Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (326/327 > 99%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Norwegian University of Science and Technology Curated by ChEMBL | Assay Description Inhibition of EGFR by Z-LYTE assay | Eur J Med Chem 46: 6002-14 (2011) Article DOI: 10.1016/j.ejmech.2011.10.012 BindingDB Entry DOI: 10.7270/Q26M377V | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,G719S] (327/327 = 100%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 11.3 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Cancer Cell 11: 217-27 (2007) Article DOI: 10.1016/j.ccr.2006.12.017 BindingDB Entry DOI: 10.7270/Q2JQ0ZBW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (325/327 > 99%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1.70 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Cancer Cell 11: 217-27 (2007) Article DOI: 10.1016/j.ccr.2006.12.017 BindingDB Entry DOI: 10.7270/Q2JQ0ZBW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,T790M] (325/327 > 99%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 27.6 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Proc Natl Acad Sci U S A 105: 2070-5 (2008) Article DOI: 10.1073/pnas.0709662105 BindingDB Entry DOI: 10.7270/Q2DZ06MJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,L858R] (325/327 > 99%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 1.10 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Proc Natl Acad Sci U S A 105: 2070-5 (2008) Article DOI: 10.1073/pnas.0709662105 BindingDB Entry DOI: 10.7270/Q2DZ06MJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1022,T790M,L858R] (324/327 > 99%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 18.6 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Proc Natl Acad Sci U S A 105: 2070-5 (2008) Article DOI: 10.1073/pnas.0709662105 BindingDB Entry DOI: 10.7270/Q2DZ06MJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (326/327 > 99%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 10.9 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Cancer Cell 11: 217-27 (2007) Article DOI: 10.1016/j.ccr.2006.12.017 BindingDB Entry DOI: 10.7270/Q2JQ0ZBW | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (326/327 > 99%)† (Homo sapiens (Human)) | BDBM26105 (6-{4-[(4-ethylpiperazin-1-yl)methyl]phenyl}-N-[(1R...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | 7.4 | 22 |
Harvard Medical School | Assay Description The fluorescence buffer was degassed and aerated with pure nitrogen gas to remove dissolved oxygen. The assay was carried out on a FluoroMax-2 fluoro... | Proc Natl Acad Sci U S A 105: 2070-5 (2008) Article DOI: 10.1073/pnas.0709662105 BindingDB Entry DOI: 10.7270/Q2DZ06MJ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |