(35)20-36-27-18-8-14-23-24(27)15-7-16-25(23)33-19-9-17-26(33)31-32-29(21-10-3-1-4-11-21)30(37-31)22-12-5-2-6-13-22/h1-6,8,10-14,18,25-26H,7,9,15-17,19-20H2,(H,34,35)/p-1/t25-,26-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Ability to inhibit binding of [3H]iloprost to cloned human prostaglandin I2 receptor				Bioorg Med Chem Lett 15: 3279-83 (2005) Article DOI: 10.1016/j.bmcl.2005.04.042 BindingDB Entry DOI: 10.7270/Q2J103X8
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50167890 (CHEMBL190497 | FR-193262 | Sodium; {(R)-5-[(R)-2-(...) Show SMILES [O-]C(=O)COc1cccc2[C@@H](CCCc12)N1CCC[C@@H]1c1nc(c(o1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C31H30N2O4/c34-28(35)20-36-27-18-8-14-23-24(27)15-7-16-25(23)33-19-9-17-26(33)31-32-29(21-10-3-1-4-11-21)30(37-31)22-12-5-2-6-13-22/h1-6,8,10-14,18,25-26H,7,9,15-17,19-20H2,(H,34,35)/p-1/t25-,26-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]iloprost from human Prostanoid IP receptor				Bioorg Med Chem Lett 15: 3091-5 (2005) Article DOI: 10.1016/j.bmcl.2005.04.047 BindingDB Entry DOI: 10.7270/Q2SF2WXV
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50109546 (5-[(3aS,4R,5R,6aS)-5-Hydroxy-4-((S)-3-hydroxy-oct-...) Show SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2C\C(C[C@H]12)=C\CCCC(O)=O Show InChI InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h7,10-11,16-20,22-23H,2-6,8-9,12-14H2,1H3,(H,24,25)/b11-10+,15-7-/t16-,17-,18+,19-,20+/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	16.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Royal Postgraduate Medical School Curated by PDSP Ki Database									Br J Pharmacol 72: 435-41 (1981) Article DOI: 10.1111/j.1476-5381.1981.tb10994.x BindingDB Entry DOI: 10.7270/Q2HM56XZ
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM85179 (CAS_94079-80-8 | CICAPROST | NSC_72023) Show SMILES CCC#CCC(C)C(O)C#CC1C(O)CC2CC(CC12)=CCOCC(O)=O |w:20.22| Show InChI InChI=1S/C22H30O5/c1-3-4-5-6-15(2)20(23)8-7-18-19-12-16(9-10-27-14-22(25)26)11-17(19)13-21(18)24/h9,15,17-21,23-24H,3,6,10-14H2,1-2H3,(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by PDSP Ki Database									Biochim Biophys Acta 1483: 285-93 (2000) Article DOI: 10.1016/s1388-1981(99)00164-x BindingDB Entry DOI: 10.7270/Q2J964XQ
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50223834 (CHEMBL9910) Show SMILES COc1ccc(Cc2ccc(NC3=NCCN3)cc2)cc1 |t:12| Show InChI InChI=1S/C17H19N3O/c1-21-16-8-4-14(5-9-16)12-13-2-6-15(7-3-13)20-17-18-10-11-19-17/h2-9H,10-12H2,1H3,(H2,18,19,20)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand				Bioorg Med Chem Lett 14: 1053-6 (2004) BindingDB Entry DOI: 10.7270/Q2M90BVN
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50223868 (CHEMBL9604) Show SMILES CC(C)Oc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 |t:14| Show InChI InChI=1S/C18H21N3OS/c1-13(2)22-15-5-9-17(10-6-15)23-16-7-3-14(4-8-16)21-18-19-11-12-20-18/h3-10,13H,11-12H2,1-2H3,(H2,19,20,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand				Bioorg Med Chem Lett 14: 1053-6 (2004) BindingDB Entry DOI: 10.7270/Q2M90BVN
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50152515 (CHEMBL364841 | {2-Methyl-1-[4-(4-methyl-3,4-dihydr...) Show SMILES CN1C[C@@H](COc2ccc(cc2)C(=O)n2c(C)cc3c(CC(O)=O)cccc23)Oc2ccccc12 Show InChI InChI=1S/C28H26N2O5/c1-18-14-23-20(15-27(31)32)6-5-8-24(23)30(18)28(33)19-10-12-21(13-11-19)34-17-22-16-29(2)25-7-3-4-9-26(25)35-22/h3-14,22H,15-17H2,1-2H3,(H,31,32)/t22-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Ono Pharmaceutical Co., Ltd Curated by ChEMBL					Assay Description Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting				Bioorg Med Chem 19: 6935-48 (2011) Article DOI: 10.1016/j.bmc.2011.08.065 BindingDB Entry DOI: 10.7270/Q2K35V22
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50152515 (CHEMBL364841 | {2-Methyl-1-[4-(4-methyl-3,4-dihydr...) Show SMILES CN1C[C@@H](COc2ccc(cc2)C(=O)n2c(C)cc3c(CC(O)=O)cccc23)Oc2ccccc12 Show InChI InChI=1S/C28H26N2O5/c1-18-14-23-20(15-27(31)32)6-5-8-24(23)30(18)28(33)19-10-12-21(13-11-19)34-17-22-16-29(2)25-7-3-4-9-26(25)35-22/h3-14,22H,15-17H2,1-2H3,(H,31,32)/t22-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]Iloprost from human prostanoid IP receptor expressed in CHO cells after 60 mins by liquid scintillation counting				Bioorg Med Chem 19: 5361-71 (2011) Article DOI: 10.1016/j.bmc.2011.08.007 BindingDB Entry DOI: 10.7270/Q2X067DJ
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50152515 (CHEMBL364841 | {2-Methyl-1-[4-(4-methyl-3,4-dihydr...) Show SMILES CN1C[C@@H](COc2ccc(cc2)C(=O)n2c(C)cc3c(CC(O)=O)cccc23)Oc2ccccc12 Show InChI InChI=1S/C28H26N2O5/c1-18-14-23-20(15-27(31)32)6-5-8-24(23)30(18)28(33)19-10-12-21(13-11-19)34-17-22-16-29(2)25-7-3-4-9-26(25)35-22/h3-14,22H,15-17H2,1-2H3,(H,31,32)/t22-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	37	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting				Bioorg Med Chem 19: 4574-88 (2011) Article DOI: 10.1016/j.bmc.2011.06.014 BindingDB Entry DOI: 10.7270/Q2FB5398
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50223861 (CHEMBL9552) Show SMILES CCOc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 |t:13| Show InChI InChI=1S/C17H19N3OS/c1-2-21-14-5-9-16(10-6-14)22-15-7-3-13(4-8-15)20-17-18-11-12-19-17/h3-10H,2,11-12H2,1H3,(H2,18,19,20)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand				Bioorg Med Chem Lett 14: 1053-6 (2004) BindingDB Entry DOI: 10.7270/Q2M90BVN
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50168291 (CHEMBL363350 | Sodium; {3-[(S)-2-(4,5-diphenyl-oxa...) Show SMILES [O-]C(=O)COc1cccc(C[C@@H]2CCC=C2c2nc(c(o2)-c2ccccc2)-c2ccccc2)c1 |c:14| Show InChI InChI=1S/C29H25NO4/c31-26(32)19-33-24-15-7-9-20(18-24)17-23-14-8-16-25(23)29-30-27(21-10-3-1-4-11-21)28(34-29)22-12-5-2-6-13-22/h1-7,9-13,15-16,18,23H,8,14,17,19H2,(H,31,32)/p-1/t23-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fujisawa Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of [3H]-Iloprost binding to human Prostanoid IP receptor				Bioorg Med Chem Lett 15: 3284-7 (2005) Article DOI: 10.1016/j.bmcl.2005.04.076 BindingDB Entry DOI: 10.7270/Q2C53KCV
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50350368 (CHEMBL1813117) Show SMILES CN1C[C@@H](COc2ccc(cc2)C(=O)n2c(C)c(CC(O)=O)c3cc(Cl)ccc23)Oc2ccccc12 |r| Show InChI InChI=1S/C28H25ClN2O5/c1-17-22(14-27(32)33)23-13-19(29)9-12-24(23)31(17)28(34)18-7-10-20(11-8-18)35-16-21-15-30(2)25-5-3-4-6-26(25)36-21/h3-13,21H,14-16H2,1-2H3,(H,32,33)/t21-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	49	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Minase Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]-Iloprost from human IP receptor expressed in CHO cells after 30 mins by liquid scintillation counting				Bioorg Med Chem 19: 4574-88 (2011) Article DOI: 10.1016/j.bmc.2011.06.014 BindingDB Entry DOI: 10.7270/Q2FB5398
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50223848 (CHEMBL10241) Show SMILES COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 |t:12| Show InChI InChI=1S/C16H17N3OS/c1-20-13-4-8-15(9-5-13)21-14-6-2-12(3-7-14)19-16-17-10-11-18-16/h2-9H,10-11H2,1H3,(H2,17,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand				Bioorg Med Chem Lett 14: 1053-6 (2004) BindingDB Entry DOI: 10.7270/Q2M90BVN
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50223860 (CHEMBL9846) Show SMILES CCOC(=O)c1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 |t:15| Show InChI InChI=1S/C18H19N3O2S/c1-2-23-17(22)13-3-7-15(8-4-13)24-16-9-5-14(6-10-16)21-18-19-11-12-20-18/h3-10H,2,11-12H2,1H3,(H2,19,20,21)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand				Bioorg Med Chem Lett 14: 1053-6 (2004) BindingDB Entry DOI: 10.7270/Q2M90BVN
					More data for this Ligand-Target Pair
Prostacyclin receptor (Homo sapiens (Human))	BDBM50223848 (CHEMBL10241) Show SMILES COc1ccc(Sc2ccc(NC3=NCCN3)cc2)cc1 |t:12| Show InChI InChI=1S/C16H17N3OS/c1-20-13-4-8-15(9-5-13)21-14-6-2-12(3-7-14)19-16-17-10-11-18-16/h2-9H,10-11H2,1H3,(H2,17,18,19)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	50	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Roche Palo Alto Curated by ChEMBL					Assay Description Binding affinity towards prostacyclin receptor on rat NG-108-15 neuroblastoma cells, using [3H]iloprost as a radioligand				Bioorg Med Chem Lett 14: 1053-6 (2004) BindingDB Entry DOI: 10.7270/Q2M90BVN
					More data for this Ligand-Target Pair

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