Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Diacylglycerol O-acyltransferase 1 (Rattus norvegicus (rat)) | BDBM27950 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27950 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27947 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Diacylglycerol O-acyltransferase 1 (Rattus norvegicus (rat)) | BDBM27947 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27951 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27949 (4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27952 (2-[5-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27953 (2-[3-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27954 (3-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27950 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27947 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27951 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27949 (4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27952 (2-[5-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.80E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27954 (3-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sterol O-acyltransferase 1 (Homo sapiens (Human)) | BDBM27953 (2-[3-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, cholesterol solubilized in Triton WR-1339, and glutathione in a 96-deep well plate. The r... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM27950 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Diacylglycerol O-acyltransferase 2 (Homo sapiens (Human)) | BDBM27947 (2-[4-(4-{4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description The assay mixture contains test compound, membrane protein, and 1,2 dioleoyl-sn-glycerol in a 96-deep well plate. The reaction was started by adding ... | J Med Chem 52: 1558-68 (2009) Article DOI: 10.1021/jm801507v BindingDB Entry DOI: 10.7270/Q2N014VR | |||||||||||
More data for this Ligand-Target Pair |