Found 30 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Chymase
(Homo sapiens (Human)) | BDBM50210107
(7-chloro-3-(4-chlorophenylsulfonyl)quinazoline-2,4...)Show SMILES Clc1ccc(cc1)S(=O)(=O)n1c(=O)[nH]c2cc(Cl)ccc2c1=O Show InChI InChI=1S/C14H8Cl2N2O4S/c15-8-1-4-10(5-2-8)23(21,22)18-13(19)11-6-3-9(16)7-12(11)17-14(18)20/h1-7H,(H,17,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210098
(6-(4,5-dichloro-2-methoxybenzyl)-4-(4-chlorophenyl...)Show SMILES COc1cc(Cl)c(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H17Cl3N2O5S/c1-29-17-8-16(22)15(21)7-11(17)6-12-9-23-18(25)10-24(19(12)26)30(27,28)14-4-2-13(20)3-5-14/h2-5,7-8,12H,6,9-10H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210116
(6-(5-fluoro-2-methoxybenzyl)-4-(4-chlorophenylsulf...)Show SMILES COc1ccc(F)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18ClFN2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210120
((S)-6-(5-chloro-2-methoxybenzyl)-4-(4-chlorophenyl...)Show SMILES COc1ccc(Cl)cc1C[C@H]1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)/t13-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210094
(3-((1-(4-chlorophenylsulfonyl)-3,7-dioxo-1,4-diaze...)Show SMILES COc1ccc(cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1)C#N Show InChI InChI=1S/C20H18ClN3O5S/c1-29-18-7-2-13(10-22)8-14(18)9-15-11-23-19(25)12-24(20(15)26)30(27,28)17-5-3-16(21)4-6-17/h2-8,15H,9,11-12H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM100740
(CHEMBL391608 | US8507714, 29)Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 34 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210099
(CHEMBL246964 | rac-2q)Show SMILES OC(=O)COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H18Cl2N2O7S/c21-14-1-4-16(5-2-14)32(29,30)24-10-18(25)23-9-13(20(24)28)7-12-8-15(22)3-6-17(12)31-11-19(26)27/h1-6,8,13H,7,9-11H2,(H,23,25)(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210096
(2-(4-chloro-2-((1-(4-chlorophenylsulfonyl)-3,7-dio...)Show SMILES CNC(=O)COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H21Cl2N3O6S/c1-24-20(28)12-32-18-7-4-16(23)9-13(18)8-14-10-25-19(27)11-26(21(14)29)33(30,31)17-5-2-15(22)3-6-17/h2-7,9,14H,8,10-12H2,1H3,(H,24,28)(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM87059
(CHEMBL247767 | Chymostatin)Show SMILES CC(C)C[C@H](NC(=O)[C@@H](NC(=O)N[C@@H](Cc1ccccc1)C(O)=O)C1CCNC(N)=N1)C(=O)N[C@@H](Cc1ccccc1)C=O |c:30| Show InChI InChI=1S/C31H41N7O6/c1-19(2)15-24(27(40)34-22(18-39)16-20-9-5-3-6-10-20)35-28(41)26(23-13-14-33-30(32)36-23)38-31(44)37-25(29(42)43)17-21-11-7-4-8-12-21/h3-12,18-19,22-26H,13-17H2,1-2H3,(H,34,40)(H,35,41)(H,42,43)(H3,32,33,36)(H2,37,38,44)/t22-,23?,24-,25-,26-/m0/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210113
(6-(5-chloro-2-ethoxybenzyl)-4-(4-chlorophenylsulfo...)Show SMILES CCOc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H20Cl2N2O5S/c1-2-29-18-8-5-16(22)10-13(18)9-14-11-23-19(25)12-24(20(14)26)30(27,28)17-6-3-15(21)4-7-17/h3-8,10,14H,2,9,11-12H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210097
(6-(2-chlorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2ccccc2Cl)C1=O Show InChI InChI=1S/C18H16Cl2N2O4S/c19-14-5-7-15(8-6-14)27(25,26)22-11-17(23)21-10-13(18(22)24)9-12-3-1-2-4-16(12)20/h1-8,13H,9-11H2,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210115
(6-(2-methoxybenzyl)-4-(4-chlorophenylsulfonyl)-1,4...)Show SMILES COc1ccccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H19ClN2O5S/c1-27-17-5-3-2-4-13(17)10-14-11-21-18(23)12-22(19(14)24)28(25,26)16-8-6-15(20)7-9-16/h2-9,14H,10-12H2,1H3,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210121
(6-(2-fluorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)Show SMILES Fc1ccccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C18H16ClFN2O4S/c19-14-5-7-15(8-6-14)27(25,26)22-11-17(23)21-10-13(18(22)24)9-12-3-1-2-4-16(12)20/h1-8,13H,9-11H2,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210109
(6-(2-ethoxybenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)Show SMILES CCOc1ccccc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H21ClN2O5S/c1-2-28-18-6-4-3-5-14(18)11-15-12-22-19(24)13-23(20(15)25)29(26,27)17-9-7-16(21)8-10-17/h3-10,15H,2,11-13H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210110
(6-(5-chloro-2-propoxybenzyl)-4-(4-chlorophenylsulf...)Show SMILES CCCOc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H22Cl2N2O5S/c1-2-9-30-19-8-5-17(23)11-14(19)10-15-12-24-20(26)13-25(21(15)27)31(28,29)18-6-3-16(22)4-7-18/h3-8,11,15H,2,9-10,12-13H2,1H3,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210114
(6-(2-butoxy-5-chlorobenzyl)-4-(4-chlorophenylsulfo...)Show SMILES CCCCOc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C22H24Cl2N2O5S/c1-2-3-10-31-20-9-6-18(24)12-15(20)11-16-13-25-21(27)14-26(22(16)28)32(29,30)19-7-4-17(23)5-8-19/h4-9,12,16H,2-3,10-11,13-14H2,1H3,(H,25,27) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210118
(6-(3-chlorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2cccc(Cl)c2)C1=O Show InChI InChI=1S/C18H16Cl2N2O4S/c19-14-4-6-16(7-5-14)27(25,26)22-11-17(23)21-10-13(18(22)24)8-12-2-1-3-15(20)9-12/h1-7,9,13H,8,10-11H2,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210117
(6-benzyl-4-(4-chlorophenylsulfonyl)-1,4-diazepane-...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2ccccc2)C1=O Show InChI InChI=1S/C18H17ClN2O4S/c19-15-6-8-16(9-7-15)26(24,25)21-12-17(22)20-11-14(18(21)23)10-13-4-2-1-3-5-13/h1-9,14H,10-12H2,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210106
(6-(4-chlorobenzyl)-4-(4-chlorophenylsulfonyl)-1,4-...)Show SMILES Clc1ccc(CC2CNC(=O)CN(C2=O)S(=O)(=O)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C18H16Cl2N2O4S/c19-14-3-1-12(2-4-14)9-13-10-21-17(23)11-22(18(13)24)27(25,26)16-7-5-15(20)6-8-16/h1-8,13H,9-11H2,(H,21,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 460 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210108
(6-(5-hydroxy-2-methoxybenzyl)-4-(4-chlorophenylsul...)Show SMILES COc1ccc(O)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H19ClN2O6S/c1-28-17-7-4-15(23)9-12(17)8-13-10-21-18(24)11-22(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13,23H,8,10-11H2,1H3,(H,21,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210105
((E)-6-benzylidene-4-(4-chlorophenylsulfonyl)-1,4-d...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NC\C(=C/c2ccccc2)C1=O Show InChI InChI=1S/C18H15ClN2O4S/c19-15-6-8-16(9-7-15)26(24,25)21-12-17(22)20-11-14(18(21)23)10-13-4-2-1-3-5-13/h1-10H,11-12H2,(H,20,22)/b14-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Cathepsin G
(Homo sapiens (Human)) | BDBM100740
(CHEMBL391608 | US8507714, 29)Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human neutrophil cathepsin G |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210101
(6-(3-chloro-5-fluoro-2-methoxybenzyl)-4-(4-chlorop...)Show SMILES COc1c(Cl)cc(F)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H17Cl2FN2O5S/c1-29-18-11(7-14(22)8-16(18)21)6-12-9-23-17(25)10-24(19(12)26)30(27,28)15-4-2-13(20)3-5-15/h2-5,7-8,12H,6,9-10H2,1H3,(H,23,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210103
(6-(2,5-dimethoxybenzyl)-4-(4-chlorophenylsulfonyl)...)Show SMILES COc1ccc(OC)c(CC2CNC(=O)CN(C2=O)S(=O)(=O)c2ccc(Cl)cc2)c1 Show InChI InChI=1S/C20H21ClN2O6S/c1-28-16-5-8-18(29-2)13(10-16)9-14-11-22-19(24)12-23(20(14)25)30(26,27)17-6-3-15(21)4-7-17/h3-8,10,14H,9,11-12H2,1-2H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210095
(4-(4-chlorophenylsulfonyl)-6-(pyridin-4-ylmethyl)-...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2ccncc2)C1=O Show InChI InChI=1S/C17H16ClN3O4S/c18-14-1-3-15(4-2-14)26(24,25)21-11-16(22)20-10-13(17(21)23)9-12-5-7-19-8-6-12/h1-8,13H,9-11H2,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Neutrophil elastase
(Homo sapiens (Human)) | BDBM100740
(CHEMBL391608 | US8507714, 29)Show SMILES COc1ccc(Cl)cc1CC1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human neutrophil elastase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210119
(4-(4-chlorophenylsulfonyl)-6-(pyridin-3-ylmethyl)-...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2cccnc2)C1=O Show InChI InChI=1S/C17H16ClN3O4S/c18-14-3-5-15(6-4-14)26(24,25)21-11-16(22)20-10-13(17(21)23)8-12-2-1-7-19-9-12/h1-7,9,13H,8,10-11H2,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210104
((R)-6-(5-chloro-2-methoxybenzyl)-4-(4-chlorophenyl...)Show SMILES COc1ccc(Cl)cc1C[C@@H]1CNC(=O)CN(C1=O)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C19H18Cl2N2O5S/c1-28-17-7-4-15(21)9-12(17)8-13-10-22-18(24)11-23(19(13)25)29(26,27)16-5-2-14(20)3-6-16/h2-7,9,13H,8,10-11H2,1H3,(H,22,24)/t13-/m1/s1 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210102
(4-(4-chlorophenylsulfonyl)-6-(naphthalen-2-ylmethy...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(Cc2ccc3ccccc3c2)C1=O Show InChI InChI=1S/C22H19ClN2O4S/c23-19-7-9-20(10-8-19)30(28,29)25-14-21(26)24-13-18(22(25)27)12-15-5-6-16-3-1-2-4-17(16)11-15/h1-11,18H,12-14H2,(H,24,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
Chymase
(Homo sapiens (Human)) | BDBM50210111
(4-(4-chlorophenylsulfonyl)-6-(cyclohexylmethyl)-1,...)Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CC(=O)NCC(CC2CCCCC2)C1=O Show InChI InChI=1S/C18H23ClN2O4S/c19-15-6-8-16(9-7-15)26(24,25)21-12-17(22)20-11-14(18(21)23)10-13-4-2-1-3-5-13/h6-9,13-14H,1-5,10-12H2,(H,20,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Pharma Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant chymase |
Bioorg Med Chem Lett 17: 3431-4 (2007)
Article DOI: 10.1016/j.bmcl.2007.03.038
BindingDB Entry DOI: 10.7270/Q2G160H9 |
More data for this
Ligand-Target Pair | |
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