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PubMed code 15990298

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50058163
PNG
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)|
Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
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PubMed
3.70n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50058163
PNG
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)|
Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3
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3.70n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054245
PNG
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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20n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054245
PNG
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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20n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169569
PNG
(7-(2,4-Dichloro-6-methyl-phenyl)-2-ethyl-6,7-dihyd...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(Cl)cc1Cl
Show InChI InChI=1S/C21H23Cl2F3N4O/c1-3-16-18(19(31)28(10-13-4-5-13)11-21(24,25)26)30-7-6-29(20(30)27-16)17-12(2)8-14(22)9-15(17)23/h8-9,13H,3-7,10-11H2,1-2H3
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24n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169563
PNG
(7-(2-Bromo-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihydr...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(C)cc1Br
Show InChI InChI=1S/C22H26BrF3N4O/c1-4-17-19(20(31)28(11-15-5-6-15)12-22(24,25)26)30-8-7-29(21(30)27-17)18-14(3)9-13(2)10-16(18)23/h9-10,15H,4-8,11-12H2,1-3H3
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26n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169575
PNG
(7-(2-Chloro-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihyd...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(C)cc1Cl
Show InChI InChI=1S/C22H26ClF3N4O/c1-4-17-19(20(31)28(11-15-5-6-15)12-22(24,25)26)30-8-7-29(21(30)27-17)18-14(3)9-13(2)10-16(18)23/h9-10,15H,4-8,11-12H2,1-3H3
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41n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169584
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H29F3N4O/c1-5-18-20(21(31)28(12-17-6-7-17)13-23(24,25)26)30-9-8-29(22(30)27-18)19-15(3)10-14(2)11-16(19)4/h10-11,17H,5-9,12-13H2,1-4H3
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41n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169559
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4O/c1-6-10-26(15-19-8-9-19)23(29)22-20(7-2)25-24-27(11-12-28(22)24)21-17(4)13-16(3)14-18(21)5/h13-14,19H,6-12,15H2,1-5H3
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42n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169576
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(CC(F)(F)F)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C22H29F3N4O/c1-6-8-27(13-22(23,24)25)20(30)19-17(7-2)26-21-28(9-10-29(19)21)18-15(4)11-14(3)12-16(18)5/h11-12H,6-10,13H2,1-5H3
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61n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169589
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)C(F)(F)F)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H29F5N4O/c1-5-18-20(21(34)31(12-17-6-7-17)13-23(25,26)24(27,28)29)33-9-8-32(22(33)30-18)19-15(3)10-14(2)11-16(19)4/h10-11,17H,5-9,12-13H2,1-4H3
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63n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169579
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC1CC1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H34N4O/c1-5-21-23(24(30)27(14-19-6-7-19)15-20-8-9-20)29-11-10-28(25(29)26-21)22-17(3)12-16(2)13-18(22)4/h12-13,19-20H,5-11,14-15H2,1-4H3
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68n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169588
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CCC(F)(F)F)CC1CC1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H31F3N4O/c1-5-19-21(22(32)29(14-18-6-7-18)9-8-24(25,26)27)31-11-10-30(23(31)28-19)20-16(3)12-15(2)13-17(20)4/h12-13,18H,5-11,14H2,1-4H3
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73n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169581
PNG
(7-(2,4-Dichloro-6-methyl-phenyl)-2-ethyl-6,7-dihyd...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(Cl)cc1Cl
Show InChI InChI=1S/C22H28Cl2N4O/c1-4-8-26(13-15-6-7-15)21(29)20-18(5-2)25-22-27(9-10-28(20)22)19-14(3)11-16(23)12-17(19)24/h11-12,15H,4-10,13H2,1-3H3
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75n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169558
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N4O/c1-6-19-21(22(28)25(7-2)14-18-8-9-18)27-11-10-26(23(27)24-19)20-16(4)12-15(3)13-17(20)5/h12-13,18H,6-11,14H2,1-5H3
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94n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169591
PNG
(7-(2-Chloro-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihyd...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1Cl
Show InChI InChI=1S/C23H31ClN4O/c1-5-9-26(14-17-7-8-17)22(29)21-19(6-2)25-23-27(10-11-28(21)23)20-16(4)12-15(3)13-18(20)24/h12-13,17H,5-11,14H2,1-4H3
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94n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169557
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(CCC)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H34N4O/c1-7-10-25(11-8-2)22(28)21-19(9-3)24-23-26(12-13-27(21)23)20-17(5)14-16(4)15-18(20)6/h14-15H,7-13H2,1-6H3
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100n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169573
PNG
(7-(2-Bromo-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihydr...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1Br
Show InChI InChI=1S/C23H31BrN4O/c1-5-9-26(14-17-7-8-17)22(29)21-19(6-2)25-23-27(10-11-28(21)23)20-16(4)12-15(3)13-18(20)24/h12-13,17H,5-11,14H2,1-4H3
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126n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169585
PNG
(2-Methyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(C)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N4O/c1-6-9-25(14-19-7-8-19)22(28)21-18(5)24-23-26(10-11-27(21)23)20-16(3)12-15(2)13-17(20)4/h12-13,19H,6-11,14H2,1-5H3
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220n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169593
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(CCC(F)(F)F)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H31F3N4O/c1-6-9-28(10-8-23(24,25)26)21(31)20-18(7-2)27-22-29(11-12-30(20)22)19-16(4)13-15(3)14-17(19)5/h13-14H,6-12H2,1-5H3
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220n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169578
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(CCc1ccccc1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C28H36N4O/c1-6-14-30(15-13-23-11-9-8-10-12-23)27(33)26-24(7-2)29-28-31(16-17-32(26)28)25-21(4)18-20(3)19-22(25)5/h8-12,18-19H,6-7,13-17H2,1-5H3
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220n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169590
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CCC(F)(F)F)Cc1ccc(Cl)cc1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H30ClF3N4O/c1-5-22-24(25(36)33(11-10-27(29,30)31)16-20-6-8-21(28)9-7-20)35-13-12-34(26(35)32-22)23-18(3)14-17(2)15-19(23)4/h6-9,14-15H,5,10-13,16H2,1-4H3
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270n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169582
PNG
(7-(2-Bromo-4-isopropyl-phenyl)-2-ethyl-6,7-dihydro...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C23H28BrF3N4O/c1-4-18-20(21(32)29(12-15-5-6-15)13-23(25,26)27)31-10-9-30(22(31)28-18)19-8-7-16(14(2)3)11-17(19)24/h7-8,11,14-15H,4-6,9-10,12-13H2,1-3H3
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270n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169560
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCCN(CC)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H34N4O/c1-7-10-11-25(9-3)22(28)21-19(8-2)24-23-26(12-13-27(21)23)20-17(5)14-16(4)15-18(20)6/h14-15H,7-13H2,1-6H3
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290n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169592
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCN(CCC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4O/c1-6-20-22(23(29)26(7-2)11-10-19-8-9-19)28-13-12-27(24(28)25-20)21-17(4)14-16(3)15-18(21)5/h14-15,19H,6-13H2,1-5H3
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610n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169587
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CCC1CC1)CCC(F)(F)F)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H33F3N4O/c1-5-20-22(23(33)30(10-8-19-6-7-19)11-9-25(26,27)28)32-13-12-31(24(32)29-20)21-17(3)14-16(2)15-18(21)4/h14-15,19H,5-13H2,1-4H3
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650n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169567
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CCC(F)(F)F)Cc1ccccc1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H31F3N4O/c1-5-22-24(25(35)32(12-11-27(28,29)30)17-21-9-7-6-8-10-21)34-14-13-33(26(34)31-22)23-19(3)15-18(2)16-20(23)4/h6-10,15-16H,5,11-14,17H2,1-4H3
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660n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169556
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(CC=C)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N4O/c1-7-10-25(11-8-2)22(28)21-19(9-3)24-23-26(12-13-27(21)23)20-17(5)14-16(4)15-18(20)6/h7,14-15H,1,8-13H2,2-6H3
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740n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169565
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(CCC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H36N4O/c1-6-11-27(12-10-20-8-9-20)24(30)23-21(7-2)26-25-28(13-14-29(23)25)22-18(4)15-17(3)16-19(22)5/h15-16,20H,6-14H2,1-5H3
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770n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169572
PNG
(7-(2-Bromo-4-isopropyl-phenyl)-2-ethyl-6,7-dihydro...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1ccc(cc1Br)C(C)C
Show InChI InChI=1S/C24H33BrN4O/c1-5-11-27(15-17-7-8-17)23(30)22-20(6-2)26-24-28(12-13-29(22)24)21-10-9-18(16(3)4)14-19(21)25/h9-10,14,16-17H,5-8,11-13,15H2,1-4H3
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PubMed
1.56E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169566
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(Cc1ccc(Cl)cc1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H33ClN4O/c1-6-12-30(17-21-8-10-22(28)11-9-21)26(33)25-23(7-2)29-27-31(13-14-32(25)27)24-19(4)15-18(3)16-20(24)5/h8-11,15-16H,6-7,12-14,17H2,1-5H3
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3.00E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169574
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC=C)CC=C)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H30N4O/c1-7-10-25(11-8-2)22(28)21-19(9-3)24-23-26(12-13-27(21)23)20-17(5)14-16(4)15-18(20)6/h7-8,14-15H,1-2,9-13H2,3-6H3
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3.00E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169562
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(Cc1ccccc1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H34N4O/c1-6-13-29(18-22-11-9-8-10-12-22)26(32)25-23(7-2)28-27-30(14-15-31(25)27)24-20(4)16-19(3)17-21(24)5/h8-12,16-17H,6-7,13-15,18H2,1-5H3
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PubMed
4.10E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169564
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCCN(Cc1cccc(F)c1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H33FN4O/c1-6-11-30(17-21-9-8-10-22(28)16-21)26(33)25-23(7-2)29-27-31(12-13-32(25)27)24-19(4)14-18(3)15-20(24)5/h8-10,14-16H,6-7,11-13,17H2,1-5H3
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PubMed
4.20E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169571
PNG
(CHEMBL362799 | Cyclopropylmethyl-[2-methyl-7-(2,4,...)
Show SMILES CCCN(CC1CC1)Cc1c(C)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H34N4/c1-6-9-25(14-20-7-8-20)15-21-19(5)24-23-26(21)10-11-27(23)22-17(3)12-16(2)13-18(22)4/h12-13,20H,6-11,14-15H2,1-5H3
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PubMed
6.60E+3n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169570
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)Nc1ccccc1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H26N4O/c1-5-19-21(22(28)24-18-9-7-6-8-10-18)27-12-11-26(23(27)25-19)20-16(3)13-15(2)14-17(20)4/h6-10,13-14H,5,11-12H2,1-4H3,(H,24,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169568
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)NN1CCN(CC1)C(C)=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N6O2/c1-6-19-21(22(31)25-27-9-7-26(8-10-27)18(5)30)29-12-11-28(23(29)24-19)20-16(3)13-15(2)14-17(20)4/h13-14H,6-12H2,1-5H3,(H,25,31)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169577
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)NN1CCOCC1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H29N5O2/c1-5-17-19(20(27)23-24-8-10-28-11-9-24)26-7-6-25(21(26)22-17)18-15(3)12-14(2)13-16(18)4/h12-13H,5-11H2,1-4H3,(H,23,27)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169586
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)N(Cc1ccccc1)Cc1ccccc1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C31H34N4O/c1-5-27-29(35-17-16-34(31(35)32-27)28-23(3)18-22(2)19-24(28)4)30(36)33(20-25-12-8-6-9-13-25)21-26-14-10-7-11-15-26/h6-15,18-19H,5,16-17,20-21H2,1-4H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169561
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCN(CCN(C)C)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H35N5O/c1-8-19-21(22(29)26(9-2)11-10-25(6)7)28-13-12-27(23(28)24-19)20-17(4)14-16(3)15-18(20)5/h14-15H,8-13H2,1-7H3
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169555
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)NN1CCNCC1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H30N6O/c1-5-17-19(20(28)24-25-8-6-22-7-9-25)27-11-10-26(21(27)23-17)18-15(3)12-14(2)13-16(18)4/h12-13,22H,5-11H2,1-4H3,(H,24,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169583
PNG
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)
Show SMILES CCc1nc2N(CCn2c1C(=O)NN1CCN(CC1)c1ccccc1F)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H33FN6O/c1-5-22-25(26(35)30-32-12-10-31(11-13-32)23-9-7-6-8-21(23)28)34-15-14-33(27(34)29-22)24-19(3)16-18(2)17-20(24)4/h6-9,16-17H,5,10-15H2,1-4H3,(H,30,35)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))
BDBM50169580
PNG
(CHEMBL179985 | Cyclopropylmethyl-[2-ethyl-7-(2,4,6...)
Show SMILES CCCN(CC1CC1)Cc1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H36N4/c1-6-10-26(15-20-8-9-20)16-22-21(7-2)25-24-27(22)11-12-28(24)23-18(4)13-17(3)14-19(23)5/h13-14,20H,6-12,15-16H2,1-5H3
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1.90E+4n/an/an/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells


Bioorg Med Chem Lett 15: 3870-3 (2005)


Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%