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Patent code US9284319

Compile Data Set for Download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214639
PNG
(US9284319, 7)
Show SMILES OC[C@@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-12-13-7-8-22(11-13)19-6-5-18-20-10-15(23(18)21-19)17-9-14-3-1-2-4-16(14)25-17/h1-6,9-10,13,24H,7-8,11-12H2/t13-/m1/s1
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US Patent
n/an/a 4n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214635
PNG
(US9284319, 3)
Show SMILES OC1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2
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n/an/a 6n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214633
PNG
(US9284319, 1)
Show SMILES OC[C@@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m0/s1
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n/an/a 7n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214649
PNG
(US9284319, R7 | US9730929, Example R7 | US9783543,...)
Show SMILES CN(C)CCNc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H19N5O/c1-22(2)10-9-19-17-7-8-18-20-12-14(23(18)21-17)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10H2,1-2H3,(H,19,21)
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n/an/a 11n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214638
PNG
(US9284319, 6)
Show SMILES OC1CN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H14N4O2/c22-12-9-20(10-12)17-6-5-16-18-8-13(21(16)19-17)15-7-11-3-1-2-4-14(11)23-15/h1-8,12,22H,9-10H2
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n/an/a 12n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214649
PNG
(US9284319, R7 | US9730929, Example R7 | US9783543,...)
Show SMILES CN(C)CCNc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H19N5O/c1-22(2)10-9-19-17-7-8-18-20-12-14(23(18)21-17)16-11-13-5-3-4-6-15(13)24-16/h3-8,11-12H,9-10H2,1-2H3,(H,19,21)
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n/an/a 13n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214637
PNG
(US9284319, 5)
Show SMILES OCC1CCCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-13-14-4-3-9-23(12-14)20-8-7-19-21-11-16(24(19)22-20)18-10-15-5-1-2-6-17(15)26-18/h1-2,5-8,10-11,14,25H,3-4,9,12-13H2
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n/an/a 13n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214639
PNG
(US9284319, 7)
Show SMILES OC[C@@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-12-13-7-8-22(11-13)19-6-5-18-20-10-15(23(18)21-19)17-9-14-3-1-2-4-16(14)25-17/h1-6,9-10,13,24H,7-8,11-12H2/t13-/m1/s1
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n/an/a 14n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214636
PNG
(US9284319, 4)
Show SMILES O[C@@H]1CCCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-14-5-3-9-22(12-14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m1/s1
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n/an/a 15n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214641
PNG
(US9284319, 9)
Show SMILES O[C@@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2/t13-/m1/s1
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n/an/a 15n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214640
PNG
(US9284319, 8)
Show SMILES O[C@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2/t13-/m0/s1
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n/an/a 15n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214648
PNG
(US9284319, R6 | US9730929, Example R6 | US9783543,...)
Show SMILES C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H17N5O/c1-2-7-18-15(5-1)13-19(27-18)17-14-24-21-9-8-20(25-26(17)21)23-12-10-16-6-3-4-11-22-16/h1-9,11,13-14H,10,12H2,(H,23,25)
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n/an/a 17n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214635
PNG
(US9284319, 3)
Show SMILES OC1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2
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n/an/a 17n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214633
PNG
(US9284319, 1)
Show SMILES OC[C@@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m0/s1
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n/an/a 19n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214640
PNG
(US9284319, 8)
Show SMILES O[C@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C18H16N4O2/c23-13-7-8-21(11-13)18-6-5-17-19-10-14(22(17)20-18)16-9-12-3-1-2-4-15(12)24-16/h1-6,9-10,13,23H,7-8,11H2/t13-/m0/s1
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n/an/a 19n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214642
PNG
(US9284319, 10)
Show SMILES OC[C@H]1CCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-12-13-7-8-22(11-13)19-6-5-18-20-10-15(23(18)21-19)17-9-14-3-1-2-4-16(14)25-17/h1-6,9-10,13,24H,7-8,11-12H2/t13-/m0/s1
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n/an/a 20n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214634
PNG
(US9284319, 2)
Show SMILES OC[C@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m1/s1
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n/an/a 22n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214650
PNG
(US10688093, Compound 229_0237_0073 | US11701353, C...)
Show SMILES C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1
Show InChI InChI=1S/C20H15N5O/c1-2-4-17-15(3-1)11-18(26-17)16-13-23-20-6-5-19(24-25(16)20)22-12-14-7-9-21-10-8-14/h1-11,13H,12H2,(H,22,24)
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n/an/a 23n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214638
PNG
(US9284319, 6)
Show SMILES OC1CN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C17H14N4O2/c22-12-9-20(10-12)17-6-5-16-18-8-13(21(16)19-17)15-7-11-3-1-2-4-14(11)23-15/h1-8,12,22H,9-10H2
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n/an/a 33n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214650
PNG
(US10688093, Compound 229_0237_0073 | US11701353, C...)
Show SMILES C(Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1)c1ccncc1
Show InChI InChI=1S/C20H15N5O/c1-2-4-17-15(3-1)11-18(26-17)16-13-23-20-6-5-19(24-25(16)20)22-12-14-7-9-21-10-8-14/h1-11,13H,12H2,(H,22,24)
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n/an/a 34n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214637
PNG
(US9284319, 5)
Show SMILES OCC1CCCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C20H20N4O2/c25-13-14-4-3-9-23(12-14)20-8-7-19-21-11-16(24(19)22-20)18-10-15-5-1-2-6-17(15)26-18/h1-2,5-8,10-11,14,25H,3-4,9,12-13H2
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n/an/a 37n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214634
PNG
(US9284319, 2)
Show SMILES OC[C@H]1CCCN1c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-12-14-5-3-9-22(14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m1/s1
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n/an/a 42n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214636
PNG
(US9284319, 4)
Show SMILES O[C@@H]1CCCN(C1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1 |r|
Show InChI InChI=1S/C19H18N4O2/c24-14-5-3-9-22(12-14)19-8-7-18-20-11-15(23(18)21-19)17-10-13-4-1-2-6-16(13)25-17/h1-2,4,6-8,10-11,14,24H,3,5,9,12H2/t14-/m1/s1
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n/an/a 44n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214644
PNG
(US9284319, R2 | US9730929, Example R2 | US9783543,...)
Show SMILES N(c1ccccc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H13N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h1-12H,(H,20,21)
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n/an/a 64n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214645
PNG
(US9284319, R2 | US9730929, Example R3 | US9783543,...)
Show SMILES C1CCC(CC1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H19N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h6-12,14H,1-5H2,(H,20,21)
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n/an/a 118n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214644
PNG
(US9284319, R2 | US9730929, Example R2 | US9783543,...)
Show SMILES N(c1ccccc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H13N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h1-12H,(H,20,21)
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n/an/a 170n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214643
PNG
(US9284319, R1 | US9730929, Example R1 | US9783543,...)
Show SMILES C(Nc1ccc2ncc(-c3ccncc3)n2n1)c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-4-14(5-3-1)12-20-17-6-7-18-21-13-16(23(18)22-17)15-8-10-19-11-9-15/h1-11,13H,12H2,(H,20,22)
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n/an/a 181n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214647
PNG
(US10688093, Compound BF000817099 | US11701353, Com...)
Show SMILES C1CC(CCO1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H17N5O/c1-2-16-18-11-14(12-3-7-17-8-4-12)21(16)20-15(1)19-13-5-9-22-10-6-13/h1-4,7-8,11,13H,5-6,9-10H2,(H,19,20)
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n/an/a 192n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214645
PNG
(US9284319, R2 | US9730929, Example R3 | US9783543,...)
Show SMILES C1CCC(CC1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C17H19N5/c1-2-4-14(5-3-1)20-16-6-7-17-19-12-15(22(17)21-16)13-8-10-18-11-9-13/h6-12,14H,1-5H2,(H,20,21)
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n/an/a 230n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214646
PNG
(US9284319, R4 | US9730929, Example R4 | US9783543,...)
Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)
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n/an/a 245n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214648
PNG
(US9284319, R6 | US9730929, Example R6 | US9783543,...)
Show SMILES C(Cc1ccccn1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C21H17N5O/c1-2-7-18-15(5-1)13-19(27-18)17-14-24-21-9-8-20(25-26(17)21)23-12-10-16-6-3-4-11-22-16/h1-9,11,13-14H,10,12H2,(H,23,25)
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n/an/a 250n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214643
PNG
(US9284319, R1 | US9730929, Example R1 | US9783543,...)
Show SMILES C(Nc1ccc2ncc(-c3ccncc3)n2n1)c1ccccc1
Show InChI InChI=1S/C18H15N5/c1-2-4-14(5-3-1)12-20-17-6-7-18-21-13-16(23(18)22-17)15-8-10-19-11-9-15/h1-11,13H,12H2,(H,20,22)
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n/an/a 370n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214647
PNG
(US10688093, Compound BF000817099 | US11701353, Com...)
Show SMILES C1CC(CCO1)Nc1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H17N5O/c1-2-16-18-11-14(12-3-7-17-8-4-12)21(16)20-15(1)19-13-5-9-22-10-6-13/h1-4,7-8,11,13H,5-6,9-10H2,(H,19,20)
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n/an/a 480n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
Glutathione S-transferase A1/Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a) [T344D]


(Homo sapiens (Human))		BDBM214646
PNG
(US9284319, R4 | US9730929, Example R4 | US9783543,...)
Show SMILES N(c1ccncc1)c1ccc2ncc(-c3ccncc3)n2n1
Show InChI InChI=1S/C16H12N6/c1-2-16-19-11-14(12-3-7-17-8-4-12)22(16)21-15(1)20-13-5-9-18-10-6-13/h1-11H,(H,18,20,21)
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n/an/a 810n/an/an/an/a7.522



BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...

US Patent US9284319 (2016)


BindingDB Entry DOI: 10.7270/Q2765D6D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%