Affinity Data by PubMed id=12877583

PubMed code 12877583

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50092657 (2-[4-(2,4-Diamino-quinazolin-6-ylmethoxycarbonyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101643 (6-[(Methyl-phenyl-amino)-methyl]-quinazoline-2,4-d...) Show SMILES CN(Cc1ccc2nc(N)nc(N)c2c1)c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50092656 (2-[4-(2,4-Diamino-pteridin-6-ylmethoxycarbonyl)-be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50131565 (2-[4-(2,4-Diamino-quinazolin-6-ylmethoxycarbonyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50131564 (2-[4-(2,4-Diamino-quinazolin-6-ylmethoxycarbonyl)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101641 (Benzoic acid 2,4-diamino-5-methyl-pyrido[2,3-d]pyr...) Show SMILES Cc1c(COC(=O)c2ccccc2)cnc2nc(N)nc(N)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101634 (Benzoic acid 2,4-diamino-quinazolin-6-ylmethyl est...) Show SMILES Nc1nc(N)c2cc(COC(=O)c3ccccc3)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101635 (2,4-Diamino-quinazoline-6-carboxylic acid benzyl e...) Show SMILES Nc1nc(N)c2cc(ccc2n1)C(=O)OCc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101637 (6-Phenylaminomethyl-quinazoline-2,4-diamine \| CHEM...) Show SMILES Nc1nc(N)c2cc(CNc3ccccc3)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101648 (CHEMBL77409 \| Terephthalic acid mono-(2,4-diamino-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101642 (CHEMBL78631 \| Phenyl-acetic acid 2,4-diamino-quina...) Show SMILES Nc1nc(N)c2cc(COC(=O)Cc3ccccc3)ccc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101632 (Benzoic acid 2,4-diamino-pyrido[2,3-d]pyrimidin-6-...) Show SMILES Nc1nc(N)c2cc(COC(=O)c3ccccc3)cnc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Rattus norvegicus (rat))	BDBM50101640 (Benzoic acid 2,4-diamino-pteridin-6-ylmethyl ester...) Show SMILES Nc1nc(N)c2nc(COC(=O)c3ccccc3)cnc2n1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Uppsala University Curated by ChEMBL					Assay Description Inhibition of rat liver Dihydrofolate reductase (rlDHFR)				J Med Chem 46: 3455-62 (2003) Article DOI: 10.1021/jm021062y BindingDB Entry DOI: 10.7270/Q2SJ1MC1
Uppsala University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%