Affinity Data by PubMed id=17324932

PubMed code 17324932

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human))	BDBM22590 ((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	60	-41.4	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Phosphoribosylglycinamide formyltransferase (Escherichia coli (strain K12))	BDBM22590 ((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	100	-40.1	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM22585 (1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...) Show SMILES O=C1NS(=O)(=O)Nc2nc[nH]c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	130	-38.9	n/a	n/a	n/a	n/a	n/a	7.4	22
The Scripps Research Institute					Assay Description The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM22588 (Nucleotide, 3 \| {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	150	-38.6	n/a	n/a	n/a	n/a	n/a	7.4	22
The Scripps Research Institute					Assay Description The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM22587 (7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	230	-37.5	n/a	n/a	n/a	n/a	n/a	7.4	22
The Scripps Research Institute					Assay Description The human ATIC enzyme was used for the inhibition assay using the spectrophotometric method monitoring the appearance of IMP by measuring absorbance ...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human))	BDBM22588 (Nucleotide, 3 \| {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	4.80E+3	-30.5	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Phosphoribosylglycinamide formyltransferase (Escherichia coli (strain K12))	BDBM22588 (Nucleotide, 3 \| {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+5	>-22.9	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Phosphoribosylglycinamide formyltransferase (Escherichia coli (strain K12))	BDBM22585 (1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...) Show SMILES O=C1NS(=O)(=O)Nc2nc[nH]c12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	>1.00E+5	>-22.9	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM22588 (Nucleotide, 3 \| {[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+5	>-22.6	n/a	n/a	n/a	n/a	n/a	7.5	22
The Scripps Research Institute					Assay Description Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human))	BDBM22585 (1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...) Show SMILES O=C1NS(=O)(=O)Nc2nc[nH]c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	>1.00E+5	>-22.9	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Phosphoribosylglycinamide formyltransferase (Escherichia coli (strain K12))	BDBM22587 (7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+5	>-22.9	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM22587 (7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+5	>-22.6	n/a	n/a	n/a	n/a	n/a	7.5	22
The Scripps Research Institute					Assay Description Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Trifunctional purine biosynthetic protein adenosine-3 (Homo sapiens (Human))	BDBM22587 (7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)ox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	>1.00E+5	>-22.9	n/a	n/a	n/a	n/a	n/a	7.5	26
The Scripps Research Institute					Assay Description Assays were initiated by the addition of GAR to the reaction mixture containing GAR Tfase, test compounds, and cofactor. The assay monitors the defor...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM22585 (1H,3H,4H,7H-2,1,3,5,7-imidazo[4,5-c][1,2,6]thiadia...) Show SMILES O=C1NS(=O)(=O)Nc2nc[nH]c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	>1.00E+5	>-22.6	n/a	n/a	n/a	n/a	n/a	7.5	22
The Scripps Research Institute					Assay Description Recombinant human AICAR Tfase was used in the inhibition assay. The reaction was monitored at 298 nm by measuring the increase in absorbance correspo...				J Biol Chem 282: 13033-46 (2007) Article DOI: 10.1074/jbc.M607293200 BindingDB Entry DOI: 10.7270/Q2GM85MB
The Scripps Research Institute					More data for this Ligand-Target Pair

* indicates data uncertainty>20%