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PubMed code 18778936

Compile data set for download or QSAR
Found 37 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264025
PNG
(2-hydroxy-7-phenyl-6,11-dihydro-5H-benzo[a]carbazo...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cccc(-c5ccccc5)c34)-c2cc1O
Show InChI InChI=1S/C23H17NO3/c25-20-12-17-14(11-18(20)23(26)27)9-10-16-21-15(13-5-2-1-3-6-13)7-4-8-19(21)24-22(16)17/h1-8,11-12,24-25H,9-10H2,(H,26,27)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264023
PNG
(8-cyano-2-hydroxy-6,11-dihydro-5H-benzo[a]carbazol...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4ccc(cc34)C#N)-c2cc1O
Show InChI InChI=1S/C18H12N2O3/c19-8-9-1-4-15-13(5-9)11-3-2-10-6-14(18(22)23)16(21)7-12(10)17(11)20-15/h1,4-7,20-21H,2-3H2,(H,22,23)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263505
PNG
(9-(4-butylphenyl)-10-fluoro-6,11-dihydro-5H-benzo[...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(ccc4-c3[nH]c2c1F)C(O)=O
Show InChI InChI=1S/C27H24FNO2/c1-2-3-4-16-5-7-17(8-6-16)20-13-14-23-22-12-9-18-15-19(27(30)31)10-11-21(18)25(22)29-26(23)24(20)28/h5-8,10-11,13-15,29H,2-4,9,12H2,1H3,(H,30,31)
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n/an/an/an/a 55n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263507
PNG
(9-(4-butylphenyl)-6,11-dihydro-5H-benzo[a]carbazol...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(ccc4-c3[nH]c2c1)C(N)=O
Show InChI InChI=1S/C27H26N2O/c1-2-3-4-17-5-7-18(8-6-17)19-9-13-23-24-14-10-20-15-21(27(28)30)11-12-22(20)26(24)29-25(23)16-19/h5-9,11-13,15-16,29H,2-4,10,14H2,1H3,(H2,28,30)
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n/an/an/an/a 76n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263909
PNG
(2-methoxy-11H-benzo[a]carbazole-3-carboxylic acid ...)
Show SMILES COc1cc2c3[nH]c4ccccc4c3ccc2cc1C(O)=O
Show InChI InChI=1S/C18H13NO3/c1-22-16-9-13-10(8-14(16)18(20)21)6-7-12-11-4-2-3-5-15(11)19-17(12)13/h2-9,19H,1H3,(H,20,21)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263957
PNG
(2-(2-hydroxy-9-methyl-11H-benzo[a]carbazol-3-yl)ac...)
Show SMILES Cc1ccc2c(c1)[nH]c1c2ccc2cc(CC(O)=O)c(O)cc12
Show InChI InChI=1S/C19H15NO3/c1-10-2-4-13-14-5-3-11-7-12(8-18(22)23)17(21)9-15(11)19(14)20-16(13)6-10/h2-7,9,20-21H,8H2,1H3,(H,22,23)
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n/an/an/an/a 9.20E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263959
PNG
(2-hydroxy-9-(trifluoromethyl)-6,11-dihydro-5H-benz...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C18H12F3NO3/c19-18(20,21)9-2-4-10-11-3-1-8-5-13(17(24)25)15(23)7-12(8)16(11)22-14(10)6-9/h2,4-7,22-23H,1,3H2,(H,24,25)
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n/an/an/an/a 473n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264022
PNG
(2-hydroxy-10-(trifluoromethyl)-6,11-dihydro-5H-ben...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4c(cccc34)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C18H12F3NO3/c19-18(20,21)13-3-1-2-9-10-5-4-8-6-12(17(24)25)14(23)7-11(8)15(10)22-16(9)13/h1-3,6-7,22-23H,4-5H2,(H,24,25)
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n/an/an/an/a 7.83E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264024
PNG
(2-hydroxy-6,11-dihydro-5H-benzo[a]carbazole-3,9-di...)
Show SMILES OC(=O)c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C18H13NO5/c20-15-7-12-8(5-13(15)18(23)24)1-4-11-10-3-2-9(17(21)22)6-14(10)19-16(11)12/h2-3,5-7,19-20H,1,4H2,(H,21,22)(H,23,24)
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n/an/an/an/a 7.79E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264026
PNG
(2-hydroxy-8-phenyl-6,11-dihydro-5H-benzo[a]carbazo...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4ccc(cc34)-c3ccccc3)-c2cc1O
Show InChI InChI=1S/C23H17NO3/c25-21-12-17-15(11-19(21)23(26)27)6-8-16-18-10-14(13-4-2-1-3-5-13)7-9-20(18)24-22(16)17/h1-5,7,9-12,24-25H,6,8H2,(H,26,27)
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n/an/an/an/a 569n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263332
PNG
(9-(3,4-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-b...)
Show SMILES Cc1ccc(cc1C)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO3/c1-13-3-4-15(9-14(13)2)16-5-7-18-19-8-6-17-10-21(25(28)29)23(27)12-20(17)24(19)26-22(18)11-16/h3-5,7,9-12,26-27H,6,8H2,1-2H3,(H,28,29)
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n/an/an/an/a 65n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263906
PNG
(2-hydroxy-11H-benzo[a]carbazole-3-carboxylic acid ...)
Show SMILES OC(=O)c1cc2ccc3c4ccccc4[nH]c3c2cc1O
Show InChI InChI=1S/C17H11NO3/c19-15-8-12-9(7-13(15)17(20)21)5-6-11-10-3-1-2-4-14(10)18-16(11)12/h1-8,18-19H,(H,20,21)
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n/an/an/an/a 3.40E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263908
PNG
(2-hydroxy-11-methyl-11H-benzo[a]carbazole-3-carbox...)
Show SMILES Cn1c2ccccc2c2ccc3cc(C(O)=O)c(O)cc3c12
Show InChI InChI=1S/C18H13NO3/c1-19-15-5-3-2-4-11(15)12-7-6-10-8-14(18(21)22)16(20)9-13(10)17(12)19/h2-9,20H,1H3,(H,21,22)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263910
PNG
(CHEMBL490412 | methyl 2-hydroxy-11H-benzo[a]carbaz...)
Show SMILES COC(=O)c1cc2ccc3c4ccccc4[nH]c3c2cc1O
Show InChI InChI=1S/C18H13NO3/c1-22-18(21)14-8-10-6-7-12-11-4-2-3-5-15(11)19-17(12)13(10)9-16(14)20/h2-9,19-20H,1H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264077
PNG
(2-hydroxy-9-phenyl-6,11-dihydro-5H-benzo[a]carbazo...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)-c3ccccc3)-c2cc1O
Show InChI InChI=1S/C23H17NO3/c25-21-12-18-15(10-19(21)23(26)27)7-9-17-16-8-6-14(11-20(16)24-22(17)18)13-4-2-1-3-5-13/h1-6,8,10-12,24-25H,7,9H2,(H,26,27)
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n/an/an/an/a 373n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263335
PNG
(2-hydroxy-9-(3-(trifluoromethyl)phenyl)-6,11-dihyd...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)-c3cccc(c3)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C24H16F3NO3/c25-24(26,27)15-3-1-2-12(8-15)13-4-6-16-17-7-5-14-9-19(23(30)31)21(29)11-18(14)22(17)28-20(16)10-13/h1-4,6,8-11,28-29H,5,7H2,(H,30,31)
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n/an/an/an/a 148n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263506
PNG
(9-(4-butylphenyl)-3-(1H-tetrazol-5-yl)-6,11-dihydr...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(ccc4-c3[nH]c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C27H25N5/c1-2-3-4-17-5-7-18(8-6-17)19-9-13-23-24-14-10-20-15-21(27-29-31-32-30-27)11-12-22(20)26(24)28-25(23)16-19/h5-9,11-13,15-16,28H,2-4,10,14H2,1H3,(H,29,30,31,32)
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n/an/an/an/a 119n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263546
PNG
(3-(4,5-dihydro-1H-imidazol-2-yl)-10-fluoro-9-(4-fl...)
Show SMILES Cc1cc(ccc1F)-c1ccc2c3CCc4cc(ccc4-c3[nH]c2c1F)C1=NCCN1 |t:31|
Show InChI InChI=1S/C26H21F2N3/c1-14-12-15(4-9-22(14)27)18-7-8-21-20-6-2-16-13-17(26-29-10-11-30-26)3-5-19(16)24(20)31-25(21)23(18)28/h3-5,7-9,12-13,31H,2,6,10-11H2,1H3,(H,29,30)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264081
PNG
(9-(2,6-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-b...)
Show SMILES Cc1cccc(C)c1-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO3/c1-13-4-3-5-14(2)23(13)16-7-8-17-18-9-6-15-10-20(25(28)29)22(27)12-19(15)24(18)26-21(17)11-16/h3-5,7-8,10-12,26-27H,6,9H2,1-2H3,(H,28,29)
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n/an/an/an/a 232n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263362
PNG
(9-(4-(dimethylamino)phenyl)-2-hydroxy-6,11-dihydro...)
Show SMILES CN(C)c1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H22N2O3/c1-27(2)17-7-3-14(4-8-17)15-5-9-18-19-10-6-16-11-21(25(29)30)23(28)13-20(16)24(19)26-22(18)12-15/h3-5,7-9,11-13,26,28H,6,10H2,1-2H3,(H,29,30)
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n/an/an/an/a 284n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263454
PNG
(9-(4-butylphenyl)-2-hydroxy-6,11-dihydro-5H-benzo[...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C27H25NO3/c1-2-3-4-16-5-7-17(8-6-16)18-9-11-20-21-12-10-19-13-23(27(30)31)25(29)15-22(19)26(21)28-24(20)14-18/h5-9,11,13-15,28-29H,2-4,10,12H2,1H3,(H,30,31)
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n/an/an/an/a 26n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263456
PNG
(2-hydroxy-9-(4-(methoxymethyl)phenyl)-6,11-dihydro...)
Show SMILES COCc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO4/c1-30-13-14-2-4-15(5-3-14)16-6-8-18-19-9-7-17-10-21(25(28)29)23(27)12-20(17)24(19)26-22(18)11-16/h2-6,8,10-12,26-27H,7,9,13H2,1H3,(H,28,29)
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n/an/an/an/a 452n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263958
PNG
(2-hydroxy-9-(trifluoromethyl)-11H-benzo[a]carbazol...)
Show SMILES OC(=O)c1cc2ccc3c4ccc(cc4[nH]c3c2cc1O)C(F)(F)F
Show InChI InChI=1S/C18H10F3NO3/c19-18(20,21)9-2-4-10-11-3-1-8-5-13(17(24)25)15(23)7-12(8)16(11)22-14(10)6-9/h1-7,22-23H,(H,24,25)
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n/an/an/an/a 143n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263960
PNG
(10-fluoro-2-hydroxy-7-(trifluoromethyl)-6,11-dihyd...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4c(F)ccc(c34)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C18H11F4NO3/c19-12-4-3-11(18(20,21)22)14-8-2-1-7-5-10(17(25)26)13(24)6-9(7)15(8)23-16(12)14/h3-6,23-24H,1-2H2,(H,25,26)
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n/an/an/an/a 799n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263333
PNG
(9-(3,5-dimethylphenyl)-2-hydroxy-6,11-dihydro-5H-b...)
Show SMILES Cc1cc(C)cc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C25H21NO3/c1-13-7-14(2)9-17(8-13)15-3-5-18-19-6-4-16-10-21(25(28)29)23(27)12-20(16)24(19)26-22(18)11-15/h3,5,7-12,26-27H,4,6H2,1-2H3,(H,28,29)
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n/an/an/an/a 67n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263545
PNG
(9-(4-butylphenyl)-N,N-dimethyl-6,11-dihydro-5H-ben...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(ccc4-c3[nH]c2c1)C(=O)N(C)C
Show InChI InChI=1S/C29H30N2O/c1-4-5-6-19-7-9-20(10-8-19)21-11-15-25-26-16-12-22-17-23(29(32)31(2)3)13-14-24(22)28(26)30-27(25)18-21/h7-11,13-15,17-18,30H,4-6,12,16H2,1-3H3
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n/an/an/an/a 127n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263961
PNG
(2-hydroxy-8-(trifluoromethyl)-6,11-dihydro-5H-benz...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4ccc(cc34)C(F)(F)F)-c2cc1O
Show InChI InChI=1S/C18H12F3NO3/c19-18(20,21)9-2-4-14-12(6-9)10-3-1-8-5-13(17(24)25)15(23)7-11(8)16(10)22-14/h2,4-7,22-23H,1,3H2,(H,24,25)
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n/an/an/an/a 333n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264079
PNG
(2-hydroxy-9-m-tolyl-6,11-dihydro-5H-benzo[a]carbaz...)
Show SMILES Cc1cccc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H19NO3/c1-13-3-2-4-14(9-13)15-5-7-17-18-8-6-16-10-20(24(27)28)22(26)12-19(16)23(18)25-21(17)11-15/h2-5,7,9-12,25-26H,6,8H2,1H3,(H,27,28)
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n/an/an/an/a 194n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263334
PNG
(9-(4-fluoro-3-methylphenyl)-2-hydroxy-6,11-dihydro...)
Show SMILES Cc1cc(ccc1F)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H18FNO3/c1-12-8-13(4-7-20(12)25)14-2-5-16-17-6-3-15-9-19(24(28)29)22(27)11-18(15)23(17)26-21(16)10-14/h2,4-5,7-11,26-27H,3,6H2,1H3,(H,28,29)
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n/an/an/an/a 35n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263455
PNG
(2-hydroxy-9-(4-propoxyphenyl)-6,11-dihydro-5H-benz...)
Show SMILES CCCOc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C26H23NO4/c1-2-11-31-18-7-3-15(4-8-18)16-5-9-19-20-10-6-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-5,7-9,12-14,27-28H,2,6,10-11H2,1H3,(H,29,30)
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n/an/an/an/a 41n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263457
PNG
(2-hydroxy-9-(3-propoxyphenyl)-6,11-dihydro-5H-benz...)
Show SMILES CCCOc1cccc(c1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C26H23NO4/c1-2-10-31-18-5-3-4-15(11-18)16-6-8-19-20-9-7-17-12-22(26(29)30)24(28)14-21(17)25(20)27-23(19)13-16/h3-6,8,11-14,27-28H,2,7,9-10H2,1H3,(H,29,30)
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n/an/an/an/a 43n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263911
PNG
(2-hydroxy-9-methyl-11H-benzo[a]carbazole-3-carboxy...)
Show SMILES Cc1ccc2c(c1)[nH]c1c2ccc2cc(C(O)=O)c(O)cc12
Show InChI InChI=1S/C18H13NO3/c1-9-2-4-11-12-5-3-10-7-14(18(21)22)16(20)8-13(10)17(12)19-15(11)6-9/h2-8,19-20H,1H3,(H,21,22)
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n/an/an/an/a 870n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264078
PNG
(9-cyclohexyl-2-hydroxy-6,11-dihydro-5H-benzo[a]car...)
Show SMILES OC(=O)c1cc2CCc3c([nH]c4cc(ccc34)C3CCCCC3)-c2cc1O
Show InChI InChI=1S/C23H23NO3/c25-21-12-18-15(10-19(21)23(26)27)7-9-17-16-8-6-14(11-20(16)24-22(17)18)13-4-2-1-3-5-13/h6,8,10-13,24-25H,1-5,7,9H2,(H,26,27)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50248106
PNG
(CHEMBL461101 | ELTROMBOPAG | Eltrombopag olamine)
Show SMILES Cc1[nH]n(-c2ccc(C)c(C)c2)c(=O)c1N=Nc1cccc(-c2cccc(c2)C(O)=O)c1O |w:16.18|
Show InChI InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,28,30H,1-3H3,(H,32,33)
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n/an/an/an/a 38n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50264080
PNG
(2-hydroxy-9-p-tolyl-6,11-dihydro-5H-benzo[a]carbaz...)
Show SMILES Cc1ccc(cc1)-c1ccc2c3CCc4cc(C(O)=O)c(O)cc4-c3[nH]c2c1
Show InChI InChI=1S/C24H19NO3/c1-13-2-4-14(5-3-13)15-6-8-17-18-9-7-16-10-20(24(27)28)22(26)12-19(16)23(18)25-21(17)11-15/h2-6,8,10-12,25-26H,7,9H2,1H3,(H,27,28)
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n/an/an/an/a 109n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263907
PNG
(3-(hydroxymethyl)-11H-benzo[a]carbazol-2-ol | CHEM...)
Show SMILES OCc1cc2ccc3c4ccccc4[nH]c3c2cc1O
Show InChI InChI=1S/C17H13NO2/c19-9-11-7-10-5-6-13-12-3-1-2-4-15(12)18-17(13)14(10)8-16(11)20/h1-8,18-20H,9H2
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n/an/an/an/a>3.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))		BDBM50263504
PNG
(9-(4-butylphenyl)-6,11-dihydro-5H-benzo[a]carbazol...)
Show SMILES CCCCc1ccc(cc1)-c1ccc2c3CCc4cc(ccc4-c3[nH]c2c1)C(O)=O
Show InChI InChI=1S/C27H25NO2/c1-2-3-4-17-5-7-18(8-6-17)19-9-13-23-24-14-10-20-15-21(27(29)30)11-12-22(20)26(24)28-25(23)16-19/h5-9,11-13,15-16,28H,2-4,10,14H2,1H3,(H,29,30)
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n/an/an/an/a 111n/an/an/an/a



Genomics Institute of the Novartis Research Foundation (GNF)

Curated by ChEMBL


Assay Description
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression

Bioorg Med Chem Lett 18: 5255-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.068
BindingDB Entry DOI: 10.7270/Q2HH6M05
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%