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PubMed code 16789740

Compile data set for download or QSAR
Found 109 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17579
PNG
(2-({2-[3-(diethylamino)propyl]benzene}sulfonamido)...)
Show SMILES CCN(CC)CCCc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32N2O4S/c1-3-26(4-2)17-9-12-19-11-6-8-14-22(19)31(29,30)25-21-16-15-18-10-5-7-13-20(18)23(21)24(27)28/h6,8,11,14-16,25H,3-5,7,9-10,12-13,17H2,1-2H3,(H,27,28)
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n/an/a 9n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17573
PNG
(2-({2-[(1Z)-3-[ethyl(methyl)amino]prop-1-en-1-yl]b...)
Show SMILES CCN(C)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H28N2O4S/c1-3-25(2)16-8-11-18-10-5-7-13-21(18)30(28,29)24-20-15-14-17-9-4-6-12-19(17)22(20)23(26)27/h5,7-8,10-11,13-15,24H,3-4,6,9,12,16H2,1-2H3,(H,26,27)/b11-8-
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n/an/a 9n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17505
PNG
(2-[(2-{[3-(1H-imidazol-1-yl)propyl]amino}benzene)s...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCn2ccnc2)ccc2CCCCc12
Show InChI InChI=1S/C23H26N4O4S/c28-23(29)22-18-7-2-1-6-17(18)10-11-20(22)26-32(30,31)21-9-4-3-8-19(21)25-12-5-14-27-15-13-24-16-27/h3-4,8-11,13,15-16,25-26H,1-2,5-7,12,14H2,(H,28,29)
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n/an/a 10n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17564
PNG
(2-({4-fluoro-2-[(1Z)-3-(pyrrolidin-1-yl)but-1-en-1...)
Show SMILES CC(\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O)N1CCCC1
Show InChI InChI=1S/C25H29FN2O4S/c1-17(28-14-4-5-15-28)8-9-19-16-20(26)11-13-23(19)33(31,32)27-22-12-10-18-6-2-3-7-21(18)24(22)25(29)30/h8-13,16-17,27H,2-7,14-15H2,1H3,(H,29,30)/b9-8-
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n/an/a 10n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17583
PNG
(2-({2-[3-(dimethylamino)propyl]benzene}sulfonamido...)
Show SMILES CN(C)CCCc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C22H28N2O4S/c1-24(2)15-7-10-17-9-4-6-12-20(17)29(27,28)23-19-14-13-16-8-3-5-11-18(16)21(19)22(25)26/h4,6,9,12-14,23H,3,5,7-8,10-11,15H2,1-2H3,(H,25,26)
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n/an/a 10n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17478
PNG
(2-benzenesulfonamido-5,6,7,8-tetrahydronaphthalene...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2)ccc2CCCCc12
Show InChI InChI=1S/C17H17NO4S/c19-17(20)16-14-9-5-4-6-12(14)10-11-15(16)18-23(21,22)13-7-2-1-3-8-13/h1-3,7-8,10-11,18H,4-6,9H2,(H,19,20)
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n/an/a 10n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17560
PNG
(2-({2-[(1Z)-3-(diethylamino)prop-1-en-1-yl]-4-fluo...)
Show SMILES CCN(CC)C\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H29FN2O4S/c1-3-27(4-2)15-7-9-18-16-19(25)12-14-22(18)32(30,31)26-21-13-11-17-8-5-6-10-20(17)23(21)24(28)29/h7,9,11-14,16,26H,3-6,8,10,15H2,1-2H3,(H,28,29)/b9-7-
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n/an/a 11n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17519
PNG
(2-[(2-{[4-(dimethylamino)butyl]amino}benzene)sulfo...)
Show SMILES CN(C)CCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H31N3O4S/c1-26(2)16-8-7-15-24-19-11-5-6-12-21(19)31(29,30)25-20-14-13-17-9-3-4-10-18(17)22(20)23(27)28/h5-6,11-14,24-25H,3-4,7-10,15-16H2,1-2H3,(H,27,28)
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n/an/a 12n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17575
PNG
(2-({2-[(1Z)-3-[methyl(propan-2-yl)amino]prop-1-en-...)
Show SMILES CC(C)N(C)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H30N2O4S/c1-17(2)26(3)16-8-11-19-10-5-7-13-22(19)31(29,30)25-21-15-14-18-9-4-6-12-20(18)23(21)24(27)28/h5,7-8,10-11,13-15,17,25H,4,6,9,12,16H2,1-3H3,(H,27,28)/b11-8-
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n/an/a 12n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17488
PNG
(2-[(2-{[3-(ethylamino)propyl]amino}benzene)sulfona...)
Show SMILES CCNCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C22H29N3O4S/c1-2-23-14-7-15-24-18-10-5-6-11-20(18)30(28,29)25-19-13-12-16-8-3-4-9-17(16)21(19)22(26)27/h5-6,10-13,23-25H,2-4,7-9,14-15H2,1H3,(H,26,27)
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n/an/a 12n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17559
PNG
(2-({2-[(1Z)-3-(diethylamino)prop-1-en-1-yl]benzene...)
Show SMILES CCN(CC)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H30N2O4S/c1-3-26(4-2)17-9-12-19-11-6-8-14-22(19)31(29,30)25-21-16-15-18-10-5-7-13-20(18)23(21)24(27)28/h6,8-9,11-12,14-16,25H,3-5,7,10,13,17H2,1-2H3,(H,27,28)/b12-9-
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n/an/a 12n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17521
PNG
(2-[(2-aminobenzene)sulfonamido]-5,6,7,8-tetrahydro...)
Show SMILES Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C17H18N2O4S/c18-13-7-3-4-8-15(13)24(22,23)19-14-10-9-11-5-1-2-6-12(11)16(14)17(20)21/h3-4,7-10,19H,1-2,5-6,18H2,(H,20,21)
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n/an/a 13n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17492
PNG
(2-({2-[(3-aminopropyl)amino]benzene}sulfonamido)-5...)
Show SMILES NCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C20H25N3O4S/c21-12-5-13-22-16-8-3-4-9-18(16)28(26,27)23-17-11-10-14-6-1-2-7-15(14)19(17)20(24)25/h3-4,8-11,22-23H,1-2,5-7,12-13,21H2,(H,24,25)
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n/an/a 13n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17483
PNG
(2-[(2-{[3-(dimethylamino)propyl]amino}benzene)sulf...)
Show SMILES CN(C)CCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C22H29N3O4S/c1-25(2)15-7-14-23-18-10-5-6-11-20(18)30(28,29)24-19-13-12-16-8-3-4-9-17(16)21(19)22(26)27/h5-6,10-13,23-24H,3-4,7-9,14-15H2,1-2H3,(H,26,27)
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n/an/a 14n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17569
PNG
(2-({2-[(1Z)-3-[ethyl(2-hydroxyethyl)amino]prop-1-e...)
Show SMILES CCN(CCO)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H30N2O5S/c1-2-26(16-17-27)15-7-10-19-9-4-6-12-22(19)32(30,31)25-21-14-13-18-8-3-5-11-20(18)23(21)24(28)29/h4,6-7,9-10,12-14,25,27H,2-3,5,8,11,15-17H2,1H3,(H,28,29)/b10-7-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17489
PNG
(2-{[2-({3-[(2-hydroxyethyl)amino]propyl}amino)benz...)
Show SMILES OCCNCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C22H29N3O5S/c26-15-14-23-12-5-13-24-18-8-3-4-9-20(18)31(29,30)25-19-11-10-16-6-1-2-7-17(16)21(19)22(27)28/h3-4,8-11,23-26H,1-2,5-7,12-15H2,(H,27,28)
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n/an/a 15n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17527
PNG
(2-[(2-{[(1-methylpiperidin-4-yl)methyl]amino}benze...)
Show SMILES CN1CCC(CNc2ccccc2S(=O)(=O)Nc2ccc3CCCCc3c2C(O)=O)CC1
Show InChI InChI=1S/C24H31N3O4S/c1-27-14-12-17(13-15-27)16-25-20-8-4-5-9-22(20)32(30,31)26-21-11-10-18-6-2-3-7-19(18)23(21)24(28)29/h4-5,8-11,17,25-26H,2-3,6-7,12-16H2,1H3,(H,28,29)
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n/an/a 15n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17512
PNG
(2-[(3-chloro-2-{[3-(diethylamino)propyl]amino}benz...)
Show SMILES CCN(CC)CCCNc1c(Cl)cccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32ClN3O4S/c1-3-28(4-2)16-8-15-26-23-19(25)11-7-12-21(23)33(31,32)27-20-14-13-17-9-5-6-10-18(17)22(20)24(29)30/h7,11-14,26-27H,3-6,8-10,15-16H2,1-2H3,(H,29,30)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17574
PNG
(2-({2-[(1Z)-3-[(2-hydroxyethyl)(methyl)amino]prop-...)
Show SMILES CN(CCO)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H28N2O5S/c1-25(15-16-26)14-6-9-18-8-3-5-11-21(18)31(29,30)24-20-13-12-17-7-2-4-10-19(17)22(20)23(27)28/h3,5-6,8-9,11-13,24,26H,2,4,7,10,14-16H2,1H3,(H,27,28)/b9-6-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17508
PNG
(2-[(2-{[2-(pyridin-4-yl)ethyl]amino}benzene)sulfon...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCc2ccncc2)ccc2CCCCc12
Show InChI InChI=1S/C24H25N3O4S/c28-24(29)23-19-6-2-1-5-18(19)9-10-21(23)27-32(30,31)22-8-4-3-7-20(22)26-16-13-17-11-14-25-15-12-17/h3-4,7-12,14-15,26-27H,1-2,5-6,13,16H2,(H,28,29)
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n/an/a 16n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17561
PNG
(2-({2-[(1Z)-4-(diethylamino)but-1-en-1-yl]benzene}...)
Show SMILES CCN(CC)CC\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H32N2O4S/c1-3-27(4-2)18-10-9-13-20-12-6-8-15-23(20)32(30,31)26-22-17-16-19-11-5-7-14-21(19)24(22)25(28)29/h6,8-9,12-13,15-17,26H,3-5,7,10-11,14,18H2,1-2H3,(H,28,29)/b13-9-
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n/an/a 16n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17566
PNG
(2-({2-[(1Z)-3-(diethylamino)but-1-en-1-yl]-4-fluor...)
Show SMILES CCN(CC)C(C)\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H31FN2O4S/c1-4-28(5-2)17(3)10-11-19-16-20(26)13-15-23(19)33(31,32)27-22-14-12-18-8-6-7-9-21(18)24(22)25(29)30/h10-17,27H,4-9H2,1-3H3,(H,29,30)/b11-10-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17571
PNG
(2-({2-[(1Z)-3-(dimethylamino)prop-1-en-1-yl]benzen...)
Show SMILES CN(C)C\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C22H26N2O4S/c1-24(2)15-7-10-17-9-4-6-12-20(17)29(27,28)23-19-14-13-16-8-3-5-11-18(16)21(19)22(25)26/h4,6-7,9-10,12-14,23H,3,5,8,11,15H2,1-2H3,(H,25,26)/b10-7-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17496
PNG
(2-[(2-{[3-(pyrrolidin-1-yl)propyl]amino}benzene)su...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCCC2)ccc2CCCCc12
Show InChI InChI=1S/C24H31N3O4S/c28-24(29)23-19-9-2-1-8-18(19)12-13-21(23)26-32(30,31)22-11-4-3-10-20(22)25-14-7-17-27-15-5-6-16-27/h3-4,10-13,25-26H,1-2,5-9,14-17H2,(H,28,29)
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n/an/a 17n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17502
PNG
(2-({2-[(piperidin-4-ylmethyl)amino]benzene}sulfona...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCC2CCNCC2)ccc2CCCCc12
Show InChI InChI=1S/C23H29N3O4S/c27-23(28)22-18-6-2-1-5-17(18)9-10-20(22)26-31(29,30)21-8-4-3-7-19(21)25-15-16-11-13-24-14-12-16/h3-4,7-10,16,24-26H,1-2,5-6,11-15H2,(H,27,28)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17534
PNG
(2-{[2-({[2-(diethylamino)ethyl]carbamoyl}amino)ben...)
Show SMILES CCN(CC)CCNC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32N4O5S/c1-3-28(4-2)16-15-25-24(31)26-19-11-7-8-12-21(19)34(32,33)27-20-14-13-17-9-5-6-10-18(17)22(20)23(29)30/h7-8,11-14,27H,3-6,9-10,15-16H2,1-2H3,(H,29,30)(H2,25,26,31)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17580
PNG
(2-({2-[3-(diethylamino)propyl]-4-fluorobenzene}sul...)
Show SMILES CCN(CC)CCCc1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H31FN2O4S/c1-3-27(4-2)15-7-9-18-16-19(25)12-14-22(18)32(30,31)26-21-13-11-17-8-5-6-10-20(17)23(21)24(28)29/h11-14,16,26H,3-10,15H2,1-2H3,(H,28,29)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17497
PNG
(2-[(2-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}ben...)
Show SMILES CN1CCCC1CCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H31N3O4S/c1-27-16-6-8-18(27)14-15-25-20-10-4-5-11-22(20)32(30,31)26-21-13-12-17-7-2-3-9-19(17)23(21)24(28)29/h4-5,10-13,18,25-26H,2-3,6-9,14-16H2,1H3,(H,28,29)
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n/an/a 17n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17570
PNG
(2-({2-[(1Z)-3-(4-methylpiperazin-1-yl)prop-1-en-1-...)
Show SMILES CN1CCN(C\C=C/c2ccccc2S(=O)(=O)Nc2ccc3CCCCc3c2C(O)=O)CC1
Show InChI InChI=1S/C25H31N3O4S/c1-27-15-17-28(18-16-27)14-6-9-20-8-3-5-11-23(20)33(31,32)26-22-13-12-19-7-2-4-10-21(19)24(22)25(29)30/h3,5-6,8-9,11-13,26H,2,4,7,10,14-18H2,1H3,(H,29,30)/b9-6-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17486
PNG
(2-{[2-({2-[(dimethylamino)methyl]-2-methylpropyl}a...)
Show SMILES CN(C)CC(C)(C)CNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H33N3O4S/c1-24(2,16-27(3)4)15-25-19-11-7-8-12-21(19)32(30,31)26-20-14-13-17-9-5-6-10-18(17)22(20)23(28)29/h7-8,11-14,25-26H,5-6,9-10,15-16H2,1-4H3,(H,28,29)
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n/an/a 18n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17572
PNG
(2-({2-[(1Z)-3-(dimethylamino)prop-1-en-1-yl]-4-flu...)
Show SMILES CN(C)C\C=C/c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C22H25FN2O4S/c1-25(2)13-5-7-16-14-17(23)10-12-20(16)30(28,29)24-19-11-9-15-6-3-4-8-18(15)21(19)22(26)27/h5,7,9-12,14,24H,3-4,6,8,13H2,1-2H3,(H,26,27)/b7-5-
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n/an/a 19n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17565
PNG
(2-({2-[(1Z)-3-(diethylamino)but-1-en-1-yl]benzene}...)
Show SMILES CCN(CC)C(C)\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H32N2O4S/c1-4-27(5-2)18(3)14-15-20-11-7-9-13-23(20)32(30,31)26-22-17-16-19-10-6-8-12-21(19)24(22)25(28)29/h7,9,11,13-18,26H,4-6,8,10,12H2,1-3H3,(H,28,29)/b15-14-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17510
PNG
(2-[(2-{[3-(diethylamino)propyl]amino}-6-fluorobenz...)
Show SMILES CCN(CC)CCCNc1cccc(F)c1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32FN3O4S/c1-3-28(4-2)16-8-15-26-21-12-7-11-19(25)23(21)33(31,32)27-20-14-13-17-9-5-6-10-18(17)22(20)24(29)30/h7,11-14,26-27H,3-6,8-10,15-16H2,1-2H3,(H,29,30)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17581
PNG
(2-({2-[4-(diethylamino)butyl]benzene}sulfonamido)-...)
Show SMILES CCN(CC)CCCCc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H34N2O4S/c1-3-27(4-2)18-10-9-13-20-12-6-8-15-23(20)32(30,31)26-22-17-16-19-11-5-7-14-21(19)24(22)25(28)29/h6,8,12,15-17,26H,3-5,7,9-11,13-14,18H2,1-2H3,(H,28,29)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17494
PNG
(2-[(2-{[3-(piperidin-1-yl)propyl]amino}benzene)sul...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C25H33N3O4S/c29-25(30)24-20-10-3-2-9-19(20)13-14-22(24)27-33(31,32)23-12-5-4-11-21(23)26-15-8-18-28-16-6-1-7-17-28/h4-5,11-14,26-27H,1-3,6-10,15-18H2,(H,29,30)
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n/an/a 20n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17498
PNG
(2-({2-[(1-benzylpiperidin-4-yl)amino]benzene}sulfo...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NC2CCN(Cc3ccccc3)CC2)ccc2CCCCc12
Show InChI InChI=1S/C29H33N3O4S/c33-29(34)28-24-11-5-4-10-22(24)14-15-26(28)31-37(35,36)27-13-7-6-12-25(27)30-23-16-18-32(19-17-23)20-21-8-2-1-3-9-21/h1-3,6-9,12-15,23,30-31H,4-5,10-11,16-20H2,(H,33,34)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17567
PNG
(2-({2-[(1Z)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]benz...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2\C=C/CN2CCCC2)ccc2CCCCc12
Show InChI InChI=1S/C24H28N2O4S/c27-24(28)23-20-11-3-1-8-18(20)13-14-21(23)25-31(29,30)22-12-4-2-9-19(22)10-7-17-26-15-5-6-16-26/h2,4,7,9-10,12-14,25H,1,3,5-6,8,11,15-17H2,(H,27,28)/b10-7-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17578
PNG
(2-({2-[(1E)-5-(diethylamino)pent-1-en-1-yl]benzene...)
Show SMILES CCN(CC)CCC\C=C\c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C26H34N2O4S/c1-3-28(4-2)19-11-5-6-13-21-14-8-10-16-24(21)33(31,32)27-23-18-17-20-12-7-9-15-22(20)25(23)26(29)30/h6,8,10,13-14,16-18,27H,3-5,7,9,11-12,15,19H2,1-2H3,(H,29,30)/b13-6+
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17568
PNG
(2-({4-fluoro-2-[(1Z)-3-(pyrrolidin-1-yl)prop-1-en-...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccc(F)cc2\C=C/CN2CCCC2)ccc2CCCCc12
Show InChI InChI=1S/C24H27FN2O4S/c25-19-10-12-22(18(16-19)7-5-15-27-13-3-4-14-27)32(30,31)26-21-11-9-17-6-1-2-8-20(17)23(21)24(28)29/h5,7,9-12,16,26H,1-4,6,8,13-15H2,(H,28,29)/b7-5-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17495
PNG
(2-[(2-{[3-(morpholin-4-yl)propyl]amino}benzene)sul...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCOCC2)ccc2CCCCc12
Show InChI InChI=1S/C24H31N3O5S/c28-24(29)23-19-7-2-1-6-18(19)10-11-21(23)26-33(30,31)22-9-4-3-8-20(22)25-12-5-13-27-14-16-32-17-15-27/h3-4,8-11,25-26H,1-2,5-7,12-17H2,(H,28,29)
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n/an/a 22n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17503
PNG
(2-[(2-{[2-(pyrrolidin-2-yl)ethyl]amino}benzene)sul...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCC2CCCN2)ccc2CCCCc12
Show InChI InChI=1S/C23H29N3O4S/c27-23(28)22-18-8-2-1-6-16(18)11-12-20(22)26-31(29,30)21-10-4-3-9-19(21)25-15-13-17-7-5-14-24-17/h3-4,9-12,17,24-26H,1-2,5-8,13-15H2,(H,27,28)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17577
PNG
(2-({2-[(1E)-4-(diethylamino)but-1-en-1-yl]benzene}...)
Show SMILES CCN(CC)CC\C=C\c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H32N2O4S/c1-3-27(4-2)18-10-9-13-20-12-6-8-15-23(20)32(30,31)26-22-17-16-19-11-5-7-14-21(19)24(22)25(28)29/h6,8-9,12-13,15-17,26H,3-5,7,10-11,14,18H2,1-2H3,(H,28,29)/b13-9+
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17484
PNG
(2-[(2-{[3-(diethylamino)propyl]amino}benzene)sulfo...)
Show SMILES CCN(CC)CCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H33N3O4S/c1-3-27(4-2)17-9-16-25-20-12-7-8-13-22(20)32(30,31)26-21-15-14-18-10-5-6-11-19(18)23(21)24(28)29/h7-8,12-15,25-26H,3-6,9-11,16-17H2,1-2H3,(H,28,29)
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n/an/a 25n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17555
PNG
(2-[(2-{[3-(diethylamino)propyl]carbamoyl}benzene)s...)
Show SMILES CCN(CC)CCCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H33N3O5S/c1-3-28(4-2)17-9-16-26-24(29)20-12-7-8-13-22(20)34(32,33)27-21-15-14-18-10-5-6-11-19(18)23(21)25(30)31/h7-8,12-15,27H,3-6,9-11,16-17H2,1-2H3,(H,26,29)(H,30,31)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17493
PNG
(2-[(2-{[3-(4-methylpiperazin-1-yl)propyl]amino}ben...)
Show SMILES CN1CCN(CCCNc2ccccc2S(=O)(=O)Nc2ccc3CCCCc3c2C(O)=O)CC1
Show InChI InChI=1S/C25H34N4O4S/c1-28-15-17-29(18-16-28)14-6-13-26-21-9-4-5-10-23(21)34(32,33)27-22-12-11-19-7-2-3-8-20(19)24(22)25(30)31/h4-5,9-12,26-27H,2-3,6-8,13-18H2,1H3,(H,30,31)
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n/an/a 26n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17487
PNG
(2-{[2-({3-[bis(2-hydroxyethyl)amino]propyl}amino)b...)
Show SMILES OCCN(CCO)CCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H33N3O6S/c28-16-14-27(15-17-29)13-5-12-25-20-8-3-4-9-22(20)34(32,33)26-21-11-10-18-6-1-2-7-19(18)23(21)24(30)31/h3-4,8-11,25-26,28-29H,1-2,5-7,12-17H2,(H,30,31)
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n/an/a 26n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17576
PNG
(2-({2-[(1E)-3-(diethylamino)prop-1-en-1-yl]benzene...)
Show SMILES CCN(CC)C\C=C\c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H30N2O4S/c1-3-26(4-2)17-9-12-19-11-6-8-14-22(19)31(29,30)25-21-16-15-18-10-5-7-13-20(18)23(21)24(27)28/h6,8-9,11-12,14-16,25H,3-5,7,10,13,17H2,1-2H3,(H,27,28)/b12-9+
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17562
PNG
(2-({2-[(1Z)-5-(diethylamino)pent-1-en-1-yl]benzene...)
Show SMILES CCN(CC)CCC\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C26H34N2O4S/c1-3-28(4-2)19-11-5-6-13-21-14-8-10-16-24(21)33(31,32)27-23-18-17-20-12-7-9-15-22(20)25(23)26(29)30/h6,8,10,13-14,16-18,27H,3-5,7,9,11-12,15,19H2,1-2H3,(H,29,30)/b13-6-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17544
PNG
(2-[(2-{[2-(dimethylamino)ethyl]sulfanyl}-4-fluorob...)
Show SMILES CN(C)CCSc1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C21H25FN2O4S2/c1-24(2)11-12-29-18-13-15(22)8-10-19(18)30(27,28)23-17-9-7-14-5-3-4-6-16(14)20(17)21(25)26/h7-10,13,23H,3-6,11-12H2,1-2H3,(H,25,26)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17563
PNG
(2-({2-[(1Z)-3-(pyrrolidin-1-yl)but-1-en-1-yl]benze...)
Show SMILES CC(\C=C/c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O)N1CCCC1
Show InChI InChI=1S/C25H30N2O4S/c1-18(27-16-6-7-17-27)12-13-20-9-3-5-11-23(20)32(30,31)26-22-15-14-19-8-2-4-10-21(19)24(22)25(28)29/h3,5,9,11-15,18,26H,2,4,6-8,10,16-17H2,1H3,(H,28,29)/b13-12-
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17480
PNG
(2-[(2-{[2-(diethylamino)ethyl]amino}benzene)sulfon...)
Show SMILES CCN(CC)CCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H31N3O4S/c1-3-26(4-2)16-15-24-19-11-7-8-12-21(19)31(29,30)25-20-14-13-17-9-5-6-10-18(17)22(20)23(27)28/h7-8,11-14,24-25H,3-6,9-10,15-16H2,1-2H3,(H,27,28)
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n/an/a 31n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17552
PNG
(2-[(2-{[2-(diethylamino)ethyl]carbamoyl}benzene)su...)
Show SMILES CCN(CC)CCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H31N3O5S/c1-3-27(4-2)16-15-25-23(28)19-11-7-8-12-21(19)33(31,32)26-20-14-13-17-9-5-6-10-18(17)22(20)24(29)30/h7-8,11-14,26H,3-6,9-10,15-16H2,1-2H3,(H,25,28)(H,29,30)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17481
PNG
(2-{[2-({2-[bis(propan-2-yl)amino]ethyl}amino)benze...)
Show SMILES CC(C)N(CCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O)C(C)C
Show InChI InChI=1S/C25H35N3O4S/c1-17(2)28(18(3)4)16-15-26-21-11-7-8-12-23(21)33(31,32)27-22-14-13-19-9-5-6-10-20(19)24(22)25(29)30/h7-8,11-14,17-18,26-27H,5-6,9-10,15-16H2,1-4H3,(H,29,30)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17533
PNG
(2-({2-[4-(piperidin-1-yl)butanamido]benzene}sulfon...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NC(=O)CCCN2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C26H33N3O5S/c30-24(13-8-18-29-16-6-1-7-17-29)27-21-11-4-5-12-23(21)35(33,34)28-22-15-14-19-9-2-3-10-20(19)25(22)26(31)32/h4-5,11-12,14-15,28H,1-3,6-10,13,16-18H2,(H,27,30)(H,31,32)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17501
PNG
(2-({2-[(pyrrolidin-3-ylmethyl)amino]benzene}sulfon...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCC2CCNC2)ccc2CCCCc12
Show InChI InChI=1S/C22H27N3O4S/c26-22(27)21-17-6-2-1-5-16(17)9-10-19(21)25-30(28,29)20-8-4-3-7-18(20)24-14-15-11-12-23-13-15/h3-4,7-10,15,23-25H,1-2,5-6,11-14H2,(H,26,27)
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n/an/a 34n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17500
PNG
(2-({2-[(piperidin-3-ylmethyl)amino]benzene}sulfona...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCC2CCCNC2)ccc2CCCCc12
Show InChI InChI=1S/C23H29N3O4S/c27-23(28)22-18-8-2-1-7-17(18)11-12-20(22)26-31(29,30)21-10-4-3-9-19(21)25-15-16-6-5-13-24-14-16/h3-4,9-12,16,24-26H,1-2,5-8,13-15H2,(H,27,28)
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n/an/a 35n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17506
PNG
(2-({2-[(pyridin-4-ylmethyl)amino]benzene}sulfonami...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCc2ccncc2)ccc2CCCCc12
Show InChI InChI=1S/C23H23N3O4S/c27-23(28)22-18-6-2-1-5-17(18)9-10-20(22)26-31(29,30)21-8-4-3-7-19(21)25-15-16-11-13-24-14-12-16/h3-4,7-14,25-26H,1-2,5-6,15H2,(H,27,28)
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n/an/a 35n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17553
PNG
(2-[(2-{[2-(1-methylpyrrolidin-2-yl)ethyl]carbamoyl...)
Show SMILES CN1CCCC1CCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H31N3O5S/c1-28-16-6-8-18(28)14-15-26-24(29)20-10-4-5-11-22(20)34(32,33)27-21-13-12-17-7-2-3-9-19(17)23(21)25(30)31/h4-5,10-13,18,27H,2-3,6-9,14-16H2,1H3,(H,26,29)(H,30,31)
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n/an/a 37n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17543
PNG
(2-[(2-{[2-(diethylamino)ethyl]sulfanyl}-4-fluorobe...)
Show SMILES CCN(CC)CCSc1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H29FN2O4S2/c1-3-26(4-2)13-14-31-20-15-17(24)10-12-21(20)32(29,30)25-19-11-9-16-7-5-6-8-18(16)22(19)23(27)28/h9-12,15,25H,3-8,13-14H2,1-2H3,(H,27,28)
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n/an/a 37n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17529
PNG
(2-({2-[2-(diethylamino)acetamido]benzene}sulfonami...)
Show SMILES CCN(CC)CC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H29N3O5S/c1-3-26(4-2)15-21(27)24-18-11-7-8-12-20(18)32(30,31)25-19-14-13-16-9-5-6-10-17(16)22(19)23(28)29/h7-8,11-14,25H,3-6,9-10,15H2,1-2H3,(H,24,27)(H,28,29)
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n/an/a 38n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17546
PNG
(2-[(2-{[2-(diethylamino)ethane]sulfinyl}benzene)su...)
Show SMILES CCN(CC)CCS(=O)c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H30N2O5S2/c1-3-25(4-2)15-16-31(28)20-11-7-8-12-21(20)32(29,30)24-19-14-13-17-9-5-6-10-18(17)22(19)23(26)27/h7-8,11-14,24H,3-6,9-10,15-16H2,1-2H3,(H,26,27)
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n/an/a 39n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17509
PNG
(2-[(2-{[3-(2-oxopyrrolidin-1-yl)propyl]amino}benze...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCCC2=O)ccc2CCCCc12
Show InChI InChI=1S/C24H29N3O5S/c28-22-11-5-15-27(22)16-6-14-25-19-9-3-4-10-21(19)33(31,32)26-20-13-12-17-7-1-2-8-18(17)23(20)24(29)30/h3-4,9-10,12-13,25-26H,1-2,5-8,11,14-16H2,(H,29,30)
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n/an/a 40n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17532
PNG
(2-({2-[4-(pyrrolidin-1-yl)butanamido]benzene}sulfo...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NC(=O)CCCN2CCCC2)ccc2CCCCc12
Show InChI InChI=1S/C25H31N3O5S/c29-23(12-7-17-28-15-5-6-16-28)26-20-10-3-4-11-22(20)34(32,33)27-21-14-13-18-8-1-2-9-19(18)24(21)25(30)31/h3-4,10-11,13-14,27H,1-2,5-9,12,15-17H2,(H,26,29)(H,30,31)
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n/an/a 42n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17539
PNG
(2-{[2-({[3-(piperidin-1-yl)propyl]carbamoyl}amino)...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NC(=O)NCCCN2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C26H34N4O5S/c31-25(32)24-20-10-3-2-9-19(20)13-14-22(24)29-36(34,35)23-12-5-4-11-21(23)28-26(33)27-15-8-18-30-16-6-1-7-17-30/h4-5,11-14,29H,1-3,6-10,15-18H2,(H,31,32)(H2,27,28,33)
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n/an/a 42n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17542
PNG
(2-[(2-{[3-(diethylamino)propyl]sulfanyl}benzene)su...)
Show SMILES CCN(CC)CCCSc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32N2O4S2/c1-3-26(4-2)16-9-17-31-21-12-7-8-13-22(21)32(29,30)25-20-15-14-18-10-5-6-11-19(18)23(20)24(27)28/h7-8,12-15,25H,3-6,9-11,16-17H2,1-2H3,(H,27,28)
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n/an/a 43n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17556
PNG
(2-[(2-{[4-(diethylamino)butyl]carbamoyl}benzene)su...)
Show SMILES CCN(CC)CCCCNC(=O)c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C26H35N3O5S/c1-3-29(4-2)18-10-9-17-27-25(30)21-13-7-8-14-23(21)35(33,34)28-22-16-15-19-11-5-6-12-20(19)24(22)26(31)32/h7-8,13-16,28H,3-6,9-12,17-18H2,1-2H3,(H,27,30)(H,31,32)
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n/an/a 44n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17582
PNG
(2-({2-[5-(diethylamino)pentyl]benzene}sulfonamido)...)
Show SMILES CCN(CC)CCCCCc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C26H36N2O4S/c1-3-28(4-2)19-11-5-6-13-21-14-8-10-16-24(21)33(31,32)27-23-18-17-20-12-7-9-15-22(20)25(23)26(29)30/h8,10,14,16-18,27H,3-7,9,11-13,15,19H2,1-2H3,(H,29,30)
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n/an/a 45n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17522
PNG
(2-{[2-({[1-(propan-2-yl)piperidin-4-yl]methyl}amin...)
Show SMILES CC(C)N1CCC(CNc2ccccc2S(=O)(=O)Nc2ccc3CCCCc3c2C(O)=O)CC1
Show InChI InChI=1S/C26H35N3O4S/c1-18(2)29-15-13-19(14-16-29)17-27-22-9-5-6-10-24(22)34(32,33)28-23-12-11-20-7-3-4-8-21(20)25(23)26(30)31/h5-6,9-12,18-19,27-28H,3-4,7-8,13-17H2,1-2H3,(H,30,31)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17541
PNG
(2-[(2-{[2-(diethylamino)ethyl]sulfanyl}benzene)sul...)
Show SMILES CCN(CC)CCSc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H30N2O4S2/c1-3-25(4-2)15-16-30-20-11-7-8-12-21(20)31(28,29)24-19-14-13-17-9-5-6-10-18(17)22(19)23(26)27/h7-8,11-14,24H,3-6,9-10,15-16H2,1-2H3,(H,26,27)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17479
PNG
(2-[(2-{[2-(dimethylamino)ethyl]amino}benzene)sulfo...)
Show SMILES CN(C)CCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C21H27N3O4S/c1-24(2)14-13-22-17-9-5-6-10-19(17)29(27,28)23-18-12-11-15-7-3-4-8-16(15)20(18)21(25)26/h5-6,9-12,22-23H,3-4,7-8,13-14H2,1-2H3,(H,25,26)
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n/an/a 48n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17554
PNG
(2-[(2-{[2-(piperidin-1-yl)ethyl]carbamoyl}benzene)...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2C(=O)NCCN2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C25H31N3O5S/c29-24(26-14-17-28-15-6-1-7-16-28)20-10-4-5-11-22(20)34(32,33)27-21-13-12-18-8-2-3-9-19(18)23(21)25(30)31/h4-5,10-13,27H,1-3,6-9,14-17H2,(H,26,29)(H,30,31)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17540
PNG
(2-{[2-({[2-(diethylamino)ethoxy]carbonyl}amino)ben...)
Show SMILES CCN(CC)CCOC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H31N3O6S/c1-3-27(4-2)15-16-33-24(30)25-19-11-7-8-12-21(19)34(31,32)26-20-14-13-17-9-5-6-10-18(17)22(20)23(28)29/h7-8,11-14,26H,3-6,9-10,15-16H2,1-2H3,(H,25,30)(H,28,29)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17485
PNG
(2-[(2-{[3-(dibutylamino)propyl]amino}benzene)sulfo...)
Show SMILES CCCCN(CCCC)CCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C28H41N3O4S/c1-3-5-19-31(20-6-4-2)21-11-18-29-24-14-9-10-15-26(24)36(34,35)30-25-17-16-22-12-7-8-13-23(22)27(25)28(32)33/h9-10,14-17,29-30H,3-8,11-13,18-21H2,1-2H3,(H,32,33)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17545
PNG
(2-[(2-{[2-(dimethylamino)ethyl]sulfanyl}benzene)su...)
Show SMILES CN(C)CCSc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C21H26N2O4S2/c1-23(2)13-14-28-18-9-5-6-10-19(18)29(26,27)22-17-12-11-15-7-3-4-8-16(15)20(17)21(24)25/h5-6,9-12,22H,3-4,7-8,13-14H2,1-2H3,(H,24,25)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17507
PNG
(2-[(2-{[2-(pyridin-2-yl)ethyl]amino}benzene)sulfon...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCc2ccccn2)ccc2CCCCc12
Show InChI InChI=1S/C24H25N3O4S/c28-24(29)23-19-9-2-1-7-17(19)12-13-21(23)27-32(30,31)22-11-4-3-10-20(22)26-16-14-18-8-5-6-15-25-18/h3-6,8,10-13,15,26-27H,1-2,7,9,14,16H2,(H,28,29)
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n/an/a 53n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17584
PNG
(2-[(2-{2-[(diethylamino)methyl]cyclopropyl}-4-fluo...)
Show SMILES CCN(CC)CC1CC1c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H31FN2O4S/c1-3-28(4-2)15-17-13-20(17)21-14-18(26)10-12-23(21)33(31,32)27-22-11-9-16-7-5-6-8-19(16)24(22)25(29)30/h9-12,14,17,20,27H,3-8,13,15H2,1-2H3,(H,29,30)
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n/an/a 54n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17549
PNG
(2-[(2-{[2-(dimethylamino)ethane]sulfinyl}benzene)s...)
Show SMILES CN(C)CCS(=O)c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C21H26N2O5S2/c1-23(2)13-14-29(26)18-9-5-6-10-19(18)30(27,28)22-17-12-11-15-7-3-4-8-16(15)20(17)21(24)25/h5-6,9-12,22H,3-4,7-8,13-14H2,1-2H3,(H,24,25)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17528
PNG
(2-{[2-({[1-(1-methylpiperidin-4-yl)piperidin-4-yl]...)
Show SMILES CN1CCC(CC1)N1CCC(CNc2ccccc2S(=O)(=O)Nc2ccc3CCCCc3c2C(O)=O)CC1
Show InChI InChI=1S/C29H40N4O4S/c1-32-16-14-23(15-17-32)33-18-12-21(13-19-33)20-30-25-8-4-5-9-27(25)38(36,37)31-26-11-10-22-6-2-3-7-24(22)28(26)29(34)35/h4-5,8-11,21,23,30-31H,2-3,6-7,12-20H2,1H3,(H,34,35)
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n/an/a 55n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17585
PNG
(2-[(2-{2-[(dimethylamino)methyl]cyclopropyl}-4-flu...)
Show SMILES CN(C)CC1CC1c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H27FN2O4S/c1-26(2)13-15-11-18(15)19-12-16(24)8-10-21(19)31(29,30)25-20-9-7-14-5-3-4-6-17(14)22(20)23(27)28/h7-10,12,15,18,25H,3-6,11,13H2,1-2H3,(H,27,28)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17547
PNG
(2-[(2-{[2-(diethylamino)ethane]sulfinyl}-4-fluorob...)
Show SMILES CCN(CC)CCS(=O)c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C23H29FN2O5S2/c1-3-26(4-2)13-14-32(29)20-15-17(24)10-12-21(20)33(30,31)25-19-11-9-16-7-5-6-8-18(16)22(19)23(27)28/h9-12,15,25H,3-8,13-14H2,1-2H3,(H,27,28)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17538
PNG
(2-{[2-({[3-(morpholin-4-yl)propyl]carbamoyl}amino)...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NC(=O)NCCCN2CCOCC2)ccc2CCCCc12
Show InChI InChI=1S/C25H32N4O6S/c30-24(31)23-19-7-2-1-6-18(19)10-11-21(23)28-36(33,34)22-9-4-3-8-20(22)27-25(32)26-12-5-13-29-14-16-35-17-15-29/h3-4,8-11,28H,1-2,5-7,12-17H2,(H,30,31)(H2,26,27,32)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17513
PNG
(2-[(5-chloro-2-{[3-(diethylamino)propyl]amino}benz...)
Show SMILES CCN(CC)CCCNc1ccc(Cl)cc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32ClN3O4S/c1-3-28(4-2)15-7-14-26-20-13-11-18(25)16-22(20)33(31,32)27-21-12-10-17-8-5-6-9-19(17)23(21)24(29)30/h10-13,16,26-27H,3-9,14-15H2,1-2H3,(H,29,30)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17504
PNG
(2-{[2-({3-[4-(piperidin-1-yl)piperidin-1-yl]propyl...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCCN2CCC(CC2)N2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C30H42N4O4S/c35-30(36)29-25-10-3-2-9-23(25)13-14-27(29)32-39(37,38)28-12-5-4-11-26(28)31-17-8-18-33-21-15-24(16-22-33)34-19-6-1-7-20-34/h4-5,11-14,24,31-32H,1-3,6-10,15-22H2,(H,35,36)
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n/an/a 58n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17530
PNG
(2-({2-[3-(diethylamino)propanamido]benzene}sulfona...)
Show SMILES CCN(CC)CCC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H31N3O5S/c1-3-27(4-2)16-15-22(28)25-19-11-7-8-12-21(19)33(31,32)26-20-14-13-17-9-5-6-10-18(17)23(20)24(29)30/h7-8,11-14,26H,3-6,9-10,15-16H2,1-2H3,(H,25,28)(H,29,30)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17531
PNG
(2-({2-[4-(diethylamino)butanamido]benzene}sulfonam...)
Show SMILES CCN(CC)CCCC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H33N3O5S/c1-3-28(4-2)17-9-14-23(29)26-20-12-7-8-13-22(20)34(32,33)27-21-16-15-18-10-5-6-11-19(18)24(21)25(30)31/h7-8,12-13,15-16,27H,3-6,9-11,14,17H2,1-2H3,(H,26,29)(H,30,31)
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n/an/a 59n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17548
PNG
(2-[(2-{[2-(dimethylamino)ethane]sulfinyl}-4-fluoro...)
Show SMILES CN(C)CCS(=O)c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C21H25FN2O5S2/c1-24(2)11-12-30(27)18-13-15(22)8-10-19(18)31(28,29)23-17-9-7-14-5-3-4-6-16(14)20(17)21(25)26/h7-10,13,23H,3-6,11-12H2,1-2H3,(H,25,26)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17526
PNG
(2-{[2-({2-[1-(propan-2-yl)pyrrolidin-2-yl]ethyl}am...)
Show SMILES CC(C)N1CCCC1CCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C26H35N3O4S/c1-18(2)29-17-7-9-20(29)15-16-27-22-11-5-6-12-24(22)34(32,33)28-23-14-13-19-8-3-4-10-21(19)25(23)26(30)31/h5-6,11-14,18,20,27-28H,3-4,7-10,15-17H2,1-2H3,(H,30,31)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17515
PNG
(2-[(2-{[3-(diethylamino)propyl]amino}-5-methylbenz...)
Show SMILES CCN(CC)CCCNc1ccc(C)cc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H35N3O4S/c1-4-28(5-2)16-8-15-26-21-13-11-18(3)17-23(21)33(31,32)27-22-14-12-19-9-6-7-10-20(19)24(22)25(29)30/h11-14,17,26-27H,4-10,15-16H2,1-3H3,(H,29,30)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17557
PNG
(2-[(2-{[5-(diethylamino)pentan-2-yl]carbamoyl}-4-f...)
Show SMILES CCN(CC)CCCC(C)NC(=O)c1cc(F)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C27H36FN3O5S/c1-4-31(5-2)16-8-9-18(3)29-26(32)22-17-20(28)13-15-24(22)37(35,36)30-23-14-12-19-10-6-7-11-21(19)25(23)27(33)34/h12-15,17-18,30H,4-11,16H2,1-3H3,(H,29,32)(H,33,34)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17482
PNG
(2-[(2-{[2-(pyrrolidin-1-yl)ethyl]amino}benzene)sul...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCN2CCCC2)ccc2CCCCc12
Show InChI InChI=1S/C23H29N3O4S/c27-23(28)22-18-8-2-1-7-17(18)11-12-20(22)25-31(29,30)21-10-4-3-9-19(21)24-13-16-26-14-5-6-15-26/h3-4,9-12,24-25H,1-2,5-8,13-16H2,(H,27,28)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17525
PNG
(2-[(2-{[2-(1-cyclohexylpyrrolidin-2-yl)ethyl]amino...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCC2CCCN2C2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C29H39N3O4S/c33-29(34)28-24-13-5-4-9-21(24)16-17-26(28)31-37(35,36)27-15-7-6-14-25(27)30-19-18-23-12-8-20-32(23)22-10-2-1-3-11-22/h6-7,14-17,22-23,30-31H,1-5,8-13,18-20H2,(H,33,34)
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Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17524
PNG
(2-{[2-({2-[1-(1-methylpiperidin-4-yl)pyrrolidin-2-...)
Show SMILES CN1CCC(CC1)N1CCCC1CCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C29H40N4O4S/c1-32-19-15-23(16-20-32)33-18-6-8-22(33)14-17-30-25-10-4-5-11-27(25)38(36,37)31-26-13-12-21-7-2-3-9-24(21)28(26)29(34)35/h4-5,10-13,22-23,30-31H,2-3,6-9,14-20H2,1H3,(H,34,35)
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n/an/a 70n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17535
PNG
(2-{[2-({[2-(1-methylpyrrolidin-2-yl)ethyl]carbamoy...)
Show SMILES CN1CCCC1CCNC(=O)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H32N4O5S/c1-29-16-6-8-18(29)14-15-26-25(32)27-20-10-4-5-11-22(20)35(33,34)28-21-13-12-17-7-2-3-9-19(17)23(21)24(30)31/h4-5,10-13,18,28H,2-3,6-9,14-16H2,1H3,(H,30,31)(H2,26,27,32)
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n/an/a 72n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17490
PNG
(2-({2-[(3-{[(tert-butoxy)carbonyl]amino}propyl)ami...)
Show SMILES CC(C)(C)OC(=O)NCCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H33N3O6S/c1-25(2,3)34-24(31)27-16-8-15-26-19-11-6-7-12-21(19)35(32,33)28-20-14-13-17-9-4-5-10-18(17)22(20)23(29)30/h6-7,11-14,26,28H,4-5,8-10,15-16H2,1-3H3,(H,27,31)(H,29,30)
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n/an/a 77n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17536
PNG
(2-{[2-({[2-(piperidin-1-yl)ethyl]carbamoyl}amino)b...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NC(=O)NCCN2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C25H32N4O5S/c30-24(31)23-19-9-3-2-8-18(19)12-13-21(23)28-35(33,34)22-11-5-4-10-20(22)27-25(32)26-14-17-29-15-6-1-7-16-29/h4-5,10-13,28H,1-3,6-9,14-17H2,(H,30,31)(H2,26,27,32)
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n/an/a 82n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17499
PNG
(2-({2-[(1,2,2,6,6-pentamethylpiperidin-4-yl)amino]...)
Show SMILES CN1C(C)(C)CC(CC1(C)C)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C27H37N3O4S/c1-26(2)16-19(17-27(3,4)30(26)5)28-21-12-8-9-13-23(21)35(33,34)29-22-15-14-18-10-6-7-11-20(18)24(22)25(31)32/h8-9,12-15,19,28-29H,6-7,10-11,16-17H2,1-5H3,(H,31,32)
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n/an/a 91n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17537
PNG
(2-{[2-({[2-(morpholin-4-yl)ethyl]carbamoyl}amino)b...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NC(=O)NCCN2CCOCC2)ccc2CCCCc12
Show InChI InChI=1S/C24H30N4O6S/c29-23(30)22-18-6-2-1-5-17(18)9-10-20(22)27-35(32,33)21-8-4-3-7-19(21)26-24(31)25-11-12-28-13-15-34-16-14-28/h3-4,7-10,27H,1-2,5-6,11-16H2,(H,29,30)(H2,25,26,31)
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n/an/a 110n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17491
PNG
(2-({2-[(3-{[(tert-butoxy)carbonyl](methyl)amino}pr...)
Show SMILES CN(CCCNc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O)C(=O)OC(C)(C)C
Show InChI InChI=1S/C26H35N3O6S/c1-26(2,3)35-25(32)29(4)17-9-16-27-20-12-7-8-13-22(20)36(33,34)28-21-15-14-18-10-5-6-11-19(18)23(21)24(30)31/h7-8,12-15,27-28H,5-6,9-11,16-17H2,1-4H3,(H,30,31)
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n/an/a 110n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17516
PNG
(2-[(4-chloro-2-{[3-(diethylamino)propyl]amino}benz...)
Show SMILES CCN(CC)CCCNc1cc(Cl)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32ClN3O4S/c1-3-28(4-2)15-7-14-26-21-16-18(25)11-13-22(21)33(31,32)27-20-12-10-17-8-5-6-9-19(17)23(20)24(29)30/h10-13,16,26-27H,3-9,14-15H2,1-2H3,(H,29,30)
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n/an/a 110n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17520
PNG
(2-[(2-{[5-(diethylamino)pentan-2-yl]amino}benzene)...)
Show SMILES CCN(CC)CCCC(C)Nc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C26H37N3O4S/c1-4-29(5-2)18-10-11-19(3)27-22-14-8-9-15-24(22)34(32,33)28-23-17-16-20-12-6-7-13-21(20)25(23)26(30)31/h8-9,14-17,19,27-28H,4-7,10-13,18H2,1-3H3,(H,30,31)
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n/an/a 130n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17517
PNG
(2-[(2-{[3-(diethylamino)propyl]amino}-4-methylbenz...)
Show SMILES CCN(CC)CCCNc1cc(C)ccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C25H35N3O4S/c1-4-28(5-2)16-8-15-26-22-17-18(3)11-14-23(22)33(31,32)27-21-13-12-19-9-6-7-10-20(19)24(21)25(29)30/h11-14,17,26-27H,4-10,15-16H2,1-3H3,(H,29,30)
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n/an/a 150n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17523
PNG
(2-{[2-({2-[1-(cyclohexylmethyl)pyrrolidin-2-yl]eth...)
Show SMILES OC(=O)c1c(NS(=O)(=O)c2ccccc2NCCC2CCCN2CC2CCCCC2)ccc2CCCCc12
Show InChI InChI=1S/C30H41N3O4S/c34-30(35)29-25-13-5-4-11-23(25)16-17-27(29)32-38(36,37)28-15-7-6-14-26(28)31-19-18-24-12-8-20-33(24)21-22-9-2-1-3-10-22/h6-7,14-17,22,24,31-32H,1-5,8-13,18-21H2,(H,34,35)
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n/an/a 150n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17558
PNG
(2-[(2-{[5-(diethylamino)pentan-2-yl]carbamoyl}benz...)
Show SMILES CCN(CC)CCCC(C)NC(=O)c1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C27H37N3O5S/c1-4-30(5-2)18-10-11-19(3)28-26(31)22-14-8-9-15-24(22)36(34,35)29-23-17-16-20-12-6-7-13-21(20)25(23)27(32)33/h8-9,14-17,19,29H,4-7,10-13,18H2,1-3H3,(H,28,31)(H,32,33)
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n/an/a 170n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17511
PNG
(2-[(2-{[3-(diethylamino)propyl]amino}-5-fluorobenz...)
Show SMILES CCN(CC)CCCNc1ccc(F)cc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32FN3O4S/c1-3-28(4-2)15-7-14-26-20-13-11-18(25)16-22(20)33(31,32)27-21-12-10-17-8-5-6-9-19(17)23(21)24(29)30/h10-13,16,26-27H,3-9,14-15H2,1-2H3,(H,29,30)
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n/an/a 180n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17550
PNG
(2-({2-[3-(diethylamino)propoxy]benzene}sulfonamido...)
Show SMILES CCN(CC)CCCOc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H32N2O5S/c1-3-26(4-2)16-9-17-31-21-12-7-8-13-22(21)32(29,30)25-20-15-14-18-10-5-6-11-19(18)23(20)24(27)28/h7-8,12-15,25H,3-6,9-11,16-17H2,1-2H3,(H,27,28)
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n/an/a 180n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17551
PNG
(2-({2-[2-(1-methylpyrrolidin-2-yl)ethoxy]benzene}s...)
Show SMILES CN1CCCC1CCOc1ccccc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H30N2O5S/c1-26-15-6-8-18(26)14-16-31-21-10-4-5-11-22(21)32(29,30)25-20-13-12-17-7-2-3-9-19(17)23(20)24(27)28/h4-5,10-13,18,25H,2-3,6-9,14-16H2,1H3,(H,27,28)
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n/an/a 430n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17518
PNG
(2-[(2-{[3-(diethylamino)propyl]amino}-5-(trifluoro...)
Show SMILES CCN(CC)CCCNc1ccc(cc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O)C(F)(F)F
Show InChI InChI=1S/C25H32F3N3O4S/c1-3-31(4-2)15-7-14-29-20-13-11-18(25(26,27)28)16-22(20)36(34,35)30-21-12-10-17-8-5-6-9-19(17)23(21)24(32)33/h10-13,16,29-30H,3-9,14-15H2,1-2H3,(H,32,33)
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n/an/a 690n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17514
PNG
(2-[(4-chloro-2-{[3-(diethylamino)propyl]amino}-5-f...)
Show SMILES CCN(CC)CCCNc1cc(Cl)c(F)cc1S(=O)(=O)Nc1ccc2CCCCc2c1C(O)=O
Show InChI InChI=1S/C24H31ClFN3O4S/c1-3-29(4-2)13-7-12-27-21-14-18(25)19(26)15-22(21)34(32,33)28-20-11-10-16-8-5-6-9-17(16)23(20)24(30)31/h10-11,14-15,27-28H,3-9,12-13H2,1-2H3,(H,30,31)
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n/an/a 790n/an/an/an/an/a25



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM17477
PNG
(2-benzenesulfonamido-5-methylbenzoic acid | A44414...)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccccc2)c(c1)C(O)=O
Show InChI InChI=1S/C14H13NO4S/c1-10-7-8-13(12(9-10)14(16)17)15-20(18,19)11-5-3-2-4-6-11/h2-9,15H,1H3,(H,16,17)
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n/an/a 1.40E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase-2 activity by monitoring the production of free methionine with...

J Med Chem 49: 3832-49 (2006)


Article DOI: 10.1021/jm0601001
BindingDB Entry DOI: 10.7270/Q22V2DDZ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
* indicates data uncertainty>20%