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PubMed code 19217280

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266857
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccccn1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-7-6-16-13-20-26(33-24(31)17-3-1-2-11-27-17)9-8-19(30)23-25(26,21(16)22(18)32-23)10-12-28(20)14-15-4-5-15/h1-3,6-7,11,15,20,23,29H,4-5,8-10,12-14H2/t20-,23+,25+,26-/m1/s1
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0.140n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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0.260n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50247803
PNG
(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Show SMILES COC(=O)\C=C\C(=O)N[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45 |r|
Show InChI InChI=1S/C25H30N2O6/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29)/b7-6+/t16-,18-,23+,24+,25-/m1/s1
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0.410n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50247803
PNG
(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Show SMILES COC(=O)\C=C\C(=O)N[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45 |r|
Show InChI InChI=1S/C25H30N2O6/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29)/b7-6+/t16-,18-,23+,24+,25-/m1/s1
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0.940n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266887
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccc2ccccc2n1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-10-8-19-15-24-30(37-28(35)21-9-7-18-3-1-2-4-20(18)31-21)12-11-23(34)27-29(30,25(19)26(22)36-27)13-14-32(24)16-17-5-6-17/h1-4,7-10,17,24,27,33H,5-6,11-16H2/t24-,27+,29+,30-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266858
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cccnc1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-6-5-16-12-20-26(33-24(31)17-2-1-10-27-13-17)8-7-19(30)23-25(26,21(16)22(18)32-23)9-11-28(20)14-15-3-4-15/h1-2,5-6,10,13,15,20,23,29H,3-4,7-9,11-12,14H2/t20-,23+,25+,26-/m1/s1
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1.60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266827
PNG
(CHEMBL500766 | D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O)C(C)(C)S)C(O)=O |r,wU:40.51,26.38,11.11,67.72,wD:7.7,3.3,58.61,52.57,15.22,1.1,(40.38,-16.39,;41.72,-15.62,;43.06,-16.39,;41.72,-14.08,;40.39,-13.31,;39.06,-14.08,;39.06,-15.62,;37.72,-13.31,;36.39,-14.08,;36.39,-15.62,;37.72,-16.39,;35.06,-16.39,;35.06,-17.93,;33.72,-18.7,;32.39,-17.92,;33.72,-20.24,;35.06,-21.01,;36.39,-20.24,;37.72,-21,;39.05,-20.23,;40.39,-21,;40.39,-22.54,;41.72,-20.23,;32.39,-21.01,;32.39,-22.55,;33.72,-23.31,;31.06,-23.31,;29.72,-22.54,;29.72,-21.01,;30.96,-20.1,;30.48,-18.64,;28.94,-18.64,;27.91,-17.49,;26.4,-17.82,;25.93,-19.28,;26.96,-20.42,;28.47,-20.1,;31.06,-24.85,;29.72,-25.62,;28.39,-24.85,;29.72,-27.17,;31.06,-27.94,;32.39,-27.16,;33.73,-27.93,;35.06,-27.16,;35.06,-25.62,;36.39,-24.85,;33.72,-24.85,;32.39,-25.62,;28.39,-27.94,;27.06,-27.17,;27.06,-25.63,;25.72,-27.94,;25.72,-29.48,;27.06,-30.25,;24.39,-27.17,;23.05,-27.94,;23.05,-29.48,;21.72,-27.17,;20.38,-27.94,;21.72,-25.63,;23.05,-24.86,;24.38,-25.63,;25.72,-24.86,;25.72,-23.32,;24.38,-22.55,;23.05,-23.32,;33.72,-15.61,;32.38,-16.39,;33.72,-14.08,;37.72,-11.77,;39.26,-11.76,;36.18,-11.78,;37.71,-10.22,;43.06,-13.3,;44.4,-14.07,;43.06,-11.74,)|
Show InChI InChI=1S/C51H70N12O12S2/c1-26(64)39(47(72)63-41(51(3,4)77)48(73)62-40(27(2)65)49(74)75)61-43(68)35(15-10-20-55-50(53)54)57-45(70)37(23-30-24-56-34-14-9-8-13-32(30)34)59-44(69)36(22-29-16-18-31(66)19-17-29)58-46(71)38(25-76)60-42(67)33(52)21-28-11-6-5-7-12-28/h5-9,11-14,16-19,24,26-27,33,35-41,56,64-66,76-77H,10,15,20-23,25,52H2,1-4H3,(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,62,73)(H,63,72)(H,74,75)(H4,53,54,55)/t26-,27-,33-,35+,36-,37+,38+,39+,40+,41+/m1/s1
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2n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266888
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cnc2ccccc2c1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-8-7-19-14-24-30(37-28(35)20-13-18-3-1-2-4-21(18)31-15-20)10-9-23(34)27-29(30,25(19)26(22)36-27)11-12-32(24)16-17-5-6-17/h1-4,7-8,13,15,17,24,27,33H,5-6,9-12,14,16H2/t24-,27+,29+,30-/m1/s1
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2.70n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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5.20n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266859
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccncc1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-4-3-17-13-20-26(33-24(31)16-6-10-27-11-7-16)8-5-19(30)23-25(26,21(17)22(18)32-23)9-12-28(20)14-15-1-2-15/h3-4,6-7,10-11,15,20,23,29H,1-2,5,8-9,12-14H2/t20-,23+,25+,26-/m1/s1
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5.60n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266887
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccc2ccccc2n1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-10-8-19-15-24-30(37-28(35)21-9-7-18-3-1-2-4-20(18)31-21)12-11-23(34)27-29(30,25(19)26(22)36-27)13-14-32(24)16-17-5-6-17/h1-4,7-10,17,24,27,33H,5-6,11-16H2/t24-,27+,29+,30-/m1/s1
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23n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266857
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccccn1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-7-6-16-13-20-26(33-24(31)17-3-1-2-11-27-17)9-8-19(30)23-25(26,21(16)22(18)32-23)10-12-28(20)14-15-4-5-15/h1-3,6-7,11,15,20,23,29H,4-5,8-10,12-14H2/t20-,23+,25+,26-/m1/s1
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26n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50247803
PNG
(Beta-Funeltrexamine | CHEMBL473136 | beta-funaltre...)
Show SMILES COC(=O)\C=C\C(=O)N[C@@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC1CC1)c45 |r|
Show InChI InChI=1S/C25H30N2O6/c1-32-20(30)7-6-19(29)26-16-8-9-25(31)18-12-15-4-5-17(28)22-21(15)24(25,23(16)33-22)10-11-27(18)13-14-2-3-14/h4-7,14,16,18,23,28,31H,2-3,8-13H2,1H3,(H,26,29)/b7-6+/t16-,18-,23+,24+,25-/m1/s1
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28n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266918
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C31H29NO5/c33-23-10-9-21-16-25-31(37-29(35)22-8-7-19-3-1-2-4-20(19)15-22)12-11-24(34)28-30(31,26(21)27(23)36-28)13-14-32(25)17-18-5-6-18/h1-4,7-10,15,18,25,28,33H,5-6,11-14,16-17H2/t25-,28+,30+,31-/m1/s1
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47n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266858
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cccnc1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-6-5-16-12-20-26(33-24(31)17-2-1-10-27-13-17)8-7-19(30)23-25(26,21(16)22(18)32-23)9-11-28(20)14-15-3-4-15/h1-2,5-6,10,13,15,20,23,29H,3-4,7-9,11-12,14H2/t20-,23+,25+,26-/m1/s1
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48n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266859
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccncc1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-4-3-17-13-20-26(33-24(31)16-6-10-27-11-7-16)8-5-19(30)23-25(26,21(17)22(18)32-23)9-12-28(20)14-15-1-2-15/h3-4,6-7,10-11,15,20,23,29H,1-2,5,8-9,12-14H2/t20-,23+,25+,26-/m1/s1
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49n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266887
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccc2ccccc2n1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-10-8-19-15-24-30(37-28(35)21-9-7-18-3-1-2-4-20(18)31-21)12-11-23(34)27-29(30,25(19)26(22)36-27)13-14-32(24)16-17-5-6-17/h1-4,7-10,17,24,27,33H,5-6,11-16H2/t24-,27+,29+,30-/m1/s1
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67n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266886
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cc2ccccc2cn1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-8-7-19-14-24-30(37-28(35)21-13-18-3-1-2-4-20(18)15-31-21)10-9-23(34)27-29(30,25(19)26(22)36-27)11-12-32(24)16-17-5-6-17/h1-4,7-8,13,15,17,24,27,33H,5-6,9-12,14,16H2/t24-,27+,29+,30-/m1/s1
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68n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM60212
PNG
((4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,9-bis(o...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O
Show InChI InChI=1S/C20H23NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,15,18,22,24H,1-2,5-10H2/t15-,18+,19+,20-/m1/s1
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117n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266857
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccccn1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-7-6-16-13-20-26(33-24(31)17-3-1-2-11-27-17)9-8-19(30)23-25(26,21(16)22(18)32-23)10-12-28(20)14-15-4-5-15/h1-3,6-7,11,15,20,23,29H,4-5,8-10,12-14H2/t20-,23+,25+,26-/m1/s1
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117n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266860
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H27NO5/c29-19-9-8-18-14-21-27(33-25(31)17-4-2-1-3-5-17)11-10-20(30)24-26(27,22(18)23(19)32-24)12-13-28(21)15-16-6-7-16/h1-5,8-9,16,21,24,29H,6-7,10-15H2/t21-,24+,26+,27-/m1/s1
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123n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266888
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cnc2ccccc2c1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-8-7-19-14-24-30(37-28(35)20-13-18-3-1-2-4-21(18)31-15-20)10-9-23(34)27-29(30,25(19)26(22)36-27)11-12-32(24)16-17-5-6-17/h1-4,7-8,13,15,17,24,27,33H,5-6,9-12,14,16H2/t24-,27+,29+,30-/m1/s1
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148n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266858
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cccnc1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-6-5-16-12-20-26(33-24(31)17-2-1-10-27-13-17)8-7-19(30)23-25(26,21(16)22(18)32-23)9-11-28(20)14-15-3-4-15/h1-2,5-6,10,13,15,20,23,29H,3-4,7-9,11-12,14H2/t20-,23+,25+,26-/m1/s1
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170n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50266918
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C31H29NO5/c33-23-10-9-21-16-25-31(37-29(35)22-8-7-19-3-1-2-4-20(19)15-22)12-11-24(34)28-30(31,26(21)27(23)36-28)13-14-32(25)17-18-5-6-18/h1-4,7-10,15,18,25,28,33H,5-6,11-14,16-17H2/t25-,28+,30+,31-/m1/s1
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225n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]DAMGO from mu opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266859
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccncc1 |r|
Show InChI InChI=1S/C26H26N2O5/c29-18-4-3-17-13-20-26(33-24(31)16-6-10-27-11-7-16)8-5-19(30)23-25(26,21(17)22(18)32-23)9-12-28(20)14-15-1-2-15/h3-4,6-7,10-11,15,20,23,29H,1-2,5,8-9,12-14H2/t20-,23+,25+,26-/m1/s1
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405n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266860
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H27NO5/c29-19-9-8-18-14-21-27(33-25(31)17-4-2-1-3-5-17)11-10-20(30)24-26(27,22(18)23(19)32-24)12-13-28(21)15-16-6-7-16/h1-5,8-9,16,21,24,29H,6-7,10-15H2/t21-,24+,26+,27-/m1/s1
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586n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266888
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cnc2ccccc2c1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-8-7-19-14-24-30(37-28(35)20-13-18-3-1-2-4-21(18)31-15-20)10-9-23(34)27-29(30,25(19)26(22)36-27)11-12-32(24)16-17-5-6-17/h1-4,7-8,13,15,17,24,27,33H,5-6,9-12,14,16H2/t24-,27+,29+,30-/m1/s1
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818n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266918
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccc2ccccc2c1 |r|
Show InChI InChI=1S/C31H29NO5/c33-23-10-9-21-16-25-31(37-29(35)22-8-7-19-3-1-2-4-20(19)15-22)12-11-24(34)28-30(31,26(21)27(23)36-28)13-14-32(25)17-18-5-6-18/h1-4,7-10,15,18,25,28,33H,5-6,11-14,16-17H2/t25-,28+,30+,31-/m1/s1
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907n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266827
PNG
(CHEMBL500766 | D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O)C(C)(C)S)C(O)=O |r,wU:40.51,26.38,11.11,67.72,wD:7.7,3.3,58.61,52.57,15.22,1.1,(40.38,-16.39,;41.72,-15.62,;43.06,-16.39,;41.72,-14.08,;40.39,-13.31,;39.06,-14.08,;39.06,-15.62,;37.72,-13.31,;36.39,-14.08,;36.39,-15.62,;37.72,-16.39,;35.06,-16.39,;35.06,-17.93,;33.72,-18.7,;32.39,-17.92,;33.72,-20.24,;35.06,-21.01,;36.39,-20.24,;37.72,-21,;39.05,-20.23,;40.39,-21,;40.39,-22.54,;41.72,-20.23,;32.39,-21.01,;32.39,-22.55,;33.72,-23.31,;31.06,-23.31,;29.72,-22.54,;29.72,-21.01,;30.96,-20.1,;30.48,-18.64,;28.94,-18.64,;27.91,-17.49,;26.4,-17.82,;25.93,-19.28,;26.96,-20.42,;28.47,-20.1,;31.06,-24.85,;29.72,-25.62,;28.39,-24.85,;29.72,-27.17,;31.06,-27.94,;32.39,-27.16,;33.73,-27.93,;35.06,-27.16,;35.06,-25.62,;36.39,-24.85,;33.72,-24.85,;32.39,-25.62,;28.39,-27.94,;27.06,-27.17,;27.06,-25.63,;25.72,-27.94,;25.72,-29.48,;27.06,-30.25,;24.39,-27.17,;23.05,-27.94,;23.05,-29.48,;21.72,-27.17,;20.38,-27.94,;21.72,-25.63,;23.05,-24.86,;24.38,-25.63,;25.72,-24.86,;25.72,-23.32,;24.38,-22.55,;23.05,-23.32,;33.72,-15.61,;32.38,-16.39,;33.72,-14.08,;37.72,-11.77,;39.26,-11.76,;36.18,-11.78,;37.71,-10.22,;43.06,-13.3,;44.4,-14.07,;43.06,-11.74,)|
Show InChI InChI=1S/C51H70N12O12S2/c1-26(64)39(47(72)63-41(51(3,4)77)48(73)62-40(27(2)65)49(74)75)61-43(68)35(15-10-20-55-50(53)54)57-45(70)37(23-30-24-56-34-14-9-8-13-32(30)34)59-44(69)36(22-29-16-18-31(66)19-17-29)58-46(71)38(25-76)60-42(67)33(52)21-28-11-6-5-7-12-28/h5-9,11-14,16-19,24,26-27,33,35-41,56,64-66,76-77H,10,15,20-23,25,52H2,1-4H3,(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,62,73)(H,63,72)(H,74,75)(H4,53,54,55)/t26-,27-,33-,35+,36-,37+,38+,39+,40+,41+/m1/s1
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1.01E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266827
PNG
(CHEMBL500766 | D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](N)Cc1ccccc1)[C@@H](C)O)C(C)(C)S)C(O)=O |r,wU:40.51,26.38,11.11,67.72,wD:7.7,3.3,58.61,52.57,15.22,1.1,(40.38,-16.39,;41.72,-15.62,;43.06,-16.39,;41.72,-14.08,;40.39,-13.31,;39.06,-14.08,;39.06,-15.62,;37.72,-13.31,;36.39,-14.08,;36.39,-15.62,;37.72,-16.39,;35.06,-16.39,;35.06,-17.93,;33.72,-18.7,;32.39,-17.92,;33.72,-20.24,;35.06,-21.01,;36.39,-20.24,;37.72,-21,;39.05,-20.23,;40.39,-21,;40.39,-22.54,;41.72,-20.23,;32.39,-21.01,;32.39,-22.55,;33.72,-23.31,;31.06,-23.31,;29.72,-22.54,;29.72,-21.01,;30.96,-20.1,;30.48,-18.64,;28.94,-18.64,;27.91,-17.49,;26.4,-17.82,;25.93,-19.28,;26.96,-20.42,;28.47,-20.1,;31.06,-24.85,;29.72,-25.62,;28.39,-24.85,;29.72,-27.17,;31.06,-27.94,;32.39,-27.16,;33.73,-27.93,;35.06,-27.16,;35.06,-25.62,;36.39,-24.85,;33.72,-24.85,;32.39,-25.62,;28.39,-27.94,;27.06,-27.17,;27.06,-25.63,;25.72,-27.94,;25.72,-29.48,;27.06,-30.25,;24.39,-27.17,;23.05,-27.94,;23.05,-29.48,;21.72,-27.17,;20.38,-27.94,;21.72,-25.63,;23.05,-24.86,;24.38,-25.63,;25.72,-24.86,;25.72,-23.32,;24.38,-22.55,;23.05,-23.32,;33.72,-15.61,;32.38,-16.39,;33.72,-14.08,;37.72,-11.77,;39.26,-11.76,;36.18,-11.78,;37.71,-10.22,;43.06,-13.3,;44.4,-14.07,;43.06,-11.74,)|
Show InChI InChI=1S/C51H70N12O12S2/c1-26(64)39(47(72)63-41(51(3,4)77)48(73)62-40(27(2)65)49(74)75)61-43(68)35(15-10-20-55-50(53)54)57-45(70)37(23-30-24-56-34-14-9-8-13-32(30)34)59-44(69)36(22-29-16-18-31(66)19-17-29)58-46(71)38(25-76)60-42(67)33(52)21-28-11-6-5-7-12-28/h5-9,11-14,16-19,24,26-27,33,35-41,56,64-66,76-77H,10,15,20-23,25,52H2,1-4H3,(H,57,70)(H,58,71)(H,59,69)(H,60,67)(H,61,68)(H,62,73)(H,63,72)(H,74,75)(H4,53,54,55)/t26-,27-,33-,35+,36-,37+,38+,39+,40+,41+/m1/s1
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1.44E+3n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50266886
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cc2ccccc2cn1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-8-7-19-14-24-30(37-28(35)21-13-18-3-1-2-4-20(18)15-31-21)10-9-23(34)27-29(30,25(19)26(22)36-27)11-12-32(24)16-17-5-6-17/h1-4,7-8,13,15,17,24,27,33H,5-6,9-12,14,16H2/t24-,27+,29+,30-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]norBNI from kappa opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266886
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1cc2ccccc2cn1 |r|
Show InChI InChI=1S/C30H28N2O5/c33-22-8-7-19-14-24-30(37-28(35)21-13-18-3-1-2-4-20(18)15-31-21)10-9-23(34)27-29(30,25(19)26(22)36-27)11-12-32(24)16-17-5-6-17/h1-4,7-8,13,15,17,24,27,33H,5-6,9-12,14,16H2/t24-,27+,29+,30-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50266860
PNG
((1S,5R,13R,17S)-4-(cyclopropylmethyl)-10-hydroxy-1...)
Show SMILES Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35OC(=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H27NO5/c29-19-9-8-18-14-21-27(33-25(31)17-4-2-1-3-5-17)11-10-20(30)24-26(27,22(18)23(19)32-24)12-13-28(21)15-16-6-7-16/h1-5,8-9,16,21,24,29H,6-7,10-15H2/t21-,24+,26+,27-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Displacement of [3H]NTI from delta opioid receptor expressed in CHO cells


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM21015
PNG
((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
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n/an/an/an/a 45n/an/an/an/a



Virginia Commonwealth University

Curated by ChEMBL


Assay Description
Agonist activity against mu opioid receptor expressed in CHO cells assessed as stimulation [35S]GTPgammaS binding relative to basal level


Bioorg Med Chem Lett 19: 1825-9 (2009)


Article DOI: 10.1016/j.bmcl.2008.12.093
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%