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PubMed code 11859003

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))		BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES [H][C@@]12CC[C@@](O)(C#CC)[C@@]1(C)C[C@@H](C1=C3CCC(=O)C=C3CC[C@@]21[H])c1ccc(cc1)N(C)C |r,c:14,20|
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))		BDBM50110505
PNG
(4-methyl-5-(2-methyl-1,2-dihydrospiro[3,1-benzoxaz...)
Show SMILES CC1Nc2ccc(cc2C2(CCCCC2)O1)-c1sc(cc1C)C#N
Show InChI InChI=1S/C20H22N2OS/c1-13-10-16(12-21)24-19(13)15-6-7-18-17(11-15)20(23-14(2)22-18)8-4-3-5-9-20/h6-7,10-11,14,22H,3-5,8-9H2,1-2H3
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n/an/a 2.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |r,t:20|
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity for Progesterone receptor (PR) in human T47D breast carcinoma cells

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110509
PNG
(4-(4,4-Dimethyl-2-trifluoromethyl-1,4-dihydro-2H-b...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1csc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-15(2)12-6-9(10-5-11(7-20)23-8-10)3-4-13(12)21-14(22-15)16(17,18)19/h3-6,8,14,21H,1-2H3
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n/an/a 4.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110495
PNG
(3-(4,4-Dimethyl-2-trifluoromethyl-1,4-dihydro-2H-b...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C18H14F4N2O/c1-17(2)14-8-11(12-5-10(9-23)6-13(19)7-12)3-4-15(14)24-16(25-17)18(20,21)22/h3-8,16,24H,1-2H3
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n/an/a 7.10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110501
PNG
(3-Fluoro-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H17FN2O/c1-11-21-17-5-4-13(9-16(17)18(2,3)22-11)14-6-12(10-20)7-15(19)8-14/h4-9,11,21H,1-3H3
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n/an/a 7.30n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110512
PNG
(2,2-Dimethyl-propionic acid 6-(5-cyano-thiophen-3-...)
Show SMILES CC(C)(C)C(=O)OCN1C(OC(C)(C)c2cc(ccc12)-c1csc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O3S/c1-20(2,3)19(28)29-12-27-17-7-6-13(14-8-15(10-26)31-11-14)9-16(17)21(4,5)30-18(27)22(23,24)25/h6-9,11,18H,12H2,1-5H3
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n/an/a 7.90n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110516
PNG
(4-Methyl-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1sc(cc1C)C#N
Show InChI InChI=1S/C17H18N2OS/c1-10-7-13(9-18)21-16(10)12-5-6-15-14(8-12)17(3,4)20-11(2)19-15/h5-8,11,19H,1-4H3
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n/an/a 8.10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110497
PNG
(6-(3-Chloro-phenyl)-2,4,4-trimethyl-1,4-dihydro-2H...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H18ClNO/c1-11-19-16-8-7-13(10-15(16)17(2,3)20-11)12-5-4-6-14(18)9-12/h4-11,19H,1-3H3
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n/an/a 9n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110506
PNG
(6-(3-Chloro-phenyl)-2,2,4,4-tetramethyl-1,4-dihydr...)
Show SMILES CC1(C)Nc2ccc(cc2C(C)(C)O1)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H20ClNO/c1-17(2)15-11-13(12-6-5-7-14(19)10-12)8-9-16(15)20-18(3,4)21-17/h5-11,20H,1-4H3
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n/an/a 10n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12 |r,t:28|
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity for Progesterone receptor (PR) in human T47D breast carcinoma cells

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110517
PNG
(4-(2-methyl-1,2-dihydrospiro[3,1-benzoxazine-4,1'-...)
Show SMILES CC1Nc2ccc(cc2C2(CCCCC2)O1)-c1csc(c1)C#N
Show InChI InChI=1S/C19H20N2OS/c1-13-21-18-6-5-14(15-9-16(11-20)23-12-15)10-17(18)19(22-13)7-3-2-4-8-19/h5-6,9-10,12-13,21H,2-4,7-8H2,1H3
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n/an/a 12n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110520
PNG
(4-(2,4,4-Trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxa...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1csc(c1)C#N
Show InChI InChI=1S/C16H16N2OS/c1-10-18-15-5-4-11(7-14(15)16(2,3)19-10)12-6-13(8-17)20-9-12/h4-7,9-10,18H,1-3H3
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n/an/a 12n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110499
PNG
(6-(3-Fluoro-phenyl)-2,4,4-trimethyl-1,4-dihydro-2H...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1cccc(F)c1
Show InChI InChI=1S/C17H18FNO/c1-11-19-16-8-7-13(10-15(16)17(2,3)20-11)12-5-4-6-14(18)9-12/h4-11,19H,1-3H3
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n/an/a 23n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110500
PNG
(3-(2,4-Dimethyl-4-phenyl-1,4-dihydro-2H-benzo[d][1...)
Show SMILES CC1Nc2ccc(cc2C(C)(O1)c1ccccc1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C23H19FN2O/c1-15-26-22-9-8-17(18-10-16(14-25)11-20(24)12-18)13-21(22)23(2,27-15)19-6-4-3-5-7-19/h3-13,15,26H,1-2H3
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n/an/a 25n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110498
PNG
(5-(2,4,4-Trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxa...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1ccc(s1)C#N
Show InChI InChI=1S/C16H16N2OS/c1-10-18-14-6-4-11(8-13(14)16(2,3)19-10)15-7-5-12(9-17)20-15/h4-8,10,18H,1-3H3
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n/an/a 27n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50066526
PNG
(3-Fluoro-5-(2,2,4-trimethyl-1,2-dihydro-quinolin-6...)
Show SMILES CC1=CC(C)(C)Nc2ccc(cc12)-c1cc(F)cc(c1)C#N |t:1|
Show InChI InChI=1S/C19H17FN2/c1-12-10-19(2,3)22-18-5-4-14(9-17(12)18)15-6-13(11-21)7-16(20)8-15/h4-10,22H,1-3H3
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n/an/a 37n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110496
PNG
(6-(3-Chloro-phenyl)-4,4-dimethyl-2-trifluoromethyl...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cccc(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C17H15ClF3NO/c1-16(2)13-9-11(10-4-3-5-12(18)8-10)6-7-14(13)22-15(23-16)17(19,20)21/h3-9,15,22H,1-2H3
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n/an/a 41n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110514
PNG
(3-Fluoro-5-(2,2,4,4-tetramethyl-1,4-dihydro-2H-ben...)
Show SMILES CC1(C)Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C19H19FN2O/c1-18(2)16-10-13(5-6-17(16)22-19(3,4)23-18)14-7-12(11-21)8-15(20)9-14/h5-10,22H,1-4H3
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n/an/a 42n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110515
PNG
(3-Fluoro-5-(2-isopropyl-4,4-dimethyl-1,4-dihydro-2...)
Show SMILES CC(C)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H21FN2O/c1-12(2)19-23-18-6-5-14(10-17(18)20(3,4)24-19)15-7-13(11-22)8-16(21)9-15/h5-10,12,19,23H,1-4H3
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n/an/a 47n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110511
PNG
(3-(4,4-Dimethyl-2-thiophen-2-yl-1,4-dihydro-2H-ben...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1cccs1
Show InChI InChI=1S/C21H17FN2OS/c1-21(2)17-11-14(15-8-13(12-23)9-16(22)10-15)5-6-18(17)24-20(25-21)19-4-3-7-26-19/h3-11,20,24H,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110519
PNG
(3-(4,4-Dimethyl-2-phenyl-1,4-dihydro-2H-benzo[d][1...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccccc1
Show InChI InChI=1S/C23H19FN2O/c1-23(2)20-13-17(18-10-15(14-25)11-19(24)12-18)8-9-21(20)26-22(27-23)16-6-4-3-5-7-16/h3-13,22,26H,1-2H3
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n/an/a 93n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110507
PNG
(2-(4-Amino-3'-chloro-biphenyl-3-yl)-propan-2-ol | ...)
Show SMILES CC(C)(O)c1cc(ccc1N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNO/c1-15(2,18)13-9-11(6-7-14(13)17)10-4-3-5-12(16)8-10/h3-9,18H,17H2,1-2H3
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n/an/a 103n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110510
PNG
(4-(2,4,4-Trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxa...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1coc(c1)C#N
Show InChI InChI=1S/C16H16N2O2/c1-10-18-15-5-4-11(7-14(15)16(2,3)20-10)12-6-13(8-17)19-9-12/h4-7,9-10,18H,1-3H3
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n/an/a 113n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110504
PNG
(3-(2-tert-Butyl-4,4-dimethyl-1,4-dihydro-2H-benzo[...)
Show SMILES CC(C)(C)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C21H23FN2O/c1-20(2,3)19-24-18-7-6-14(11-17(18)21(4,5)25-19)15-8-13(12-23)9-16(22)10-15/h6-11,19,24H,1-5H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110513
PNG
(6-(3-Cyano-5-fluoro-phenyl)-4,4-dimethyl-1,4-dihyd...)
Show SMILES CCOC(=O)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H19FN2O3/c1-4-25-19(24)18-23-17-6-5-13(10-16(17)20(2,3)26-18)14-7-12(11-22)8-15(21)9-14/h5-10,18,23H,4H2,1-3H3
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n/an/a 159n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110508
PNG
(2-Fluoro-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1ccc(F)c(c1)C#N
Show InChI InChI=1S/C18H17FN2O/c1-11-21-17-7-5-13(9-15(17)18(2,3)22-11)12-4-6-16(19)14(8-12)10-20/h4-9,11,21H,1-3H3
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n/an/a 166n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110503
PNG
(6-(3-Chloro-4-fluoro-phenyl)-2,4,4-trimethyl-1,4-d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H17ClFNO/c1-10-20-16-7-5-11(8-13(16)17(2,3)21-10)12-4-6-15(19)14(18)9-12/h4-10,20H,1-3H3
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n/an/a 213n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110507
PNG
(2-(4-Amino-3'-chloro-biphenyl-3-yl)-propan-2-ol | ...)
Show SMILES CC(C)(O)c1cc(ccc1N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNO/c1-15(2,18)13-9-11(6-7-14(13)17)10-4-3-5-12(16)8-10/h3-9,18H,17H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110511
PNG
(3-(4,4-Dimethyl-2-thiophen-2-yl-1,4-dihydro-2H-ben...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1cccs1
Show InChI InChI=1S/C21H17FN2OS/c1-21(2)17-11-14(15-8-13(12-23)9-16(22)10-15)5-6-18(17)24-20(25-21)19-4-3-7-26-19/h3-11,20,24H,1-2H3
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n/an/a 1.68E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110513
PNG
(6-(3-Cyano-5-fluoro-phenyl)-4,4-dimethyl-1,4-dihyd...)
Show SMILES CCOC(=O)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H19FN2O3/c1-4-25-19(24)18-23-17-6-5-13(10-16(17)20(2,3)26-18)14-7-12(11-22)8-15(21)9-14/h5-10,18,23H,4H2,1-3H3
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n/an/a 1.79E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110519
PNG
(3-(4,4-Dimethyl-2-phenyl-1,4-dihydro-2H-benzo[d][1...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccccc1
Show InChI InChI=1S/C23H19FN2O/c1-23(2)20-13-17(18-10-15(14-25)11-19(24)12-18)8-9-21(20)26-22(27-23)16-6-4-3-5-7-16/h3-13,22,26H,1-2H3
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n/an/a 2.06E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110502
PNG
(4-(1-Acetyl-4,4-dimethyl-2-trifluoromethyl-1,4-dih...)
Show SMILES CC(=O)N1C(OC(C)(C)c2cc(ccc12)-c1csc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O2S/c1-10(24)23-15-5-4-11(12-6-13(8-22)26-9-12)7-14(15)17(2,3)25-16(23)18(19,20)21/h4-7,9,16H,1-3H3
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n/an/a 2.09E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110504
PNG
(3-(2-tert-Butyl-4,4-dimethyl-1,4-dihydro-2H-benzo[...)
Show SMILES CC(C)(C)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C21H23FN2O/c1-20(2,3)19-24-18-7-6-14(11-17(18)21(4,5)25-19)15-8-13(12-23)9-16(22)10-15/h6-11,19,24H,1-5H3
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n/an/a 3.04E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110515
PNG
(3-Fluoro-5-(2-isopropyl-4,4-dimethyl-1,4-dihydro-2...)
Show SMILES CC(C)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H21FN2O/c1-12(2)19-23-18-6-5-14(10-17(18)20(3,4)24-19)15-7-13(11-22)8-16(21)9-15/h5-10,12,19,23H,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110511
PNG
(3-(4,4-Dimethyl-2-thiophen-2-yl-1,4-dihydro-2H-ben...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1cccs1
Show InChI InChI=1S/C21H17FN2OS/c1-21(2)17-11-14(15-8-13(12-23)9-16(22)10-15)5-6-18(17)24-20(25-21)19-4-3-7-26-19/h3-11,20,24H,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110497
PNG
(6-(3-Chloro-phenyl)-2,4,4-trimethyl-1,4-dihydro-2H...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1cccc(Cl)c1
Show InChI InChI=1S/C17H18ClNO/c1-11-19-16-8-7-13(10-15(16)17(2,3)20-11)12-5-4-6-14(18)9-12/h4-11,19H,1-3H3
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n/an/an/an/a 2.40n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110508
PNG
(2-Fluoro-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1ccc(F)c(c1)C#N
Show InChI InChI=1S/C18H17FN2O/c1-11-21-17-7-5-13(9-15(17)18(2,3)22-11)12-4-6-16(19)14(8-12)10-20/h4-9,11,21H,1-3H3
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n/an/an/an/a 23n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110505
PNG
(4-methyl-5-(2-methyl-1,2-dihydrospiro[3,1-benzoxaz...)
Show SMILES CC1Nc2ccc(cc2C2(CCCCC2)O1)-c1sc(cc1C)C#N
Show InChI InChI=1S/C20H22N2OS/c1-13-10-16(12-21)24-19(13)15-6-7-18-17(11-15)20(23-14(2)22-18)8-4-3-5-9-20/h6-7,10-11,14,22H,3-5,8-9H2,1-2H3
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n/an/an/an/a 2.40n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110517
PNG
(4-(2-methyl-1,2-dihydrospiro[3,1-benzoxazine-4,1'-...)
Show SMILES CC1Nc2ccc(cc2C2(CCCCC2)O1)-c1csc(c1)C#N
Show InChI InChI=1S/C19H20N2OS/c1-13-21-18-6-5-14(15-9-16(11-20)23-12-15)10-17(18)19(22-13)7-3-2-4-8-19/h5-6,9-10,12-13,21H,2-4,7-8H2,1H3
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n/an/an/an/a 3.5n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES [H][C@@]12CC[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C |r,t:20|
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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n/an/an/an/a 0.920n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110506
PNG
(6-(3-Chloro-phenyl)-2,2,4,4-tetramethyl-1,4-dihydr...)
Show SMILES CC1(C)Nc2ccc(cc2C(C)(C)O1)-c1cccc(Cl)c1
Show InChI InChI=1S/C18H20ClNO/c1-17(2)15-11-13(12-6-5-7-14(19)10-12)8-9-16(15)20-18(3,4)21-17/h5-11,20H,1-4H3
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n/an/an/an/a 32n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110499
PNG
(6-(3-Fluoro-phenyl)-2,4,4-trimethyl-1,4-dihydro-2H...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1cccc(F)c1
Show InChI InChI=1S/C17H18FNO/c1-11-19-16-8-7-13(10-15(16)17(2,3)20-11)12-5-4-6-14(18)9-12/h4-11,19H,1-3H3
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n/an/an/an/a 2.60n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110496
PNG
(6-(3-Chloro-phenyl)-4,4-dimethyl-2-trifluoromethyl...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cccc(Cl)c1)C(F)(F)F
Show InChI InChI=1S/C17H15ClF3NO/c1-16(2)13-9-11(10-4-3-5-12(18)8-10)6-7-14(13)22-15(23-16)17(19,20)21/h3-9,15,22H,1-2H3
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n/an/an/an/a 2.90n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110519
PNG
(3-(4,4-Dimethyl-2-phenyl-1,4-dihydro-2H-benzo[d][1...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)c1ccccc1
Show InChI InChI=1S/C23H19FN2O/c1-23(2)20-13-17(18-10-15(14-25)11-19(24)12-18)8-9-21(20)26-22(27-23)16-6-4-3-5-7-16/h3-13,22,26H,1-2H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50067678
PNG
((6alpha)-17-(Acetyloxy)-6-methylpreg-4-ene-3,20-di...)
Show SMILES C[C@H]1C[C@H]2[C@@H]3CC[C@](OC(C)=O)(C(C)=O)[C@@]3(C)CC[C@@H]2[C@@]2(C)CCC(=O)C=C12 |r,t:28|
Show InChI InChI=1S/C24H34O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h13-14,18-20H,6-12H2,1-5H3/t14-,18+,19-,20-,22+,23-,24-/m0/s1
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n/an/an/an/a 0.120n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110509
PNG
(4-(4,4-Dimethyl-2-trifluoromethyl-1,4-dihydro-2H-b...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1csc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C16H13F3N2OS/c1-15(2)12-6-9(10-5-11(7-20)23-8-10)3-4-13(12)21-14(22-15)16(17,18)19/h3-6,8,14,21H,1-2H3
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n/an/an/an/a 0.800n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110512
PNG
(2,2-Dimethyl-propionic acid 6-(5-cyano-thiophen-3-...)
Show SMILES CC(C)(C)C(=O)OCN1C(OC(C)(C)c2cc(ccc12)-c1csc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C22H23F3N2O3S/c1-20(2,3)19(28)29-12-27-17-7-6-13(14-8-15(10-26)31-11-14)9-16(17)21(4,5)30-18(27)22(23,24)25/h6-9,11,18H,12H2,1-5H3
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n/an/an/an/a 0.900n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110507
PNG
(2-(4-Amino-3'-chloro-biphenyl-3-yl)-propan-2-ol | ...)
Show SMILES CC(C)(O)c1cc(ccc1N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H16ClNO/c1-15(2,18)13-9-11(6-7-14(13)17)10-4-3-5-12(16)8-10/h3-9,18H,17H2,1-2H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110513
PNG
(6-(3-Cyano-5-fluoro-phenyl)-4,4-dimethyl-1,4-dihyd...)
Show SMILES CCOC(=O)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C20H19FN2O3/c1-4-25-19(24)18-23-17-6-5-13(10-16(17)20(2,3)26-18)14-7-12(11-22)8-15(21)9-14/h5-10,18,23H,4H2,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110514
PNG
(3-Fluoro-5-(2,2,4,4-tetramethyl-1,4-dihydro-2H-ben...)
Show SMILES CC1(C)Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C19H19FN2O/c1-18(2)16-10-13(5-6-17(16)22-19(3,4)23-18)14-7-12(11-21)8-15(20)9-14/h5-10,22H,1-4H3
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n/an/an/an/a 11n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110503
PNG
(6-(3-Chloro-4-fluoro-phenyl)-2,4,4-trimethyl-1,4-d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C17H17ClFNO/c1-10-20-16-7-5-11(8-13(16)17(2,3)21-10)12-4-6-15(19)14(18)9-12/h4-10,20H,1-3H3
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n/an/an/an/a 32n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Binding affinity against progesterone receptor using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110521
PNG
(6-(5-Cyano-thiophen-3-yl)-4,4-dimethyl-2-trifluoro...)
Show SMILES COC(=O)N1C(OC(C)(C)c2cc(ccc12)-c1csc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O3S/c1-17(2)13-7-10(11-6-12(8-22)27-9-11)4-5-14(13)23(16(24)25-3)15(26-17)18(19,20)21/h4-7,9,15H,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110501
PNG
(3-Fluoro-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C18H17FN2O/c1-11-21-17-5-4-13(9-16(17)18(2,3)22-11)14-6-12(10-20)7-15(19)8-14/h4-9,11,21H,1-3H3
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n/an/an/an/a 0.350n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonist activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110510
PNG
(4-(2,4,4-Trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxa...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1coc(c1)C#N
Show InChI InChI=1S/C16H16N2O2/c1-10-18-15-5-4-11(7-14(15)16(2,3)20-10)12-6-13(8-17)19-9-12/h4-7,9-10,18H,1-3H3
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n/an/an/an/a 4.60n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110502
PNG
(4-(1-Acetyl-4,4-dimethyl-2-trifluoromethyl-1,4-dih...)
Show SMILES CC(=O)N1C(OC(C)(C)c2cc(ccc12)-c1csc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C18H15F3N2O2S/c1-10(24)23-15-5-4-11(12-6-13(8-22)26-9-12)7-14(15)17(2,3)25-16(23)18(19,20)21/h4-7,9,16H,1-3H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110520
PNG
(4-(2,4,4-Trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxa...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1csc(c1)C#N
Show InChI InChI=1S/C16H16N2OS/c1-10-18-15-5-4-11(7-14(15)16(2,3)19-10)12-6-13(8-17)20-9-12/h4-7,9-10,18H,1-3H3
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n/an/an/an/a 0.350n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110498
PNG
(5-(2,4,4-Trimethyl-1,4-dihydro-2H-benzo[d][1,3]oxa...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1ccc(s1)C#N
Show InChI InChI=1S/C16H16N2OS/c1-10-18-14-6-4-11(8-13(14)16(2,3)19-10)15-7-5-12(9-17)20-15/h4-8,10,18H,1-3H3
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n/an/an/an/a 1.10n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110522
PNG
(4-(2,2,4,4-Tetramethyl-1,4-dihydro-2H-benzo[d][1,3...)
Show SMILES CC1(C)Nc2ccc(cc2C(C)(C)O1)-c1csc(c1)C#N
Show InChI InChI=1S/C17H18N2OS/c1-16(2)14-8-11(12-7-13(9-18)21-10-12)5-6-15(14)19-17(3,4)20-16/h5-8,10,19H,1-4H3
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n/an/an/an/a 9.20n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110504
PNG
(3-(2-tert-Butyl-4,4-dimethyl-1,4-dihydro-2H-benzo[...)
Show SMILES CC(C)(C)C1Nc2ccc(cc2C(C)(C)O1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C21H23FN2O/c1-20(2,3)19-24-18-7-6-14(11-17(18)21(4,5)25-19)15-8-13(12-23)9-16(22)10-15/h6-11,19,24H,1-5H3
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Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110516
PNG
(4-Methyl-5-(2,4,4-trimethyl-1,4-dihydro-2H-benzo[d...)
Show SMILES CC1Nc2ccc(cc2C(C)(C)O1)-c1sc(cc1C)C#N
Show InChI InChI=1S/C17H18N2OS/c1-10-7-13(9-18)21-16(10)12-5-6-15-14(8-12)17(3,4)20-11(2)19-15/h5-8,11,19H,1-4H3
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n/an/an/an/a 0.200n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110500
PNG
(3-(2,4-Dimethyl-4-phenyl-1,4-dihydro-2H-benzo[d][1...)
Show SMILES CC1Nc2ccc(cc2C(C)(O1)c1ccccc1)-c1cc(F)cc(c1)C#N
Show InChI InChI=1S/C23H19FN2O/c1-15-26-22-9-8-17(18-10-16(14-25)11-20(24)12-18)13-21(22)23(2,27-15)19-6-4-3-5-7-19/h3-13,15,26H,1-2H3
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n/an/an/an/a 8.20n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))		BDBM50110495
PNG
(3-(4,4-Dimethyl-2-trifluoromethyl-1,4-dihydro-2H-b...)
Show SMILES CC1(C)OC(Nc2ccc(cc12)-c1cc(F)cc(c1)C#N)C(F)(F)F
Show InChI InChI=1S/C18H14F4N2O/c1-17(2)14-8-11(12-5-10(9-23)6-13(19)7-12)3-4-15(14)24-16(25-17)18(20,21)22/h3-8,16,24H,1-2H3
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n/an/an/an/a 1.70n/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Agonistic activity against progesterone receptor in alkaline phosphatase assay using human T47D breast carcinoma cell line

Bioorg Med Chem Lett 12: 787-90 (2002)


BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%