Affinity Data by PubMed id=18189347

PubMed code 18189347

Found 12 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21337 (6-Azido-uridine 5-O-Monophosphate \| C6-Uridine Der...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	190	-42.2	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21338 (6-Amino-uridine 5-O-Monophosphate \| C6-Uridine Der...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	840	-38.2	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM21340 (6-aza-UMP \| C6-Uridine Derivative, 18 \| {[(2R,3S,4...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	1.10E+3	-35.4	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM21337 (6-Azido-uridine 5-O-Monophosphate \| C6-Uridine Der...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	2.00E+3	-33.8	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM21338 (6-Amino-uridine 5-O-Monophosphate \| C6-Uridine Der...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	2.10E+3	-33.7	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21340 (6-aza-UMP \| C6-Uridine Derivative, 18 \| {[(2R,3S,4...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	1.24E+4	-30.8	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine-5'-phosphate decarboxylase (Plasmodium vivax (malaria parasite P. vivax))	BDBM21339 (6-Methyl-uridine 5-O-Monophosphate \| C6-Uridine De...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	2.24E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM21335 (6-cyanouridine 5-monophosphate \| C6-Uridine Deriva...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	2.60E+4	-27.2	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21335 (6-cyanouridine 5-monophosphate \| C6-Uridine Deriva...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	2.90E+4	-28.5	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine-5'-phosphate decarboxylase (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM21339 (6-Methyl-uridine 5-O-Monophosphate \| C6-Uridine De...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	3.41E+4	-26.5	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (docked)
Orotidine-5'-phosphate decarboxylase (Plasmodium vivax (malaria parasite P. vivax))	BDBM21335 (6-cyanouridine 5-monophosphate \| C6-Uridine Deriva...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	6.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21339 (6-Methyl-uridine 5-O-Monophosphate \| C6-Uridine De...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	1.34E+5	-24.3	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 51: 439-48 (2008) Article DOI: 10.1021/jm7010673 BindingDB Entry DOI: 10.7270/Q27H1GWS
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%