Found 22 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079667
((S)-2-[3-({(4-Cyano-benzyl)-[3-(4-cyano-benzyl)-3H...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cncn2Cc2ccc(cc2)C#N)Cc2ccc(cc2)C#N)c1)C(O)=O Show InChI InChI=1S/C33H32N6O3S/c1-43-14-13-31(33(41)42)37-32(40)29-4-2-3-28(15-29)20-38(19-26-9-5-24(16-34)6-10-26)22-30-18-36-23-39(30)21-27-11-7-25(17-35)8-12-27/h2-12,15,18,23,31H,13-14,19-22H2,1H3,(H,37,40)(H,41,42)/t31-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079661
((S)-2-[3-({(4-Cyano-benzyl)-[3-(4-cyano-benzyl)-3H...)Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1cccc(CN(Cc2cncn2Cc2ccc(cc2)C#N)Cc2ccc(cc2)C#N)c1 Show InChI InChI=1S/C34H34N6O3S/c1-43-34(42)32(14-15-44-2)38-33(41)30-5-3-4-29(16-30)21-39(20-27-10-6-25(17-35)7-11-27)23-31-19-37-24-40(31)22-28-12-8-26(18-36)9-13-28/h3-13,16,19,24,32H,14-15,20-23H2,1-2H3,(H,38,41)/t32-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079664
((S)-2-(3-{[(4-Cyano-benzyl)-(3H-imidazol-4-ylmethy...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccc(cc2)C#N)c1)C(O)=O Show InChI InChI=1S/C25H27N5O3S/c1-34-10-9-23(25(32)33)29-24(31)21-4-2-3-20(11-21)15-30(16-22-13-27-17-28-22)14-19-7-5-18(12-26)6-8-19/h2-8,11,13,17,23H,9-10,14-16H2,1H3,(H,27,28)(H,29,31)(H,32,33)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ha-Ras by bovine brain farensyltransferase |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079674
((S)-2-[3-({Butyl-[3-(4-cyano-benzyl)-3H-imidazol-4...)Show SMILES CCCCN(Cc1cncn1Cc1ccc(cc1)C#N)Cc1cccc(c1)C(=O)N[C@@H](CCSC)C(O)=O Show InChI InChI=1S/C29H35N5O3S/c1-3-4-13-33(20-26-17-31-21-34(26)19-23-10-8-22(16-30)9-11-23)18-24-6-5-7-25(15-24)28(35)32-27(29(36)37)12-14-38-2/h5-11,15,17,21,27H,3-4,12-14,18-20H2,1-2H3,(H,32,35)(H,36,37)/t27-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079666
((S)-2-[3-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmet...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CNCc2cncn2Cc2ccc(cc2)C#N)c1)C(O)=O Show InChI InChI=1S/C25H27N5O3S/c1-34-10-9-23(25(32)33)29-24(31)21-4-2-3-20(11-21)13-27-14-22-15-28-17-30(22)16-19-7-5-18(12-26)6-8-19/h2-8,11,15,17,23,27H,9-10,13-14,16H2,1H3,(H,29,31)(H,32,33)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079675
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-nitro-benzy...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccc(cc2)[N+]([O-])=O)c1)C(O)=O Show InChI InChI=1S/C24H27N5O5S/c1-35-10-9-22(24(31)32)27-23(30)19-4-2-3-18(11-19)14-28(15-20-12-25-16-26-20)13-17-5-7-21(8-6-17)29(33)34/h2-8,11-12,16,22H,9-10,13-15H2,1H3,(H,25,26)(H,27,30)(H,31,32)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079663
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-naphthalen-2-y...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccc3ccccc3c2)c1)C(O)=O Show InChI InChI=1S/C28H30N4O3S/c1-36-12-11-26(28(34)35)31-27(33)24-8-4-5-20(14-24)16-32(18-25-15-29-19-30-25)17-21-9-10-22-6-2-3-7-23(22)13-21/h2-10,13-15,19,26H,11-12,16-18H2,1H3,(H,29,30)(H,31,33)(H,34,35)/t26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079660
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-naphthalen-1-y...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2cccc3ccccc23)c1)C(O)=O Show InChI InChI=1S/C28H30N4O3S/c1-36-13-12-26(28(34)35)31-27(33)22-9-4-6-20(14-22)16-32(18-24-15-29-19-30-24)17-23-10-5-8-21-7-2-3-11-25(21)23/h2-11,14-15,19,26H,12-13,16-18H2,1H3,(H,29,30)(H,31,33)(H,34,35)/t26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079678
((S)-2-[3-({Butyl-[3-(4-cyano-benzyl)-3H-imidazol-4...)Show SMILES CCCCN(Cc1cncn1Cc1ccc(cc1)C#N)Cc1cccc(c1)C(=O)N[C@@H](CCSC)C(=O)OC Show InChI InChI=1S/C30H37N5O3S/c1-4-5-14-34(21-27-18-32-22-35(27)20-24-11-9-23(17-31)10-12-24)19-25-7-6-8-26(16-25)29(36)33-28(13-15-39-3)30(37)38-2/h6-12,16,18,22,28H,4-5,13-15,19-21H2,1-3H3,(H,33,36)/t28-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 183 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079676
((S)-2-(3-{[Benzyl-(1H-imidazol-4-ylmethyl)-amino]-...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccccc2)c1)C(O)=O Show InChI InChI=1S/C24H28N4O3S/c1-32-11-10-22(24(30)31)27-23(29)20-9-5-8-19(12-20)15-28(16-21-13-25-17-26-21)14-18-6-3-2-4-7-18/h2-9,12-13,17,22H,10-11,14-16H2,1H3,(H,25,26)(H,27,29)(H,30,31)/t22-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 255 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079677
((S)-2-[3-({[3-(4-Cyano-benzyl)-3H-imidazol-4-ylmet...)Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1cccc(CNCc2cncn2Cc2ccc(cc2)C#N)c1 Show InChI InChI=1S/C26H29N5O3S/c1-34-26(33)24(10-11-35-2)30-25(32)22-5-3-4-21(12-22)14-28-15-23-16-29-18-31(23)17-20-8-6-19(13-27)7-9-20/h3-9,12,16,18,24,28H,10-11,14-15,17H2,1-2H3,(H,30,32)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079673
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-phenethyl-amin...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(CCc2ccccc2)Cc2cnc[nH]2)c1)C(O)=O Show InChI InChI=1S/C25H30N4O3S/c1-33-13-11-23(25(31)32)28-24(30)21-9-5-8-20(14-21)16-29(17-22-15-26-18-27-22)12-10-19-6-3-2-4-7-19/h2-9,14-15,18,23H,10-13,16-17H2,1H3,(H,26,27)(H,28,30)(H,31,32)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079672
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-(4-methoxy-ben...)Show SMILES COc1ccc(CN(Cc2cnc[nH]2)Cc2cccc(c2)C(=O)N[C@@H](CCSC)C(O)=O)cc1 Show InChI InChI=1S/C25H30N4O4S/c1-33-22-8-6-18(7-9-22)14-29(16-21-13-26-17-27-21)15-19-4-3-5-20(12-19)24(30)28-23(25(31)32)10-11-34-2/h3-9,12-13,17,23H,10-11,14-16H2,1-2H3,(H,26,27)(H,28,30)(H,31,32)/t23-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 355 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079671
((S)-2-(3-{[Bis-(1H-imidazol-4-ylmethyl)-amino]-met...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2cnc[nH]2)c1)C(O)=O Show InChI InChI=1S/C21H26N6O3S/c1-31-6-5-19(21(29)30)26-20(28)16-4-2-3-15(7-16)10-27(11-17-8-22-13-24-17)12-18-9-23-14-25-18/h2-4,7-9,13-14,19H,5-6,10-12H2,1H3,(H,22,24)(H,23,25)(H,26,28)(H,29,30)/t19-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 870 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-FPP incorporation into recombinant Ha-Ras by bovine brain farensyltransferase |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079670
((S)-2-(3-{[(4-Cyano-benzyl)-(3H-imidazol-4-ylmethy...)Show SMILES COC(=O)[C@H](CCSC)NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccc(cc2)C#N)c1 Show InChI InChI=1S/C26H29N5O3S/c1-34-26(33)24(10-11-35-2)30-25(32)22-5-3-4-21(12-22)16-31(17-23-14-28-18-29-23)15-20-8-6-19(13-27)7-9-20/h3-9,12,14,18,24H,10-11,15-17H2,1-2H3,(H,28,29)(H,30,32)/t24-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079668
((S)-2-(3-{[Bis-(4-nitro-benzyl)-amino]-methyl}-ben...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2ccc(cc2)[N+]([O-])=O)Cc2ccc(cc2)[N+]([O-])=O)c1)C(O)=O Show InChI InChI=1S/C27H28N4O7S/c1-39-14-13-25(27(33)34)28-26(32)22-4-2-3-21(15-22)18-29(16-19-5-9-23(10-6-19)30(35)36)17-20-7-11-24(12-8-20)31(37)38/h2-12,15,25H,13-14,16-18H2,1H3,(H,28,32)(H,33,34)/t25-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079659
((S)-2-(3-{[Benzoyl-(1H-imidazol-4-ylmethyl)-amino]...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)C(=O)c2ccccc2)c1)C(O)=O Show InChI InChI=1S/C24H26N4O4S/c1-33-11-10-21(24(31)32)27-22(29)19-9-5-6-17(12-19)14-28(15-20-13-25-16-26-20)23(30)18-7-3-2-4-8-18/h2-9,12-13,16,21H,10-11,14-15H2,1H3,(H,25,26)(H,27,29)(H,31,32)/t21-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079664
((S)-2-(3-{[(4-Cyano-benzyl)-(3H-imidazol-4-ylmethy...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2ccc(cc2)C#N)c1)C(O)=O Show InChI InChI=1S/C25H27N5O3S/c1-34-10-9-23(25(32)33)29-24(31)21-4-2-3-20(11-21)15-30(16-22-13-27-17-28-22)14-19-7-5-18(12-26)6-8-19/h2-8,11,13,17,23H,9-10,14-16H2,1H3,(H,27,28)(H,29,31)(H,32,33)/t23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of geranyl geranyl transferase I (GGTase-I) |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079669
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-methyl-amino]-...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(C)Cc2cnc[nH]2)c1)C(O)=O Show InChI InChI=1S/C18H24N4O3S/c1-22(11-15-9-19-12-20-15)10-13-4-3-5-14(8-13)17(23)21-16(18(24)25)6-7-26-2/h3-5,8-9,12,16H,6-7,10-11H2,1-2H3,(H,19,20)(H,21,23)(H,24,25)/t16-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079671
((S)-2-(3-{[Bis-(1H-imidazol-4-ylmethyl)-amino]-met...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CN(Cc2cnc[nH]2)Cc2cnc[nH]2)c1)C(O)=O Show InChI InChI=1S/C21H26N6O3S/c1-31-6-5-19(21(29)30)26-20(28)16-4-2-3-15(7-16)10-27(11-17-8-22-13-24-17)12-18-9-23-14-25-18/h2-4,7-9,13-14,19H,5-6,10-12H2,1H3,(H,22,24)(H,23,25)(H,26,28)(H,29,30)/t19-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of geranyl geranyl transferase I (GGTase-I) |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079665
((S)-2-(3-{[(1H-Imidazol-4-ylmethyl)-amino]-methyl}...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CNCc2cnc[nH]2)c1)C(O)=O Show InChI InChI=1S/C17H22N4O3S/c1-25-6-5-15(17(23)24)21-16(22)13-4-2-3-12(7-13)8-18-9-14-10-19-11-20-14/h2-4,7,10-11,15,18H,5-6,8-9H2,1H3,(H,19,20)(H,21,22)(H,23,24)/t15-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50079662
((S)-4-Methylsulfanyl-2-{3-[(4-nitro-benzylamino)-m...)Show SMILES CSCC[C@H](NC(=O)c1cccc(CNCc2ccc(cc2)[N+]([O-])=O)c1)C(O)=O Show InChI InChI=1S/C20H23N3O5S/c1-29-10-9-18(20(25)26)22-19(24)16-4-2-3-15(11-16)13-21-12-14-5-7-17(8-6-14)23(27)28/h2-8,11,18,21H,9-10,12-13H2,1H3,(H,22,24)(H,25,26)/t18-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Reduction in the FTase-catalyzed (enzyme purified from bovine brain) incorporation of [3H]-FPP into recombinant Ha-Ras. |
Bioorg Med Chem Lett 9: 1991-6 (1999)
BindingDB Entry DOI: 10.7270/Q2ZG6RFB |
More data for this
Ligand-Target Pair | |
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