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Patent code US9284333

Compile Data Set for Download or QSAR

Found 390 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218253
PNG
(US9284333, 16c)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(c(Cl)c1)C(F)(F)F |r|
Show InChI InChI=1S/C24H27ClF3N3O3/c1-3-19(15-6-7-17(18(25)11-15)24(26,27)28)29-22(32)16-12-20(31-9-10-34-13-21(16)31)23(33)30-8-4-5-14(30)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,29,32)/t14-,19+/m0/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218383
PNG
(US9284333, 16eb | US9884860, Example 16eb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C27H27F4N3O3/c1-3-22(18-4-8-19(9-5-18)27(29,30)31)33-25(35)21-14-23(34-12-13-37-15-24(21)34)26(36)32-16(2)17-6-10-20(28)11-7-17/h4-11,14,16,22H,3,12-13,15H2,1-2H3,(H,32,36)(H,33,35)/t16-,22-/m1/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218357
PNG
(US9284333, 16cy | US9884860, Example 16cy)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCCC2)n2CCOCc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C22H26ClN3O3/c1-2-18(15-7-3-4-8-17(15)23)24-21(27)16-13-19(22(28)25-9-5-6-10-25)26-11-12-29-14-20(16)26/h3-4,7-8,13,18H,2,5-6,9-12,14H2,1H3,(H,24,27)/t18-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218361
PNG
(US9284333, 16de | US9884860, Example 16de)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCCC2)n2CCOCc12)c1ccc(F)cc1F |r|
Show InChI InChI=1S/C22H25F2N3O3/c1-2-18(15-6-5-14(23)11-17(15)24)25-21(28)16-12-19(22(29)26-7-3-4-8-26)27-9-10-30-13-20(16)27/h5-6,11-12,18H,2-4,7-10,13H2,1H3,(H,25,28)/t18-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218370
PNG
(US9284333, 16dn | US9884860, Example 16dn)
Show SMILES C[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H26FN3O3/c1-16(18-6-4-3-5-7-18)27-24(30)21-14-22(29-12-13-32-15-23(21)29)25(31)28-17(2)19-8-10-20(26)11-9-19/h3-11,14,16-17H,12-13,15H2,1-2H3,(H,27,30)(H,28,31)/t16-,17-/m1/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218377
PNG
(US9284333, 16dv)
Show SMILES CC[C@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccccc2)n2CCOCc12)c1cnc(OC)cn1 |r|
Show InChI InChI=1S/C25H29N5O4/c1-4-19(20-13-27-23(33-3)14-26-20)29-24(31)18-12-21(30-10-11-34-15-22(18)30)25(32)28-16(2)17-8-6-5-7-9-17/h5-9,12-14,16,19H,4,10-11,15H2,1-3H3,(H,28,32)(H,29,31)/t16-,19+/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218380
PNG
(US9284333, 16dy | US9884860, Example 16dy)
Show SMILES C[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ncccn2)c2COCCn12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C23H24FN5O3/c1-14(16-4-6-17(24)7-5-16)27-23(31)19-12-18(20-13-32-11-10-29(19)20)22(30)28-15(2)21-25-8-3-9-26-21/h3-9,12,14-15H,10-11,13H2,1-2H3,(H,27,31)(H,28,30)/t14-,15-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218408
PNG
(US9284333, 16fg | US9884860, Example 16fg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CC[C@@H](C2)OCC(C)C)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H35N3O4/c1-4-22(19-8-6-5-7-9-19)27-25(30)21-14-23(29-12-13-32-17-24(21)29)26(31)28-11-10-20(15-28)33-16-18(2)3/h5-9,14,18,20,22H,4,10-13,15-17H2,1-3H3,(H,27,30)/t20-,22+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218416
PNG
(US9284333, 16fo | US9884860, Example 16fo)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2CC(=O)OC(C)C)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H35N3O5/c1-4-22(19-9-6-5-7-10-19)28-26(32)21-16-23(30-13-14-34-17-24(21)30)27(33)29-12-8-11-20(29)15-25(31)35-18(2)3/h5-7,9-10,16,18,20,22H,4,8,11-15,17H2,1-3H3,(H,28,32)/t20-,22-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218422
PNG
(US9284333, 16fu | US9884860, Example 16fu)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CC[C@@H](C2)Oc2ccc(F)cc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C28H30FN3O4/c1-2-24(19-6-4-3-5-7-19)30-27(33)23-16-25(32-14-15-35-18-26(23)32)28(34)31-13-12-22(17-31)36-21-10-8-20(29)9-11-21/h3-11,16,22,24H,2,12-15,17-18H2,1H3,(H,30,33)/t22-,24+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218614
PNG
(US9284333, 16gg | US9884860, Example 16gg)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)COC)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C22H29N3O4/c1-4-18(16-8-6-5-7-9-16)24-21(26)17-12-19(22(27)23-15(2)13-28-3)25-10-11-29-14-20(17)25/h5-9,12,15,18H,4,10-11,13-14H2,1-3H3,(H,23,27)(H,24,26)/t15?,18-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218616
PNG
(US9284333, 16gi | US9884860, Example 16gi)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC2CC2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C21H25N3O3/c1-2-17(14-6-4-3-5-7-14)23-20(25)16-12-18(21(26)22-15-8-9-15)24-10-11-27-13-19(16)24/h3-7,12,15,17H,2,8-11,13H2,1H3,(H,22,26)(H,23,25)/t17-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218440
PNG
(US9284333, 16gz | US9884860, Example 16gz)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2cc(OC)cc(OC)c2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H31N3O5/c1-4-23(19-8-6-5-7-9-19)29-26(31)22-15-24(30-10-11-35-17-25(22)30)27(32)28-16-18-12-20(33-2)14-21(13-18)34-3/h5-9,12-15,23H,4,10-11,16-17H2,1-3H3,(H,28,32)(H,29,31)/t23-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218444
PNG
(US9284333, 16hd | US9884860, Example 16hd)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2ncccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N5O3/c1-3-19(17-8-5-4-6-9-17)28-23(30)18-14-20(29-12-13-32-15-21(18)29)24(31)27-16(2)22-25-10-7-11-26-22/h4-11,14,16,19H,3,12-13,15H2,1-2H3,(H,27,31)(H,28,30)/t16?,19-/m1/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218461
PNG
(US9284333, 16hw | US9884860, Example 16hw)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2cnccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H29N5O3/c1-3-19(17-8-6-5-7-9-17)28-24(31)18-14-22(30-12-13-33-16-23(18)30)25(32)29-20(4-2)21-15-26-10-11-27-21/h5-11,14-15,19-20H,3-4,12-13,16H2,1-2H3,(H,28,31)(H,29,32)/t19-,20-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218464
PNG
(US9284333, 16hz | US9884860, Example 16hz)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](CC)c2cnc(OC)cn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H31N5O4/c1-4-19(17-9-7-6-8-10-17)29-25(32)18-13-22(31-11-12-35-16-23(18)31)26(33)30-20(5-2)21-14-28-24(34-3)15-27-21/h6-10,13-15,19-20H,4-5,11-12,16H2,1-3H3,(H,29,32)(H,30,33)/t19-,20+/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218477
PNG
(US9284333, 16im | US9284333, 16in | US9884860, Exa...)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2ccon2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H26N4O4/c1-3-18(16-7-5-4-6-8-16)25-22(28)17-13-20(27-10-12-30-14-21(17)27)23(29)24-15(2)19-9-11-31-26-19/h4-9,11,13,15,18H,3,10,12,14H2,1-2H3,(H,24,29)(H,25,28)/t15?,18-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218481
PNG
(US9284333, 16iq | US9884860, Example 16iq)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2cccc(c2)C(=O)OC)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C27H29N3O5/c1-3-22(19-9-5-4-6-10-19)29-25(31)21-15-23(30-12-13-35-17-24(21)30)26(32)28-16-18-8-7-11-20(14-18)27(33)34-2/h4-11,14-15,22H,3,12-13,16-17H2,1-2H3,(H,28,32)(H,29,31)/t22-/m1/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218483
PNG
(US9284333, 16is | US9884860, Example 16is)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2ccc(CC(=O)OC)cc2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C28H31N3O5/c1-3-23(21-7-5-4-6-8-21)30-27(33)22-16-24(31-13-14-36-18-25(22)31)28(34)29-17-20-11-9-19(10-12-20)15-26(32)35-2/h4-12,16,23H,3,13-15,17-18H2,1-2H3,(H,29,34)(H,30,33)/t23-/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218485
PNG
(US9284333, 16iu | US9284333, 16iw | US9884860, Exa...)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N(C)CC(=O)OC(C)C)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C24H31N3O5/c1-5-19(17-9-7-6-8-10-17)25-23(29)18-13-20(27-11-12-31-15-21(18)27)24(30)26(4)14-22(28)32-16(2)3/h6-10,13,16,19H,5,11-12,14-15H2,1-4H3,(H,25,29)/t19-/m1/s1
PDB

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n/an/a 120n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218486
PNG
(US9284333, 16iv | US9884860, Example 16iv)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2cnc(OC)cn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C25H29N5O4/c1-4-19(17-8-6-5-7-9-17)29-24(31)18-12-21(30-10-11-34-15-22(18)30)25(32)28-16(2)20-13-27-23(33-3)14-26-20/h5-9,12-14,16,19H,4,10-11,15H2,1-3H3,(H,28,32)(H,29,31)/t16?,19-/m1/s1
PDB

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n/an/a 120n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218492
PNG
(US9284333, 16jc | US9884860, Example 16jc)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N(C)Cc2ncccn2)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C24H27N5O3/c1-3-19(17-8-5-4-6-9-17)27-23(30)18-14-20(29-12-13-32-16-21(18)29)24(31)28(2)15-22-25-10-7-11-26-22/h4-11,14,19H,3,12-13,15-16H2,1-2H3,(H,27,30)/t19-/m1/s1
PDB

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n/an/a 2.70E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218499
PNG
(US9284333, 16jj | US9884860, Example 16jj)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@@H](CO)C(C)C)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H31N3O4/c1-4-18(16-8-6-5-7-9-16)24-22(28)17-12-20(26-10-11-30-14-21(17)26)23(29)25-19(13-27)15(2)3/h5-9,12,15,18-19,27H,4,10-11,13-14H2,1-3H3,(H,24,28)(H,25,29)/t18-,19+/m1/s1
PDB

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n/an/a 4.40E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218500
PNG
(US9284333, 16jk | US9884860, Example 16jk)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)Nc2c(C)noc2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H26N4O4/c1-4-18(16-8-6-5-7-9-16)24-23(29)19-12-17(20-13-30-11-10-27(19)20)22(28)25-21-14(2)26-31-15(21)3/h5-9,12,18H,4,10-11,13H2,1-3H3,(H,24,29)(H,25,28)/t18-/m1/s1
PDB

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n/an/a 620n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218501
PNG
(US9284333, 16jl | US9884860, Example 16jl)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NCc2c(C)noc2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C24H28N4O4/c1-4-20(17-8-6-5-7-9-17)26-24(30)21-12-18(22-14-31-11-10-28(21)22)23(29)25-13-19-15(2)27-32-16(19)3/h5-9,12,20H,4,10-11,13-14H2,1-3H3,(H,25,29)(H,26,30)/t20-/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218507
PNG
(US9284333, 16jr | US9884860, Example 16jr)
Show SMILES CC[C@H](NC(=O)c1cc(C(=O)NCC2CC2)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C22H27N3O3/c1-2-18(16-6-4-3-5-7-16)24-22(27)19-12-17(20-14-28-11-10-25(19)20)21(26)23-13-15-8-9-15/h3-7,12,15,18H,2,8-11,13-14H2,1H3,(H,23,26)(H,24,27)/t18-/m0/s1
PDB

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n/an/a 470n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218513
PNG
(US9284333, 16jx | US9884860, Example 16jx)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)Nc2cc(ccc2Cl)C(F)(F)F)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C25H23ClF3N3O3/c1-2-19(15-6-4-3-5-7-15)30-24(34)21-13-17(22-14-35-11-10-32(21)22)23(33)31-20-12-16(25(27,28)29)8-9-18(20)26/h3-9,12-13,19H,2,10-11,14H2,1H3,(H,30,34)(H,31,33)/t19-/m1/s1
PDB

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n/an/a 220n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218523
PNG
(US9284333, 16kh)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCOC[C@@H]2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N3O4/c1-3-19(17-7-5-4-6-8-17)24-22(27)20-13-18(21-15-30-12-10-26(20)21)23(28)25-9-11-29-14-16(25)2/h4-8,13,16,19H,3,9-12,14-15H2,1-2H3,(H,24,27)/t16-,19+/m0/s1
PDB

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n/an/a 990n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218524
PNG
(US9284333, 16ki | US9884860, Example 16kr)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2COCCn12)c1ccccc1 |r|
Show InChI InChI=1S/C23H29N3O3/c1-3-19(17-9-5-4-6-10-17)24-22(27)20-14-18(21-15-29-13-12-26(20)21)23(28)25-11-7-8-16(25)2/h4-6,9-10,14,16,19H,3,7-8,11-13,15H2,1-2H3,(H,24,27)/t16-,19+/m0/s1
PDB

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n/an/a 200n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218537
PNG
(US9284333, 16kv | US9884860, Example 16kv)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](CC)c2ccccc2)n2CCSc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H29N3O2S/c1-3-21(18-11-7-5-8-12-18)27-24(30)20-17-23(29-15-16-32-26(20)29)25(31)28-22(4-2)19-13-9-6-10-14-19/h5-14,17,21-22H,3-4,15-16H2,1-2H3,(H,27,30)(H,28,31)/t21-,22-/m1/s1
PDB

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n/an/a 320n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218542
PNG
(US9284333, 16la | US9884860, Example 16la)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N[C@H](C)c2ccc(F)cc2)n2CCSCc12)c1ccccc1 |r|
Show InChI InChI=1S/C26H28FN3O2S/c1-3-22(19-7-5-4-6-8-19)29-25(31)21-15-23(30-13-14-33-16-24(21)30)26(32)28-17(2)18-9-11-20(27)12-10-18/h4-12,15,17,22H,3,13-14,16H2,1-2H3,(H,28,32)(H,29,31)/t17-,22-/m1/s1
PDB

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n/an/a 150n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218560
PNG
(US9284333, 16lu | US9884860, Example 16lu)
Show SMILES C[C@@H](NC(=O)c1cc(C(=O)NC(C)c2ncccn2)c2CCCCn12)c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H26FN5O2/c1-15(17-7-9-18(25)10-8-17)28-24(32)21-14-19(20-6-3-4-13-30(20)21)23(31)29-16(2)22-26-11-5-12-27-22/h5,7-12,14-16H,3-4,6,13H2,1-2H3,(H,28,32)(H,29,31)/t15-,16?/m1/s1
PDB

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n/an/a 450n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218573
PNG
(US9284333, 16nh | US9884860, Example 16nh)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)c2COCCn12)c1ccccc1Cl |r|
Show InChI InChI=1S/C23H28ClN3O3/c1-3-19(16-8-4-5-9-18(16)24)25-22(28)20-13-17(21-14-30-12-11-27(20)21)23(29)26-10-6-7-15(26)2/h4-5,8-9,13,15,19H,3,6-7,10-12,14H2,1-2H3,(H,25,28)/t15-,19+/m0/s1
PDB

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n/an/a 90n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218579
PNG
(US9284333, 16nn | US9884860, Example 16nn)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CC[C@@H](C2)OC)n2CCOCc12)c1ccc(F)cc1Cl |r|
Show InChI InChI=1S/C23H27ClFN3O4/c1-3-19(16-5-4-14(25)10-18(16)24)26-22(29)17-11-20(28-8-9-32-13-21(17)28)23(30)27-7-6-15(12-27)31-2/h4-5,10-11,15,19H,3,6-9,12-13H2,1-2H3,(H,26,29)/t15-,19+/m0/s1
PDB

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n/an/a 270n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218583
PNG
(US9284333, 16nr | US9884860, Example 16nr)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)NC(C)c2ncccn2)n2CCOCc12)c1ccccc1Cl |r|
Show InChI InChI=1S/C24H26ClN5O3/c1-3-19(16-7-4-5-8-18(16)25)29-23(31)17-13-20(30-11-12-33-14-21(17)30)24(32)28-15(2)22-26-9-6-10-27-22/h4-10,13,15,19H,3,11-12,14H2,1-2H3,(H,28,32)(H,29,31)/t15?,19-/m1/s1
PDB

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n/an/a 310n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218266
PNG
(US9284333, 16o | US9884860, Example 16o)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C(F)(F)F)n2CCOCc12)c1ccc(nc1)C(F)(F)F |r|
Show InChI InChI=1S/C23H24F6N4O3/c1-2-15(13-5-6-18(30-11-13)22(24,25)26)31-20(34)14-10-16(32-8-9-36-12-17(14)32)21(35)33-7-3-4-19(33)23(27,28)29/h5-6,10-11,15,19H,2-4,7-9,12H2,1H3,(H,31,34)/t15-,19-/m1/s1
PDB

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n/an/a 410n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218646
PNG
(US9284333, 16rb | US9884860, Example 16rb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C21H26ClN3O3S/c1-3-15(18-6-7-19(22)29-18)23-20(26)14-11-16(25-9-10-28-12-17(14)25)21(27)24-8-4-5-13(24)2/h6-7,11,13,15H,3-5,8-10,12H2,1-2H3,(H,23,26)/t13-,15+/m0/s1
PDB

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n/an/a 230n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218650
PNG
(US9284333, 16rf | US9884860, Example 16co)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cnc(C#N)c(Cl)c1 |r|
Show InChI InChI=1S/C23H26ClN5O3/c1-3-18(15-9-17(24)19(11-25)26-12-15)27-22(30)16-10-20(29-7-8-32-13-21(16)29)23(31)28-6-4-5-14(28)2/h9-10,12,14,18H,3-8,13H2,1-2H3,(H,27,30)/t14-,18+/m0/s1
PDB

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n/an/a 1.00E+3n/an/an/an/an/a25



Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218667
PNG
(US9284333, 16rw | US9884860, Example 16rw)
Show SMILES CC[C@@H](NC(=O)c1c(Cl)c(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccccc1 |r|
Show InChI InChI=1S/C23H28ClN3O3/c1-3-17(16-9-5-4-6-10-16)25-22(28)19-18-14-30-13-12-27(18)21(20(19)24)23(29)26-11-7-8-15(26)2/h4-6,9-10,15,17H,3,7-8,11-14H2,1-2H3,(H,25,28)/t15-,17+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218282
PNG
(US9284333, 16w | US9884860, Example 16w)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cc(F)ccc1Cl |r|
Show InChI InChI=1S/C23H27ClFN3O3/c1-3-19(16-11-15(25)6-7-18(16)24)26-22(29)17-12-20(28-9-10-31-13-21(17)28)23(30)27-8-4-5-14(27)2/h6-7,11-12,14,19H,3-5,8-10,13H2,1-2H3,(H,26,29)/t14-,19+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218294
PNG
(US9284333, 16ak | US9884860, Example 16ak)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(cc1)C#N |r|
Show InChI InChI=1S/C24H28N4O3/c1-3-20(18-8-6-17(14-25)7-9-18)26-23(29)19-13-21(28-11-12-31-15-22(19)28)24(30)27-10-4-5-16(27)2/h6-9,13,16,20H,3-5,10-12,15H2,1-2H3,(H,26,29)/t16-,20+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218299
PNG
(US9284333, 16ap | US9884860, Example 16ap)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cccc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C23H27F3N4O3/c1-3-16(17-7-4-8-20(27-17)23(24,25)26)28-21(31)15-12-18(30-10-11-33-13-19(15)30)22(32)29-9-5-6-14(29)2/h4,7-8,12,14,16H,3,5-6,9-11,13H2,1-2H3,(H,28,31)/t14-,16+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218301
PNG
(US9284333, 16ar | US9884860, Example 16ar)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(Cl)nc1 |r|
Show InChI InChI=1S/C22H27ClN4O3/c1-3-17(15-6-7-20(23)24-12-15)25-21(28)16-11-18(27-9-10-30-13-19(16)27)22(29)26-8-4-5-14(26)2/h6-7,11-12,14,17H,3-5,8-10,13H2,1-2H3,(H,25,28)/t14-,17+/m0/s1
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US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218331
PNG
(US9284333, 16bw | US9884860, Example 16bw)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccncc1Cl |r|
Show InChI InChI=1S/C22H27ClN4O3/c1-3-18(15-6-7-24-12-17(15)23)25-21(28)16-11-19(27-9-10-30-13-20(16)27)22(29)26-8-4-5-14(26)2/h6-7,11-12,14,18H,3-5,8-10,13H2,1-2H3,(H,25,28)/t14-,18+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218334
PNG
(US9284333, 16bz)
Show SMILES CC[C@@H](NCc1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc2OC(F)(F)Oc2c1 |r|
Show InChI InChI=1S/C24H29F2N3O4/c1-3-18(16-6-7-21-22(12-16)33-24(25,26)32-21)27-13-17-11-19(29-9-10-31-14-20(17)29)23(30)28-8-4-5-15(28)2/h6-7,11-12,15,18,27H,3-5,8-10,13-14H2,1-2H3/t15-,18+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218335
PNG
(US9284333, 16ca | US9884860, Example 16ca)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cc(F)c(C#N)c(F)c1 |r|
Show InChI InChI=1S/C24H26F2N4O3/c1-3-20(15-9-18(25)17(12-27)19(26)10-15)28-23(31)16-11-21(30-7-8-33-13-22(16)30)24(32)29-6-4-5-14(29)2/h9-11,14,20H,3-8,13H2,1-2H3,(H,28,31)/t14-,20+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium channel subfamily K member 3


(Homo sapiens (Human))		BDBM218336
PNG
(US9284333, 16cb | US9884860, Example 16cb)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(nc1C)C(F)(F)F |r|
Show InChI InChI=1S/C24H29F3N4O3/c1-4-18(16-7-8-21(24(25,26)27)28-15(16)3)29-22(32)17-12-19(31-10-11-34-13-20(17)31)23(33)30-9-5-6-14(30)2/h7-8,12,14,18H,4-6,9-11,13H2,1-3H3,(H,29,32)/t14-,18+/m0/s1
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Sanofi

US Patent


Assay Description
Human TASK-1 channels were expressed in Xenopus oocytes. For this purpose, oocytes were isolated from Xenopus laevis and defoliculated. Subsequently,...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218252
PNG
(US9284333, 16b | US9884860, Example 16b)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1cnc(OC)c(Cl)c1 |r|
Show InChI InChI=1S/C23H29ClN4O4/c1-4-18(15-10-17(24)22(31-3)25-12-15)26-21(29)16-11-19(28-8-9-32-13-20(16)28)23(30)27-7-5-6-14(27)2/h10-12,14,18H,4-9,13H2,1-3H3,(H,26,29)/t14-,18+/m0/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218254
PNG
(US9284333, 16d | US9884860, Example 16d)
Show SMILES CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(C#N)c(Cl)c1 |r|
Show InChI InChI=1S/C24H27ClN4O3/c1-3-20(16-6-7-17(13-26)19(25)11-16)27-23(30)18-12-21(29-9-10-32-14-22(18)29)24(31)28-8-4-5-15(28)2/h6-7,11-12,15,20H,3-5,8-10,14H2,1-2H3,(H,27,30)/t15-,20+/m0/s1
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Sanofi

US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM218364
PNG
(US9284333, 16dh | US9884860, Example 16dh)
Show SMILES Fc1ccc(cc1)[C@@H](NC(=O)c1cc(C(=O)N2CCCC2)n2CCOCc12)C1CC1 |r|
Show InChI InChI=1S/C23H26FN3O3/c24-17-7-5-16(6-8-17)21(15-3-4-15)25-22(28)18-13-19(23(29)26-9-1-2-10-26)27-11-12-30-14-20(18)27/h5-8,13,15,21H,1-4,9-12,14H2,(H,25,28)/t21-/m0/s1
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US Patent


Assay Description
The effect of compounds of the formula I on the cloned human cardiac hERG channel was evaluated in an in vitro model using a whole-cell patch-clampin...

US Patent US9284333 (2016)


BindingDB Entry DOI: 10.7270/Q2FJ2FMC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%