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PubMed code 18249537

Compile data set for download or QSAR
Found 56 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24876
PNG
(2-{5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H30N8S/c1-42-33-35-20-26-19-27(23-7-3-2-4-8-23)29(36-30(26)38-33)24-12-10-22(11-13-24)21-41-17-14-25(15-18-41)31-37-32(40-39-31)28-9-5-6-16-34-28/h2-13,16,19-20,25H,14-15,17-18,21H2,1H3,(H,37,39,40)
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n/an/a 3.80n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24883
PNG
(1-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)n2ncc3c(N)ncnc23)cc1
Show InChI InChI=1S/C31H29N9S/c1-41-31-33-16-23-15-25(21-5-3-2-4-6-21)27(37-29(23)38-31)22-9-7-20(8-10-22)18-39-13-11-24(12-14-39)40-30-26(17-36-40)28(32)34-19-35-30/h2-10,15-17,19,24H,11-14,18H2,1H3,(H2,32,34,35)
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n/an/a 4n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24875
PNG
(4-{3-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2cc(n[nH]2)-c2ccncc2)cc1
Show InChI InChI=1S/C34H31N7S/c1-42-34-36-21-28-19-29(24-5-3-2-4-6-24)32(37-33(28)38-34)27-9-7-23(8-10-27)22-41-17-13-26(14-18-41)31-20-30(39-40-31)25-11-15-35-16-12-25/h2-12,15-16,19-21,26H,13-14,17-18,22H2,1H3,(H,39,40)
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n/an/a 4.5n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24880
PNG
(CHEMBL252857 | N-methyl-6-phenyl-7-[4-({4-[5-(pyri...)
Show SMILES CNc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H31N9/c1-34-33-36-20-26-19-27(23-7-3-2-4-8-23)29(37-30(26)39-33)24-12-10-22(11-13-24)21-42-17-14-25(15-18-42)31-38-32(41-40-31)28-9-5-6-16-35-28/h2-13,16,19-20,25H,14-15,17-18,21H2,1H3,(H,38,40,41)(H,34,36,37,39)
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n/an/a 6n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24879
PNG
(6-phenyl-7-[4-({4-[5-(pyridin-2-yl)-4H-1,2,4-triaz...)
Show SMILES NC(=O)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H29N9O/c34-29(43)33-36-19-25-18-26(22-6-2-1-3-7-22)28(37-30(25)38-33)23-11-9-21(10-12-23)20-42-16-13-24(14-17-42)31-39-32(41-40-31)27-8-4-5-15-35-27/h1-12,15,18-19,24H,13-14,16-17,20H2,(H2,34,43)(H,39,40,41)
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n/an/a 6.20n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24872
PNG
(5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc(N)s2)cc1
Show InChI InChI=1S/C28H27N7S2/c1-36-28-30-16-22-15-23(19-5-3-2-4-6-19)24(31-25(22)32-28)20-9-7-18(8-10-20)17-35-13-11-21(12-14-35)26-33-34-27(29)37-26/h2-10,15-16,21H,11-14,17H2,1H3,(H2,29,34)
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n/an/a 8.5n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24873
PNG
(1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyr...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)C(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C32H30N6OS/c1-40-32-34-20-26-19-28(23-5-3-2-4-6-23)29(36-30(26)37-32)24-9-7-22(8-10-24)21-38-17-13-25(14-18-38)31(39)35-27-11-15-33-16-12-27/h2-12,15-16,19-20,25H,13-14,17-18,21H2,1H3,(H,33,35,39)
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n/an/a 9.70n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24882
PNG
(7-{4-[(4-{4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2nc3ncnc(N)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C30H28N10/c31-27-24-14-23(20-4-2-1-3-5-20)26(38-29(24)35-17-33-27)21-8-6-19(7-9-21)16-39-12-10-22(11-13-39)40-30-25(15-37-40)28(32)34-18-36-30/h1-9,14-15,17-18,22H,10-13,16H2,(H2,32,34,36)(H2,31,33,35,38)
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n/an/a 14n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24867
PNG
(1-(2-aminophenyl)-3-[({4-[2-(methylsulfanyl)-6-phe...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCC(=O)c2ccccc2N)cc1
Show InChI InChI=1S/C30H27N5OS/c1-37-30-33-19-23-17-25(21-7-3-2-4-8-21)28(34-29(23)35-30)22-13-11-20(12-14-22)18-32-16-15-27(36)24-9-5-6-10-26(24)31/h2-14,17,19,32H,15-16,18,31H2,1H3
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n/an/a 15n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24881
PNG
(7-(4-{[4-(6-fluoro-1H-1,3-benzodiazol-2-yl)piperid...)
Show SMILES Nc1ncnc2nc(-c3ccc(CN4CCC(CC4)c4nc5ccc(F)cc5[nH]4)cc3)c(cc12)-c1ccccc1
Show InChI InChI=1S/C32H28FN7/c33-24-10-11-27-28(16-24)38-31(37-27)23-12-14-40(15-13-23)18-20-6-8-22(9-7-20)29-25(21-4-2-1-3-5-21)17-26-30(34)35-19-36-32(26)39-29/h1-11,16-17,19,23H,12-15,18H2,(H,37,38)(H2,34,35,36,39)
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n/an/a 18n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24877
PNG
(2-(5-{1-[(4-{2-methoxy-6-phenylpyrido[2,3-d]pyrimi...)
Show SMILES COc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H30N8O/c1-42-33-35-20-26-19-27(23-7-3-2-4-8-23)29(36-30(26)38-33)24-12-10-22(11-13-24)21-41-17-14-25(15-18-41)31-37-32(40-39-31)28-9-5-6-16-34-28/h2-13,16,19-20,25H,14-15,17-18,21H2,1H3,(H,37,39,40)
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n/an/a 23.6n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24878
PNG
(6-phenyl-7-[4-({4-[5-(pyridin-2-yl)-4H-1,2,4-triaz...)
Show SMILES N#Cc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H27N9/c34-19-29-36-20-26-18-27(23-6-2-1-3-7-23)30(38-31(26)37-29)24-11-9-22(10-12-24)21-42-16-13-25(14-17-42)32-39-33(41-40-32)28-8-4-5-15-35-28/h1-12,15,18,20,25H,13-14,16-17,21H2,(H,39,40,41)
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n/an/a 24n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24876
PNG
(2-{5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H30N8S/c1-42-33-35-20-26-19-27(23-7-3-2-4-8-23)29(36-30(26)38-33)24-12-10-22(11-13-24)21-41-17-14-25(15-18-41)31-37-32(40-39-31)28-9-5-6-16-34-28/h2-13,16,19-20,25H,14-15,17-18,21H2,1H3,(H,37,39,40)
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n/an/a 26n/an/an/an/an/an/a



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Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24868
PNG
(1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyr...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)C(N)=O)cc1
Show InChI InChI=1S/C27H27N5OS/c1-34-27-29-16-22-15-23(19-5-3-2-4-6-19)24(30-26(22)31-27)20-9-7-18(8-10-20)17-32-13-11-21(12-14-32)25(28)33/h2-10,15-16,21H,11-14,17H2,1H3,(H2,28,33)
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n/an/a 29n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24879
PNG
(6-phenyl-7-[4-({4-[5-(pyridin-2-yl)-4H-1,2,4-triaz...)
Show SMILES NC(=O)c1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H29N9O/c34-29(43)33-36-19-25-18-26(22-6-2-1-3-7-22)28(37-30(25)38-33)23-11-9-21(10-12-23)20-42-16-13-24(14-17-42)31-39-32(41-40-31)27-8-4-5-15-35-27/h1-12,15,18-19,24H,13-14,16-17,20H2,(H2,34,43)(H,39,40,41)
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n/an/a 35n/an/an/an/an/an/a



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Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24883
PNG
(1-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)n2ncc3c(N)ncnc23)cc1
Show InChI InChI=1S/C31H29N9S/c1-41-31-33-16-23-15-25(21-5-3-2-4-6-21)27(37-29(23)38-31)22-9-7-20(8-10-22)18-39-13-11-24(12-14-39)40-30-26(17-36-40)28(32)34-19-35-30/h2-10,15-17,19,24H,11-14,18H2,1H3,(H2,32,34,35)
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n/an/a 44n/an/an/an/an/an/a



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Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24866
PNG
(5-{2-[({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc(N)s2)cc1
Show InChI InChI=1S/C25H23N7S2/c1-33-25-28-15-19-13-20(17-5-3-2-4-6-17)22(29-23(19)30-25)18-9-7-16(8-10-18)14-27-12-11-21-31-32-24(26)34-21/h2-10,13,15,27H,11-12,14H2,1H3,(H2,26,32)
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n/an/a 46n/an/an/an/a7.522



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Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24875
PNG
(4-{3-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2cc(n[nH]2)-c2ccncc2)cc1
Show InChI InChI=1S/C34H31N7S/c1-42-34-36-21-28-19-29(24-5-3-2-4-6-24)32(37-33(28)38-34)27-9-7-23(8-10-27)22-41-17-13-26(14-18-41)31-20-30(39-40-31)25-11-15-35-16-12-25/h2-12,15-16,19-21,26H,13-14,17-18,22H2,1H3,(H,39,40)
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n/an/a 57n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24878
PNG
(6-phenyl-7-[4-({4-[5-(pyridin-2-yl)-4H-1,2,4-triaz...)
Show SMILES N#Cc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H27N9/c34-19-29-36-20-26-18-27(23-6-2-1-3-7-23)30(38-31(26)37-29)24-11-9-22(10-12-24)21-42-16-13-25(14-17-42)32-39-33(41-40-32)28-8-4-5-15-35-28/h1-12,15,18,20,25H,13-14,16-17,21H2,(H,39,40,41)
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n/an/a 59n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24865
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc([nH]2)-c2ccccc2)cc1
Show InChI InChI=1S/C31H27N7S/c1-39-31-33-20-25-18-26(22-8-4-2-5-9-22)28(35-29(25)36-31)23-14-12-21(13-15-23)19-32-17-16-27-34-30(38-37-27)24-10-6-3-7-11-24/h2-15,18,20,32H,16-17,19H2,1H3,(H,34,37,38)
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n/an/a 63n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24874
PNG
(5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nc(no2)-c2cccnc2)cc1
Show InChI InChI=1S/C33H29N7OS/c1-42-33-35-20-27-18-28(23-6-3-2-4-7-23)29(36-30(27)38-33)24-11-9-22(10-12-24)21-40-16-13-25(14-17-40)32-37-31(39-41-32)26-8-5-15-34-19-26/h2-12,15,18-20,25H,13-14,16-17,21H2,1H3
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n/an/a 64n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24869
PNG
(3-ethyl-1-[1-({4-[2-(methylsulfanyl)-6-phenylpyrid...)
Show SMILES CCNC(=O)NC1CCN(Cc2ccc(cc2)-c2nc3nc(SC)ncc3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-3-30-28(36)32-24-13-15-35(16-14-24)19-20-9-11-22(12-10-20)26-25(21-7-5-4-6-8-21)17-23-18-31-29(37-2)34-27(23)33-26/h4-12,17-18,24H,3,13-16,19H2,1-2H3,(H2,30,32,36)
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n/an/a 81n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24861
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2cccnc2)cc1
Show InChI InChI=1S/C28H25N5S/c1-34-28-31-19-24-16-25(22-7-3-2-4-8-22)26(32-27(24)33-28)23-11-9-21(10-12-23)18-30-15-13-20-6-5-14-29-17-20/h2-12,14,16-17,19,30H,13,15,18H2,1H3
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n/an/a 90n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24867
PNG
(1-(2-aminophenyl)-3-[({4-[2-(methylsulfanyl)-6-phe...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCC(=O)c2ccccc2N)cc1
Show InChI InChI=1S/C30H27N5OS/c1-37-30-33-19-23-17-25(21-7-3-2-4-8-21)28(34-29(23)35-30)22-13-11-20(12-14-22)18-32-16-15-27(36)24-9-5-6-10-26(24)31/h2-14,17,19,32H,15-16,18,31H2,1H3
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n/an/a 90n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24870
PNG
(3-{[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)C(=O)NCCC(N)=O)cc1
Show InChI InChI=1S/C30H32N6O2S/c1-39-30-33-18-24-17-25(21-5-3-2-4-6-21)27(34-28(24)35-30)22-9-7-20(8-10-22)19-36-15-12-23(13-16-36)29(38)32-14-11-26(31)37/h2-10,17-18,23H,11-16,19H2,1H3,(H2,31,37)(H,32,38)
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n/an/a 91n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24880
PNG
(CHEMBL252857 | N-methyl-6-phenyl-7-[4-({4-[5-(pyri...)
Show SMILES CNc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H31N9/c1-34-33-36-20-26-19-27(23-7-3-2-4-8-23)29(37-30(26)39-33)24-12-10-22(11-13-24)21-42-17-14-25(15-18-42)31-38-32(41-40-31)28-9-5-6-16-35-28/h2-13,16,19-20,25H,14-15,17-18,21H2,1H3,(H,38,40,41)(H,34,36,37,39)
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n/an/a 94.4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24882
PNG
(7-{4-[(4-{4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl...)
Show SMILES Nc1ncnc2n(ncc12)C1CCN(Cc2ccc(cc2)-c2nc3ncnc(N)c3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C30H28N10/c31-27-24-14-23(20-4-2-1-3-5-20)26(38-29(24)35-17-33-27)21-8-6-19(7-9-21)16-39-12-10-22(11-13-39)40-30-25(15-37-40)28(32)34-18-36-30/h1-9,14-15,17-18,22H,10-13,16H2,(H2,32,34,36)(H2,31,33,35,38)
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n/an/a 99n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24858
PNG
(Pyridopyrimidine, 12c | [2-(1H-imidazol-4-yl)ethyl...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C26H24N6S/c1-33-26-29-15-21-13-23(19-5-3-2-4-6-19)24(31-25(21)32-26)20-9-7-18(8-10-20)14-27-12-11-22-16-28-17-30-22/h2-10,13,15-17,27H,11-12,14H2,1H3,(H,28,30)
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n/an/a 99n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24877
PNG
(2-(5-{1-[(4-{2-methoxy-6-phenylpyrido[2,3-d]pyrimi...)
Show SMILES COc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc([nH]2)-c2ccccn2)cc1
Show InChI InChI=1S/C33H30N8O/c1-42-33-35-20-26-19-27(23-7-3-2-4-8-23)29(36-30(26)38-33)24-12-10-22(11-13-24)21-41-17-14-25(15-18-41)31-37-32(40-39-31)28-9-5-6-16-34-28/h2-13,16,19-20,25H,14-15,17-18,21H2,1H3,(H,37,39,40)
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n/an/a 107n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24862
PNG
(Pyridopyrimidine, 12g | [3-(1H-imidazol-1-yl)propy...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCCn2ccnc2)cc1
Show InChI InChI=1S/C27H26N6S/c1-34-27-30-18-23-16-24(21-6-3-2-4-7-21)25(31-26(23)32-27)22-10-8-20(9-11-22)17-28-12-5-14-33-15-13-29-19-33/h2-4,6-11,13,15-16,18-19,28H,5,12,14,17H2,1H3
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n/an/a 137n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24859
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc[nH]2)cc1
Show InChI InChI=1S/C25H23N7S/c1-33-25-27-15-20-13-21(18-5-3-2-4-6-18)23(30-24(20)31-25)19-9-7-17(8-10-19)14-26-12-11-22-28-16-29-32-22/h2-10,13,15-16,26H,11-12,14H2,1H3,(H,28,29,32)
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n/an/a 139n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24864
PNG
(Pyridopyrimidine, 12i | [2-(5-methyl-1H-1,2,4-tria...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc(C)[nH]2)cc1
Show InChI InChI=1S/C26H25N7S/c1-17-29-23(33-32-17)12-13-27-15-18-8-10-20(11-9-18)24-22(19-6-4-3-5-7-19)14-21-16-28-26(34-2)31-25(21)30-24/h3-11,14,16,27H,12-13,15H2,1-2H3,(H,29,32,33)
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n/an/a 162n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24860
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nccs2)cc1
Show InChI InChI=1S/C26H23N5S2/c1-32-26-29-17-21-15-22(19-5-3-2-4-6-19)24(30-25(21)31-26)20-9-7-18(8-10-20)16-27-12-11-23-28-13-14-33-23/h2-10,13-15,17,27H,11-12,16H2,1H3
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n/an/a 198n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24856
PNG
(3-[({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]py...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCC(N)=O)cc1
Show InChI InChI=1S/C24H23N5OS/c1-31-24-27-15-19-13-20(17-5-3-2-4-6-17)22(28-23(19)29-24)18-9-7-16(8-10-18)14-26-12-11-21(25)30/h2-10,13,15,26H,11-12,14H2,1H3,(H2,25,30)
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n/an/a 226n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24881
PNG
(7-(4-{[4-(6-fluoro-1H-1,3-benzodiazol-2-yl)piperid...)
Show SMILES Nc1ncnc2nc(-c3ccc(CN4CCC(CC4)c4nc5ccc(F)cc5[nH]4)cc3)c(cc12)-c1ccccc1
Show InChI InChI=1S/C32H28FN7/c33-24-10-11-27-28(16-24)38-31(37-27)23-12-14-40(15-13-23)18-20-6-8-22(9-7-20)29-25(21-4-2-1-3-5-21)17-26-30(34)35-19-36-32(26)39-29/h1-11,16-17,19,23H,12-15,18H2,(H,37,38)(H2,34,35,36,39)
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n/an/a 239n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24872
PNG
(5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nnc(N)s2)cc1
Show InChI InChI=1S/C28H27N7S2/c1-36-28-30-16-22-15-23(19-5-3-2-4-6-19)24(31-25(22)32-28)20-9-7-18(8-10-20)17-35-13-11-21(12-14-35)26-33-34-27(29)37-26/h2-10,15-16,21H,11-14,17H2,1H3,(H2,29,34)
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n/an/a 267n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24871
PNG
(2-acetamido-N-[1-({4-[2-(methylsulfanyl)-6-phenylp...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)NC(=O)CNC(C)=O)cc1
Show InChI InChI=1S/C30H32N6O2S/c1-20(37)31-18-27(38)33-25-12-14-36(15-13-25)19-21-8-10-23(11-9-21)28-26(22-6-4-3-5-7-22)16-24-17-32-30(39-2)35-29(24)34-28/h3-11,16-17,25H,12-15,18-19H2,1-2H3,(H,31,37)(H,33,38)
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n/an/a 286n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24873
PNG
(1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyr...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)C(=O)Nc2ccncc2)cc1
Show InChI InChI=1S/C32H30N6OS/c1-40-32-34-20-26-19-28(23-5-3-2-4-6-23)29(36-30(26)37-32)24-9-7-22(8-10-24)21-38-17-13-25(14-18-38)31(39)35-27-11-15-33-16-12-27/h2-12,15-16,19-20,25H,13-14,17-18,21H2,1H3,(H,33,35,39)
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n/an/a 301n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24865
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc([nH]2)-c2ccccc2)cc1
Show InChI InChI=1S/C31H27N7S/c1-39-31-33-20-25-18-26(22-8-4-2-5-9-22)28(35-29(25)36-31)23-14-12-21(13-15-23)19-32-17-16-27-34-30(38-37-27)24-10-6-3-7-11-24/h2-15,18,20,32H,16-17,19H2,1H3,(H,34,37,38)
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n/an/a 494n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24866
PNG
(5-{2-[({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc(N)s2)cc1
Show InChI InChI=1S/C25H23N7S2/c1-33-25-28-15-19-13-20(17-5-3-2-4-6-17)22(29-23(19)30-25)18-9-7-16(8-10-18)14-27-12-11-21-31-32-24(26)34-21/h2-10,13,15,27H,11-12,14H2,1H3,(H2,26,32)
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n/an/a 529n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24857
PNG
(Pyridopyrimidine, 12b | [3-(4-methylpiperazin-1-yl...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCCN2CCN(C)CC2)cc1
Show InChI InChI=1S/C29H34N6S/c1-34-15-17-35(18-16-34)14-6-13-30-20-22-9-11-24(12-10-22)27-26(23-7-4-3-5-8-23)19-25-21-31-29(36-2)33-28(25)32-27/h3-5,7-12,19,21,30H,6,13-18,20H2,1-2H3
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n/an/a 765n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24868
PNG
(1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyr...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)C(N)=O)cc1
Show InChI InChI=1S/C27H27N5OS/c1-34-27-29-16-22-15-23(19-5-3-2-4-6-19)24(30-26(22)31-27)20-9-7-18(8-10-20)17-32-13-11-21(12-14-32)25(28)33/h2-10,15-16,21H,11-14,17H2,1H3,(H2,28,33)
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n/an/a 928n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24861
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2cccnc2)cc1
Show InChI InChI=1S/C28H25N5S/c1-34-28-31-19-24-16-25(22-7-3-2-4-8-22)26(32-27(24)33-28)23-11-9-21(10-12-23)18-30-15-13-20-6-5-14-29-17-20/h2-12,14,16-17,19,30H,13,15,18H2,1H3
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n/an/a 1.16E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24858
PNG
(Pyridopyrimidine, 12c | [2-(1H-imidazol-4-yl)ethyl...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C26H24N6S/c1-33-26-29-15-21-13-23(19-5-3-2-4-6-19)24(31-25(21)32-26)20-9-7-18(8-10-20)14-27-12-11-22-16-28-17-30-22/h2-10,13,15-17,27H,11-12,14H2,1H3,(H,28,30)
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n/an/a 1.24E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24856
PNG
(3-[({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]py...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCC(N)=O)cc1
Show InChI InChI=1S/C24H23N5OS/c1-31-24-27-15-19-13-20(17-5-3-2-4-6-17)22(28-23(19)29-24)18-9-7-16(8-10-18)14-26-12-11-21(25)30/h2-10,13,15,26H,11-12,14H2,1H3,(H2,25,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24874
PNG
(5-[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)c2nc(no2)-c2cccnc2)cc1
Show InChI InChI=1S/C33H29N7OS/c1-42-33-35-20-27-18-28(23-6-3-2-4-7-23)29(36-30(27)38-33)24-11-9-22(10-12-24)21-40-16-13-25(14-17-40)32-37-31(39-41-32)26-8-5-15-34-19-26/h2-12,15,18-20,25H,13-14,16-17,21H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24860
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nccs2)cc1
Show InChI InChI=1S/C26H23N5S2/c1-32-26-29-17-21-15-22(19-5-3-2-4-6-19)24(30-25(21)31-26)20-9-7-18(8-10-20)16-27-12-11-23-28-13-14-33-23/h2-10,13-15,17,27H,11-12,16H2,1H3
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n/an/a 1.38E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24862
PNG
(Pyridopyrimidine, 12g | [3-(1H-imidazol-1-yl)propy...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCCn2ccnc2)cc1
Show InChI InChI=1S/C27H26N6S/c1-34-27-30-18-23-16-24(21-6-3-2-4-7-21)25(31-26(23)32-27)22-10-8-20(9-11-22)17-28-12-5-14-33-15-13-29-19-33/h2-4,6-11,13,15-16,18-19,28H,5,12,14,17H2,1H3
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n/an/a 1.51E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24863
PNG
(Pyridopyrimidine, 12h | methyl({4-[2-(methylsulfan...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN(C)CCc2cn[nH]c2)cc1
Show InChI InChI=1S/C27H26N6S/c1-33(13-12-20-15-29-30-16-20)18-19-8-10-22(11-9-19)25-24(21-6-4-3-5-7-21)14-23-17-28-27(34-2)32-26(23)31-25/h3-11,14-17H,12-13,18H2,1-2H3,(H,29,30)
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n/an/a 1.52E+3n/an/an/an/a7.522



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24859
PNG
(({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d]pyrim...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc[nH]2)cc1
Show InChI InChI=1S/C25H23N7S/c1-33-25-27-15-20-13-21(18-5-3-2-4-6-18)23(30-24(20)31-25)19-9-7-17(8-10-19)14-26-12-11-22-28-16-29-32-22/h2-10,13,15-16,26H,11-12,14H2,1H3,(H,28,29,32)
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n/an/a 1.71E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24864
PNG
(Pyridopyrimidine, 12i | [2-(5-methyl-1H-1,2,4-tria...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCc2nnc(C)[nH]2)cc1
Show InChI InChI=1S/C26H25N7S/c1-17-29-23(33-32-17)12-13-27-15-18-8-10-20(11-9-18)24-22(19-6-4-3-5-7-19)14-21-16-28-26(34-2)31-25(21)30-24/h3-11,14,16,27H,12-13,15H2,1-2H3,(H,29,32,33)
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n/an/a 1.79E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24869
PNG
(3-ethyl-1-[1-({4-[2-(methylsulfanyl)-6-phenylpyrid...)
Show SMILES CCNC(=O)NC1CCN(Cc2ccc(cc2)-c2nc3nc(SC)ncc3cc2-c2ccccc2)CC1
Show InChI InChI=1S/C29H32N6OS/c1-3-30-28(36)32-24-13-15-35(16-14-24)19-20-9-11-22(12-10-20)26-25(21-7-5-4-6-8-21)17-23-18-31-29(37-2)34-27(23)33-26/h4-12,17-18,24H,3,13-16,19H2,1-2H3,(H2,30,32,36)
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n/an/a 1.91E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24870
PNG
(3-{[1-({4-[2-(methylsulfanyl)-6-phenylpyrido[2,3-d...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)C(=O)NCCC(N)=O)cc1
Show InChI InChI=1S/C30H32N6O2S/c1-39-30-33-18-24-17-25(21-5-3-2-4-6-21)27(34-28(24)35-30)22-9-7-20(8-10-22)19-36-15-12-23(13-16-36)29(38)32-14-11-26(31)37/h2-10,17-18,23H,11-16,19H2,1H3,(H2,31,37)(H,32,38)
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n/an/a 2.11E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24871
PNG
(2-acetamido-N-[1-({4-[2-(methylsulfanyl)-6-phenylp...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CCC(CC2)NC(=O)CNC(C)=O)cc1
Show InChI InChI=1S/C30H32N6O2S/c1-20(37)31-18-27(38)33-25-12-14-36(15-13-25)19-21-8-10-23(11-9-21)28-26(22-6-4-3-5-7-22)16-24-17-32-30(39-2)35-29(24)34-28/h3-11,16-17,25H,12-15,18-19H2,1-2H3,(H,31,37)(H,33,38)
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n/an/a 5.13E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24857
PNG
(Pyridopyrimidine, 12b | [3-(4-methylpiperazin-1-yl...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CNCCCN2CCN(C)CC2)cc1
Show InChI InChI=1S/C29H34N6S/c1-34-15-17-35(18-16-34)14-6-13-30-20-22-9-11-24(12-10-22)27-26(23-7-4-3-5-8-23)19-25-21-31-29(36-2)33-28(25)32-27/h3-5,7-12,19,21,30H,6,13-18,20H2,1-2H3
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Article
PubMed
n/an/a 8.92E+3n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
RAC-beta serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM24863
PNG
(Pyridopyrimidine, 12h | methyl({4-[2-(methylsulfan...)
Show SMILES CSc1ncc2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN(C)CCc2cn[nH]c2)cc1
Show InChI InChI=1S/C27H26N6S/c1-33(13-12-20-15-29-30-16-20)18-19-8-10-22(11-9-19)25-24(21-6-4-3-5-7-21)14-23-17-28-27(34-2)32-26(23)31-25/h3-11,14-17H,12-13,18H2,1-2H3,(H,29,30)
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antibodypedia
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UniChem

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Article
PubMed
n/an/a 1.75E+4n/an/an/an/an/an/a



Merck Research Laboratories



Assay Description
Purified recombinant human Akt kinase was monitored for kinase activity in the presence or absence of inhibitors in a 96-well format. Detection was d...

Bioorg Med Chem Lett 18: 1274-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.054
BindingDB Entry DOI: 10.7270/Q2G73C02
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%