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Patent code US9321756

Compile Data Set for Download or QSAR

Found 823 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224943
PNG
(US9321756, 204)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(NCC4CC4)n3)c2c1
Show InChI InChI=1S/C19H18N6S/c20-19-25-24-18(26-19)12-6-7-15-13(8-12)14(10-21-15)16-2-1-3-17(23-16)22-9-11-4-5-11/h1-3,6-8,10-11,21H,4-5,9H2,(H2,20,25)(H,22,23)
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n/an/a 18.2n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224951
PNG
(US9321756, 218)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cn[nH]c3)c2c1
Show InChI InChI=1S/C14H12N6S/c1-15-14-20-19-13(21-14)8-2-3-12-10(4-8)11(7-16-12)9-5-17-18-6-9/h2-7,16H,1H3,(H,15,20)(H,17,18)
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n/an/a 123n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224960
PNG
(US9321756, 227)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCCCC3)c2c1
Show InChI InChI=1S/C20H21N7S/c1-21-20-26-25-19(28-20)13-5-6-16-14(9-13)15(10-23-16)17-11-22-12-18(24-17)27-7-3-2-4-8-27/h5-6,9-12,23H,2-4,7-8H2,1H3,(H,21,26)
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n/an/a 1.42n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224967
PNG
(US9321756, 234)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)-n3ccnc3C)c2c1
Show InChI InChI=1S/C20H17N7S/c1-12-22-8-9-27(12)18-5-3-4-17(24-18)15-11-23-16-7-6-13(10-14(15)16)19-25-26-20(21-2)28-19/h3-11,23H,1-2H3,(H,21,26)
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n/an/a 18.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224972
PNG
(US9321756, 239)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(F)n3)c2c1
Show InChI InChI=1S/C16H12FN5S/c1-18-16-22-21-15(23-16)9-5-6-12-10(7-9)11(8-19-12)13-3-2-4-14(17)20-13/h2-8,19H,1H3,(H,18,22)
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n/an/a 170n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224973
PNG
(US9321756, 240)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3csc(n3)-c3ccoc3)c2c1
Show InChI InChI=1S/C18H13N5OS2/c1-19-18-23-22-17(26-18)10-2-3-14-12(6-10)13(7-20-14)15-9-25-16(21-15)11-4-5-24-8-11/h2-9,20H,1H3,(H,19,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224974
PNG
(US9321756, 241)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3ccc(s3)-c3cccs3)c2c1
Show InChI InChI=1S/C19H14N4S3/c1-20-19-23-22-18(26-19)11-4-5-14-12(9-11)13(10-21-14)15-6-7-17(25-15)16-3-2-8-24-16/h2-10,21H,1H3,(H,20,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224979
PNG
(US9321756, 246)
Show SMILES C1CC1c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(o1)N1CCNCC1
Show InChI InChI=1S/C21H21N7O/c1-2-13(1)18-11-23-12-19(25-18)16-10-24-17-4-3-14(9-15(16)17)20-26-27-21(29-20)28-7-5-22-6-8-28/h3-4,9-13,22,24H,1-2,5-8H2
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n/an/a 7.11n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM224998
PNG
(US9321756, 264 | US9321756, 265)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-17-14(9-13)15(10-22-17)18-21-8-7-16(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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n/an/a 0.435n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))		BDBM225001
PNG
(US9321756, 267)
Show SMILES CC(Nc1nnc(o1)-c1ccc2[nH]cc(-c3ccccn3)c2c1)c1ccccc1 |w:1.0|
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n/an/a 56.1n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224844
PNG
(BDBM225043 | US9321756, 103)
Show SMILES CC(C)Nc1ccnc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)o1
Show InChI InChI=1S/C17H17N7O/c1-9(2)21-14-5-6-19-15(22-14)12-8-20-13-4-3-10(7-11(12)13)16-23-24-17(18)25-16/h3-9,20H,1-2H3,(H2,18,24)(H,19,21,22)
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n/an/a 6.91n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225044
PNG
(US9321756, 6)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H18N6O2/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)
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n/an/a 5.91n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224868
PNG
(BDBM225046 | US9321756, 123)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)-c3ccccc3F)c2c1
Show InChI InChI=1S/C20H13FN6O/c21-15-4-2-1-3-12(15)17-7-8-23-18(25-17)14-10-24-16-6-5-11(9-13(14)16)19-26-27-20(22)28-19/h1-10,24H,(H2,22,27)
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n/an/a 10.6n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225049
PNG
(US9321756, 11)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H17N7OS/c19-18-24-23-17(27-18)11-1-2-14-12(9-11)13(10-21-14)16-20-4-3-15(22-16)25-5-7-26-8-6-25/h1-4,9-10,21H,5-8H2,(H2,19,24)
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n/an/a 19.7n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225050
PNG
(US9321756, 12)
Show SMILES NCCCNc1nnc(s1)-c1ccc2[nH]cc(-c3ccccc3F)c2c1
Show InChI InChI=1S/C19H18FN5S/c20-16-5-2-1-4-13(16)15-11-23-17-7-6-12(10-14(15)17)18-24-25-19(26-18)22-9-3-8-21/h1-2,4-7,10-11,23H,3,8-9,21H2,(H,22,25)
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n/an/a 51.6n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225051
PNG
(US9321756, 13)
Show SMILES CN1CCN(CC1)c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C20H21N7S/c1-26-7-9-27(10-8-26)18-4-2-3-17(23-18)15-12-22-16-6-5-13(11-14(15)16)19-24-25-20(21)28-19/h2-6,11-12,22H,7-10H2,1H3,(H2,21,25)
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n/an/a 2.02n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225072
PNG
(US9321756, 41)
Show SMILES CNc1nnc(o1)-c1ccc2[nH]cc(-c3cccc(OC(C)C)n3)c2c1
Show InChI InChI=1S/C19H19N5O2/c1-11(2)25-17-6-4-5-16(22-17)14-10-21-15-8-7-12(9-13(14)15)18-23-24-19(20-3)26-18/h4-11,21H,1-3H3,(H,20,24)
PDB
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n/an/a 6.48n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225074
PNG
(US9321756, 43)
Show SMILES C1CC1c1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H17N5O/c1-2-11(1)16-7-8-21-18(23-16)15-10-22-17-6-5-13(9-14(15)17)20-25-24-19(26-20)12-3-4-12/h5-12,22H,1-4H2
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n/an/a 7.58n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225102
PNG
(US9321756, 71)
Show SMILES CC(C)Oc1cncc(n1)-c1c[nH]c2ccc(cc12)-c1noc(N)n1
Show InChI InChI=1S/C17H16N6O2/c1-9(2)24-15-8-19-7-14(21-15)12-6-20-13-4-3-10(5-11(12)13)16-22-17(18)25-23-16/h3-9,20H,1-2H3,(H2,18,22,23)
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n/an/a 69.5n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225104
PNG
(US9321756, 73)
Show SMILES CC(C)Nc1nc(no1)-c1ccc2[nH]cc(-c3cncc(OC(C)C)n3)c2c1
Show InChI InChI=1S/C20H22N6O2/c1-11(2)23-20-25-19(26-28-20)13-5-6-16-14(7-13)15(8-22-16)17-9-21-10-18(24-17)27-12(3)4/h5-12,22H,1-4H3,(H,23,25,26)
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n/an/a 45.9n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224829
PNG
(US9321756, 88)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCC(F)(F)C3)c2c1
Show InChI InChI=1S/C18H15F2N7O/c19-18(20)3-4-27(9-18)15-8-22-7-14(24-15)12-6-23-13-2-1-10(5-11(12)13)16-25-26-17(21)28-16/h1-2,5-8,23H,3-4,9H2,(H2,21,26)
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n/an/a 1.92n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224833
PNG
(US9321756, 92)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(Oc4ccccc4)n3)c2c1
Show InChI InChI=1S/C20H14N6O2/c21-20-26-25-19(28-20)12-6-7-16-14(8-12)15(9-23-16)17-10-22-11-18(24-17)27-13-4-2-1-3-5-13/h1-11,23H,(H2,21,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224863
PNG
(US9321756, 118)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)-c3ccccc3Cl)c2c1
Show InChI InChI=1S/C20H13ClN6O/c21-15-4-2-1-3-12(15)17-7-8-23-18(25-17)14-10-24-16-6-5-11(9-13(14)16)19-26-27-20(22)28-19/h1-10,24H,(H2,22,27)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224871
PNG
(US9321756, 126)
Show SMILES CC(C)Oc1cccc(c1)-c1c[nH]c2ccc(nc12)-c1nnc(N)o1
Show InChI InChI=1S/C18H17N5O2/c1-10(2)24-12-5-3-4-11(8-12)13-9-20-14-6-7-15(21-16(13)14)17-22-23-18(19)25-17/h3-10,20H,1-2H3,(H2,19,23)
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n/an/a 272n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224872
PNG
(US9321756, 127)
Show SMILES CC(C)Cn1cc(cn1)-c1c[nH]c2ccc(nc12)-c1nnc(N)o1
Show InChI InChI=1S/C16H17N7O/c1-9(2)7-23-8-10(5-19-23)11-6-18-12-3-4-13(20-14(11)12)15-21-22-16(17)24-15/h3-6,8-9,18H,7H2,1-2H3,(H2,17,22)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224877
PNG
(US9321756, 132)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCN(C)CC3)c2c1
Show InChI InChI=1S/C20H22N8S/c1-21-20-26-25-19(29-20)13-3-4-16-14(11-13)15(12-23-16)18-22-6-5-17(24-18)28-9-7-27(2)8-10-28/h3-6,11-12,23H,7-10H2,1-2H3,(H,21,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224879
PNG
(US9321756, 134)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H19N7OS/c1-20-19-25-24-18(28-19)12-2-3-15-13(10-12)14(11-22-15)17-21-5-4-16(23-17)26-6-8-27-9-7-26/h2-5,10-11,22H,6-9H2,1H3,(H,20,25)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061606
PNG
(CHEMBL3394064 | US9321756, 138)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3c(F)cccc3F)c2c1 |(-7.36,1.9,;-6.13,2.04,;-5.37,3.37,;-3.86,3.05,;-3.71,1.53,;-5.1,.89,;-2.38,.77,;-2.38,-.77,;-1.03,-1.55,;.3,-.77,;1.76,-1.24,;2.66,.02,;1.76,1.24,;2.23,2.7,;1.29,3.91,;.07,3.74,;1.86,5.34,;3.38,5.55,;4.33,4.34,;3.76,2.91,;4.52,1.94,;.3,.77,;-1.03,1.55,)|
Show InChI InChI=1S/C16H10F2N4S/c17-11-2-1-3-12(18)14(11)10-7-20-13-5-4-8(6-9(10)13)15-21-22-16(19)23-15/h1-7,20H,(H2,19,22)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224895
PNG
(US9321756, 148)
Show SMILES CC(=O)Nc1ccc(CNc2nnc(s2)-c2ccc3[nH]cc(-c4ccc(F)cc4F)c3c2)cc1
Show InChI InChI=1S/C25H19F2N5OS/c1-14(33)30-18-6-2-15(3-7-18)12-29-25-32-31-24(34-25)16-4-9-23-20(10-16)21(13-28-23)19-8-5-17(26)11-22(19)27/h2-11,13,28H,12H2,1H3,(H,29,32)(H,30,33)
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n/an/a 777n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224899
PNG
(US9321756, 152)
Show SMILES N[C@H]1CCCCN1c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1 |r|
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n/an/a 1.79n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224902
PNG
(US9321756, 154)
Show SMILES CCN(CC)c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H19N7S/c1-3-25(4-2)16-10-20-9-15(22-16)13-8-21-14-6-5-11(7-12(13)14)17-23-24-18(19)26-17/h5-10,21H,3-4H2,1-2H3,(H2,19,24)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061603
PNG
(CHEMBL3394167 | US9321756, 157)
Show SMILES CC(C)Oc1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H17N5OS/c1-10(2)24-16-5-3-4-15(21-16)13-9-20-14-7-6-11(8-12(13)14)17-22-23-18(19)25-17/h3-10,20H,1-2H3,(H2,19,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224906
PNG
(US9321756, 162)
Show SMILES CC1CCN(CC1)c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C20H21N7S/c1-12-4-6-27(7-5-12)18-11-22-10-17(24-18)15-9-23-16-3-2-13(8-14(15)16)19-25-26-20(21)28-19/h2-3,8-12,23H,4-7H2,1H3,(H2,21,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061612
PNG
(CHEMBL3394168 | US9321756, 163)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCCC4)n3)c2c1
Show InChI InChI=1S/C20H19N5OS/c21-20-25-24-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(23-17)26-13-4-1-2-5-13/h3,6-11,13,22H,1-2,4-5H2,(H2,21,25)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224916
PNG
(US9321756, 174)
Show SMILES C[C@@H]1CCCN(C1)c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1 |r|
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n/an/a 41.0n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224917
PNG
(US9321756, 175)
Show SMILES CC1CCN(CC1)c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C21H22N6S/c1-13-7-9-27(10-8-13)19-4-2-3-18(24-19)16-12-23-17-6-5-14(11-15(16)17)20-25-26-21(22)28-20/h2-6,11-13,23H,7-10H2,1H3,(H2,22,26)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224925
PNG
(US9321756, 184)
Show SMILES C[C@H]1CCCCN1c1nc(cs1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1 |r|
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224929
PNG
(US9321756, 188)
Show SMILES CCN(C)c1cnc(cn1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C17H17N7S/c1-3-24(2)15-9-20-14(8-21-15)12-7-19-13-5-4-10(6-11(12)13)16-22-23-17(18)25-16/h4-9,19H,3H2,1-2H3,(H2,18,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224936
PNG
(US9321756, 196)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(O)n3)c2c1
Show InChI InChI=1S/C15H11N5OS/c16-15-20-19-14(22-15)8-4-5-11-9(6-8)10(7-17-11)12-2-1-3-13(21)18-12/h1-7,17H,(H2,16,20)(H,18,21)
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n/an/a 2.07E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224937
PNG
(US9321756, 197)
Show SMILES Cc1ccn(n1)-c1cnc(cn1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H14N8S/c1-10-4-5-26(25-10)16-9-21-15(8-22-16)13-7-20-14-3-2-11(6-12(13)14)17-23-24-18(19)27-17/h2-9,20H,1H3,(H2,19,24)
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n/an/a 2.27E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224939
PNG
(US9321756, 199)
Show SMILES COc1cncc(c1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C16H13N5OS/c1-22-11-4-10(6-18-7-11)13-8-19-14-3-2-9(5-12(13)14)15-20-21-16(17)23-15/h2-8,19H,1H3,(H2,17,21)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224940
PNG
(US9321756, 200)
Show SMILES COc1cc(nc(OC(C)C)n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C18H18N6O2S/c1-9(2)26-18-21-14(7-15(22-18)25-3)12-8-20-13-5-4-10(6-11(12)13)16-23-24-17(19)27-16/h4-9,20H,1-3H3,(H2,19,24)
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n/an/a 15.4n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224944
PNG
(US9321756, 207)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NCC4CC4)n3)c2c1
Show InChI InChI=1S/C18H17N7S/c19-18-25-24-17(26-18)11-3-4-14-12(5-11)13(7-21-14)15-8-20-9-16(23-15)22-6-10-1-2-10/h3-5,7-10,21H,1-2,6H2,(H2,19,25)(H,22,23)
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AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM50061628
PNG
(CHEMBL3394067 | US9321756, 24)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(n3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H18N6OS/c20-19-24-23-18(27-19)12-4-5-15-13(10-12)14(11-21-15)16-2-1-3-17(22-16)25-6-8-26-9-7-25/h1-5,10-11,21H,6-9H2,(H2,20,24)
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US Patent
n/an/a 94.9n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224965
PNG
(US9321756, 232)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(OC4CCC4)n3)c2c1
Show InChI InChI=1S/C20H19N5OS/c1-21-20-25-24-19(27-20)12-8-9-16-14(10-12)15(11-22-16)17-6-3-7-18(23-17)26-13-4-2-5-13/h3,6-11,13,22H,2,4-5H2,1H3,(H,21,25)
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n/an/a 57.0n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224972
PNG
(US9321756, 239)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(F)n3)c2c1
Show InChI InChI=1S/C16H12FN5S/c1-18-16-22-21-15(23-16)9-5-6-12-10(7-9)11(8-19-12)13-3-2-4-14(17)20-13/h2-8,19H,1H3,(H,18,22)
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n/an/a 1.03E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM224998
PNG
(US9321756, 264 | US9321756, 265)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-17-14(9-13)15(10-22-17)18-21-8-7-16(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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n/an/a 1.40n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225028
PNG
(US9321756, 295)
Show SMILES CNC(=O)c1ccc(nc1)-c1c[nH]c2ccc(cc12)-c1nnc(NC(C)C)o1
Show InChI InChI=1S/C20H20N6O2/c1-11(2)24-20-26-25-19(28-20)12-4-6-16-14(8-12)15(10-23-16)17-7-5-13(9-22-17)18(27)21-3/h4-11,23H,1-3H3,(H,21,27)(H,24,26)
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n/an/a 578n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM225029
PNG
(US9321756, 296)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(c3)C(=O)N(C)C)c2c1
Show InChI InChI=1S/C21H22N6O2/c1-12(2)24-21-26-25-19(29-21)13-5-6-18-16(8-13)17(11-23-18)14-7-15(10-22-9-14)20(28)27(3)4/h5-12,23H,1-4H3,(H,24,26)
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n/an/a>1.00E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))		BDBM225040
PNG
(US9321756, 2)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C19H17F2N7O/c20-19(21)3-5-28(6-4-19)16-10-23-9-15(25-16)13-8-24-14-2-1-11(7-12(13)14)17-26-27-18(22)29-17/h1-2,7-10,24H,3-6H2,(H2,22,27)
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n/an/a 2.26n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...

US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
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