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Patent code US9284333

Compile Data Set for Download or QSAR

Found 390 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218253
PNG
(US9284333, 16c)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(c(Cl)c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H27ClF3N3O3/c1-3-19(15-6-7-17(18(25)11-15)24(26,27)28)29-22(32)16-12-20(31-9-10-34-13-21(16)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/m0/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218254
PNG
(US9284333, 16d | US9884860, Example 16d)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(C#N)c(Cl)c1 |r|
Show InChI InChI=1S/C24H27ClN4O3/c1-3-20(16-6-7-17(13-26)19(25)11-16)27-23(30)18-12-21(29-9-10-32-14-22(18)29)24(31)28-8-4-5-15(28)2/h6-7,11-12,15,20H,3-5,8-10,14H2,1-2H3,(H,27,30)/t15-,20+/m0/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218258
PNG
(US9284333, 16h | US9884860, Example 16h)
Show SMILES CC[C@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ncccn1 |r|
Show InChI InChI=1S/C24H26FN5O3/c1-3-19(22-26-9-4-10-27-22)29-23(31)18-13-20(30-11-12-33-14-21(18)30)24(32)28-15(2)16-5-7-17(25)8-6-16/h4-10,13,15,19H,3,11-12,14H2,1-2H3,(H,28,32)(H,29,31)/t15-,19+/m1/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218259
PNG
(BDBM218669 | US9284333, 16i | US9884860, Example 1...)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H31N3O3/c1-3-22(19-11-7-5-8-12-19)28-26(31)21-17-24(30-15-16-33-18-25(21)30)27(32)29-23(4-2)20-13-9-6-10-14-20/h5-14,17,22-23H,3-4,15-16,18H2,1-2H3,(H,28,31)(H,29,32)/t22-,23-/m1/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218337
PNG
(US9284333, 16cc | US9884860, Example 16cc)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(nc1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C23H26ClF3N4O3/c1-3-16(14-6-7-19(23(25,26)27)29-20(14)24)28-21(32)15-11-17(31-9-10-34-12-18(15)31)22(33)30-8-4-5-13(30)2/h6-7,11,13,16H,3-5,8-10,12H2,1-2H3,(H,28,32)/t13-,16+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218346
PNG
(US9284333, 16cl | US9884860, Example 16cl)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1c(F)cc(cc1F)C(F)(F)F |r|
Show InChI InChI=1S/C24H26F5N3O3/c1-3-18(21-16(25)9-14(10-17(21)26)24(27,28)29)30-22(33)15-11-19(32-7-8-35-12-20(15)32)23(34)31-6-4-5-13(31)2/h9-11,13,18H,3-8,12H2,1-2H3,(H,30,33)/t13-,18+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218349
PNG
(US9284333, 16co)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cnc(Cl)c(Cl)c1 |r|
Show InChI InChI=1S/C22H26Cl2N4O3/c1-3-17(14-9-16(23)20(24)25-11-14)26-21(29)15-10-18(28-7-8-31-12-19(15)28)22(30)27-6-4-5-13(27)2/h9-11,13,17H,3-8,12H2,1-2H3,(H,26,29)/t13-,17+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218352
PNG
(US9284333, 16cs | US9884860, Example 16cs)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(Cl)c(c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H27ClF3N3O3/c1-3-19(15-6-7-18(25)17(11-15)24(26,27)28)29-22(32)16-12-20(31-9-10-34-13-21(16)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218367
PNG
(US9284333, 16dk)
Show SMILES C[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C(F)(F)F)c2COCCn12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H23F4N3O3/c1-13(14-4-6-15(23)7-5-14)27-20(30)17-11-16(18-12-32-10-9-28(17)18)21(31)29-8-2-3-19(29)22(24,25)26/h4-7,11,13,19H,2-3,8-10,12H2,1H3,(H,27,30)/t13-,19-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218375
PNG
(US9284333, 16dt | US9884860, Example 16dt)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1cccnc1C(F)(F)F |r|
Show InChI InChI=1S/C26H26F4N4O3/c1-3-20(18-5-4-10-31-23(18)26(28,29)30)33-24(35)19-13-21(34-11-12-37-14-22(19)34)25(36)32-15(2)16-6-8-17(27)9-7-16/h4-10,13,15,20H,3,11-12,14H2,1-2H3,(H,32,36)(H,33,35)/t15-,20-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218393
PNG
(US9284333, 16ep | US9884860, Example 16ep)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2[C@@H](COC)CC[C@@H]2COC)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H35N3O5/c1-4-22(18-8-6-5-7-9-18)27-25(30)21-14-23(28-12-13-34-17-24(21)28)26(31)29-19(15-32-2)10-11-20(29)16-33-3/h5-9,14,19-20,22H,4,10-13,15-17H2,1-3H3,(H,27,30)/t19-,20-,22-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218398
PNG
(US9284333, 16eu | US9884860, Example 16eu)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C(F)(F)F)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H26F3N3O3/c1-2-17(15-7-4-3-5-8-15)27-21(30)16-13-18(28-11-12-32-14-19(16)28)22(31)29-10-6-9-20(29)23(24,25)26/h3-5,7-8,13,17,20H,2,6,9-12,14H2,1H3,(H,27,30)/t17-,20-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218405
PNG
(US9284333, 16fc | US9884860, Example 16fc)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2CC)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C24H31N3O3/c1-3-18-11-8-12-26(18)24(29)21-15-19(22-16-30-14-13-27(21)22)23(28)25-20(4-2)17-9-6-5-7-10-17/h5-7,9-10,15,18,20H,3-4,8,11-14,16H2,1-2H3,(H,25,28)/t18-,20+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218410
PNG
(US9284333, 16fi | US9884860, Example 16fi)
Show SMILES CCOC(=O)C[C@H]1CCCN1C(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)c2COCCn12 |r|
Show InChI InChI=1S/C26H33N3O5/c1-3-21(18-9-6-5-7-10-18)27-25(31)20-16-22(29-13-14-33-17-23(20)29)26(32)28-12-8-11-19(28)15-24(30)34-4-2/h5-7,9-10,16,19,21H,3-4,8,11-15,17H2,1-2H3,(H,27,31)/t19-,21-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218417
PNG
(US9284333, 16fp | US9884860, Example 16fp)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2c2cnccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H29N5O3/c1-2-20(18-7-4-3-5-8-18)29-25(32)19-15-23(30-13-14-34-17-24(19)30)26(33)31-12-6-9-22(31)21-16-27-10-11-28-21/h3-5,7-8,10-11,15-16,20,22H,2,6,9,12-14,17H2,1H3,(H,29,32)/t20-,22-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218614
PNG
(US9284333, 16gg | US9884860, Example 16gg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)COC)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C22H29N3O4/c1-4-18(16-8-6-5-7-9-16)24-21(26)17-12-19(22(27)23-15(2)13-28-3)25-10-11-29-14-20(17)25/h5-9,12,15,18H,4,10-11,13-14H2,1-3H3,(H,23,27)(H,24,26)/t15?,18-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218617
PNG
(US9284333, 16gj | US9884860, Example 16gj)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H]2CCc3ccccc23)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H29N3O3/c1-2-22(19-9-4-3-5-10-19)28-26(31)21-16-24(30-14-15-33-17-25(21)30)27(32)29-23-13-12-18-8-6-7-11-20(18)23/h3-11,16,22-23H,2,12-15,17H2,1H3,(H,28,31)(H,29,32)/t22-,23+/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218268
PNG
(US9284333, 16gr | US9884860, Example 16gr)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H30N4O3/c1-3-20(18-10-6-5-7-11-18)28-25(31)19-16-23(30-14-15-33-17-24(19)30)26(32)29-21(4-2)22-12-8-9-13-27-22/h5-13,16,20-21H,3-4,14-15,17H2,1-2H3,(H,28,31)(H,29,32)/t20-,21-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218442
PNG
(US9284333, 16hb | US9884860, Example 16hb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C2CC2)C2CC2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H31N3O3/c1-2-20(16-6-4-3-5-7-16)26-24(29)19-14-21(28-12-13-31-15-22(19)28)25(30)27-23(17-8-9-17)18-10-11-18/h3-7,14,17-18,20,23H,2,8-13,15H2,1H3,(H,26,29)(H,27,30)/t20-/m1/s1
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n/an/a 13n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218447
PNG
(US9284333, 16hg | US9884860, Example 16hg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)Nc2c(C)noc2C)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H26N4O4/c1-4-18(16-8-6-5-7-9-16)24-22(28)17-12-19(27-10-11-30-13-20(17)27)23(29)25-21-14(2)26-31-15(21)3/h5-9,12,18H,4,10-11,13H2,1-3H3,(H,24,28)(H,25,29)/t18-/m1/s1
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n/an/a 600n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218451
PNG
(US9284333, 16hk | US9884860, Example 16hk)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N(CCO)CC2CC2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C24H31N3O4/c1-2-20(18-6-4-3-5-7-18)25-23(29)19-14-21(27-11-13-31-16-22(19)27)24(30)26(10-12-28)15-17-8-9-17/h3-7,14,17,20,28H,2,8-13,15-16H2,1H3,(H,25,29)/t20-/m1/s1
PDB

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n/an/a 1.40E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218456
PNG
(US9284333, 16hp | US9884860, Example 16hp)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](CC)c2ccc(OC)nc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H32N4O4/c1-4-21(18-9-7-6-8-10-18)29-26(32)20-15-23(31-13-14-35-17-24(20)31)27(33)30-22(5-2)19-11-12-25(34-3)28-16-19/h6-12,15-16,21-22H,4-5,13-14,17H2,1-3H3,(H,29,32)(H,30,33)/t21-,22+/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218465
PNG
(US9284333, 16ia | US9884860, Example 16ia)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ncccc2OC)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H32N4O4/c1-4-20(18-10-7-6-8-11-18)29-26(32)19-16-22(31-14-15-35-17-23(19)31)27(33)30-21(5-2)25-24(34-3)12-9-13-28-25/h6-13,16,20-21H,4-5,14-15,17H2,1-3H3,(H,29,32)(H,30,33)/t20-,21-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218468
PNG
(US9284333, 16id | US9884860, Example 16id)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccc(nc2)C(F)(F)F)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H29F3N4O3/c1-3-20(17-8-6-5-7-9-17)32-25(35)19-14-22(34-12-13-37-16-23(19)34)26(36)33-21(4-2)18-10-11-24(31-15-18)27(28,29)30/h5-11,14-15,20-21H,3-4,12-13,16H2,1-2H3,(H,32,35)(H,33,36)/t20-,21-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218474
PNG
(US9284333, 16ij | US9884860, Example 16ij)
Show SMILES CCC(NC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)c2COCCn12)c1nccs1 |r|
Show InChI InChI=1S/C24H28N4O3S/c1-3-18(16-8-6-5-7-9-16)26-22(29)17-14-20(28-11-12-31-15-21(17)28)23(30)27-19(4-2)24-25-10-13-32-24/h5-10,13-14,18-19H,3-4,11-12,15H2,1-2H3,(H,26,29)(H,27,30)/t18-,19?/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218260
PNG
(US9284333, 16j | US9884860, Example 16j)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccc(OC)nc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H32N4O4/c1-4-21(18-9-7-6-8-10-18)29-26(32)20-15-23(31-13-14-35-17-24(20)31)27(33)30-22(5-2)19-11-12-25(34-3)28-16-19/h6-12,15-16,21-22H,4-5,13-14,17H2,1-3H3,(H,29,32)(H,30,33)/t21-,22-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218502
PNG
(US9284333, 16jm | US9884860, Example 16jm)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2ncccn2)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H25N5O3/c1-2-18(16-7-4-3-5-8-16)27-23(30)19-13-17(20-15-31-12-11-28(19)20)22(29)26-14-21-24-9-6-10-25-21/h3-10,13,18H,2,11-12,14-15H2,1H3,(H,26,29)(H,27,30)/t18-/m1/s1
PDB

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n/an/a 1.50E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218533
PNG
(US9284333, 16kr)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2CSCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N3O2S/c1-3-19(17-9-5-4-6-10-17)24-22(27)20-14-18(21-15-29-13-12-26(20)21)23(28)25-11-7-8-16(25)2/h4-6,9-10,14,16,19H,3,7-8,11-13,15H2,1-2H3,(H,24,27)/t16-,19+/m0/s1
PDB

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n/an/a 470n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218541
PNG
(US9284333, 16kz | US9884860, Example 16kz)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCSCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N3O2S/c1-3-19(17-9-5-4-6-10-17)24-22(27)18-14-20(26-12-13-29-15-21(18)26)23(28)25-11-7-8-16(25)2/h4-6,9-10,14,16,19H,3,7-8,11-13,15H2,1-2H3,(H,24,27)/t16-,19+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218549
PNG
(US9284333, 16li | US9884860, Example 16li)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2cnccn2)n2CCOC(C)c12)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N5O3/c1-3-20(17-7-5-4-6-8-17)28-23(30)19-13-21(29-11-12-32-16(2)22(19)29)24(31)27-15-18-14-25-9-10-26-18/h4-10,13-14,16,20H,3,11-12,15H2,1-2H3,(H,27,31)(H,28,30)/t16?,20-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218550
PNG
(US9284333, 16lj | US9884860, Example 16lj)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2COCCn12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H30FN3O3/c1-15(2)22(17-6-8-18(25)9-7-17)26-23(29)20-13-19(21-14-31-12-11-28(20)21)24(30)27-10-4-5-16(27)3/h6-9,13,15-16,22H,4-5,10-12,14H2,1-3H3,(H,26,29)/t16-,22+/m0/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218556
PNG
(US9284333, 16lp | US9284333, 16lq | US9884860, Exa...)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(C(=O)NC(C)c2cnccn2)c2COCCn12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C25H28FN5O3/c1-15(2)23(17-4-6-18(26)7-5-17)30-25(33)21-12-19(22-14-34-11-10-31(21)22)24(32)29-16(3)20-13-27-8-9-28-20/h4-9,12-13,15-16,23H,10-11,14H2,1-3H3,(H,29,32)(H,30,33)/t16?,23-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218560
PNG
(US9284333, 16lu | US9884860, Example 16lu)
Show SMILES C[C@@H](NC(=O)c1cc(C(=O)NC(C)c2ncccn2)c2CCCCn12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H26FN5O2/c1-15(17-7-9-18(25)10-8-17)28-24(32)21-14-19(20-6-3-4-13-30(20)21)23(31)29-16(2)22-26-11-5-12-27-22/h5,7-12,14-16H,3-4,6,13H2,1-2H3,(H,28,32)(H,29,31)/t15-,16?/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218564
PNG
(US9284333, 16ly | US9884860, Example 16ly)
Show SMILES C[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCCCc12)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C23H28ClN3O2/c1-15-6-5-13-26(15)23(29)21-14-19(20-7-3-4-12-27(20)21)22(28)25-16(2)17-8-10-18(24)11-9-17/h8-11,14-16H,3-7,12-13H2,1-2H3,(H,25,28)/t15-,16+/m0/s1
PDB

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n/an/a 92n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218568
PNG
(US9284333, 16md | US9884860, Example 16md)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2nccs2)c2CCCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H26N4O2S/c1-2-18(16-8-4-3-5-9-16)26-23(29)20-14-17(19-10-6-7-12-27(19)20)22(28)25-15-21-24-11-13-30-21/h3-5,8-9,11,13-14,18H,2,6-7,10,12,15H2,1H3,(H,25,28)(H,26,29)/t18-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218569
PNG
(US9284333, 16me | US9884860, Example 16me)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)Nc2nc(C)c(C)s2)c2CCCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C24H28N4O2S/c1-4-19(17-10-6-5-7-11-17)26-23(30)21-14-18(20-12-8-9-13-28(20)21)22(29)27-24-25-15(2)16(3)31-24/h5-7,10-11,14,19H,4,8-9,12-13H2,1-3H3,(H,26,30)(H,25,27,29)/t19-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218624
PNG
(US9284333, 16mf | US9884860, Example 16mf)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCC2CC2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N3O2/c1-2-19(17-8-4-3-5-9-17)25-22(27)18-14-21(23(28)24-15-16-11-12-16)26-13-7-6-10-20(18)26/h3-5,8-9,14,16,19H,2,6-7,10-13,15H2,1H3,(H,24,28)(H,25,27)/t19-/m1/s1
PDB

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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218633
PNG
(US9284333, 16mp | US9884860, Example 16mp)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCC2CCCCC2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H35N3O2/c1-2-22(20-13-7-4-8-14-20)28-25(30)21-17-24(29-16-10-9-15-23(21)29)26(31)27-18-19-11-5-3-6-12-19/h4,7-8,13-14,17,19,22H,2-3,5-6,9-12,15-16,18H2,1H3,(H,27,31)(H,28,30)/t22-/m1/s1
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n/an/a 93n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218641
PNG
(US9284333, 16mx | US9884860, Example 16mx)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCCc2ccc(F)cc2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H30FN3O2/c1-2-23(20-8-4-3-5-9-20)30-26(32)22-18-25(31-17-7-6-10-24(22)31)27(33)29-16-15-19-11-13-21(28)14-12-19/h3-5,8-9,11-14,18,23H,2,6-7,10,15-17H2,1H3,(H,29,33)(H,30,32)/t23-/m1/s1
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n/an/a 97n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218642
PNG
(US9284333, 16my | US9884860, Example 16my)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCC2CCCC2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H33N3O2/c1-2-21(19-12-4-3-5-13-19)27-24(29)20-16-23(28-15-9-8-14-22(20)28)25(30)26-17-18-10-6-7-11-18/h3-5,12-13,16,18,21H,2,6-11,14-15,17H2,1H3,(H,26,30)(H,27,29)/t21-/m1/s1
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n/an/a 120n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218644
PNG
(US9284333, 16na | US9884860, Example 16na)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCC(CC2CC2)c2ccccc2)n2CCCCc12)c1ccccc1 |r|
Show InChI InChI=1S/C31H37N3O2/c1-2-27(24-13-7-4-8-14-24)33-30(35)26-20-29(34-18-10-9-15-28(26)34)31(36)32-21-25(19-22-16-17-22)23-11-5-3-6-12-23/h3-8,11-14,20,22,25,27H,2,9-10,15-19,21H2,1H3,(H,32,36)(H,33,35)/t25?,27-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218573
PNG
(US9284333, 16nh | US9884860, Example 16nh)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2COCCn12)c1ccccc1Cl |r|
Show InChI InChI=1S/C23H28ClN3O3/c1-3-19(16-8-4-5-9-18(16)24)25-22(28)20-13-17(21-14-30-12-11-27(20)21)23(29)26-10-6-7-15(26)2/h4-5,8-9,13,15,19H,3,6-7,10-12,14H2,1-2H3,(H,25,28)/t15-,19+/m0/s1
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n/an/a 90n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218586
PNG
(US9284333, 16nu | US9884860, Example 16nu)
Show SMILES C[C@H]1CCCN1C(=O)c1cc(C(=O)NCc2c(F)cccc2Cl)c2COCCn12 |r|
Show InChI InChI=1S/C21H23ClFN3O3/c1-13-4-3-7-25(13)21(28)18-10-14(19-12-29-9-8-26(18)19)20(27)24-11-15-16(22)5-2-6-17(15)23/h2,5-6,10,13H,3-4,7-9,11-12H2,1H3,(H,24,27)/t13-/m0/s1
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n/an/a 150n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218591
PNG
(US9284333, 16nz | US9884860, Example 16nz)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)C2CC2)n2CCOCc12)c1ccc(nc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H27F3N4O3/c1-3-17(15-6-7-20(27-11-15)23(24,25)26)29-21(31)16-10-18(30-8-9-33-12-19(16)30)22(32)28-13(2)14-4-5-14/h6-7,10-11,13-14,17H,3-5,8-9,12H2,1-2H3,(H,28,32)(H,29,31)/t13-,17-/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218275
PNG
(US9284333, 16p | US9884860, Example 16p)
Show SMILES CC(C)[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H30FN3O3/c1-15(2)22(17-6-8-18(25)9-7-17)26-23(29)19-13-20(28-11-12-31-14-21(19)28)24(30)27-10-4-5-16(27)3/h6-9,13,15-16,22H,4-5,10-12,14H2,1-3H3,(H,26,29)/t16-,22+/m0/s1
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n/an/a 380n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218654
PNG
(US9284333, 16rj | US9884860, Example 16rj)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2cccc(c2)S(=O)(=O)N(C)C)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C28H34N4O5S/c1-5-24(20-10-7-6-8-11-20)30-27(33)23-17-25(32-14-15-37-18-26(23)32)28(34)29-19(2)21-12-9-13-22(16-21)38(35,36)31(3)4/h6-13,16-17,19,24H,5,14-15,18H2,1-4H3,(H,29,34)(H,30,33)/t19?,24-/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218665
PNG
(US9284333, 16ru | US9884860, Example 16ru)
Show SMILES CC[C@@H](NC(=O)c1c(Br)c(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(nc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H26BrF3N4O3/c1-3-15(14-6-7-17(28-11-14)23(25,26)27)29-21(32)18-16-12-34-10-9-31(16)20(19(18)24)22(33)30-8-4-5-13(30)2/h6-7,11,13,15H,3-5,8-10,12H2,1-2H3,(H,29,32)/t13-,15+/m0/s1
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n/an/a 820n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218311
PNG
(US9284333, 16bb | US9884860, Example 16bb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(cc1Cl)C#N |r|
Show InChI InChI=1S/C24H27ClN4O3/c1-3-20(17-7-6-16(13-26)11-19(17)25)27-23(30)18-12-21(29-9-10-32-14-22(18)29)24(31)28-8-4-5-15(28)2/h6-7,11-12,15,20H,3-5,8-10,14H2,1-2H3,(H,27,30)/t15-,20+/m0/s1
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n/an/a 790n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218326
PNG
(US9284333, 16br | US9884860, Example 16br)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cnc(cc1Cl)C(F)(F)F |r|
Show InChI InChI=1S/C23H26ClF3N4O3/c1-3-17(15-11-28-20(10-16(15)24)23(25,26)27)29-21(32)14-9-18(31-7-8-34-12-19(14)31)22(33)30-6-4-5-13(30)2/h9-11,13,17H,3-8,12H2,1-2H3,(H,29,32)/t13-,17+/m0/s1
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n/an/a 880n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218261
PNG
(US9284333, 16k | US9884860, Example 16k)
Show SMILES CCOC(=O)CNC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)c2COCCn12 |r|
Show InChI InChI=1S/C22H27N3O5/c1-3-17(15-8-6-5-7-9-15)24-21(27)16-12-18(25-10-11-29-14-19(16)25)22(28)23-13-20(26)30-4-2/h5-9,12,17H,3-4,10-11,13-14H2,1-2H3,(H,23,28)(H,24,27)/t17-/m1/s1
PDB
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%