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PubMed code 20227877

Compile data set for download or QSAR
Found 29 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315141
PNG
(CHEMBL1093969 | isopropyl 4-((6-(4-(2-methoxyethyl...)
Show SMILES COCCN1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C22H36N4O4/c1-18(2)30-22(27)26-8-6-19(7-9-26)17-29-20-4-5-21(23-16-20)25-12-10-24(11-13-25)14-15-28-3/h4-5,16,18-19H,6-15,17H2,1-3H3
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n/an/an/an/a 2.60E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315162
PNG
(CHEMBL1090169 | isopropyl 4-(6-(4-(ethylsulfonyl)p...)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc(OC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C20H32N4O5S/c1-4-30(26,27)24-13-11-22(12-14-24)19-6-5-18(15-21-19)29-17-7-9-23(10-8-17)20(25)28-16(2)3/h5-6,15-17H,4,7-14H2,1-3H3
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n/an/an/an/a 2.10E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315155
PNG
(CHEMBL1092333 | N-tert-butyl-4-((6-(4-(propylsulfo...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)NC(C)(C)C)cn1
Show InChI InChI=1S/C23H39N5O4S/c1-5-16-33(30,31)28-14-12-26(13-15-28)21-7-6-20(17-24-21)32-18-19-8-10-27(11-9-19)22(29)25-23(2,3)4/h6-7,17,19H,5,8-16,18H2,1-4H3,(H,25,29)
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n/an/an/an/a 800n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315145
PNG
(CHEMBL1088852 | isopropyl 4-((6-(4-(butylsulfonyl)...)
Show SMILES CCCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C23H38N4O5S/c1-4-5-16-33(29,30)27-14-12-25(13-15-27)22-7-6-21(17-24-22)31-18-20-8-10-26(11-9-20)23(28)32-19(2)3/h6-7,17,19-20H,4-5,8-16,18H2,1-3H3
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n/an/an/an/a 100n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315146
PNG
(CHEMBL1088853 | isopropyl 4-((6-(4-(2-methoxyethyl...)
Show SMILES COCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C22H36N4O6S/c1-18(2)32-22(27)25-8-6-19(7-9-25)17-31-20-4-5-21(23-16-20)24-10-12-26(13-11-24)33(28,29)15-14-30-3/h4-5,16,18-19H,6-15,17H2,1-3H3
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n/an/an/an/a 300n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315154
PNG
(3-methyl-1-(4-((6-(4-(propylsulfonyl)piperazin-1-y...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)CC(C)C)cn1
Show InChI InChI=1S/C23H38N4O4S/c1-4-15-32(29,30)27-13-11-25(12-14-27)22-6-5-21(17-24-22)31-18-20-7-9-26(10-8-20)23(28)16-19(2)3/h5-6,17,19-20H,4,7-16,18H2,1-3H3
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n/an/an/an/a 1.60E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315156
PNG
(3,3-dimethyl-1-(4-((6-(4-(propylsulfonyl)piperazin...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)CC(C)(C)C)cn1
Show InChI InChI=1S/C24H40N4O4S/c1-5-16-33(30,31)28-14-12-26(13-15-28)22-7-6-21(18-25-22)32-19-20-8-10-27(11-9-20)23(29)17-24(2,3)4/h6-7,18,20H,5,8-17,19H2,1-4H3
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n/an/an/an/a 2.80E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315139
PNG
(CHEMBL1092630 | isopropyl 4-((6-(4-acetylpiperazin...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)C(C)=O)CC1
Show InChI InChI=1S/C21H32N4O4/c1-16(2)29-21(27)25-8-6-18(7-9-25)15-28-19-4-5-20(22-14-19)24-12-10-23(11-13-24)17(3)26/h4-5,14,16,18H,6-13,15H2,1-3H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315152
PNG
(CHEMBL1090559 | isopropyl 4-((6-(4-(piperidin-1-yl...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)S(=O)(=O)N2CCCCC2)CC1
Show InChI InChI=1S/C24H39N5O5S/c1-20(2)34-24(30)27-12-8-21(9-13-27)19-33-22-6-7-23(25-18-22)26-14-16-29(17-15-26)35(31,32)28-10-4-3-5-11-28/h6-7,18,20-21H,3-5,8-17,19H2,1-2H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315161
PNG
(CHEMBL1089839 | N-(4-isopropylphenyl)-4-((6-(4-(pr...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)Nc2ccc(cc2)C(C)C)cn1
Show InChI InChI=1S/C28H41N5O4S/c1-4-19-38(35,36)33-17-15-31(16-18-33)27-10-9-26(20-29-27)37-21-23-11-13-32(14-12-23)28(34)30-25-7-5-24(6-8-25)22(2)3/h5-10,20,22-23H,4,11-19,21H2,1-3H3,(H,30,34)
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n/an/an/an/a 900n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315164
PNG
(CHEMBL1093453 | isopropyl 4-(2-(6-(4-(propylsulfon...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C23H38N4O5S/c1-4-17-33(29,30)27-14-12-25(13-15-27)22-6-5-21(18-24-22)31-16-9-20-7-10-26(11-8-20)23(28)32-19(2)3/h5-6,18-20H,4,7-17H2,1-3H3
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n/an/an/an/a 700n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315142
PNG
(CHEMBL1092895 | isopropyl 4-((6-(4-(ethylsulfonyl)...)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C21H34N4O5S/c1-4-31(27,28)25-13-11-23(12-14-25)20-6-5-19(15-22-20)29-16-18-7-9-24(10-8-18)21(26)30-17(2)3/h5-6,15,17-18H,4,7-14,16H2,1-3H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315143
PNG
(CHEMBL1093150 | isopropyl 4-((6-(4-(isopropylsulfo...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)S(=O)(=O)C(C)C)CC1
Show InChI InChI=1S/C22H36N4O5S/c1-17(2)31-22(27)25-9-7-19(8-10-25)16-30-20-5-6-21(23-15-20)24-11-13-26(14-12-24)32(28,29)18(3)4/h5-6,15,17-19H,7-14,16H2,1-4H3
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n/an/an/an/a 300n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315150
PNG
(CHEMBL1091203 | isopropyl 4-((6-(4-(thiophen-2-yls...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)S(=O)(=O)c2cccs2)CC1
Show InChI InChI=1S/C23H32N4O5S2/c1-18(2)32-23(28)26-9-7-19(8-10-26)17-31-20-5-6-21(24-16-20)25-11-13-27(14-12-25)34(29,30)22-4-3-15-33-22/h3-6,15-16,18-19H,7-14,17H2,1-2H3
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n/an/an/an/a 1.80E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315163
PNG
(CHEMBL1093452 | isopropyl 4-(2-(6-(4-(ethylsulfony...)
Show SMILES CCS(=O)(=O)N1CCN(CC1)c1ccc(OCCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C22H36N4O5S/c1-4-32(28,29)26-14-12-24(13-15-26)21-6-5-20(17-23-21)30-16-9-19-7-10-25(11-8-19)22(27)31-18(2)3/h5-6,17-19H,4,7-16H2,1-3H3
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n/an/an/an/a 1.20E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315147
PNG
(CHEMBL1089528 | isopropyl 4-((6-(4-(cyclohexylsulf...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)S(=O)(=O)C2CCCCC2)CC1
Show InChI InChI=1S/C25H40N4O5S/c1-20(2)34-25(30)28-12-10-21(11-13-28)19-33-22-8-9-24(26-18-22)27-14-16-29(17-15-27)35(31,32)23-6-4-3-5-7-23/h8-9,18,20-21,23H,3-7,10-17,19H2,1-2H3
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n/an/an/an/a 200n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315148
PNG
(CHEMBL1089857 | isopropyl 4-((6-(4-(cyclohexylmeth...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)S(=O)(=O)CC2CCCCC2)CC1
Show InChI InChI=1S/C26H42N4O5S/c1-21(2)35-26(31)29-12-10-22(11-13-29)19-34-24-8-9-25(27-18-24)28-14-16-30(17-15-28)36(32,33)20-23-6-4-3-5-7-23/h8-9,18,21-23H,3-7,10-17,19-20H2,1-2H3
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n/an/an/an/a 90n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315151
PNG
(CHEMBL1090558 | isopropyl 4-((6-(4-(N,N-diethylsul...)
Show SMILES CCN(CC)S(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C23H39N5O5S/c1-5-27(6-2)34(30,31)28-15-13-25(14-16-28)22-8-7-21(17-24-22)32-18-20-9-11-26(12-10-20)23(29)33-19(3)4/h7-8,17,19-20H,5-6,9-16,18H2,1-4H3
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n/an/an/an/a 1.20E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315159
PNG
(CHEMBL1089837 | furan-2-yl(4-((6-(4-(propylsulfony...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)c2ccco2)cn1
Show InChI InChI=1S/C23H32N4O5S/c1-2-16-33(29,30)27-13-11-25(12-14-27)22-6-5-20(17-24-22)32-18-19-7-9-26(10-8-19)23(28)21-4-3-15-31-21/h3-6,15,17,19H,2,7-14,16,18H2,1H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315138
PNG
(CHEMBL1089214 | isopropyl 4-((6-(4-(2-hydroxy-2-(i...)
Show SMILES CC(C)NC(=O)CN1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C24H39N5O4/c1-18(2)26-23(30)16-27-11-13-28(14-12-27)22-6-5-21(15-25-22)32-17-20-7-9-29(10-8-20)24(31)33-19(3)4/h5-6,15,18-20H,7-14,16-17H2,1-4H3,(H,26,30)
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n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315144
PNG
(CHEMBL1093151 | isopropyl 4-((6-(4-(propylsulfonyl...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)OC(C)C)cn1
Show InChI InChI=1S/C22H36N4O5S/c1-4-15-32(28,29)26-13-11-24(12-14-26)21-6-5-20(16-23-21)30-17-19-7-9-25(10-8-19)22(27)31-18(2)3/h5-6,16,18-19H,4,7-15,17H2,1-3H3
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n/an/an/an/a 300n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315149
PNG
(CHEMBL1091202 | isopropyl 4-((6-(4-(pyridin-3-ylsu...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)S(=O)(=O)c2cccnc2)CC1
Show InChI InChI=1S/C24H33N5O5S/c1-19(2)34-24(30)28-10-7-20(8-11-28)18-33-21-5-6-23(26-16-21)27-12-14-29(15-13-27)35(31,32)22-4-3-9-25-17-22/h3-6,9,16-17,19-20H,7-8,10-15,18H2,1-2H3
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n/an/an/an/a 2.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315158
PNG
(2,2-difluoro-1-(4-((6-(4-(propylsulfonyl)piperazin...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)C(F)F)cn1
Show InChI InChI=1S/C20H30F2N4O4S/c1-2-13-31(28,29)26-11-9-24(10-12-26)18-4-3-17(14-23-18)30-15-16-5-7-25(8-6-16)20(27)19(21)22/h3-4,14,16,19H,2,5-13,15H2,1H3
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n/an/an/an/a 2.10E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315136
PNG
(CHEMBL1092240 | N-(4-(1H-1,2,4-triazol-1-yl)phenyl...)
Show SMILES [O-][N+](=O)c1c(Nc2ccc(cc2)-n2cncn2)ncnc1N1CCC(CC1)Sc1ccccn1
Show InChI InChI=1S/C22H21N9O2S/c32-31(33)20-21(28-16-4-6-17(7-5-16)30-15-23-13-27-30)25-14-26-22(20)29-11-8-18(9-12-29)34-19-3-1-2-10-24-19/h1-7,10,13-15,18H,8-9,11-12H2,(H,25,26,28)
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n/an/an/an/a 130n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor by cAMP mobilization assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315137
PNG
(CHEMBL1088915 | isopropyl 4-((6-(4-(dimethylcarbam...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)C(=O)N(C)C)CC1
Show InChI InChI=1S/C22H35N5O4/c1-17(2)31-22(29)27-9-7-18(8-10-27)16-30-19-5-6-20(23-15-19)25-11-13-26(14-12-25)21(28)24(3)4/h5-6,15,17-18H,7-14,16H2,1-4H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315140
PNG
(CHEMBL1092631 | isopropyl 4-((6-(4-(furan-2-carbon...)
Show SMILES CC(C)OC(=O)N1CCC(COc2ccc(nc2)N2CCN(CC2)C(=O)c2ccco2)CC1
Show InChI InChI=1S/C24H32N4O5/c1-18(2)33-24(30)28-9-7-19(8-10-28)17-32-20-5-6-22(25-16-20)26-11-13-27(14-12-26)23(29)21-4-3-15-31-21/h3-6,15-16,18-19H,7-14,17H2,1-2H3
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n/an/an/an/a 1.90E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315157
PNG
(CHEMBL1092657 | N-cyclohexyl-4-((6-(4-(propylsulfo...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)NC2CCCCC2)cn1
Show InChI InChI=1S/C25H41N5O4S/c1-2-18-35(32,33)30-16-14-28(15-17-30)24-9-8-23(19-26-24)34-20-21-10-12-29(13-11-21)25(31)27-22-6-4-3-5-7-22/h8-9,19,21-22H,2-7,10-18,20H2,1H3,(H,27,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315160
PNG
(CHEMBL1089838 | morpholino(4-((6-(4-(propylsulfony...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)N2CCOCC2)cn1
Show InChI InChI=1S/C23H37N5O5S/c1-2-17-34(30,31)28-11-9-25(10-12-28)22-4-3-21(18-24-22)33-19-20-5-7-26(8-6-20)23(29)27-13-15-32-16-14-27/h3-4,18,20H,2,5-17,19H2,1H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50315153
PNG
(CHEMBL1090879 | N-isopropyl-4-((6-(4-(propylsulfon...)
Show SMILES CCCS(=O)(=O)N1CCN(CC1)c1ccc(OCC2CCN(CC2)C(=O)NC(C)C)cn1
Show InChI InChI=1S/C22H37N5O4S/c1-4-15-32(29,30)27-13-11-25(12-14-27)21-6-5-20(16-23-21)31-17-19-7-9-26(10-8-19)22(28)24-18(2)3/h5-6,16,18-19H,4,7-15,17H2,1-3H3,(H,24,28)
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n/an/an/an/a 1.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells cotransfected with 6CRE-Luc after 5 hrs by luciferase reporter gene assay

Bioorg Med Chem Lett 20: 2577-81 (2010)


Article DOI: 10.1016/j.bmcl.2010.02.083
BindingDB Entry DOI: 10.7270/Q2WW7HT8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%