Found 36 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134559
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccc(cc1)[N+]([O-])=O)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H19N5O3/c1-32-19-31-17-27(32)28(23-8-3-21(15-29)4-9-23)36-18-25-11-5-22(16-30)14-24(25)10-2-20-6-12-26(13-7-20)33(34)35/h3-9,11-14,17,19,28H,18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134570
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1\C=C\c1ccc(cc1)[N+]([O-])=O)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H21N5O3/c1-32-19-31-17-27(32)28(23-8-3-21(15-29)4-9-23)36-18-25-11-5-22(16-30)14-24(25)10-2-20-6-12-26(13-7-20)33(34)35/h2-14,17,19,28H,18H2,1H3/b10-2+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.610 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134563
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CC(C)(C)C)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N4O/c1-26(2,3)12-11-22-13-20(15-28)7-10-23(22)17-31-25(24-16-29-18-30(24)4)21-8-5-19(14-27)6-9-21/h5-10,13,16,18,25H,17H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.620 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134557
(3-(4-Cyano-phenylethynyl)-4-[(4-cyano-phenyl)-(3-m...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccc(cc1)C#N)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C29H19N5O/c1-34-20-33-18-28(34)29(25-10-7-23(16-31)8-11-25)35-19-27-13-9-24(17-32)14-26(27)12-6-21-2-4-22(15-30)5-3-21/h2-5,7-11,13-14,18,20,29H,19H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134567
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CC1(O)CCCCC1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H26N4O2/c1-32-20-31-18-26(32)27(23-8-5-21(16-29)6-9-23)34-19-25-10-7-22(17-30)15-24(25)11-14-28(33)12-3-2-4-13-28/h5-10,15,18,20,27,33H,2-4,12-13,19H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.870 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134558
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES CCCCCCC#Cc1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H28N4O/c1-3-4-5-6-7-8-9-25-16-23(18-30)12-15-26(25)20-33-28(27-19-31-21-32(27)2)24-13-10-22(17-29)11-14-24/h10-16,19,21,28H,3-7,20H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134556
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1CCC(C)(C)C)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H28N4O/c1-26(2,3)12-11-22-13-20(15-28)7-10-23(22)17-31-25(24-16-29-18-30(24)4)21-8-5-19(14-27)6-9-21/h5-10,13,16,18,25H,11-12,17H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134561
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H20N4O/c1-32-20-31-18-27(32)28(24-11-8-22(16-29)9-12-24)33-19-26-14-10-23(17-30)15-25(26)13-7-21-5-3-2-4-6-21/h2-6,8-12,14-15,18,20,28H,19H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 0.950 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134555
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1cccc(O)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H20N4O2/c1-32-19-31-17-27(32)28(23-9-6-21(15-29)7-10-23)34-18-25-12-8-22(16-30)13-24(25)11-5-20-3-2-4-26(33)14-20/h2-4,6-10,12-14,17,19,28,33H,18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134564
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(cc1)-c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C32H24N4O/c1-36-22-35-20-31(36)32(28-10-7-23(18-33)8-11-28)37-21-29-12-9-24(19-34)17-30(29)27-15-13-26(14-16-27)25-5-3-2-4-6-25/h2-17,20,22,32H,21H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134566
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(cc1)C#N)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19N5O/c1-32-18-31-16-26(32)27(23-9-4-20(14-29)5-10-23)33-17-24-11-6-21(15-30)12-25(24)22-7-2-19(13-28)3-8-22/h2-12,16,18,27H,17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM13379
(4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...)Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H20N4O/c1-30-18-29-16-25(30)26(22-10-7-19(14-27)8-11-22)31-17-23-12-9-20(15-28)13-24(23)21-5-3-2-4-6-21/h2-13,16,18,26H,17H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134565
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES CCC\C=C\C=C\c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H26N4O/c1-3-4-5-6-7-8-24-15-22(17-29)11-14-25(24)19-32-27(26-18-30-20-31(26)2)23-12-9-21(16-28)10-13-23/h5-15,18,20,27H,3-4,19H2,1-2H3/b6-5+,8-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134562
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CCCc1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H24N4O/c1-34-22-33-20-29(34)30(26-14-11-24(18-31)12-15-26)35-21-28-16-13-25(19-32)17-27(28)10-6-5-9-23-7-3-2-4-8-23/h2-4,7-8,11-17,20,22,30H,5,9,21H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134569
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1\C=C\c1ccccn1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H21N5O/c1-32-19-30-17-26(32)27(22-8-5-20(15-28)6-9-22)33-18-24-10-7-21(16-29)14-23(24)11-12-25-4-2-3-13-31-25/h2-14,17,19,27H,18H2,1H3/b12-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134568
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CCCCCO)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N4O2/c1-30-19-29-17-25(30)26(22-10-7-20(15-27)8-11-22)32-18-24-12-9-21(16-28)14-23(24)6-4-2-3-5-13-31/h7-12,14,17,19,26,31H,2-3,5,13,18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134571
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccccn1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19N5O/c1-32-19-30-17-26(32)27(22-8-5-20(15-28)6-9-22)33-18-24-10-7-21(16-29)14-23(24)11-12-25-4-2-3-13-31-25/h2-10,13-14,17,19,27H,18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134560
(3-Biphenyl-4-ylethynyl-4-[(4-cyano-phenyl)-(3-meth...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccc(cc1)-c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C34H24N4O/c1-38-24-37-22-33(38)34(30-15-10-26(20-35)11-16-30)39-23-32-18-12-27(21-36)19-31(32)17-9-25-7-13-29(14-8-25)28-5-3-2-4-6-28/h2-8,10-16,18-19,22,24,34H,23H2,1H3 | PDB
MMDB
Reactome pathway
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human FTase-catalyzed incorporation of [3H]-FPP into recombinant Ras CVIM. |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134570
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1\C=C\c1ccc(cc1)[N+]([O-])=O)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H21N5O3/c1-32-19-31-17-27(32)28(23-8-3-21(15-29)4-9-23)36-18-25-11-5-22(16-30)14-24(25)10-2-20-6-12-26(13-7-20)33(34)35/h2-14,17,19,28H,18H2,1H3/b10-2+ | PDB
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UniChem
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134557
(3-(4-Cyano-phenylethynyl)-4-[(4-cyano-phenyl)-(3-m...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccc(cc1)C#N)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C29H19N5O/c1-34-20-33-18-28(34)29(25-10-7-23(16-31)8-11-25)35-19-27-13-9-24(17-32)14-26(27)12-6-21-2-4-22(15-30)5-3-21/h2-5,7-11,13-14,18,20,29H,19H2,1H3 | PDB
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PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 124 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134564
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(cc1)-c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C32H24N4O/c1-36-22-35-20-31(36)32(28-10-7-23(18-33)8-11-28)37-21-29-12-9-24(19-34)17-30(29)27-15-13-26(14-16-27)25-5-3-2-4-6-25/h2-17,20,22,32H,21H2,1H3 | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134559
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccc(cc1)[N+]([O-])=O)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H19N5O3/c1-32-19-31-17-27(32)28(23-8-3-21(15-29)4-9-23)36-18-25-11-5-22(16-30)14-24(25)10-2-20-6-12-26(13-7-20)33(34)35/h3-9,11-14,17,19,28H,18H2,1H3 | PDB
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134558
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES CCCCCCC#Cc1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C28H28N4O/c1-3-4-5-6-7-8-9-25-16-23(18-30)12-15-26(25)20-33-28(27-19-31-21-32(27)2)24-13-10-22(17-29)11-14-24/h10-16,19,21,28H,3-7,20H2,1-2H3 | PDB
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PC sid
UniChem
Similars
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134565
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES CCC\C=C\C=C\c1cc(ccc1COC(c1cncn1C)c1ccc(cc1)C#N)C#N Show InChI InChI=1S/C27H26N4O/c1-3-4-5-6-7-8-24-15-22(17-29)11-14-25(24)19-32-27(26-18-30-20-31(26)2)23-12-9-21(16-28)10-13-23/h5-15,18,20,27H,3-4,19H2,1-2H3/b6-5+,8-7+ | PDB
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Similars
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| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134556
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1CCC(C)(C)C)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H28N4O/c1-26(2,3)12-11-22-13-20(15-28)7-10-23(22)17-31-25(24-16-29-18-30(24)4)21-8-5-19(14-27)6-9-21/h5-10,13,16,18,25H,11-12,17H2,1-4H3 | PDB
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PC sid
UniChem
| PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134563
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CC(C)(C)C)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N4O/c1-26(2,3)12-11-22-13-20(15-28)7-10-23(22)17-31-25(24-16-29-18-30(24)4)21-8-5-19(14-27)6-9-21/h5-10,13,16,18,25H,17H2,1-4H3 | PDB
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PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134562
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CCCc1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C30H24N4O/c1-34-22-33-20-29(34)30(26-14-11-24(18-31)12-15-26)35-21-28-16-13-25(19-32)17-27(28)10-6-5-9-23-7-3-2-4-8-23/h2-4,7-8,11-17,20,22,30H,5,9,21H2,1H3 | PDB
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PC sid
UniChem
Similars
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| n/a | n/a | 540 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134567
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CC1(O)CCCCC1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H26N4O2/c1-32-20-31-18-26(32)27(23-8-5-21(16-29)6-9-23)34-19-25-10-7-22(17-30)15-24(25)11-14-28(33)12-3-2-4-13-28/h5-10,15,18,20,27,33H,2-4,12-13,19H2,1H3 | PDB
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PC sid
UniChem
Similars
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| n/a | n/a | 845 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134555
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1cccc(O)c1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H20N4O2/c1-32-19-31-17-27(32)28(23-9-6-21(15-29)7-10-23)34-18-25-12-8-22(16-30)13-24(25)11-5-20-3-2-4-26(33)14-20/h2-4,6-10,12-14,17,19,28,33H,18H2,1H3 | PDB
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PC sid
UniChem
Similars
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134568
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#CCCCCO)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H24N4O2/c1-30-19-29-17-25(30)26(22-10-7-20(15-27)8-11-22)32-18-24-12-9-21(16-28)14-23(24)6-4-2-3-5-13-31/h7-12,14,17,19,26,31H,2-3,5,13,18H2,1H3 | PDB
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PC sid
UniChem
Similars
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| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134569
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1\C=C\c1ccccn1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H21N5O/c1-32-19-30-17-26(32)27(22-8-5-20(15-28)6-9-22)33-18-24-10-7-21(16-29)14-23(24)11-12-25-4-2-3-13-31-25/h2-14,17,19,27H,18H2,1H3/b12-11+ | PDB
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PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134561
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C28H20N4O/c1-32-20-31-18-27(32)28(24-11-8-22(16-29)9-12-24)33-19-26-14-10-23(17-30)15-25(26)13-7-21-5-3-2-4-6-21/h2-6,8-12,14-15,18,20,28H,19H2,1H3 | PDB
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PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM13379
(4-{[(4-cyanophenyl)(1-methyl-1H-imidazol-5-yl)meth...)Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C26H20N4O/c1-30-18-29-16-25(30)26(22-10-7-19(14-27)8-11-22)31-17-23-12-9-20(15-28)13-24(23)21-5-3-2-4-6-21/h2-13,16,18,26H,17H2,1H3 | PDB
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PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134566
(6-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1-c1ccc(cc1)C#N)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19N5O/c1-32-18-31-16-26(32)27(23-9-4-20(14-29)5-10-23)33-17-24-11-6-21(15-30)12-25(24)22-7-2-19(13-28)3-8-22/h2-12,16,18,27H,17H2,1H3 | PDB
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UniChem
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| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134560
(3-Biphenyl-4-ylethynyl-4-[(4-cyano-phenyl)-(3-meth...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccc(cc1)-c1ccccc1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C34H24N4O/c1-38-24-37-22-33(38)34(30-15-10-26(20-35)11-16-30)39-23-32-18-12-27(21-36)19-31(32)17-9-25-7-13-29(14-8-25)28-5-3-2-4-6-28/h2-8,10-16,18-19,22,24,34H,23H2,1H3 | PDB
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PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50134571
(4-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-me...)Show SMILES Cn1cncc1C(OCc1ccc(cc1C#Cc1ccccn1)C#N)c1ccc(cc1)C#N Show InChI InChI=1S/C27H19N5O/c1-32-19-30-17-26(32)27(22-8-5-20(15-28)6-9-22)33-18-24-10-7-21(16-29)14-23(24)11-12-25-4-2-3-13-31-25/h2-10,13-14,17,19,27H,18H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of the human Geranylgeranyl transferase-catalyzed incorporation of [3H]-GGPP into biotinylated peptide corresponding to the C-ter... |
Bioorg Med Chem Lett 13: 3821-5 (2003)
BindingDB Entry DOI: 10.7270/Q2319V9P |
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Ligand-Target Pair | |
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