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PubMed code 12361392

Compile data set for download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50005118
PNG
((S)-3,5-Dichloro-N-(1-ethyl-pyrrolidin-2-ylmethyl)...)
Show SMILES CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(Cl)c1OC
Show InChI InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
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n/an/a 3.40n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50016900
PNG
((E)-N-[2-(3-Dimethylamino-propylsulfanyl)-phenyl]-...)
Show SMILES CN(C)CCCSc1ccccc1NC(=O)\C=C\c1ccccc1
Show InChI InChI=1S/C20H24N2OS/c1-22(2)15-8-16-24-19-12-7-6-11-18(19)21-20(23)14-13-17-9-4-3-5-10-17/h3-7,9-14H,8,15-16H2,1-2H3,(H,21,23)/b14-13+
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n/an/a 14.8n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 17.5n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119470
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-fluor...)
Show SMILES Fc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25FN4/c27-24-13-7-8-14-25(24)30-17-15-29(16-18-30)19-22-20-31(23-11-5-2-6-12-23)26(28-22)21-9-3-1-4-10-21/h1-14,20H,15-19H2
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n/an/a 25.3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119469
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-ethox...)
Show SMILES CCOc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C28H30N4O/c1-2-33-27-16-10-9-15-26(27)31-19-17-30(18-20-31)21-24-22-32(25-13-7-4-8-14-25)28(29-24)23-11-5-3-6-12-23/h3-16,22H,2,17-21H2,1H3
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n/an/a 34.7n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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n/an/a 40.7n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119471
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES CCOc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccc(F)cc2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H28F2N4O/c1-2-35-27-6-4-3-5-26(27)33-17-15-32(16-18-33)19-24-20-34(25-13-11-23(30)12-14-25)28(31-24)21-7-9-22(29)10-8-21/h3-14,20H,2,15-19H2,1H3
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n/an/a 51.9n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119469
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-ethox...)
Show SMILES CCOc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C28H30N4O/c1-2-33-27-16-10-9-15-26(27)31-19-17-30(18-20-31)21-24-22-32(25-13-7-4-8-14-25)28(29-24)23-11-5-3-6-12-23/h3-16,22H,2,17-21H2,1H3
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n/an/a 56.9n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119480
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-metho...)
Show SMILES COc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-15-9-8-14-25(26)30-18-16-29(17-19-30)20-23-21-31(24-12-6-3-7-13-24)27(28-23)22-10-4-2-5-11-22/h2-15,21H,16-20H2,1H3
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n/an/a 70.3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119480
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-metho...)
Show SMILES COc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-15-9-8-14-25(26)30-18-16-29(17-19-30)20-23-21-31(24-12-6-3-7-13-24)27(28-23)22-10-4-2-5-11-22/h2-15,21H,16-20H2,1H3
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n/an/a 73.9n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119463
PNG
(1-(4-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-22-11-13-24(14-12-22)30-17-15-29(16-18-30)19-23-20-31(25-9-5-2-6-10-25)26(28-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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n/an/a 91.8n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119472
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccc(F)cc2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C27H26F2N4O/c1-34-26-5-3-2-4-25(26)32-16-14-31(15-17-32)18-23-19-33(24-12-10-22(29)11-13-24)27(30-23)20-6-8-21(28)9-7-20/h2-13,19H,14-18H2,1H3
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n/an/a 120n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 125n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119480
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-metho...)
Show SMILES COc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-15-9-8-14-25(26)30-18-16-29(17-19-30)20-23-21-31(24-12-6-3-7-13-24)27(28-23)22-10-4-2-5-11-22/h2-15,21H,16-20H2,1H3
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n/an/a 131n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119478
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(3-trifl...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H25F3N4/c28-27(29,30)22-10-7-13-25(18-22)33-16-14-32(15-17-33)19-23-20-34(24-11-5-2-6-12-24)26(31-23)21-8-3-1-4-9-21/h1-13,18,20H,14-17,19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119476
PNG
(1-(2-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-24-13-7-8-14-25(24)30-17-15-29(16-18-30)19-22-20-31(23-11-5-2-6-12-23)26(28-22)21-9-3-1-4-10-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119473
PNG
(1-(3-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-22-10-7-13-25(18-22)30-16-14-29(15-17-30)19-23-20-31(24-11-5-2-6-12-24)26(28-23)21-8-3-1-4-9-21/h1-13,18,20H,14-17,19H2
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n/an/a 166n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119479
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES Fc1ccc(cc1)-c1nc(CN2CCN(CC2)c2ccccc2)cn1-c1ccc(F)cc1
Show InChI InChI=1S/C26H24F2N4/c27-21-8-6-20(7-9-21)26-29-23(19-32(26)25-12-10-22(28)11-13-25)18-30-14-16-31(17-15-30)24-4-2-1-3-5-24/h1-13,19H,14-18H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119464
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(3-metho...)
Show SMILES COc1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-14-8-13-25(19-26)30-17-15-29(16-18-30)20-23-21-31(24-11-6-3-7-12-24)27(28-23)22-9-4-2-5-10-22/h2-14,19,21H,15-18,20H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119472
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccc(F)cc2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C27H26F2N4O/c1-34-26-5-3-2-4-25(26)32-16-14-31(15-17-32)18-23-19-33(24-12-10-22(29)11-13-24)27(30-23)20-6-8-21(28)9-7-20/h2-13,19H,14-18H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119469
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-ethox...)
Show SMILES CCOc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C28H30N4O/c1-2-33-27-16-10-9-15-26(27)31-19-17-30(18-20-31)21-24-22-32(25-13-7-4-8-14-25)28(29-24)23-11-5-3-6-12-23/h3-16,22H,2,17-21H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119468
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-pyridin-...)
Show SMILES C(N1CCN(CC1)c1ccccn1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C25H25N5/c1-3-9-21(10-4-1)25-27-22(20-30(25)23-11-5-2-6-12-23)19-28-15-17-29(18-16-28)24-13-7-8-14-26-24/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119478
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(3-trifl...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H25F3N4/c28-27(29,30)22-10-7-13-25(18-22)33-16-14-32(15-17-33)19-23-20-34(24-11-5-2-6-12-24)26(31-23)21-8-3-1-4-9-21/h1-13,18,20H,14-17,19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119477
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-trifl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H25F3N4/c28-27(29,30)22-11-13-24(14-12-22)33-17-15-32(16-18-33)19-23-20-34(25-9-5-2-6-10-25)26(31-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119476
PNG
(1-(2-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-24-13-7-8-14-25(24)30-17-15-29(16-18-30)19-22-20-31(23-11-5-2-6-12-23)26(28-22)21-9-3-1-4-10-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119472
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccc(F)cc2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C27H26F2N4O/c1-34-26-5-3-2-4-25(26)32-16-14-31(15-17-32)18-23-19-33(24-12-10-22(29)11-13-24)27(30-23)20-6-8-21(28)9-7-20/h2-13,19H,14-18H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119471
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES CCOc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccc(F)cc2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H28F2N4O/c1-2-35-27-6-4-3-5-26(27)33-17-15-32(16-18-33)19-24-20-34(25-13-11-23(30)12-14-25)28(31-24)21-7-9-22(29)10-8-21/h3-14,20H,2,15-19H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119464
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(3-metho...)
Show SMILES COc1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-14-8-13-25(19-26)30-17-15-29(16-18-30)20-23-21-31(24-11-6-3-7-12-24)27(28-23)22-9-4-2-5-10-22/h2-14,19,21H,15-18,20H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119471
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES CCOc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccc(F)cc2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H28F2N4O/c1-2-35-27-6-4-3-5-26(27)33-17-15-32(16-18-33)19-24-20-34(25-13-11-23(30)12-14-25)28(31-24)21-7-9-22(29)10-8-21/h3-14,20H,2,15-19H2,1H3
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119476
PNG
(1-(2-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-24-13-7-8-14-25(24)30-17-15-29(16-18-30)19-22-20-31(23-11-5-2-6-12-23)26(28-22)21-9-3-1-4-10-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119463
PNG
(1-(4-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-22-11-13-24(14-12-22)30-17-15-29(16-18-30)19-23-20-31(25-9-5-2-6-10-25)26(28-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119470
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-fluor...)
Show SMILES Fc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25FN4/c27-24-13-7-8-14-25(24)30-17-15-29(16-18-30)19-22-20-31(23-11-5-2-6-12-23)26(28-22)21-9-3-1-4-10-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119470
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(2-fluor...)
Show SMILES Fc1ccccc1N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25FN4/c27-24-13-7-8-14-25(24)30-17-15-29(16-18-30)19-22-20-31(23-11-5-2-6-12-23)26(28-22)21-9-3-1-4-10-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119466
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-fluor...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25FN4/c27-22-11-13-24(14-12-22)30-17-15-29(16-18-30)19-23-20-31(25-9-5-2-6-10-25)26(28-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119479
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES Fc1ccc(cc1)-c1nc(CN2CCN(CC2)c2ccccc2)cn1-c1ccc(F)cc1
Show InChI InChI=1S/C26H24F2N4/c27-21-8-6-20(7-9-21)26-29-23(19-32(26)25-12-10-22(28)11-13-25)18-30-14-16-31(17-15-30)24-4-2-1-3-5-24/h1-13,19H,14-18H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119473
PNG
(1-(3-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-22-10-7-13-25(18-22)30-16-14-29(15-17-30)19-23-20-31(24-11-5-2-6-12-24)26(28-23)21-8-3-1-4-9-21/h1-13,18,20H,14-17,19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119479
PNG
(1-[1,2-Bis-(4-fluoro-phenyl)-1H-imidazol-4-ylmethy...)
Show SMILES Fc1ccc(cc1)-c1nc(CN2CCN(CC2)c2ccccc2)cn1-c1ccc(F)cc1
Show InChI InChI=1S/C26H24F2N4/c27-21-8-6-20(7-9-21)26-29-23(19-32(26)25-12-10-22(28)11-13-25)18-30-14-16-31(17-15-30)24-4-2-1-3-5-24/h1-13,19H,14-18H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119466
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-fluor...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25FN4/c27-22-11-13-24(14-12-22)30-17-15-29(16-18-30)19-23-20-31(25-9-5-2-6-10-25)26(28-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119477
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-trifl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H25F3N4/c28-27(29,30)22-11-13-24(14-12-22)33-17-15-32(16-18-33)19-23-20-34(25-9-5-2-6-10-25)26(31-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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n/an/a 1.00E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119475
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-phenyl-p...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C26H26N4/c1-4-10-22(11-5-1)26-27-23(21-30(26)25-14-8-3-9-15-25)20-28-16-18-29(19-17-28)24-12-6-2-7-13-24/h1-15,21H,16-20H2
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n/an/a 1.02E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119465
PNG
(1-Benzyl-4-(1,2-diphenyl-1H-imidazol-4-ylmethyl)-p...)
Show SMILES C(N1CCN(Cc2ccccc2)CC1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H28N4/c1-4-10-23(11-5-1)20-29-16-18-30(19-17-29)21-25-22-31(26-14-8-3-9-15-26)27(28-25)24-12-6-2-7-13-24/h1-15,22H,16-21H2
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n/an/a 1.13E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119466
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-fluor...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25FN4/c27-22-11-13-24(14-12-22)30-17-15-29(16-18-30)19-23-20-31(25-9-5-2-6-10-25)26(28-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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n/an/a 1.29E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119477
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-trifl...)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H25F3N4/c28-27(29,30)22-11-13-24(14-12-22)33-17-15-32(16-18-33)19-23-20-34(25-9-5-2-6-10-25)26(31-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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n/an/a 1.51E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119463
PNG
(1-(4-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-22-11-13-24(14-12-22)30-17-15-29(16-18-30)19-23-20-31(25-9-5-2-6-10-25)26(28-23)21-7-3-1-4-8-21/h1-14,20H,15-19H2
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n/an/a 1.90E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119467
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-metho...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-14-12-24(13-15-26)30-18-16-29(17-19-30)20-23-21-31(25-10-6-3-7-11-25)27(28-23)22-8-4-2-5-9-22/h2-15,21H,16-20H2,1H3
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n/an/a 1.92E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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n/an/a 1.99E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119468
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-pyridin-...)
Show SMILES C(N1CCN(CC1)c1ccccn1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C25H25N5/c1-3-9-21(10-4-1)25-27-22(20-30(25)23-11-5-2-6-12-23)19-28-15-17-29(18-16-28)24-13-7-8-14-26-24/h1-14,20H,15-19H2
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n/an/a 2.02E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12 |t:8|
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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n/an/a 2.11E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119478
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(3-trifl...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H25F3N4/c28-27(29,30)22-10-7-13-25(18-22)33-16-14-32(15-17-33)19-23-20-34(24-11-5-2-6-12-24)26(31-23)21-8-3-1-4-9-21/h1-13,18,20H,14-17,19H2
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n/an/a 2.13E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119473
PNG
(1-(3-Chloro-phenyl)-4-(1,2-diphenyl-1H-imidazol-4-...)
Show SMILES Clc1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C26H25ClN4/c27-22-10-7-13-25(18-22)30-16-14-29(15-17-30)19-23-20-31(24-11-5-2-6-12-24)26(28-23)21-8-3-1-4-9-21/h1-13,18,20H,14-17,19H2
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n/an/a 2.14E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119465
PNG
(1-Benzyl-4-(1,2-diphenyl-1H-imidazol-4-ylmethyl)-p...)
Show SMILES C(N1CCN(Cc2ccccc2)CC1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H28N4/c1-4-10-23(11-5-1)20-29-16-18-30(19-17-29)21-25-22-31(26-14-8-3-9-15-26)27(28-25)24-12-6-2-7-13-24/h1-15,22H,16-21H2
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n/an/a 2.17E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119464
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(3-metho...)
Show SMILES COc1cccc(c1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-14-8-13-25(19-26)30-17-15-29(16-18-30)20-23-21-31(24-11-6-3-7-12-24)27(28-23)22-9-4-2-5-10-22/h2-14,19,21H,15-18,20H2,1H3
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n/an/a 2.34E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119475
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-phenyl-p...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C26H26N4/c1-4-10-22(11-5-1)26-27-23(21-30(26)25-14-8-3-9-15-25)20-28-16-18-29(19-17-28)24-12-6-2-7-13-24/h1-15,21H,16-20H2
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n/an/a 2.70E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119468
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-pyridin-...)
Show SMILES C(N1CCN(CC1)c1ccccn1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C25H25N5/c1-3-9-21(10-4-1)25-27-22(20-30(25)23-11-5-2-6-12-23)19-28-15-17-29(18-16-28)24-13-7-8-14-26-24/h1-14,20H,15-19H2
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n/an/a 2.74E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119465
PNG
(1-Benzyl-4-(1,2-diphenyl-1H-imidazol-4-ylmethyl)-p...)
Show SMILES C(N1CCN(Cc2ccccc2)CC1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H28N4/c1-4-10-23(11-5-1)20-29-16-18-30(19-17-29)21-25-22-31(26-14-8-3-9-15-26)27(28-25)24-12-6-2-7-13-24/h1-15,22H,16-21H2
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n/an/a 4.91E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119467
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-metho...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-14-12-24(13-15-26)30-18-16-29(17-19-30)20-23-21-31(25-10-6-3-7-11-25)27(28-23)22-8-4-2-5-9-22/h2-15,21H,16-20H2,1H3
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n/an/a 5.80E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119467
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-(4-metho...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C27H28N4O/c1-32-26-14-12-24(13-15-26)30-18-16-29(17-19-30)20-23-21-31(25-10-6-3-7-11-25)27(28-23)22-8-4-2-5-9-22/h2-15,21H,16-20H2,1H3
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n/an/a 8.44E+3n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Rattus norvegicus (rat))		BDBM50119474
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-methyl-p...)
Show SMILES CN1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C21H24N4/c1-23-12-14-24(15-13-23)16-19-17-25(20-10-6-3-7-11-20)21(22-19)18-8-4-2-5-9-18/h2-11,17H,12-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 1A receptor fof rat cerebral cortex using [3H]8-OH-DPAT as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119474
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-methyl-p...)
Show SMILES CN1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C21H24N4/c1-23-12-14-24(15-13-23)16-19-17-25(20-10-6-3-7-11-20)21(22-19)18-8-4-2-5-9-18/h2-11,17H,12-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50119474
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-methyl-p...)
Show SMILES CN1CCN(Cc2cn(c(n2)-c2ccccc2)-c2ccccc2)CC1
Show InChI InChI=1S/C21H24N4/c1-23-12-14-24(15-13-23)16-19-17-25(20-10-6-3-7-11-20)21(22-19)18-8-4-2-5-9-18/h2-11,17H,12-16H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for Dopamine D2 receptor of rat using [3H]YM-09151 as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))		BDBM50119475
PNG
(1-(1,2-Diphenyl-1H-imidazol-4-ylmethyl)-4-phenyl-p...)
Show SMILES C(N1CCN(CC1)c1ccccc1)c1cn(c(n1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C26H26N4/c1-4-10-22(11-5-1)26-27-23(21-30(26)25-14-8-3-9-15-25)20-28-16-18-29(19-17-28)24-12-6-2-7-13-24/h1-15,21H,16-20H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Sassari

Curated by ChEMBL


Assay Description
In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligand

J Med Chem 45: 4655-68 (2002)


BindingDB Entry DOI: 10.7270/Q21G0N0M
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%