Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor (327/330 > 99%)† (Homo sapiens (Human)) | BDBM31826 (4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Chemical Genomics Centre of the Max Planck Society Curated by ChEMBL | Assay Description Inhibition of wild type EGFR by HTRF assay | J Med Chem 53: 2892-901 (2010) Article DOI: 10.1021/jm901877j BindingDB Entry DOI: 10.7270/Q2T43T7N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [668-1210] (327/330 > 99%)† (Homo sapiens (Human)) | BDBM31826 (4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati... | Bioorg Med Chem 16: 3482-8 (2008) Article DOI: 10.1016/j.bmc.2008.02.053 BindingDB Entry DOI: 10.7270/Q2R20ZQ4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor (327/330 > 99%)† (Homo sapiens (Human)) | BDBM31826 (4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.62 | n/a | n/a | n/a | n/a | n/a | n/a |
Gakushuin University Curated by ChEMBL | Assay Description Inhibition of recombinant EGFR by ELISA | Bioorg Med Chem 18: 870-9 (2010) Article DOI: 10.1016/j.bmc.2009.11.035 BindingDB Entry DOI: 10.7270/Q2DF6R97 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [696-1210,T790M] (326/327 > 99%)† (Homo sapiens (Human)) | BDBM31826 (4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...) | PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 360 | n/a | n/a | n/a | n/a | 7.5 | 23 |
Chemical Genomics Centre of the Max Planck Society | Assay Description The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati... | Bioorg Med Chem 16: 3482-8 (2008) Article DOI: 10.1016/j.bmc.2008.02.053 BindingDB Entry DOI: 10.7270/Q2R20ZQ4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |