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PubMed code 16242327

Compile data set for download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50175776
PNG
(1-ALLYL-5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H...)
Show SMILES Nc1nn(CC=C)c2nnc(cc12)-c1c(nn2ccccc12)-c1ccccc1
Show InChI InChI=1S/C21H17N7/c1-2-11-28-21-15(20(22)26-28)13-16(23-24-21)18-17-10-6-7-12-27(17)25-19(18)14-8-4-3-5-9-14/h2-10,12-13H,1,11H2,(H2,22,26)
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n/an/a 560n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against human ERK2


Bioorg Med Chem Lett 16: 55-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.055
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50175778
PNG
(1-methyl-5-(2-phenylH-pyrazolo[1,5-a]pyridin-3-yl)...)
Show SMILES Cn1nc(N)c2cc(nnc12)-c1c(nn2ccccc12)-c1ccccc1
Show InChI InChI=1S/C19H15N7/c1-25-19-13(18(20)24-25)11-14(21-22-19)16-15-9-5-6-10-26(15)23-17(16)12-7-3-2-4-8-12/h2-11H,1H3,(H2,20,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against human ERK2


Bioorg Med Chem Lett 16: 55-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.055
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50229978
PNG
(5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOL...)
Show SMILES Nc1n[nH]c2nnc(cc12)-c1c(nn2ccccc12)-c1ccccc1
Show InChI InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against human ERK2


Bioorg Med Chem Lett 16: 55-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.055
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 1


(Homo sapiens (Human))
BDBM50175777
PNG
(2-(3-amino-5-(2-phenylH-pyrazolo[1,5-a]pyridin-3-y...)
Show SMILES Nc1nn(CCO)c2nnc(cc12)-c1c(nn2ccccc12)-c1ccccc1
Show InChI InChI=1S/C20H17N7O/c21-19-14-12-15(22-23-20(14)27(25-19)10-11-28)17-16-8-4-5-9-26(16)24-18(17)13-6-2-1-3-7-13/h1-9,12,28H,10-11H2,(H2,21,25)
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n/an/a 5.10E+3n/an/an/an/an/an/a



Fujisawa Pharmaceutical Co., Ltd

Curated by ChEMBL


Assay Description
Inhibitory activity against human ERK2


Bioorg Med Chem Lett 16: 55-8 (2005)


Article DOI: 10.1016/j.bmcl.2005.09.055
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%