Found 34 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376759
(CHEMBL261497)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(c1)S(=O)(=O)CCO Show InChI InChI=1S/C28H39N7O6S/c1-28(2,29)27(38)31-24(20-41-19-22-8-4-3-5-9-22)26-32-33-34-35(26)15-7-12-25(37)30-14-13-21-10-6-11-23(18-21)42(39,40)17-16-36/h3-6,8-11,18,24,36H,7,12-17,19-20,29H2,1-2H3,(H,30,37)(H,31,38)/t24-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 105 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376783
(CHEMBL259166)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO Show InChI InChI=1S/C22H35N7O4S/c1-22(2,23)21(32)25-18(16-33-15-17-7-4-3-5-8-17)20-26-27-28-29(20)11-6-9-19(31)24-10-13-34-14-12-30/h3-5,7-8,18,30H,6,9-16,23H2,1-2H3,(H,24,31)(H,25,32)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376785
(CHEMBL261358)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO Show InChI InChI=1S/C23H37N7O4/c1-23(2,24)22(33)26-19(17-34-16-18-10-5-3-6-11-18)21-27-28-29-30(21)14-9-12-20(32)25-13-7-4-8-15-31/h3,5-6,10-11,19,31H,4,7-9,12-17,24H2,1-2H3,(H,25,32)(H,26,33)/t19-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376771
(CHEMBL409327)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1 Show InChI InChI=1S/C26H35N7O3/c1-26(2,27)25(35)29-22(19-36-18-21-12-7-4-8-13-21)24-30-31-32-33(24)17-9-14-23(34)28-16-15-20-10-5-3-6-11-20/h3-8,10-13,22H,9,14-19,27H2,1-2H3,(H,28,34)(H,29,35)/t22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50222146
((S)-4-(5-(1-(2-amino-2-methylpropanamido)-2-(benzy...)Show SMILES CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C22H35N7O3/c1-4-5-13-24-19(30)12-9-14-29-20(26-27-28-29)18(25-21(31)22(2,3)23)16-32-15-17-10-7-6-8-11-17/h6-8,10-11,18H,4-5,9,12-16,23H2,1-3H3,(H,24,30)(H,25,31)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376776
(CHEMBL258550)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO Show InChI InChI=1S/C25H33N7O5/c1-25(2,26)24(35)28-20(17-36-16-18-8-4-3-5-9-18)22-29-30-31-32(22)13-15-37-21-11-7-6-10-19(21)23(34)27-12-14-33/h3-11,20,33H,12-17,26H2,1-2H3,(H,27,34)(H,28,35)/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 11 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376778
(CHEMBL259712)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO Show InChI InChI=1S/C21H33N7O4/c1-21(2,22)20(31)24-17(15-32-14-16-8-4-3-5-9-16)19-25-26-27-28(19)12-11-23-18(30)10-6-7-13-29/h3-5,8-9,17,29H,6-7,10-15,22H2,1-2H3,(H,23,30)(H,24,31)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376760
(CHEMBL410074)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO Show InChI InChI=1S/C22H35N7O6S/c1-22(2,23)21(32)25-18(16-35-15-17-7-4-3-5-8-17)20-26-27-28-29(20)11-6-9-19(31)24-10-13-36(33,34)14-12-30/h3-5,7-8,18,30H,6,9-16,23H2,1-2H3,(H,24,31)(H,25,32)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376762
(CHEMBL411699)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO Show InChI InChI=1S/C20H31N7O4/c1-20(2,21)19(30)23-16(14-31-13-15-7-4-3-5-8-15)18-24-25-26-27(18)11-6-9-17(29)22-10-12-28/h3-5,7-8,16,28H,6,9-14,21H2,1-2H3,(H,22,29)(H,23,30)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376772
(CHEMBL415095)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1 Show InChI InChI=1S/C25H33N7O3/c1-25(2,26)24(34)28-21(18-35-17-20-12-7-4-8-13-20)23-29-30-31-32(23)15-9-14-22(33)27-16-19-10-5-3-6-11-19/h3-8,10-13,21H,9,14-18,26H2,1-2H3,(H,27,33)(H,28,34)/t21-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 32 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376764
(CHEMBL258762)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1 Show InChI InChI=1S/C27H37N7O3/c1-27(2,28)26(36)30-23(20-37-19-22-13-7-4-8-14-22)25-31-32-33-34(25)18-10-16-24(35)29-17-9-15-21-11-5-3-6-12-21/h3-8,11-14,23H,9-10,15-20,28H2,1-2H3,(H,29,35)(H,30,36)/t23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 33 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376769
(CHEMBL258761)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O Show InChI InChI=1S/C20H32N8O5S/c1-20(2,21)19(30)24-16(14-33-13-15-7-4-3-5-8-15)18-25-26-27-28(18)11-6-9-17(29)23-10-12-34(22,31)32/h3-5,7-8,16H,6,9-14,21H2,1-2H3,(H,23,29)(H,24,30)(H2,22,31,32)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376757
(CHEMBL409462)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(c1)C(=O)NCCCCO Show InChI InChI=1S/C27H37N7O5/c1-27(2,28)26(37)30-23(19-38-18-20-9-4-3-5-10-20)24-31-32-33-34(24)14-16-39-22-12-8-11-21(17-22)25(36)29-13-6-7-15-35/h3-5,8-12,17,23,35H,6-7,13-16,18-19,28H2,1-2H3,(H,29,36)(H,30,37)/t23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376770
(CHEMBL258551)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O Show InChI InChI=1S/C21H33N7O5S/c1-21(2,22)20(30)24-17(15-33-14-16-8-5-4-6-9-16)19-25-26-27-28(19)12-7-10-18(29)23-11-13-34(3,31)32/h4-6,8-9,17H,7,10-15,22H2,1-3H3,(H,23,29)(H,24,30)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376779
(CHEMBL410730)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1 |wU:7.6,28.29,wD:31.33,(-.43,-26.63,;.34,-25.3,;1.11,-23.97,;-1,-24.52,;1.68,-26.06,;3.01,-25.29,;1.68,-27.6,;.35,-28.38,;-.99,-27.61,;-2.32,-28.39,;-3.65,-27.62,;-4.98,-28.4,;-6.32,-27.63,;-7.65,-28.4,;-7.65,-29.95,;-6.32,-30.72,;-4.98,-29.95,;.36,-29.92,;-.88,-30.83,;-.4,-32.29,;1.14,-32.28,;1.61,-30.82,;3.08,-30.33,;4.23,-31.36,;5.69,-30.87,;6.84,-31.9,;6.53,-33.41,;8.3,-31.41,;8.61,-29.91,;7.45,-28.89,;7.77,-27.38,;9.24,-26.9,;9.56,-25.39,;10.38,-27.93,;10.07,-29.43,)| Show InChI InChI=1S/C24H37N7O4/c1-24(2,25)23(34)27-20(16-35-15-17-7-4-3-5-8-17)22-28-29-30-31(22)14-6-9-21(33)26-18-10-12-19(32)13-11-18/h3-5,7-8,18-20,32H,6,9-16,25H2,1-2H3,(H,26,33)(H,27,34)/t18-,19-,20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 521 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376781
(CHEMBL410085)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1 Show InChI InChI=1S/C26H35N7O4/c1-26(2,27)25(36)29-22(18-37-17-20-8-4-3-5-9-20)24-30-31-32-33(24)15-7-12-23(35)28-14-13-19-10-6-11-21(34)16-19/h3-6,8-11,16,22,34H,7,12-15,17-18,27H2,1-2H3,(H,28,35)(H,29,36)/t22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.200 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376784
(CHEMBL411697)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO Show InChI InChI=1S/C22H35N7O5/c1-22(2,23)21(32)25-18(16-34-15-17-7-4-3-5-8-17)20-26-27-28-29(20)11-6-9-19(31)24-10-13-33-14-12-30/h3-5,7-8,18,30H,6,9-16,23H2,1-2H3,(H,24,31)(H,25,32)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376787
(CHEMBL409894)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO Show InChI InChI=1S/C21H33N7O4/c1-21(2,22)20(31)24-17(15-32-14-16-8-4-3-5-9-16)19-25-26-27-28(19)12-6-10-18(30)23-11-7-13-29/h3-5,8-9,17,29H,6-7,10-15,22H2,1-2H3,(H,23,30)(H,24,31)/t17-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376758
(CHEMBL411122)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O Show InChI InChI=1S/C20H31N7O5S/c1-20(2,21)19(29)23-16(14-32-13-15-7-5-4-6-8-15)18-24-25-26-27(18)11-10-22-17(28)9-12-33(3,30)31/h4-8,16H,9-14,21H2,1-3H3,(H,22,28)(H,23,29)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 14.7 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376765
(CHEMBL410499)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F Show InChI InChI=1S/C20H28F3N7O3/c1-19(2,24)18(32)26-15(12-33-11-14-7-4-3-5-8-14)17-27-28-29-30(17)10-6-9-16(31)25-13-20(21,22)23/h3-5,7-8,15H,6,9-13,24H2,1-2H3,(H,25,31)(H,26,32)/t15-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376767
(CHEMBL409258)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(O)=O Show InChI InChI=1S/C21H31N7O5/c1-21(2,22)20(32)24-16(14-33-13-15-7-4-3-5-8-15)19-25-26-27-28(19)12-6-9-17(29)23-11-10-18(30)31/h3-5,7-8,16H,6,9-14,22H2,1-2H3,(H,23,29)(H,24,32)(H,30,31)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 204 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376768
(CHEMBL262884)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O Show InChI InChI=1S/C21H32N8O4/c1-21(2,23)20(32)25-16(14-33-13-15-7-4-3-5-8-15)19-26-27-28-29(19)12-6-9-18(31)24-11-10-17(22)30/h3-5,7-8,16H,6,9-14,23H2,1-2H3,(H2,22,30)(H,24,31)(H,25,32)/t16-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376773
(CHEMBL261234)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1 Show InChI InChI=1S/C24H31N7O3/c1-24(2,25)23(33)27-20(17-34-16-18-10-5-3-6-11-18)22-28-29-30-31(22)15-9-14-21(32)26-19-12-7-4-8-13-19/h3-8,10-13,20H,9,14-17,25H2,1-2H3,(H,26,32)(H,27,33)/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50366689
(GHRELIN)Show SMILES CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(O)=O |r,wU:65.67,185.189,192.197,230.236,120.122,11.11,69.70,129.131,19.19,164.166,37.36,173.175,201.205,48.48,218.222,111.113,56.56,wD:106.109,196.201,31.30,140.142,78.79,149.151,158.160,88.90,97.99,210.214,(-10.37,-25.43,;-9.06,-26.25,;-7.69,-25.54,;-6.4,-26.34,;-5.04,-25.62,;-3.72,-26.44,;-2.37,-25.72,;-2.31,-24.18,;-3.63,-23.36,;-.95,-23.47,;-.89,-21.92,;.45,-21.2,;1.74,-22.05,;1.71,-23.59,;.35,-24.3,;3.02,-24.41,;2.96,-25.94,;4.26,-26.76,;5.62,-26.03,;4.21,-28.3,;5.52,-29.12,;2.86,-29.01,;1.55,-28.21,;.19,-28.92,;-1.13,-28.13,;-2.49,-28.84,;-2.56,-30.38,;-3.82,-28.04,;.51,-19.67,;1.87,-18.94,;-.8,-18.87,;-.72,-17.33,;.63,-16.62,;.68,-15.08,;-2.02,-16.52,;-3.39,-17.24,;-1.98,-14.98,;-3.28,-14.16,;-4.66,-14.88,;-5.95,-14.06,;-7.3,-14.78,;-8.59,-13.97,;-8.55,-12.43,;-7.19,-11.7,;-5.88,-12.51,;-3.24,-12.62,;-4.54,-11.8,;-1.88,-11.9,;-1.81,-10.36,;-3.12,-9.54,;-3.06,-8,;-4.37,-7.19,;-1.71,-7.28,;-.46,-9.64,;.85,-10.45,;-.4,-8.1,;.96,-7.38,;1.01,-5.83,;-.31,-5.04,;2.26,-8.19,;1.95,-9.69,;3.72,-7.72,;4.22,-6.25,;5.76,-6.25,;6.23,-7.71,;4.98,-8.61,;4.98,-10.16,;3.64,-10.92,;6.3,-10.95,;7.63,-10.18,;7.63,-8.64,;8.96,-7.87,;8.96,-6.33,;10.28,-5.58,;7.63,-5.56,;8.96,-10.94,;10.3,-10.18,;8.94,-12.48,;7.6,-13.24,;6.26,-12.47,;4.93,-13.24,;3.52,-12.6,;2.48,-13.74,;3.25,-15.07,;4.76,-14.77,;7.6,-14.78,;8.93,-15.55,;6.27,-15.55,;6.27,-17.09,;4.93,-17.86,;4.93,-19.4,;3.6,-20.17,;2.27,-19.41,;3.6,-21.71,;7.6,-17.86,;7.6,-19.4,;8.93,-17.09,;10.27,-17.85,;10.27,-19.39,;11.62,-20.16,;11.62,-21.7,;12.94,-22.47,;12.93,-24.02,;11.62,-17.08,;12.94,-17.85,;11.61,-15.54,;12.94,-14.77,;14.28,-15.54,;12.94,-13.23,;11.61,-12.47,;14.27,-12.46,;14.28,-10.92,;12.95,-10.16,;12.95,-8.61,;11.61,-7.85,;10.24,-8.64,;11.61,-6.3,;15.6,-10.16,;16.95,-10.92,;15.56,-8.62,;16.9,-7.85,;16.9,-6.31,;15.56,-5.54,;15.56,-4,;16.85,-3.26,;14.22,-3.23,;18.23,-8.62,;18.23,-10.16,;19.57,-7.86,;20.92,-8.59,;22.25,-7.82,;22.25,-6.28,;23.59,-5.51,;24.89,-6.32,;26.21,-5.53,;27.53,-6.34,;26.19,-4.02,;20.92,-10.13,;19.58,-10.9,;22.23,-10.94,;22.26,-12.48,;20.93,-13.26,;20.93,-14.79,;19.59,-15.57,;18.26,-14.79,;18.23,-13.29,;23.59,-13.26,;23.59,-14.79,;24.93,-12.49,;26.28,-13.23,;26.28,-14.77,;27.62,-15.54,;27.62,-17.08,;26.27,-17.86,;28.95,-17.85,;27.62,-12.46,;27.62,-10.93,;28.94,-13.24,;30.27,-12.46,;31.6,-13.23,;32.93,-12.48,;30.27,-10.92,;28.94,-10.16,;31.61,-10.16,;31.62,-8.62,;30.29,-7.85,;30.29,-6.31,;28.95,-5.54,;28.95,-4,;27.61,-3.24,;32.95,-7.85,;34.28,-8.62,;32.94,-6.31,;34.27,-5.54,;34.27,-4,;32.94,-3.23,;32.94,-1.69,;31.61,-.92,;31.59,.62,;35.61,-6.31,;35.61,-7.85,;36.94,-5.54,;37.1,-4.04,;38.62,-3.7,;39.39,-5.03,;38.39,-6.18,;38.7,-7.66,;37.62,-8.74,;40.19,-8.15,;41.43,-7.23,;42.69,-8.12,;42.22,-9.6,;40.68,-9.6,;39.89,-10.92,;38.34,-10.89,;40.63,-12.27,;39.83,-13.59,;38.29,-13.57,;40.58,-14.95,;42.12,-14.97,;39.78,-16.26,;40.53,-17.61,;42.07,-17.63,;42.87,-16.31,;44.4,-16.34,;45.15,-17.69,;46.68,-17.73,;39.73,-18.92,;40.48,-20.27,;38.19,-18.9,;37.4,-20.22,;35.86,-20.19,;35.07,-21.51,;33.53,-21.48,;35.82,-22.85,;38.15,-21.56,;39.69,-21.6,;37.36,-22.88,;38.1,-24.23,;39.65,-24.27,;40.39,-25.61,;41.93,-25.64,;42.66,-26.99,;42.72,-24.32,;37.3,-25.55,;35.77,-25.52,;38.03,-26.89,;39.64,-27.11,;39.85,-28.64,;38.55,-29.35,;37.45,-28.32,;35.9,-28.61,;35.48,-30.09,;34.83,-27.5,)| Show InChI InChI=1S/C147H245N45O42/c1-8-9-10-11-15-45-118(205)234-78-106(169-115(200)74-165-121(208)86(153)34-26-63-163-146(158)159)138(225)187-104(76-194)137(224)184-101(71-84-32-13-12-14-33-84)134(221)183-100(70-81(4)5)133(220)188-105(77-195)143(230)189-65-28-42-108(189)140(227)179-96(51-57-117(203)204)130(217)185-102(72-85-73-162-79-166-85)135(222)178-94(48-54-113(156)198)129(216)172-87(35-16-21-58-148)122(209)167-82(6)119(206)171-92(46-52-111(154)196)127(214)176-93(47-53-112(155)197)128(215)174-91(40-27-64-164-147(160)161)124(211)173-89(37-18-23-60-150)123(210)177-95(50-56-116(201)202)131(218)186-103(75-193)136(223)175-90(38-19-24-61-151)125(212)180-97(39-20-25-62-152)141(228)191-67-30-43-109(191)144(231)190-66-29-41-107(190)139(226)168-83(7)120(207)170-88(36-17-22-59-149)126(213)182-99(69-80(2)3)132(219)181-98(49-55-114(157)199)142(229)192-68-31-44-110(192)145(232)233/h12-14,32-33,73,79-83,86-110,193-195H,8-11,15-31,34-72,74-78,148-153H2,1-7H3,(H2,154,196)(H2,155,197)(H2,156,198)(H2,157,199)(H,162,166)(H,165,208)(H,167,209)(H,168,226)(H,169,200)(H,170,207)(H,171,206)(H,172,216)(H,173,211)(H,174,215)(H,175,223)(H,176,214)(H,177,210)(H,178,222)(H,179,227)(H,180,212)(H,181,219)(H,182,213)(H,183,221)(H,184,224)(H,185,217)(H,186,218)(H,187,225)(H,188,220)(H,201,202)(H,203,204)(H,232,233)(H4,158,159,163)(H4,160,161,164)/t82-,83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376786
(CHEMBL261544)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO Show InChI InChI=1S/C22H35N7O4/c1-22(2,23)21(32)25-18(16-33-15-17-9-4-3-5-10-17)20-26-27-28-29(20)13-8-11-19(31)24-12-6-7-14-30/h3-5,9-10,18,30H,6-8,11-16,23H2,1-2H3,(H,24,31)(H,25,32)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376761
(CHEMBL411259)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO Show InChI InChI=1S/C24H39N7O4/c1-24(2,25)23(34)27-20(18-35-17-19-11-6-5-7-12-19)22-28-29-30-31(22)15-10-13-21(33)26-14-8-3-4-9-16-32/h5-7,11-12,20,32H,3-4,8-10,13-18,25H2,1-2H3,(H,26,33)(H,27,34)/t20-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376763
(CHEMBL263141)Show SMILES CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C23H35N7O5/c1-4-35-20(32)12-13-25-19(31)11-8-14-30-21(27-28-29-30)18(26-22(33)23(2,3)24)16-34-15-17-9-6-5-7-10-17/h5-7,9-10,18H,4,8,11-16,24H2,1-3H3,(H,25,31)(H,26,33)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM21941
(2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benz...)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO |r| Show InChI InChI=1S/C21H33N7O5/c1-21(2,22)19(30)24-17(15-32-14-16-8-4-3-5-9-16)18-25-26-27-28(18)11-13-33-20(31)23-10-6-7-12-29/h3-5,8-9,17,29H,6-7,10-15,22H2,1-2H3,(H,23,31)(H,24,30)/t17-/m1/s1 | PDB
Reactome pathway
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PC sid
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| Article
PubMed
| n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376774
(CHEMBL411330)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(c1)C(=O)NCCO Show InChI InChI=1S/C25H33N7O5/c1-25(2,26)24(35)28-21(17-36-16-18-7-4-3-5-8-18)22-29-30-31-32(22)12-14-37-20-10-6-9-19(15-20)23(34)27-11-13-33/h3-10,15,21,33H,11-14,16-17,26H2,1-2H3,(H,27,34)(H,28,35)/t21-/m1/s1 | PDB
Reactome pathway
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UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 8.40 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376777
(CHEMBL410135)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1 Show InChI InChI=1S/C25H33N7O4/c1-25(2,26)24(35)28-21(17-36-16-19-7-4-3-5-8-19)23-29-30-31-32(23)14-13-27-22(34)12-11-18-9-6-10-20(33)15-18/h3-10,15,21,33H,11-14,16-17,26H2,1-2H3,(H,27,34)(H,28,35)/t21-/m1/s1 | PDB
Reactome pathway
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PC sid
UniChem
Similars
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PubMed
| n/a | n/a | n/a | n/a | 0.640 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376780
(CHEMBL260849)Show SMILES CN(CCc1cccc(c1)S(=O)(=O)CCO)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C29H41N7O6S/c1-29(2,30)28(39)31-25(21-42-20-23-9-5-4-6-10-23)27-32-33-34-36(27)15-8-13-26(38)35(3)16-14-22-11-7-12-24(19-22)43(40,41)18-17-37/h4-7,9-12,19,25,37H,8,13-18,20-21,30H2,1-3H3,(H,31,39)/t25-/m1/s1 | PDB
Reactome pathway
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UniProtKB/SwissProt
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PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376766
(CHEMBL259016)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O Show InChI InChI=1S/C23H35N9O4/c1-23(2,24)21(34)27-18(16-36-15-17-7-4-3-5-8-17)20-28-29-30-32(20)12-6-9-19(33)25-10-13-31-14-11-26-22(31)35/h3-5,7-8,18H,6,9-16,24H2,1-2H3,(H,25,33)(H,26,35)(H,27,34)/t18-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376775
(CHEMBL262358)Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO Show InChI InChI=1S/C27H37N7O5/c1-27(2,28)26(37)30-22(19-38-18-20-10-4-3-5-11-20)24-31-32-33-34(24)15-17-39-23-13-7-6-12-21(23)25(36)29-14-8-9-16-35/h3-7,10-13,22,35H,8-9,14-19,28H2,1-2H3,(H,29,36)(H,30,37)/t22-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
Growth hormone secretagogue receptor type 1
(Homo sapiens (Human)) | BDBM50376782
(CHEMBL263389)Show SMILES CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N Show InChI InChI=1S/C27H37N7O4/c1-27(2,28)26(37)29-23(19-38-18-21-9-5-4-6-10-21)25-30-31-32-34(25)15-8-13-24(36)33(3)16-14-20-11-7-12-22(35)17-20/h4-7,9-12,17,23,35H,8,13-16,18-19,28H2,1-3H3,(H,29,37)/t23-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
| Assay Description
Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assay |
Bioorg Med Chem Lett 18: 2536-9 (2008)
Article DOI: 10.1016/j.bmcl.2008.03.059
BindingDB Entry DOI: 10.7270/Q2T43V0X |
More data for this
Ligand-Target Pair | |
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