Found 36 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202179
(2-(5-(3,4-bis(benzyloxy)benzylidene)-4-oxo-2-thiox...)Show SMILES OC(=O)C(N1C(=S)S\C(=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C1=O)c1ccccc1 |w:3.3| Show InChI InChI=1S/C32H25NO5S2/c34-30-28(40-32(39)33(30)29(31(35)36)25-14-8-3-9-15-25)19-24-16-17-26(37-20-22-10-4-1-5-11-22)27(18-24)38-21-23-12-6-2-7-13-23/h1-19,29H,20-21H2,(H,35,36)/b28-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202169
((R)-2-(5-(3,4-bis(benzyloxy)benzylidene)-4-oxo-2-t...)Show SMILES CC(C)[C@@H](N1C(=S)S\C(=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C1=O)C(O)=O Show InChI InChI=1S/C29H27NO5S2/c1-19(2)26(28(32)33)30-27(31)25(37-29(30)36)16-22-13-14-23(34-17-20-9-5-3-6-10-20)24(15-22)35-18-21-11-7-4-8-12-21/h3-16,19,26H,17-18H2,1-2H3,(H,32,33)/b25-16+/t26-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202174
((R)-2-(5-(3,4-bis(benzyloxy)benzylidene)-4-oxo-2-t...)Show SMILES OC(=O)[C@@H](Cc1ccccc1)N1C(=S)S\C(=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C1=O Show InChI InChI=1S/C33H27NO5S2/c35-31-30(41-33(40)34(31)27(32(36)37)18-23-10-4-1-5-11-23)20-26-16-17-28(38-21-24-12-6-2-7-13-24)29(19-26)39-22-25-14-8-3-9-15-25/h1-17,19-20,27H,18,21-22H2,(H,36,37)/b30-20+/t27-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202164
(2-(5-(3-(3,4-dichlorophenoxy)benzylidene)-4-oxo-2-...)Show SMILES OC(=O)C(N1C(=S)S\C(=C\c2cccc(Oc3ccc(Cl)c(Cl)c3)c2)C1=O)c1ccccc1 |w:3.3| Show InChI InChI=1S/C24H15Cl2NO4S2/c25-18-10-9-17(13-19(18)26)31-16-8-4-5-14(11-16)12-20-22(28)27(24(32)33-20)21(23(29)30)15-6-2-1-3-7-15/h1-13,21H,(H,29,30)/b20-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202149
(5-(3,5-bis(benzyloxy)benzylidene)-2-thioxothiazoli...)Show SMILES SC1=NC(=O)C(S1)=Cc1cc(OCc2ccccc2)cc(OCc2ccccc2)c1 |w:7.8,t:1| Show InChI InChI=1S/C24H19NO3S2/c26-23-22(30-24(29)25-23)13-19-11-20(27-15-17-7-3-1-4-8-17)14-21(12-19)28-16-18-9-5-2-6-10-18/h1-14H,15-16H2,(H,25,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202167
((R)-2-(5-(3-(3,4-dichlorophenoxy)benzylidene)-4-ox...)Show SMILES OC(=O)[C@@H](Cc1ccccc1)N1C(=S)S\C(=C\c2cccc(Oc3ccc(Cl)c(Cl)c3)c2)C1=O Show InChI InChI=1S/C25H17Cl2NO4S2/c26-19-10-9-18(14-20(19)27)32-17-8-4-7-16(11-17)13-22-23(29)28(25(33)34-22)21(24(30)31)12-15-5-2-1-3-6-15/h1-11,13-14,21H,12H2,(H,30,31)/b22-13+/t21-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202173
(5-(3-(4-tert-butylphenoxy)benzylidene)-2-thioxothi...)Show SMILES CC(C)(C)c1ccc(Oc2cccc(C=C3SC(S)=NC3=O)c2)cc1 |w:14.13,c:18| Show InChI InChI=1S/C20H19NO2S2/c1-20(2,3)14-7-9-15(10-8-14)23-16-6-4-5-13(11-16)12-17-18(22)21-19(24)25-17/h4-12H,1-3H3,(H,21,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202166
(5-(3,4-bis(benzyloxy)benzylidene)-2-thioxothiazoli...)Show SMILES SC1=NC(=O)C(S1)=Cc1ccc(OCc2ccccc2)c(OCc2ccccc2)c1 |w:7.8,t:1| Show InChI InChI=1S/C24H19NO3S2/c26-23-22(30-24(29)25-23)14-19-11-12-20(27-15-17-7-3-1-4-8-17)21(13-19)28-16-18-9-5-2-6-10-18/h1-14H,15-16H2,(H,25,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202180
((R)-2-(5-(3-(3,4-dichlorophenoxy)benzylidene)-4-ox...)Show SMILES CC(C)[C@@H](N1C(=S)S\C(=C\c2cccc(Oc3ccc(Cl)c(Cl)c3)c2)C1=O)C(O)=O Show InChI InChI=1S/C21H17Cl2NO4S2/c1-11(2)18(20(26)27)24-19(25)17(30-21(24)29)9-12-4-3-5-13(8-12)28-14-6-7-15(22)16(23)10-14/h3-11,18H,1-2H3,(H,26,27)/b17-9+/t18-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202163
((E)-5-(3-(3,5-dichlorophenoxy)benzylidene)-2-thiox...)Show SMILES SC1=NC(=O)C(S1)=Cc1cccc(Oc2cc(Cl)cc(Cl)c2)c1 |w:7.8,t:1| Show InChI InChI=1S/C16H9Cl2NO2S2/c17-10-6-11(18)8-13(7-10)21-12-3-1-2-9(4-12)5-14-15(20)19-16(22)23-14/h1-8H,(H,19,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202170
((E)-5-(3-(3,4-dichlorophenoxy)benzylidene)-2-thiox...)Show SMILES SC1=NC(=O)C(S1)=Cc1cccc(Oc2ccc(Cl)c(Cl)c2)c1 |w:7.8,t:1| Show InChI InChI=1S/C16H9Cl2NO2S2/c17-12-5-4-11(8-13(12)18)21-10-3-1-2-9(6-10)7-14-15(20)19-16(22)23-14/h1-8H,(H,19,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202158
(5-(4-(4-chlorobenzyloxy)-3-methoxybenzylidene)-2-t...)Show SMILES COc1cc(C=C2SC(=S)NC2=O)ccc1OCc1ccc(Cl)cc1 |w:5.4| Show InChI InChI=1S/C18H14ClNO3S2/c1-22-15-8-12(9-16-17(21)20-18(24)25-16)4-7-14(15)23-10-11-2-5-13(19)6-3-11/h2-9H,10H2,1H3,(H,20,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202175
(5-(3-(4-chlorophenoxy)benzylidene)-2-thioxothiazol...)Show SMILES SC1=NC(=O)C(S1)=Cc1cccc(Oc2ccc(Cl)cc2)c1 |w:7.8,t:1| Show InChI InChI=1S/C16H10ClNO2S2/c17-11-4-6-12(7-5-11)20-13-3-1-2-10(8-13)9-14-15(19)18-16(21)22-14/h1-9H,(H,18,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202177
(5-(3-(4-(trifluoromethyl)phenoxy)benzylidene)-2-th...)Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3SC(S)=NC3=O)c2)cc1 |w:14.13,c:18| Show InChI InChI=1S/C17H10F3NO2S2/c18-17(19,20)11-4-6-12(7-5-11)23-13-3-1-2-10(8-13)9-14-15(22)21-16(24)25-14/h1-9H,(H,21,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202151
(3-(5-(3,4-bis(benzyloxy)benzylidene)-4-oxo-2-thiox...)Show SMILES OC(=O)CCN1C(=S)S\C(=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C1=O Show InChI InChI=1S/C27H23NO5S2/c29-25(30)13-14-28-26(31)24(35-27(28)34)16-21-11-12-22(32-17-19-7-3-1-4-8-19)23(15-21)33-18-20-9-5-2-6-10-20/h1-12,15-16H,13-14,17-18H2,(H,29,30)/b24-16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202157
(2-(5-(3,4-bis(benzyloxy)benzylidene)-4-oxo-2-thiox...)Show SMILES OC(=O)CN1C(=S)S\C(=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C1=O Show InChI InChI=1S/C26H21NO5S2/c28-24(29)15-27-25(30)23(34-26(27)33)14-20-11-12-21(31-16-18-7-3-1-4-8-18)22(13-20)32-17-19-9-5-2-6-10-19/h1-14H,15-17H2,(H,28,29)/b23-14+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202168
(5-(3-(4-tert-butylphenoxy)benzylidene)thiazolidine...)Show SMILES CC(C)(C)c1ccc(Oc2cccc(C=C3SC(O)=NC3=O)c2)cc1 |w:14.13,c:18| Show InChI InChI=1S/C20H19NO3S/c1-20(2,3)14-7-9-15(10-8-14)24-16-6-4-5-13(11-16)12-17-18(22)21-19(23)25-17/h4-12H,1-3H3,(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202161
(5-(3-(3,5-dichlorophenoxy)benzylidene)thiazolidine...)Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Oc2cc(Cl)cc(Cl)c2)c1 |w:7.8,t:1| Show InChI InChI=1S/C16H9Cl2NO3S/c17-10-6-11(18)8-13(7-10)22-12-3-1-2-9(4-12)5-14-15(20)19-16(21)23-14/h1-8H,(H,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202162
(5-(3-(3,4-dichlorophenoxy)benzylidene)thiazolidine...)Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Oc2ccc(Cl)c(Cl)c2)c1 |w:7.8,t:1| Show InChI InChI=1S/C16H9Cl2NO3S/c17-12-5-4-11(8-13(12)18)22-10-3-1-2-9(6-10)7-14-15(20)19-16(21)23-14/h1-8H,(H,19,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202178
(2-(5-(3-(3,4-dichlorophenoxy)benzylidene)-4-oxo-2-...)Show SMILES OC(=O)CN1C(=S)S\C(=C\c2cccc(Oc3ccc(Cl)c(Cl)c3)c2)C1=O Show InChI InChI=1S/C18H11Cl2NO4S2/c19-13-5-4-12(8-14(13)20)25-11-3-1-2-10(6-11)7-15-17(24)21(9-16(22)23)18(26)27-15/h1-8H,9H2,(H,22,23)/b15-7+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202145
(5-(4-(4-methoxybenzyloxy)-3-methoxybenzylidene)-2-...)Show SMILES COc1ccc(COc2ccc(C=C3SC(=S)NC3=O)cc2OC)cc1 |w:12.11| Show InChI InChI=1S/C19H17NO4S2/c1-22-14-6-3-12(4-7-14)11-24-15-8-5-13(9-16(15)23-2)10-17-18(21)20-19(25)26-17/h3-10H,11H2,1-2H3,(H,20,21,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202165
(5-(3-(p-tolyloxy)benzylidene)-2-thioxothiazolidin-...)Show SMILES Cc1ccc(Oc2cccc(C=C3SC(S)=NC3=O)c2)cc1 |w:11.10,c:15| Show InChI InChI=1S/C17H13NO2S2/c1-11-5-7-13(8-6-11)20-14-4-2-3-12(9-14)10-15-16(19)18-17(21)22-15/h2-10H,1H3,(H,18,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202153
(5-(3-(4-methoxyphenoxy)benzylidene)-2-thioxothiazo...)Show SMILES COc1ccc(Oc2cccc(C=C3SC(S)=NC3=O)c2)cc1 |w:12.11,c:16| Show InChI InChI=1S/C17H13NO3S2/c1-20-12-5-7-13(8-6-12)21-14-4-2-3-11(9-14)10-15-16(19)18-17(22)23-15/h2-10H,1H3,(H,18,19,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202152
(5-(3-(benzyloxy)benzylidene)-2-thioxothiazolidin-4...)Show SMILES SC1=NC(=O)C(S1)=Cc1cccc(OCc2ccccc2)c1 |w:7.8,t:1| Show InChI InChI=1S/C17H13NO2S2/c19-16-15(22-17(21)18-16)10-13-7-4-8-14(9-13)20-11-12-5-2-1-3-6-12/h1-10H,11H2,(H,18,19,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202155
(5-(3-(4-chlorophenoxy)benzylidene)-1-methylimidazo...)Show SMILES CN1C(=O)NC(=O)\C1=C/c1cccc(Oc2ccc(Cl)cc2)c1 Show InChI InChI=1S/C17H13ClN2O3/c1-20-15(16(21)19-17(20)22)10-11-3-2-4-14(9-11)23-13-7-5-12(18)6-8-13/h2-10H,1H3,(H,19,21,22)/b15-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202147
(5-(3-phenoxybenzylidene)-2-thioxothiazolidin-4-one...)Show SMILES SC1=NC(=O)C(S1)=Cc1cccc(Oc2ccccc2)c1 |w:7.8,t:1| Show InChI InChI=1S/C16H11NO2S2/c18-15-14(21-16(20)17-15)10-11-5-4-8-13(9-11)19-12-6-2-1-3-7-12/h1-10H,(H,17,18,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202150
(5-(3-(4-chlorophenoxy)benzylidene)thiazolidine-2,4...)Show SMILES OC1=NC(=O)C(S1)=Cc1cccc(Oc2ccc(Cl)cc2)c1 |w:7.8,t:1| Show InChI InChI=1S/C16H10ClNO3S/c17-11-4-6-12(7-5-11)21-13-3-1-2-10(8-13)9-14-15(19)18-16(20)22-14/h1-9H,(H,18,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202146
(5-(4-(benzyloxy)-3-methoxybenzylidene)-2-thioxothi...)Show SMILES COc1cc(C=C2SC(S)=NC2=O)ccc1OCc1ccccc1 |w:5.4,c:9| Show InChI InChI=1S/C18H15NO3S2/c1-21-15-9-13(10-16-17(20)19-18(23)24-16)7-8-14(15)22-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3,(H,19,20,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >2.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202176
(5-(3,4-bis(benzyloxy)benzylidene)-3-ethyl-2-thioxo...)Show SMILES CCN1C(=S)S\C(=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C1=O Show InChI InChI=1S/C26H23NO3S2/c1-2-27-25(28)24(32-26(27)31)16-21-13-14-22(29-17-19-9-5-3-6-10-19)23(15-21)30-18-20-11-7-4-8-12-20/h3-16H,2,17-18H2,1H3/b24-16+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202156
(5-(3-(3,5-dichlorophenoxy)benzylidene)imidazolidin...)Show SMILES Clc1cc(Cl)cc(Oc2cccc(\C=C3\NC(=O)NC3=O)c2)c1 Show InChI InChI=1S/C16H10Cl2N2O3/c17-10-6-11(18)8-13(7-10)23-12-3-1-2-9(4-12)5-14-15(21)20-16(22)19-14/h1-8H,(H2,19,20,21,22)/b14-5+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202172
(5-(3,4-bis(benzyloxy)benzylidene)-3-benzyl-2-thiox...)Show SMILES O=C1N(Cc2ccccc2)C(=S)S\C1=C\c1ccc(OCc2ccccc2)c(OCc2ccccc2)c1 Show InChI InChI=1S/C31H25NO3S2/c33-30-29(37-31(36)32(30)20-23-10-4-1-5-11-23)19-26-16-17-27(34-21-24-12-6-2-7-13-24)28(18-26)35-22-25-14-8-3-9-15-25/h1-19H,20-22H2/b29-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202160
(5-(3-(4-chlorophenoxy)benzylidene)imidazolidine-2,...)Show InChI InChI=1S/C16H11ClN2O3/c17-11-4-6-12(7-5-11)22-13-3-1-2-10(8-13)9-14-15(20)19-16(21)18-14/h1-9H,(H2,18,19,20,21)/b14-9+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202171
(5-(3,4-bis(benzyloxy)benzylidene)-3-phenethyl-2-th...)Show SMILES O=C1N(CCc2ccccc2)C(=S)S\C1=C\c1ccc(OCc2ccccc2)c(OCc2ccccc2)c1 Show InChI InChI=1S/C32H27NO3S2/c34-31-30(38-32(37)33(31)19-18-24-10-4-1-5-11-24)21-27-16-17-28(35-22-25-12-6-2-7-13-25)29(20-27)36-23-26-14-8-3-9-15-26/h1-17,20-21H,18-19,22-23H2/b30-21+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202154
(5-(3,4-bis(benzyloxy)benzylidene)-3-methyl-2-thiox...)Show SMILES CN1C(=S)S\C(=C\c2ccc(OCc3ccccc3)c(OCc3ccccc3)c2)C1=O Show InChI InChI=1S/C25H21NO3S2/c1-26-24(27)23(31-25(26)30)15-20-12-13-21(28-16-18-8-4-2-5-9-18)22(14-20)29-17-19-10-6-3-7-11-19/h2-15H,16-17H2,1H3/b23-15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202148
(5-(3,4-bis(benzyloxy)benzylidene)-3-phenyl-2-thiox...)Show SMILES O=C1N(C(=S)S\C1=C\c1ccc(OCc2ccccc2)c(OCc2ccccc2)c1)c1ccccc1 Show InChI InChI=1S/C30H23NO3S2/c32-29-28(36-30(35)31(29)25-14-8-3-9-15-25)19-24-16-17-26(33-20-22-10-4-1-5-11-22)27(18-24)34-21-23-12-6-2-7-13-23/h1-19H,20-21H2/b28-19+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
A disintegrin and metalloproteinase with thrombospondin motifs 5
(Homo sapiens (Human)) | BDBM50202159
(5-(3-(4-tert-butylphenoxy)benzylidene)imidazolidin...)Show SMILES CC(C)(C)c1ccc(Oc2cccc(\C=C3\NC(=O)NC3=O)c2)cc1 Show InChI InChI=1S/C20H20N2O3/c1-20(2,3)14-7-9-15(10-8-14)25-16-6-4-5-13(11-16)12-17-18(23)22-19(24)21-17/h4-12H,1-3H3,(H2,21,22,23,24)/b17-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >6.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description
Inhibition of ADAMTS5 |
Bioorg Med Chem Lett 17: 1185-8 (2007)
Article DOI: 10.1016/j.bmcl.2006.12.027
BindingDB Entry DOI: 10.7270/Q2PN95BB |
More data for this
Ligand-Target Pair | |
Search and Browse
