Found 94 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151609
(5'',8''-dichlorospiro[cyclohexane-1,4''-(1'',2'',3...)Show InChI InChI=1S/C13H14Cl2N2O/c14-8-4-5-9(15)11-10(8)13(17-12(18)16-11)6-2-1-3-7-13/h4-5H,1-3,6-7H2,(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151615
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-4-6-13(7-5-12)18(24)25)10-15-17(16)22-19(26)23-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H,24,25)(H2,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151605
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)18-7-5-17(6-8-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)9-3-2-4-10-25/h5-8,15-16H,2-4,9-14H2,1H3,(H2,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151603
(1N-(3-dimethylaminopropyl)-3-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)13-7-12-27-23(31)18-9-6-8-17(14-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)10-4-3-5-11-25/h6,8-9,14-16H,3-5,7,10-13H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151593
(8''-chloro-6''-phenylspiro[cyclohexane-1,4''-(1'',...)Show InChI InChI=1S/C19H19ClN2O/c20-16-12-14(13-7-3-1-4-8-13)11-15-17(16)21-18(23)22-19(15)9-5-2-6-10-19/h1,3-4,7-8,11-12H,2,5-6,9-10H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151592
(1N-(3-dimethylaminopropyl)-4-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)14-6-13-27-23(31)18-9-7-17(8-10-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)11-4-3-5-12-25/h7-10,15-16H,3-6,11-14H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151598
(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)13-12-26-22(30)17-8-6-16(7-9-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)10-4-3-5-11-24/h6-9,14-15H,3-5,10-13H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151597
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-5-4-6-13(9-12)18(24)25)10-15-17(16)22-19(26)23-20(15)7-2-1-3-8-20/h4-6,9-11H,1-3,7-8H2,(H,24,25)(H2,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151594
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES NC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H20ClN3O2/c21-16-11-14(12-4-6-13(7-5-12)18(22)25)10-15-17(16)23-19(26)24-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H2,22,25)(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151602
(1N-(2-dimethylaminoethyl)-3-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)12-11-26-22(30)17-8-6-7-16(13-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)9-4-3-5-10-24/h6-8,13-15H,3-5,9-12H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151599
(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-14-11-12(15-6-2-5-9-20-15)10-13-16(14)21-17(23)22-18(13)7-3-1-4-8-18/h2,5-6,9-11H,1,3-4,7-8H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151623
(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-11-13(12-4-8-20-9-5-12)10-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151604
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-10-12-30(13-11-29)23(31)18-7-5-6-17(14-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)8-3-2-4-9-25/h5-7,14-16H,2-4,8-13H2,1H3,(H2,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151610
(8''-chloro-6''-(3-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-10-13(12-5-4-8-20-11-12)9-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151612
(8''-bromospiro[cyclohexane-1,4''-(1'',2'',3'',4''-...)Show InChI InChI=1S/C13H15BrN2O/c14-10-6-4-5-9-11(10)15-12(17)16-13(9)7-2-1-3-8-13/h4-6H,1-3,7-8H2,(H2,15,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151607
(8''-bromospiro[cycloheptane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C14H17BrN2O/c15-11-7-5-6-10-12(11)16-13(18)17-14(10)8-3-1-2-4-9-14/h5-7H,1-4,8-9H2,(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151622
(6'',8''-dichlorospiro[cyclohexane-1,4''-(1'',2'',3...)Show InChI InChI=1S/C13H14Cl2N2O/c14-8-6-9-11(10(15)7-8)16-12(18)17-13(9)4-2-1-3-5-13/h6-7H,1-5H2,(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151629
(8''-chloro-6''-methylspiro[cyclohexane-1,4''-(1'',...)Show InChI InChI=1S/C14H17ClN2O/c1-9-7-10-12(11(15)8-9)16-13(18)17-14(10)5-3-2-4-6-14/h7-8H,2-6H2,1H3,(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151614
(8''-chloro-6''-methoxyspiro[cyclohexane-1,4''-(1''...)Show InChI InChI=1S/C14H17ClN2O2/c1-19-9-7-10-12(11(15)8-9)16-13(18)17-14(10)5-3-2-4-6-14/h7-8H,2-6H2,1H3,(H2,16,17,18) | PDB
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PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151628
(8''-chlorospiro[cyclohexane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C13H15ClN2O/c14-10-6-4-5-9-11(10)15-12(17)16-13(9)7-2-1-3-8-13/h4-6H,1-3,7-8H2,(H2,15,16,17) | PDB
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| n/a | n/a | 170 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151617
(8''-bromo-4-methylspiro[cyclohexane-1,4''-(1'',2''...)Show SMILES CC1CCC2(CC1)NC(=O)Nc1c(Br)cccc21 |(.73,5.13,;.73,3.59,;2.06,2.82,;2.06,1.28,;.73,.53,;-.58,1.28,;-.58,2.82,;2.08,-.26,;2.08,-1.78,;3.41,-2.57,;.73,-2.57,;-.6,-1.78,;-1.93,-2.57,;-1.93,-4.11,;-3.26,-1.78,;-3.26,-.26,;-1.93,.53,;-.6,-.24,)| Show InChI InChI=1S/C14H17BrN2O/c1-9-5-7-14(8-6-9)10-3-2-4-11(15)12(10)16-13(18)17-14/h2-4,9H,5-8H2,1H3,(H2,16,17,18) | PDB
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PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151594
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES NC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H20ClN3O2/c21-16-11-14(12-4-6-13(7-5-12)18(22)25)10-15-17(16)23-19(26)24-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H2,22,25)(H2,23,24,26) | PDB
Reactome pathway
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PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151624
(8''-fluorospiro[cyclohexane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C13H15FN2O/c14-10-6-4-5-9-11(10)15-12(17)16-13(9)7-2-1-3-8-13/h4-6H,1-3,7-8H2,(H2,15,16,17) | PDB
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Reactome pathway
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UniChem
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PubMed
| n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151615
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-4-6-13(7-5-12)18(24)25)10-15-17(16)22-19(26)23-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H,24,25)(H2,22,23,26) | PDB
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| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151625
(5'',6''-dichlorospiro[cyclohexane-1,4''-(1'',2'',3...)Show InChI InChI=1S/C13H14Cl2N2O/c14-8-4-5-9-10(11(8)15)13(17-12(18)16-9)6-2-1-3-7-13/h4-5H,1-3,6-7H2,(H2,16,17,18) | PDB
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PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151594
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES NC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H20ClN3O2/c21-16-11-14(12-4-6-13(7-5-12)18(22)25)10-15-17(16)23-19(26)24-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H2,22,25)(H2,23,24,26) | PDB
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PubMed
| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151597
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-5-4-6-13(9-12)18(24)25)10-15-17(16)22-19(26)23-20(15)7-2-1-3-8-20/h4-6,9-11H,1-3,7-8H2,(H,24,25)(H2,22,23,26) | PDB
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| CHEMBL
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| Article
PubMed
| n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151597
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-5-4-6-13(9-12)18(24)25)10-15-17(16)22-19(26)23-20(15)7-2-1-3-8-20/h4-6,9-11H,1-3,7-8H2,(H,24,25)(H2,22,23,26) | PDB
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PubMed
| n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151620
(8''-methylspiro[cyclohexane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C14H18N2O/c1-10-6-5-7-11-12(10)15-13(17)16-14(11)8-3-2-4-9-14/h5-7H,2-4,8-9H2,1H3,(H2,15,16,17) | PDB
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UniChem
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PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151601
(5''-chlorospiro[cyclohexane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C13H15ClN2O/c14-9-5-4-6-10-11(9)13(16-12(17)15-10)7-2-1-3-8-13/h4-6H,1-3,7-8H2,(H2,15,16,17) | PDB
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PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151615
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-4-6-13(7-5-12)18(24)25)10-15-17(16)22-19(26)23-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H,24,25)(H2,22,23,26) | PDB
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| Article
PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151619
(6''-phenylspiro[cyclohexane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C19H20N2O/c22-18-20-17-10-9-15(14-7-3-1-4-8-14)13-16(17)19(21-18)11-5-2-6-12-19/h1,3-4,7-10,13H,2,5-6,11-12H2,(H2,20,21,22) | PDB
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PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151623
(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-11-13(12-4-8-20-9-5-12)10-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
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PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151594
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES NC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H20ClN3O2/c21-16-11-14(12-4-6-13(7-5-12)18(22)25)10-15-17(16)23-19(26)24-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H2,22,25)(H2,23,24,26) | PDB
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| CHEMBL
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151604
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-10-12-30(13-11-29)23(31)18-7-5-6-17(14-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)8-3-2-4-9-25/h5-7,14-16H,2-4,8-13H2,1H3,(H2,27,28,32) | PDB
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PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151606
(8''-bromospiro[cyclobutane-1,4''-(1'',2'',3'',4''-...)Show InChI InChI=1S/C11H11BrN2O/c12-8-4-1-3-7-9(8)13-10(15)14-11(7)5-2-6-11/h1,3-4H,2,5-6H2,(H2,13,14,15) | PDB
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151593
(8''-chloro-6''-phenylspiro[cyclohexane-1,4''-(1'',...)Show InChI InChI=1S/C19H19ClN2O/c20-16-12-14(13-7-3-1-4-8-13)11-15-17(16)21-18(23)22-19(15)9-5-2-6-10-19/h1,3-4,7-8,11-12H,2,5-6,9-10H2,(H2,21,22,23) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.42E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151603
(1N-(3-dimethylaminopropyl)-3-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)13-7-12-27-23(31)18-9-6-8-17(14-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)10-4-3-5-11-25/h6,8-9,14-16H,3-5,7,10-13H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
KEGG
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151592
(1N-(3-dimethylaminopropyl)-4-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)14-6-13-27-23(31)18-9-7-17(8-10-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)11-4-3-5-12-25/h7-10,15-16H,3-6,11-14H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151595
(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccccc1-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)19-8-4-3-7-18(19)17-15-20-22(21(26)16-17)27-24(32)28-25(20)9-5-2-6-10-25/h3-4,7-8,15-16H,2,5-6,9-14H2,1H3,(H2,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151610
(8''-chloro-6''-(3-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-10-13(12-5-4-8-20-11-12)9-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151602
(1N-(2-dimethylaminoethyl)-3-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)12-11-26-22(30)17-8-6-7-16(13-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)9-4-3-5-10-24/h6-8,13-15H,3-5,9-12H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151598
(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)13-12-26-22(30)17-8-6-16(7-9-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)10-4-3-5-11-24/h6-9,14-15H,3-5,10-13H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151605
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)18-7-5-17(6-8-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)9-3-2-4-10-25/h5-8,15-16H,2-4,9-14H2,1H3,(H2,27,28,32) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151599
(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-14-11-12(15-6-2-5-9-20-15)10-13-16(14)21-17(23)22-18(13)7-3-1-4-8-18/h2,5-6,9-11H,1,3-4,7-8H2,(H2,21,22,23) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151627
(8-Bromo-4,4-dipropyl-3,4-dihydro-1H-quinazolin-2-o...)Show InChI InChI=1S/C14H19BrN2O/c1-3-8-14(9-4-2)10-6-5-7-11(15)12(10)16-13(18)17-14/h5-7H,3-4,8-9H2,1-2H3,(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.66E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151616
(7''-chlorospiro[cyclohexane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C13H15ClN2O/c14-9-4-5-10-11(8-9)15-12(17)16-13(10)6-2-1-3-7-13/h4-5,8H,1-3,6-7H2,(H2,15,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151610
(8''-chloro-6''-(3-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-10-13(12-5-4-8-20-11-12)9-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
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antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151611
(8''-trifluoromethylspiro[cyclohexane-1,4''-(1'',2'...)Show InChI InChI=1S/C14H15F3N2O/c15-14(16,17)10-6-4-5-9-11(10)18-12(20)19-13(9)7-2-1-3-8-13/h4-6H,1-3,7-8H2,(H2,18,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.96E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151623
(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-11-13(12-4-8-20-9-5-12)10-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151621
(6''-methoxyspiro[cyclohexane-1,4''-(1'',2'',3'',4'...)Show InChI InChI=1S/C14H18N2O2/c1-18-10-5-6-12-11(9-10)14(16-13(17)15-12)7-3-2-4-8-14/h5-6,9H,2-4,7-8H2,1H3,(H2,15,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151593
(8''-chloro-6''-phenylspiro[cyclohexane-1,4''-(1'',...)Show InChI InChI=1S/C19H19ClN2O/c20-16-12-14(13-7-3-1-4-8-13)11-15-17(16)21-18(23)22-19(15)9-5-2-6-10-19/h1,3-4,7-8,11-12H,2,5-6,9-10H2,(H2,21,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.26E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151618
(6'',7''-dichlorospiro[cyclohexane-1,4''-(1'',2'',3...)Show InChI InChI=1S/C13H14Cl2N2O/c14-9-6-8-11(7-10(9)15)16-12(18)17-13(8)4-2-1-3-5-13/h6-7H,1-5H2,(H2,16,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151613
(6''-chlorospiro[cyclohexane-1,4''-(1'',2'',3'',4''...)Show InChI InChI=1S/C13H15ClN2O/c14-9-4-5-11-10(8-9)13(16-12(17)15-11)6-2-1-3-7-13/h4-5,8H,1-3,6-7H2,(H2,15,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151603
(1N-(3-dimethylaminopropyl)-3-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)13-7-12-27-23(31)18-9-6-8-17(14-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)10-4-3-5-11-25/h6,8-9,14-16H,3-5,7,10-13H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151598
(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)13-12-26-22(30)17-8-6-16(7-9-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)10-4-3-5-11-24/h6-9,14-15H,3-5,10-13H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151604
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-10-12-30(13-11-29)23(31)18-7-5-6-17(14-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)8-3-2-4-9-25/h5-7,14-16H,2-4,8-13H2,1H3,(H2,27,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151592
(1N-(3-dimethylaminopropyl)-4-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)14-6-13-27-23(31)18-9-7-17(8-10-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)11-4-3-5-12-25/h7-10,15-16H,3-6,11-14H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151626
(8-bromo-4,4-diethyl-1,2,3,4-tetrahydro-2-quinazoli...)Show InChI InChI=1S/C12H15BrN2O/c1-3-12(4-2)8-6-5-7-9(13)10(8)14-11(16)15-12/h5-7H,3-4H2,1-2H3,(H2,14,15,16) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151600
(CHEMBL185120 | spiro[cyclohexane-1,4''-(1'',2'',3'...)Show InChI InChI=1S/C13H16N2O/c16-12-14-11-7-3-2-6-10(11)13(15-12)8-4-1-5-9-13/h2-3,6-7H,1,4-5,8-9H2,(H2,14,15,16) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151596
(8''-iodospiro[cyclohexane-1,4''-(1'',2'',3'',4''-t...)Show InChI InChI=1S/C13H15IN2O/c14-10-6-4-5-9-11(10)15-12(17)16-13(9)7-2-1-3-8-13/h4-6H,1-3,7-8H2,(H2,15,16,17) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.85E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151605
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)18-7-5-17(6-8-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)9-3-2-4-10-25/h5-8,15-16H,2-4,9-14H2,1H3,(H2,27,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151599
(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-14-11-12(15-6-2-5-9-20-15)10-13-16(14)21-17(23)22-18(13)7-3-1-4-8-18/h2,5-6,9-11H,1,3-4,7-8H2,(H2,21,22,23) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151615
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-4-6-13(7-5-12)18(24)25)10-15-17(16)22-19(26)23-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H,24,25)(H2,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151623
(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-11-13(12-4-8-20-9-5-12)10-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
(Homo sapiens (Human)) | BDBM50151608
(7''-methoxyspiro[cyclohexane-1,4''-(1'',2'',3'',4'...)Show InChI InChI=1S/C14H18N2O2/c1-18-10-5-6-11-12(9-10)15-13(17)16-14(11)7-3-2-4-8-14/h5-6,9H,2-4,7-8H2,1H3,(H2,15,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 7A1 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151623
(8''-chloro-6''-(4-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-11-13(12-4-8-20-9-5-12)10-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.12E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151594
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES NC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H20ClN3O2/c21-16-11-14(12-4-6-13(7-5-12)18(22)25)10-15-17(16)23-19(26)24-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H2,22,25)(H2,23,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151602
(1N-(2-dimethylaminoethyl)-3-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)12-11-26-22(30)17-8-6-7-16(13-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)9-4-3-5-10-24/h6-8,13-15H,3-5,9-12H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151597
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-5-4-6-13(9-12)18(24)25)10-15-17(16)22-19(26)23-20(15)7-2-1-3-8-20/h4-6,9-11H,1-3,7-8H2,(H,24,25)(H2,22,23,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.26E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151610
(8''-chloro-6''-(3-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-10-13(12-5-4-8-20-11-12)9-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50151595
(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccccc1-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)19-8-4-3-7-18(19)17-15-20-22(21(26)16-17)27-24(32)28-25(20)9-5-2-6-10-25/h3-4,7-8,15-16H,2,5-6,9-14H2,1H3,(H2,27,28,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.57E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 4D3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151597
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-5-4-6-13(9-12)18(24)25)10-15-17(16)22-19(26)23-20(15)7-2-1-3-8-20/h4-6,9-11H,1-3,7-8H2,(H,24,25)(H2,22,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.67E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151610
(8''-chloro-6''-(3-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-15-10-13(12-5-4-8-20-11-12)9-14-16(15)21-17(23)22-18(14)6-2-1-3-7-18/h4-5,8-11H,1-3,6-7H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM50151595
(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccccc1-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)19-8-4-3-7-18(19)17-15-20-22(21(26)16-17)27-24(32)28-25(20)9-5-2-6-10-25/h3-4,7-8,15-16H,2,5-6,9-14H2,1H3,(H2,27,28,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 1 partially purified from THP-1 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151615
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES OC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C20H19ClN2O3/c21-16-11-14(12-4-6-13(7-5-12)18(24)25)10-15-17(16)22-19(26)23-20(15)8-2-1-3-9-20/h4-7,10-11H,1-3,8-9H2,(H,24,25)(H2,22,23,26) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151605
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)18-7-5-17(6-8-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)9-3-2-4-10-25/h5-8,15-16H,2-4,9-14H2,1H3,(H2,27,28,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151605
(4-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)18-7-5-17(6-8-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)9-3-2-4-10-25/h5-8,15-16H,2-4,9-14H2,1H3,(H2,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.93E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151604
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-10-12-30(13-11-29)23(31)18-7-5-6-17(14-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)8-3-2-4-9-25/h5-7,14-16H,2-4,8-13H2,1H3,(H2,27,28,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151598
(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)13-12-26-22(30)17-8-6-16(7-9-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)10-4-3-5-11-24/h6-9,14-15H,3-5,10-13H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151592
(1N-(3-dimethylaminopropyl)-4-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)14-6-13-27-23(31)18-9-7-17(8-10-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)11-4-3-5-12-25/h7-10,15-16H,3-6,11-14H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.45E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151599
(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-14-11-12(15-6-2-5-9-20-15)10-13-16(14)21-17(23)22-18(13)7-3-1-4-8-18/h2,5-6,9-11H,1,3-4,7-8H2,(H2,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151592
(1N-(3-dimethylaminopropyl)-4-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)14-6-13-27-23(31)18-9-7-17(8-10-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)11-4-3-5-12-25/h7-10,15-16H,3-6,11-14H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >5.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151604
(3-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-10-12-30(13-11-29)23(31)18-7-5-6-17(14-18)19-15-20-22(21(26)16-19)27-24(32)28-25(20)8-3-2-4-9-25/h5-7,14-16H,2-4,8-13H2,1H3,(H2,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151598
(1N-(2-dimethylaminoethyl)-4-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1ccc(cc1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)13-12-26-22(30)17-8-6-16(7-9-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)10-4-3-5-11-24/h6-9,14-15H,3-5,10-13H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.73E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151599
(8''-chloro-6''-(2-pyridyl)spiro[cyclohexane-1,4''-...)Show InChI InChI=1S/C18H18ClN3O/c19-14-11-12(15-6-2-5-9-20-15)10-13-16(14)21-17(23)22-18(13)7-3-1-4-8-18/h2,5-6,9-11H,1,3-4,7-8H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151593
(8''-chloro-6''-phenylspiro[cyclohexane-1,4''-(1'',...)Show InChI InChI=1S/C19H19ClN2O/c20-16-12-14(13-7-3-1-4-8-13)11-15-17(16)21-18(23)22-19(15)9-5-2-6-10-19/h1,3-4,7-8,11-12H,2,5-6,9-10H2,(H2,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151603
(1N-(3-dimethylaminopropyl)-3-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)13-7-12-27-23(31)18-9-6-8-17(14-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)10-4-3-5-11-25/h6,8-9,14-16H,3-5,7,10-13H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151602
(1N-(2-dimethylaminoethyl)-3-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)12-11-26-22(30)17-8-6-7-16(13-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)9-4-3-5-10-24/h6-8,13-15H,3-5,9-12H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >7.99E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151603
(1N-(3-dimethylaminopropyl)-3-[8''-chloro-2''-oxosp...)Show SMILES CN(C)CCCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H31ClN4O2/c1-30(2)13-7-12-27-23(31)18-9-6-8-17(14-18)19-15-20-22(21(26)16-19)28-24(32)29-25(20)10-4-3-5-11-25/h6,8-9,14-16H,3-5,7,10-13H2,1-2H3,(H,27,31)(H2,28,29,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >8.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151595
(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccccc1-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)19-8-4-3-7-18(19)17-15-20-22(21(26)16-17)27-24(32)28-25(20)9-5-2-6-10-25/h3-4,7-8,15-16H,2,5-6,9-14H2,1H3,(H2,27,28,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >9.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A
(Homo sapiens (Human)) | BDBM50151593
(8''-chloro-6''-phenylspiro[cyclohexane-1,4''-(1'',...)Show InChI InChI=1S/C19H19ClN2O/c20-16-12-14(13-7-3-1-4-8-13)11-15-17(16)21-18(23)22-19(15)9-5-2-6-10-19/h1,3-4,7-8,11-12H,2,5-6,9-10H2,(H2,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.01E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human Phosphodiesterase 3A3 expressed in baculovirus infected Sf9 cells |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151602
(1N-(2-dimethylaminoethyl)-3-[8''-chloro-2''-oxospi...)Show SMILES CN(C)CCNC(=O)c1cccc(c1)-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C24H29ClN4O2/c1-29(2)12-11-26-22(30)17-8-6-7-16(13-17)18-14-19-21(20(25)15-18)27-23(31)28-24(19)9-4-3-5-10-24/h6-8,13-15H,3-5,9-12H2,1-2H3,(H,26,30)(H2,27,28,31) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.01E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM50151595
(2-[8''-chloro-2''-oxospiro[cyclohexane-1,4''-(1'',...)Show SMILES CN1CCN(CC1)C(=O)c1ccccc1-c1cc(Cl)c2NC(=O)NC3(CCCCC3)c2c1 Show InChI InChI=1S/C25H29ClN4O2/c1-29-11-13-30(14-12-29)23(31)19-8-4-3-7-18(19)17-15-20-22(21(26)16-17)27-24(32)28-25(20)9-5-2-6-10-25/h3-4,7-8,15-16H,2,5-6,9-14H2,1H3,(H2,27,28,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.01E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description
In vitro inhibition of human Phosphodiesterase 5 |
Bioorg Med Chem Lett 14: 4623-6 (2004)
Article DOI: 10.1016/j.bmcl.2004.07.011
BindingDB Entry DOI: 10.7270/Q2ZG6RQX |
More data for this
Ligand-Target Pair | |
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