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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen R&D LLC Curated by ChEMBL | Assay Description Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR2 extracellular domain preincubated for 1... | J Med Chem 60: 3511-3517 (2017) Article DOI: 10.1021/acs.jmedchem.6b01836 BindingDB Entry DOI: 10.7270/Q24X5B23 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen R&D LLC Curated by ChEMBL | Assay Description Binding affinity to human TNF-alpha soluble domain assessed as decrease in complex formation with human TNFR1 extracellular domain preincubated for 1... | J Med Chem 60: 3511-3517 (2017) Article DOI: 10.1021/acs.jmedchem.6b01836 BindingDB Entry DOI: 10.7270/Q24X5B23 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 2.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University Curated by ChEMBL | Assay Description Inhibition of TNFalpha in HEK293T cells transfected with plasmid hRluc/TK/ luc2P/NF-kBRE/Hygro plasmid after 12 hrs by Dual-glo luciferase assay syst... | Eur J Med Chem 85: 119-26 (2014) Article DOI: 10.1016/j.ejmech.2014.07.091 BindingDB Entry DOI: 10.7270/Q2K9398F | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Padmashri Vikhe Patil College of Arts Curated by ChEMBL | Assay Description Inhibition of TNF-alpha (unknown origin) binding to TNFR1 by ELISA | Bioorg Med Chem Lett 28: 24-30 (2018) Article DOI: 10.1016/j.bmcl.2017.11.026 BindingDB Entry DOI: 10.7270/Q2TQ6441 | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 9.77E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % MeOH as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % MeOH as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 6.18E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 5.36E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 8.44E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % PEG3350 as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a |
University of California at San Francisco Curated by ChEMBL | Assay Description Binding affinity to TNF | Nature 450: 1001-1009 (2007) Article DOI: 10.1038/nature06526 BindingDB Entry DOI: 10.7270/Q24Q7VTV | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 7.51E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMF as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 7.34E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 5.36E+3 | n/a | n/a | n/a | 6.5 | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assay | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 3.81 | n/a | n/a | n/a | n/a | n/a |
The Second People's Hospital of Fujian Provinc Curated by ChEMBL | Assay Description Binding affinity to TNF-alpha (unknown origin) | Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 1.18E+4 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % MeOH as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Tumor necrosis factor (148/148 = 100%)† (Homo sapiens (Human)) | BDBM50373071 (CHEMBL255489) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 5.75E+3 | n/a | n/a | n/a | n/a | n/a |
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL | Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solvent | ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
