Affinity Data by PubMed id=15109661

PubMed code 15109661

Found 21 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145565 (1,2,3,4,8,9,10,11,12,13-decahydrocycloocta[b][1,4]...) Show SMILES C1Cn2c3CCCCCCc3c3cccc(CN1)c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145565 (1,2,3,4,8,9,10,11,12,13-decahydrocycloocta[b][1,4]...) Show SMILES C1Cn2c3CCCCCCc3c3cccc(CN1)c23 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	36	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145564 (4,5,6,7,9,10,11,12-Octahydro-8H-5,7a-diaza-benzo[c...) Show SMILES C1CCc2c(CC1)c1cccc3CNCCn2c13 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	38	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145562 (8,8,10,10-Tetramethyl-1,2,3,4,8,9,10,11-octahydro-...) Show SMILES CC1(C)Cc2c(c3cccc4CNCCn2c34)C(C)(C)C1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145568 (4,5,6,7,9,10-Hexahydro-8H-5,7a-diaza-benzo[cd]cycl...) Show SMILES C1Cc2c(C1)c1cccc3CNCCn2c13 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	97	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145569 (7-Fluoro-1,2,3,4,8,9,10,11-octahydro-[1,4]diazepin...) Show SMILES Fc1ccc2CNCCn3c4CCCCc4c1c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	111	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145562 (8,8,10,10-Tetramethyl-1,2,3,4,8,9,10,11-octahydro-...) Show SMILES CC1(C)Cc2c(c3cccc4CNCCn2c34)C(C)(C)C1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	152	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145559 ((R)-2-Methyl-1,2,3,4,8,9,10,11-octahydro-[1,4]diaz...) Show SMILES C[C@@H]1Cn2c3CCCCc3c3cccc(CN1)c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	189	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145564 (4,5,6,7,9,10,11,12-Octahydro-8H-5,7a-diaza-benzo[c...) Show SMILES C1CCc2c(CC1)c1cccc3CNCCn2c13 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	199	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145563 (9,9-Dimethyl-1,2,3,4,8,9,10,11-octahydro-[1,4]diaz...) Show SMILES CC1(C)CCc2c(C1)c1cccc3CNCCn2c13 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	243	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145561 (6-Chloro-1,2,3,4,8,9,10,11-octahydro-[1,4]diazepin...) Show SMILES Clc1cc2CNCCn3c4CCCCc4c(c1)c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	358	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145560 ((S)-2-Methyl-1,2,3,4,8,9,10,11-octahydro-[1,4]diaz...) Show SMILES C[C@H]1Cn2c3CCCCc3c3cccc(CN1)c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	452	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145566 (6-Methyl-1,2,3,4,8,9,10,11-octahydro-[1,4]diazepin...) Show SMILES Cc1cc2CNCCn3c4CCCCc4c(c1)c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	599	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
D(1A) dopamine receptor (RAT)	BDBM50145565 (1,2,3,4,8,9,10,11,12,13-decahydrocycloocta[b][1,4]...) Show SMILES C1Cn2c3CCCCCCc3c3cccc(CN1)c23 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	665	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity of the compound against dopamine receptor D1A				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145568 (4,5,6,7,9,10-Hexahydro-8H-5,7a-diaza-benzo[cd]cycl...) Show SMILES C1Cc2c(C1)c1cccc3CNCCn2c13 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	922	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50145567 (2-Methyl-4,5,6,7,9,10-hexahydro-8H-5,7a-diaza-benz...) Show SMILES Cc1cc2CNCCn3c4CCCc4c(c1)c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	985	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity against human 5-hydroxytryptamine 2C receptor in CHO cells using [125I]- DOI				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145566 (6-Methyl-1,2,3,4,8,9,10,11-octahydro-[1,4]diazepin...) Show SMILES Cc1cc2CNCCn3c4CCCCc4c(c1)c23 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145559 ((R)-2-Methyl-1,2,3,4,8,9,10,11-octahydro-[1,4]diaz...) Show SMILES C[C@@H]1Cn2c3CCCCc3c3cccc(CN1)c23 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145567 (2-Methyl-4,5,6,7,9,10-hexahydro-8H-5,7a-diaza-benz...) Show SMILES Cc1cc2CNCCn3c4CCCc4c(c1)c23 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Agonistic binding affinity of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50145565 (1,2,3,4,8,9,10,11,12,13-decahydrocycloocta[b][1,4]...) Show SMILES C1Cn2c3CCCCCCc3c3cccc(CN1)c23 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Binding affinity of the compound against 5-hydroxytryptamine 1A receptor				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50145565 (1,2,3,4,8,9,10,11,12,13-decahydrocycloocta[b][1,4]...) Show SMILES C1Cn2c3CCCCCCc3c3cccc(CN1)c23 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Effective concentration of the compound against human 5-hydroxytryptamine 2A receptor in CHO cells using 8-OH-DPA radioligand				Bioorg Med Chem Lett 14: 2603-7 (2004) Article DOI: 10.1016/j.bmcl.2004.02.100 BindingDB Entry DOI: 10.7270/Q2QZ29F3
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%