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PubMed code 12467617

Compile data set for download or QSAR
Found 17 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))		BDBM50220557
PNG
(CHEMBL422869)
Show SMILES Fc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28ClFN2O/c27-22-9-10-23-24-21(22)4-3-14-26(24,25(31)29-23)13-1-2-15-30-16-11-19(12-17-30)18-5-7-20(28)8-6-18/h5-11H,1-4,12-17H2,(H,29,31)
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 2n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))		BDBM50116963
PNG
(2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...)
Show SMILES O=C1Nc2cccc3CCCC1(CCCCN1CCC(=CC1)c1ccccc1)c23 |c:20|
Show InChI InChI=1S/C26H30N2O/c29-25-26(16-7-11-22-10-6-12-23(27-25)24(22)26)15-4-5-17-28-18-13-21(14-19-28)20-8-2-1-3-9-20/h1-3,6,8-10,12-13H,4-5,7,11,14-19H2,(H,27,29)
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 2.10n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))		BDBM50220558
PNG
(CHEMBL418888)
Show SMILES Fc1ccc(cc1)C1=CCN(CCCCC23CCCc4cccc(NC2=O)c34)CC1 |t:8|
Show InChI InChI=1S/C26H29FN2O/c27-22-10-8-19(9-11-22)20-12-17-29(18-13-20)16-2-1-14-26-15-4-6-21-5-3-7-23(24(21)26)28-25(26)30/h3,5,7-12H,1-2,4,6,13-18H2,(H,28,30)
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 3.5n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))		BDBM50220504
PNG
(CHEMBL348410)
Show SMILES Clc1ccc2NC(=O)C3(CCCCN4CCC(=CC4)c4ccccc4)CCCc1c23 |c:16|
Show InChI InChI=1S/C26H29ClN2O/c27-22-10-11-23-24-21(22)9-6-15-26(24,25(30)28-23)14-4-5-16-29-17-12-20(13-18-29)19-7-2-1-3-8-19/h1-3,7-8,10-12H,4-6,9,13-18H2,(H,28,30)
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 5n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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 7.20n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-HT7 receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 7


(Homo sapiens (Human))		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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 7.20n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Ability to displace the radioligand [3H]5-carboximidotryptamine ([3H]-5-CT) from cloned human 5-hydroxytryptamine 7 receptor expressed in COS-7 cells

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50220558
PNG
(CHEMBL418888)
Show SMILES Fc1ccc(cc1)C1=CCN(CCCCC23CCCc4cccc(NC2=O)c34)CC1 |t:8|
Show InChI InChI=1S/C26H29FN2O/c27-22-10-8-19(9-11-22)20-12-17-29(18-13-20)16-2-1-14-26-15-4-6-21-5-3-7-23(24(21)26)28-25(26)30/h3,5,7-12H,1-2,4,6,13-18H2,(H,28,30)
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 66n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2 receptor by the displacement of [3H]ketanserin in rat cerebral cortex membrane

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50116963
PNG
(2a-(4-(4-phenyl-5,6-dihydropyridin-1(2H)-yl)butyl)...)
Show SMILES O=C1Nc2cccc3CCCC1(CCCCN1CCC(=CC1)c1ccccc1)c23 |c:20|
Show InChI InChI=1S/C26H30N2O/c29-25-26(16-7-11-22-10-6-12-23(27-25)24(22)26)15-4-5-17-28-18-13-21(14-19-28)20-8-2-1-3-9-20/h1-3,6,8-10,12-13H,4-5,7,11,14-19H2,(H,27,29)
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 98n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2 receptor by the displacement of [3H]ketanserin in rat cerebral cortex membrane

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50220557
PNG
(CHEMBL422869)
Show SMILES Fc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28ClFN2O/c27-22-9-10-23-24-21(22)4-3-14-26(24,25(31)29-23)13-1-2-15-30-16-11-19(12-17-30)18-5-7-20(28)8-6-18/h5-11H,1-4,12-17H2,(H,29,31)
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 229n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2 receptor by the displacement of [3H]ketanserin in rat cerebral cortex membrane

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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 316n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-HT1A receptor by the displacement of [3H]-8-OH-DPAT] in human recombinant receptors in mammalian cell

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50220504
PNG
(CHEMBL348410)
Show SMILES Clc1ccc2NC(=O)C3(CCCCN4CCC(=CC4)c4ccccc4)CCCc1c23 |c:16|
Show InChI InChI=1S/C26H29ClN2O/c27-22-10-11-23-24-21(22)9-6-15-26(24,25(30)28-23)14-4-5-16-29-17-12-20(13-18-29)19-7-2-1-3-8-19/h1-3,7-8,10-12H,4-6,9,13-18H2,(H,28,30)
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 316n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2 receptor by the displacement of [3H]ketanserin in rat cerebral cortex membrane

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-HT2 receptor by the displacement of [3H]-ketanserin] in rat cerebral cortex

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(GUINEA PIG)		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-HT4 receptor by the displacement of [3H]GR-113808 in guinea-pig striatum

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1B


(Homo sapiens (Human))		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-HT1B receptor by the displacement of [3H]-5-CT] in human recombinant receptors in mammalian cell

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 6


(Homo sapiens (Human))		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards human recombinant 5-hydroxytryptamine 7 receptor by the displacement of [3H]-5-CT]

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(RAT-Rattus norvegicus (Rat)-Rattus norvegicus (rat...)		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 2 receptor by the displacement of [3H]ketanserin in rat cerebral cortex membrane

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2C


(Homo sapiens (Human))		BDBM50220503
PNG
(CHEMBL348890)
Show SMILES Clc1ccc(cc1)C1=CCN(CCCCC23CCCc4c2c(NC3=O)ccc4Cl)CC1 |t:8|
Show InChI InChI=1S/C26H28Cl2N2O/c27-20-7-5-18(6-8-20)19-11-16-30(17-12-19)15-2-1-13-26-14-3-4-21-22(28)9-10-23(24(21)26)29-25(26)31/h5-11H,1-4,12-17H2,(H,29,31)
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<1.00E+3n/an/an/an/an/an/an/an/a



Meiji Seika Kaisha Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards 5-HT2C receptor by the displacement of [3H]mesulergine] in human recombinant receptors in mammalian cell

Bioorg Med Chem Lett 13: 61-4 (2003)


BindingDB Entry DOI: 10.7270/Q2959KRF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%