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Patent code US10166239

Compile Data Set for Download or QSAR

Found 241 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164888
PNG
(US10166239, Ex. 3-2-3 | US11406644, Example 3-2-3 ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cnn(CCN4CCOCC4)c3)cc2OC)cc1
Show InChI InChI=1S/C32H36N6O4/c1-39-27-7-3-23(4-8-27)22-42-30-10-5-24(17-31(30)40-2)20-38-29-9-6-25(18-28(29)35-32(38)33)26-19-34-37(21-26)12-11-36-13-15-41-16-14-36/h3-10,17-19,21H,11-16,20,22H2,1-2H3,(H2,33,35)
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n/an/a 3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164898
PNG
(US10166239, Ex. 3-12 | US11406644, Example 3-12 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)N3CCC(N)CC3)cc2OC)cn1
Show InChI InChI=1S/C27H31N5O3/c1-33-26-13-19(3-7-25(26)35-17-20-4-8-27(34-2)29-15-20)16-32-18-30-23-14-22(5-6-24(23)32)31-11-9-21(28)10-12-31/h3-8,13-15,18,21H,9-12,16-17,28H2,1-2H3
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n/an/a 637n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164904
PNG
(US10166239, Ex. 3-18-1 | US11406644, Example 3-18-...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCC(CC3)C(C)(C)N)cc2OC)cn1
Show InChI InChI=1S/C29H36N6O3/c1-29(2,30)22-9-11-34(12-10-22)23-14-24-28(32-16-23)35(19-33-24)17-20-5-7-25(26(13-20)36-3)38-18-21-6-8-27(37-4)31-15-21/h5-8,13-16,19,22H,9-12,17-18,30H2,1-4H3
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n/an/a 57n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164909
PNG
(US10166239, Ex. 3-18-6 | US11406644, Example 3-18-...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCC(N)CC3)cc2OC)cn1
Show InChI InChI=1S/C26H30N6O3/c1-33-24-11-18(3-5-23(24)35-16-19-4-6-25(34-2)28-13-19)15-32-17-30-22-12-21(14-29-26(22)32)31-9-7-20(27)8-10-31/h3-6,11-14,17,20H,7-10,15-16,27H2,1-2H3
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n/an/a 12n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164910
PNG
(US10166239, Ex. 3-18-7 | US11406644, Example 3-18-...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCC[C@H]3C(O)=O)cc2OC)cn1 |r|
Show InChI InChI=1S/C26H27N5O5/c1-34-23-10-17(5-7-22(23)36-15-18-6-8-24(35-2)27-12-18)14-30-16-29-20-11-19(13-28-25(20)30)31-9-3-4-21(31)26(32)33/h5-8,10-13,16,21H,3-4,9,14-15H2,1-2H3,(H,32,33)/t21-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164912
PNG
(US10166239, Ex. 3-20 | US11406644, Example 3-20 | ...)
Show SMILES COc1cc(Cn2cnc3cc(cnc23)-c2cnn(c2)C2CCNCC2)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C29H31N7O2/c1-20-3-4-22(13-31-20)18-38-27-6-5-21(11-28(27)37-2)16-35-19-33-26-12-23(14-32-29(26)35)24-15-34-36(17-24)25-7-9-30-10-8-25/h3-6,11-15,17,19,25,30H,7-10,16,18H2,1-2H3
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n/an/a 0.600n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164917
PNG
(US10166239, Ex. 3-25 | US11406644, Example 3-25 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-n3cc(nn3)C3CCCNC3)cc2OC)cn1
Show InChI InChI=1S/C28H30N8O3/c1-37-26-10-19(5-7-25(26)39-17-20-6-8-27(38-2)30-12-20)15-35-18-32-23-11-22(14-31-28(23)35)36-16-24(33-34-36)21-4-3-9-29-13-21/h5-8,10-12,14,16,18,21,29H,3-4,9,13,15,17H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164922
PNG
(US10166239, Ex. 3-30 | US11406644, Example 3-30 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)C3=CC4(C)CN3CCC4)cc2OC)cn1 |t:24|
Show InChI InChI=1S/C29H31N5O3/c1-29-9-4-10-33(18-29)24(13-29)22-12-23-28(31-15-22)34(19-32-23)16-20-5-7-25(26(11-20)35-2)37-17-21-6-8-27(36-3)30-14-21/h5-8,11-15,19H,4,9-10,16-18H2,1-3H3
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n/an/a 201n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164923
PNG
(US10166239, Ex. 3-31 | US11406644, Example 3-31 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)C3=CC4(C)CN3CCC4)cc2OC)cn1 |t:24|
Show InChI InChI=1S/C30H32N4O3/c1-30-11-4-12-33(19-30)26(15-30)23-7-8-25-24(14-23)32-20-34(25)17-21-5-9-27(28(13-21)35-2)37-18-22-6-10-29(36-3)31-16-22/h5-10,13-16,20H,4,11-12,17-19H2,1-3H3
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n/an/a 1.48E+3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164924
PNG
(US10166239, Ex. 3-32 | US11406644, Example 3-32 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)C3=CC4(O)CN3CCC4)cc2OC)cn1 |t:24|
Show InChI InChI=1S/C28H29N5O4/c1-35-25-10-19(4-6-24(25)37-16-20-5-7-26(36-2)29-13-20)15-33-18-31-22-11-21(14-30-27(22)33)23-12-28(34)8-3-9-32(23)17-28/h4-7,10-14,18,34H,3,8-9,15-17H2,1-2H3
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n/an/a 41n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164931
PNG
(US10166239, Ex. 3-35-5 | US11406644, Example 3-35-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(C)n1
Show InChI InChI=1S/C23H23N7O2S/c1-14-27-18(13-33-14)12-32-20-5-4-15(6-21(20)31-3)10-30-22-19(28-23(30)24)7-16(8-25-22)17-9-26-29(2)11-17/h4-9,11,13H,10,12H2,1-3H3,(H2,24,28)
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n/an/a 0.5n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164933
PNG
(US10166239, Ex. 3-37-1 | US11406644, Example 3-37-...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccc(F)cc3)cc2OC)cn1
Show InChI InChI=1S/C27H24FN5O3/c1-34-24-11-17(3-9-23(24)36-16-18-4-10-25(35-2)30-13-18)15-33-26-22(32-27(33)29)12-20(14-31-26)19-5-7-21(28)8-6-19/h3-14H,15-16H2,1-2H3,(H2,29,32)
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n/an/a 9n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164941
PNG
(US10166239, Ex. 3-40-1 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C26H23F3N6O3/c1-34-14-19(12-32-34)18-10-21-24(31-11-18)35(25(30)33-21)13-17-5-8-22(23(9-17)36-2)37-15-16-3-6-20(7-4-16)38-26(27,28)29/h3-12,14H,13,15H2,1-2H3,(H2,30,33)
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n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164943
PNG
(US10166239, Ex. 3-40-3 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(C)C
Show InChI InChI=1S/C27H29N7O2/c1-17(2)22-7-5-19(11-29-22)16-36-24-8-6-18(9-25(24)35-4)14-34-26-23(32-27(34)28)10-20(12-30-26)21-13-31-33(3)15-21/h5-13,15,17H,14,16H2,1-4H3,(H2,28,32)
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n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164945
PNG
(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(n1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N7O2S/c1-32-10-15(8-29-32)14-6-17-20(28-7-14)33(22(27)31-17)9-13-3-4-18(19(5-13)34-2)35-11-16-12-36-21(30-16)23(24,25)26/h3-8,10,12H,9,11H2,1-2H3,(H2,27,31)
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n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164951
PNG
(US10166239, Ex. 3-46 | US11406644, Example 3-46 | ...)
Show SMILES COc1ccc(COc2ccc(cc2OC)C(C)n2c(N)nc3cc(ccc23)-c2ccc(F)cc2)cn1
Show InChI InChI=1S/C29H27FN4O3/c1-18(21-8-12-26(27(15-21)35-2)37-17-19-4-13-28(36-3)32-16-19)34-25-11-7-22(14-24(25)33-29(34)31)20-5-9-23(30)10-6-20/h4-16,18H,17H2,1-3H3,(H2,31,33)
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n/an/a 37n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164954
PNG
(US10166239, Ex. 3-48-2 | US11406644, Example 3-48-...)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C(F)(F)F)C(C)n1cnc2cc(ccc12)C#CCCO
Show InChI InChI=1S/C27H24F3N3O3/c1-18(33-17-32-22-13-19(5-3-4-12-34)6-9-23(22)33)21-8-10-24(25(14-21)35-2)36-16-20-7-11-26(31-15-20)27(28,29)30/h6-11,13-15,17-18,34H,4,12,16H2,1-2H3
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n/an/a 127n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164956
PNG
(US10166239, Ex. 3-49-6a | US11406644, Example 3-49...)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)/t16-/m0/s1
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n/an/a 0.300n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164956
PNG
(US10166239, Ex. 3-49-6a | US11406644, Example 3-49...)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)/t16-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164961
PNG
(US10166239, Ex. 3-52 | US11406644, Example 3-52 | ...)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C(F)(F)F)C(C)n1cnc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H23F3N6O2/c1-16(35-15-32-21-8-19(11-31-25(21)35)20-12-33-34(2)13-20)18-5-6-22(23(9-18)36-3)37-14-17-4-7-24(30-10-17)26(27,28)29/h4-13,15-16H,14H2,1-3H3
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n/an/a 56n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164965
PNG
(US10166239, Ex. 3-56 | US11406644, Example 3-56 | ...)
Show SMILES COc1cc(Cn2cnc3cc(cnc23)C#CCCO)ccc1OCc1ccc(nc1)C(F)F
Show InChI InChI=1S/C25H22F2N4O3/c1-33-23-11-18(6-8-22(23)34-15-19-5-7-20(24(26)27)28-13-19)14-31-16-30-21-10-17(4-2-3-9-32)12-29-25(21)31/h5-8,10-13,16,24,32H,3,9,14-15H2,1H3
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n/an/a 17n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164967
PNG
(US10166239, Ex. 3-58-1 | US11406644, Example 3-58-...)
Show SMILES COc1ccc(cn1)C(C)Oc1ccc(Cn2cnc3cc(cnc23)-c2ccnn2C)cc1OC
Show InChI InChI=1S/C26H26N6O3/c1-17(19-6-8-25(34-4)27-13-19)35-23-7-5-18(11-24(23)33-3)15-32-16-29-21-12-20(14-28-26(21)32)22-9-10-30-31(22)2/h5-14,16-17H,15H2,1-4H3
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n/an/a 219n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164887
PNG
(US10166239, Ex. 3-2-2 | US11406644, Example 3-2-2 ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3ccncc3)cc2OC)cc1
Show InChI InChI=1S/C28H26N4O3/c1-33-23-7-3-19(4-8-23)18-35-26-10-5-20(15-27(26)34-2)17-32-25-9-6-22(16-24(25)31-28(32)29)21-11-13-30-14-12-21/h3-16H,17-18H2,1-2H3,(H2,29,31)
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n/an/a 2n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164889
PNG
(US10166239, Ex. 3-3 | US11406644, Example 3-3 | US...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3ccc(nc3)P(C)(C)=O)cc2OC)cc1
Show InChI InChI=1S/C30H31N4O4P/c1-36-24-10-5-20(6-11-24)19-38-27-13-7-21(15-28(27)37-2)18-34-26-12-8-22(16-25(26)33-30(34)31)23-9-14-29(32-17-23)39(3,4)35/h5-17H,18-19H2,1-4H3,(H2,31,33)
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n/an/a 1n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164891
PNG
(US10166239, Ex. 3-5 | US11406644, Example 3-5 | US...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)-c3cnn(c3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C30H32N6O3/c1-37-29-13-21(3-7-28(29)39-19-22-4-8-30(38-2)32-15-22)17-35-20-33-26-14-23(5-6-27(26)35)24-16-34-36(18-24)25-9-11-31-12-10-25/h3-8,13-16,18,20,25,31H,9-12,17,19H2,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164907
PNG
(US10166239, Ex. 3-18-4 | US11406644, Example 3-18-...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCN4CCC3CC4)cc2OC)cn1 |(-1.02,-9.85,;-1.79,-8.52,;-1.02,-7.18,;-1.79,-5.85,;-1.02,-4.52,;.52,-4.52,;1.61,-3.43,;1.21,-1.94,;2.3,-.85,;1.53,.48,;2.3,1.82,;3.84,1.82,;4.61,3.15,;3.84,4.48,;4.75,5.73,;3.84,6.97,;2.38,6.5,;1.04,7.27,;-.29,6.5,;-.29,4.96,;1.04,4.19,;2.38,4.96,;-1.62,7.27,;-2.9,6.4,;-4.37,6.86,;-4.93,8.29,;-4.16,9.62,;-2.64,9.85,;-1.51,8.8,;-2.53,9.45,;-3.25,8.29,;4.61,.48,;3.84,-.85,;4.93,-1.94,;4.53,-3.43,;1.29,-5.85,;.52,-7.18,)|
Show InChI InChI=1S/C28H32N6O3/c1-35-26-13-20(3-5-25(26)37-18-21-4-6-27(36-2)29-15-21)17-33-19-31-24-14-23(16-30-28(24)33)34-12-11-32-9-7-22(34)8-10-32/h3-6,13-16,19,22H,7-12,17-18H2,1-2H3
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n/an/a 470n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164909
PNG
(US10166239, Ex. 3-18-6 | US11406644, Example 3-18-...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCC(N)CC3)cc2OC)cn1
Show InChI InChI=1S/C26H30N6O3/c1-33-24-11-18(3-5-23(24)35-16-19-4-6-25(34-2)28-13-19)15-32-17-30-22-12-21(14-29-26(22)32)31-9-7-20(27)8-10-31/h3-6,11-14,17,20H,7-10,15-16,27H2,1-2H3
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n/an/a 232n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164917
PNG
(US10166239, Ex. 3-25 | US11406644, Example 3-25 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-n3cc(nn3)C3CCCNC3)cc2OC)cn1
Show InChI InChI=1S/C28H30N8O3/c1-37-26-10-19(5-7-25(26)39-17-20-6-8-27(38-2)30-12-20)15-35-18-32-23-11-22(14-31-28(23)35)36-16-24(33-34-36)21-4-3-9-29-13-21/h5-8,10-12,14,16,18,21,29H,3-4,9,13,15,17H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164921
PNG
(US10166239, Ex. 3-29 | US11406644, Example 3-29 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)N3CCN(C)CC3=O)cc2OC)cn1
Show InChI InChI=1S/C27H29N5O4/c1-30-10-11-32(27(33)16-30)21-6-7-23-22(13-21)29-18-31(23)15-19-4-8-24(25(12-19)34-2)36-17-20-5-9-26(35-3)28-14-20/h4-9,12-14,18H,10-11,15-17H2,1-3H3
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n/an/a 4.28E+3n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164925
PNG
(US10166239, Ex. 3-33 | US11406644, Example 3-33 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)C3=CC4(O)CN3CCC4)cc2OC)cn1 |t:24|
Show InChI InChI=1S/C29H30N4O4/c1-35-27-12-20(4-8-26(27)37-17-21-5-9-28(36-2)30-15-21)16-33-19-31-23-13-22(6-7-24(23)33)25-14-29(34)10-3-11-32(25)18-29/h4-9,12-15,19,34H,3,10-11,16-18H2,1-2H3
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n/an/a 372n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164925
PNG
(US10166239, Ex. 3-33 | US11406644, Example 3-33 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)C3=CC4(O)CN3CCC4)cc2OC)cn1 |t:24|
Show InChI InChI=1S/C29H30N4O4/c1-35-27-12-20(4-8-26(27)37-17-21-5-9-28(36-2)30-15-21)16-33-19-31-23-13-22(6-7-24(23)33)25-14-29(34)10-3-11-32(25)18-29/h4-9,12-15,19,34H,3,10-11,16-18H2,1-2H3
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n/an/a 151n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164927
PNG
(US10166239, Ex. 3-35-1 | US11406644, Example 3-35-...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1
Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)
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n/an/a 0.600n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164928
PNG
(US10166239, Ex. 3-35-2 | US11406644, Example 3-35-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N7O2/c1-34-13-18(11-32-34)17-8-19-23(31-10-17)35(24(29)33-19)12-15-3-5-20(21(7-15)36-2)37-14-16-4-6-22(30-9-16)25(26,27)28/h3-11,13H,12,14H2,1-2H3,(H2,29,33)
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n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164936
PNG
(US10166239, Ex. 3-37-4 | US11406644, Example 3-37-...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3c(C)nn(C)c3C)cc2OC)cn1
Show InChI InChI=1S/C27H29N7O3/c1-16-25(17(2)33(3)32-16)20-11-21-26(30-13-20)34(27(28)31-21)14-18-6-8-22(23(10-18)35-4)37-15-19-7-9-24(36-5)29-12-19/h6-13H,14-15H2,1-5H3,(H2,28,31)
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n/an/a 13n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164937
PNG
(US10166239, Ex. 3-37-5 | US11406644, Example 3-37-...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccncc3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-11-17(3-5-22(23)35-16-18-4-6-24(34-2)29-13-18)15-32-25-21(31-26(32)27)12-20(14-30-25)19-7-9-28-10-8-19/h3-14H,15-16H2,1-2H3,(H2,27,31)
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n/an/a 0.700n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164939
PNG
(US10166239, Ex. 3-38 | US11406644, Example 3-38 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccccn3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-11-17(6-8-22(23)35-16-18-7-9-24(34-2)29-13-18)15-32-25-21(31-26(32)27)12-19(14-30-25)20-5-3-4-10-28-20/h3-14H,15-16H2,1-2H3,(H2,27,31)
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n/an/a 4n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164943
PNG
(US10166239, Ex. 3-40-3 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(C)C
Show InChI InChI=1S/C27H29N7O2/c1-17(2)22-7-5-19(11-29-22)16-36-24-8-6-18(9-25(24)35-4)14-34-26-23(32-27(34)28)10-20(12-30-26)21-13-31-33(3)15-21/h5-13,15,17H,14,16H2,1-4H3,(H2,28,32)
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n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164943
PNG
(US10166239, Ex. 3-40-3 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(C)C
Show InChI InChI=1S/C27H29N7O2/c1-17(2)22-7-5-19(11-29-22)16-36-24-8-6-18(9-25(24)35-4)14-34-26-23(32-27(34)28)10-20(12-30-26)21-13-31-33(3)15-21/h5-13,15,17H,14,16H2,1-4H3,(H2,28,32)
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n/an/a 5n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164944
PNG
(US10166239, Ex. 3-40-4 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(CC(F)(F)F)cc1
Show InChI InChI=1S/C27H25F3N6O2/c1-35-15-21(13-33-35)20-10-22-25(32-12-20)36(26(31)34-22)14-19-7-8-23(24(9-19)37-2)38-16-18-5-3-17(4-6-18)11-27(28,29)30/h3-10,12-13,15H,11,14,16H2,1-2H3,(H2,31,34)
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n/an/a 0.200n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164944
PNG
(US10166239, Ex. 3-40-4 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(CC(F)(F)F)cc1
Show InChI InChI=1S/C27H25F3N6O2/c1-35-15-21(13-33-35)20-10-22-25(32-12-20)36(26(31)34-22)14-19-7-8-23(24(9-19)37-2)38-16-18-5-3-17(4-6-18)11-27(28,29)30/h3-10,12-13,15H,11,14,16H2,1-2H3,(H2,31,34)
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n/an/a 0.300n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164945
PNG
(US10166239, Ex. 3-40-5 | US11406644, Example 3-40-...)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(n1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N7O2S/c1-32-10-15(8-29-32)14-6-17-20(28-7-14)33(22(27)31-17)9-13-3-4-18(19(5-13)34-2)35-11-16-12-36-21(30-16)23(24,25)26/h3-8,10,12H,9,11H2,1-2H3,(H2,27,31)
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n/an/a 7n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164950
PNG
(US10166239, Ex. 3-45 | US11406644, Example 3-45 | ...)
Show SMILES COc1ccc(COc2ccc(cc2OC)C(C)n2c(N)nc3cc(ccc23)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C27H28N6O3/c1-17(33-23-8-6-20(11-22(23)31-27(33)28)21-14-30-32(2)15-21)19-7-9-24(25(12-19)34-3)36-16-18-5-10-26(35-4)29-13-18/h5-15,17H,16H2,1-4H3,(H2,28,31)
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n/an/a 73n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164951
PNG
(US10166239, Ex. 3-46 | US11406644, Example 3-46 | ...)
Show SMILES COc1ccc(COc2ccc(cc2OC)C(C)n2c(N)nc3cc(ccc23)-c2ccc(F)cc2)cn1
Show InChI InChI=1S/C29H27FN4O3/c1-18(21-8-12-26(27(15-21)35-2)37-17-19-4-13-28(36-3)32-16-19)34-25-11-7-22(14-24(25)33-29(34)31)20-5-9-23(30)10-6-20/h4-16,18H,17H2,1-3H3,(H2,31,33)
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n/an/a 85n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM164957
PNG
(US10166239, Ex. 3-49-6b | US11406644, Example 3-49...)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1 |r|
Show InChI InChI=1S/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkA (0.4 nM, Carna 08-186) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164886
PNG
(US10166239, Ex. 3-2-1 | US11406644, Example 3-2-1 ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cncnc3)cc2OC)cc1
Show InChI InChI=1S/C27H25N5O3/c1-33-22-7-3-18(4-8-22)16-35-25-10-5-19(11-26(25)34-2)15-32-24-9-6-20(12-23(24)31-27(32)28)21-13-29-17-30-14-21/h3-14,17H,15-16H2,1-2H3,(H2,28,31)
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n/an/a 23n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164893
PNG
(US10166239, Ex. 3-7 | US11406644, Example 3-7 | US...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)-c3nnc(o3)C3CCCNC3)cc2OC)cn1
Show InChI InChI=1S/C29H30N6O4/c1-36-26-12-19(5-9-25(26)38-17-20-6-10-27(37-2)31-14-20)16-35-18-32-23-13-21(7-8-24(23)35)28-33-34-29(39-28)22-4-3-11-30-15-22/h5-10,12-14,18,22,30H,3-4,11,15-17H2,1-2H3
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n/an/a 28n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164895
PNG
(US10166239, Ex. 3-9 | US11406644, Example 3-9 | US...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)C3CCOCC3)cc2OC)cn1
Show InChI InChI=1S/C27H29N3O4/c1-31-26-13-19(3-7-25(26)34-17-20-4-8-27(32-2)28-15-20)16-30-18-29-23-14-22(5-6-24(23)30)21-9-11-33-12-10-21/h3-8,13-15,18,21H,9-12,16-17H2,1-2H3
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n/an/a 257n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM164899
PNG
(US10166239, Ex. 3-13 | US11406644, Example 3-13 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)N3CCN(C)CC3)cc2OC)cn1
Show InChI InChI=1S/C27H31N5O3/c1-30-10-12-31(13-11-30)22-6-7-24-23(15-22)29-19-32(24)17-20-4-8-25(26(14-20)33-2)35-18-21-5-9-27(34-3)28-16-21/h4-9,14-16,19H,10-13,17-18H2,1-3H3
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n/an/a 32n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, c-FMS (0.14 nM, Carna 08-155) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164901
PNG
(US10166239, Ex. 3-15 | US11406644, Example 3-15 | ...)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
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n/an/a 0.100n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor


(Homo sapiens (Human))		BDBM164903
PNG
(US10166239, Ex. 3-28 | US11274108, Example 1-254 |...)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCN(C)CC3)cc2OC)cn1
Show InChI InChI=1S/C26H30N6O3/c1-30-8-10-31(11-9-30)21-13-22-26(28-15-21)32(18-29-22)16-19-4-6-23(24(12-19)33-2)35-17-20-5-7-25(34-3)27-14-20/h4-7,12-15,18H,8-11,16-17H2,1-3H3
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n/an/a 66n/an/an/an/an/an/a



Genzyme Corporation

US Patent


Assay Description
In a 384 well polypropylene plate, TrkB (0.6 nM, Carna 08-187) was pre-incubated in a 100 mM Hepes-NaOH pH 7.5 buffer containing 0.01% Triton X-100, ...

US Patent US10166239 (2019)


BindingDB Entry DOI: 10.7270/Q2WW7KSN
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%