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PubMed code 20638279

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 5


(Rattus norvegicus (Rat))		BDBM50323546
PNG
(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Show SMILES Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
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n/an/a>1.00E+4n/an/an/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Negative allosteric modulation of rat mGluR5 expressed in CHO-K1 cells

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50323546
PNG
(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Show SMILES Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Negative allosteric modulation of human mGluR5 expressed in CHO-K1 cells

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323569
PNG
(4-(naphthalen-2-yl)pyrimidin-2-amine | CHEMBL12095...)
Show SMILES Nc1nccc(n1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C14H11N3/c15-14-16-8-7-13(17-14)12-6-5-10-3-1-2-4-11(10)9-12/h1-9H,(H2,15,16,17)
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323579
PNG
(4-(2-(thiophen-2-yl)vinyl)pyrimidin-2-amine | CHEM...)
Show SMILES Nc1nccc(\C=C\c2cccs2)n1
Show InChI InChI=1S/C10H9N3S/c11-10-12-6-5-8(13-10)3-4-9-2-1-7-14-9/h1-7H,(H2,11,12,13)/b4-3+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323548
PNG
(CHEMBL1209433 | N,N-dimethyl-4-styrylpyrimidin-2-a...)
Show SMILES CN(C)c1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C14H15N3/c1-17(2)14-15-11-10-13(16-14)9-8-12-6-4-3-5-7-12/h3-11H,1-2H3/b9-8+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323549
PNG
(CHEMBL1209434 | N-(4-styrylpyrimidin-2-yl)methanes...)
Show SMILES CS(=O)(=O)Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C13H13N3O2S/c1-19(17,18)16-13-14-10-9-12(15-13)8-7-11-5-3-2-4-6-11/h2-10H,1H3,(H,14,15,16)/b8-7+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323554
PNG
(5-methyl-4-styrylpyrimidin-2-amine | CHEMBL1209514)
Show SMILES Cc1cnc(N)nc1\C=C\c1ccccc1
Show InChI InChI=1S/C13H13N3/c1-10-9-15-13(14)16-12(10)8-7-11-5-3-2-4-6-11/h2-9H,1H3,(H2,14,15,16)/b8-7+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323557
PNG
(2-amino-6-styrylpyrimidin-4-ol | CHEMBL1209517)
Show SMILES Nc1nc(C=Cc2ccccc2)cc(=O)[nH]1 |w:5.5|
Show InChI InChI=1S/C12H11N3O/c13-12-14-10(8-11(16)15-12)7-6-9-4-2-1-3-5-9/h1-8H,(H3,13,14,15,16)
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323562
PNG
(6-styrylpyridin-2-amine | CHEMBL1209588)
Show SMILES Nc1cccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C13H12N2/c14-13-8-4-7-12(15-13)10-9-11-5-2-1-3-6-11/h1-10H,(H2,14,15)/b10-9+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323568
PNG
(4-(benzo[b]thiophen-2-yl)pyrimidin-2-amine | CHEMB...)
Show SMILES Nc1nccc(n1)-c1cc2ccccc2s1
Show InChI InChI=1S/C12H9N3S/c13-12-14-6-5-9(15-12)11-7-8-3-1-2-4-10(8)16-11/h1-7H,(H2,13,14,15)
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323571
PNG
(4-(3-fluorostyryl)pyrimidin-2-amine | CHEMBL120966...)
Show SMILES Nc1nccc(\C=C\c2cccc(F)c2)n1
Show InChI InChI=1S/C12H10FN3/c13-10-3-1-2-9(8-10)4-5-11-6-7-15-12(14)16-11/h1-8H,(H2,14,15,16)/b5-4+
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n/an/an/an/a 4.50E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323572
PNG
(4-(4-fluorostyryl)pyrimidin-2-amine | CHEMBL120966...)
Show SMILES Nc1nccc(\C=C\c2ccc(F)cc2)n1
Show InChI InChI=1S/C12H10FN3/c13-10-4-1-9(2-5-10)3-6-11-7-8-15-12(14)16-11/h1-8H,(H2,14,15,16)/b6-3+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323577
PNG
(4-(3-methylstyryl)pyrimidin-2-amine | CHEMBL120966...)
Show SMILES Cc1cccc(\C=C\c2ccnc(N)n2)c1
Show InChI InChI=1S/C13H13N3/c1-10-3-2-4-11(9-10)5-6-12-7-8-15-13(14)16-12/h2-9H,1H3,(H2,14,15,16)/b6-5+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323578
PNG
(4-(4-methylstyryl)pyrimidin-2-amine | CHEMBL120966...)
Show SMILES Cc1ccc(\C=C\c2ccnc(N)n2)cc1
Show InChI InChI=1S/C13H13N3/c1-10-2-4-11(5-3-10)6-7-12-8-9-15-13(14)16-12/h2-9H,1H3,(H2,14,15,16)/b7-6+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323546
PNG
(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Show SMILES Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human mGluR4 expressed in CHO-K1 cells

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323551
PNG
(2-phenyl-4-styrylpyrimidine | CHEMBL1209436)
Show SMILES C(=C/c1ccnc(n1)-c1ccccc1)\c1ccccc1
Show InChI InChI=1S/C18H14N2/c1-3-7-15(8-4-1)11-12-17-13-14-19-18(20-17)16-9-5-2-6-10-16/h1-14H/b12-11+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323553
PNG
(4-methyl-6-styrylpyrimidin-2-amine | CHEMBL1209438)
Show SMILES Cc1cc(\C=C\c2ccccc2)nc(N)n1
Show InChI InChI=1S/C13H13N3/c1-10-9-12(16-13(14)15-10)8-7-11-5-3-2-4-6-11/h2-9H,1H3,(H2,14,15,16)/b8-7+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323559
PNG
(4-styryl-6-(trifluoromethyl)pyrimidin-2-amine | CH...)
Show SMILES Nc1nc(\C=C\c2ccccc2)cc(n1)C(F)(F)F
Show InChI InChI=1S/C13H10F3N3/c14-13(15,16)11-8-10(18-12(17)19-11)7-6-9-4-2-1-3-5-9/h1-8H,(H2,17,18,19)/b7-6+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323574
PNG
(3-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Show SMILES Nc1nccc(\C=C\c2cccc(c2)C#N)n1
Show InChI InChI=1S/C13H10N4/c14-9-11-3-1-2-10(8-11)4-5-12-6-7-16-13(15)17-12/h1-8H,(H2,15,16,17)/b5-4+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323547
PNG
(CHEMBL1209432 | N-methyl-4-styrylpyrimidin-2-amine)
Show SMILES CNc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C13H13N3/c1-14-13-15-10-9-12(16-13)8-7-11-5-3-2-4-6-11/h2-10H,1H3,(H,14,15,16)/b8-7+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323563
PNG
(6-styrylpyrazin-2-amine | CHEMBL1209589)
Show SMILES Nc1cncc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-9-14-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,15)/b7-6+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323564
PNG
(4-phenethylpyrimidin-2-amine | CHEMBL1209590)
Show SMILES Nc1nccc(CCc2ccccc2)n1
Show InChI InChI=1S/C12H13N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-5,8-9H,6-7H2,(H2,13,14,15)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323566
PNG
(5-((1R,2R)-2-phenylcyclopropyl)pyrimidin-2-amine |...)
Show SMILES Nc1ncc(cn1)[C@@H]1C[C@H]1c1ccccc1 |r|
Show InChI InChI=1S/C13H13N3/c14-13-15-7-10(8-16-13)12-6-11(12)9-4-2-1-3-5-9/h1-5,7-8,11-12H,6H2,(H2,14,15,16)/t11-,12-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323570
PNG
(4-(2-fluorostyryl)pyrimidin-2-amine | CHEMBL120880...)
Show SMILES Nc1nccc(\C=C\c2ccccc2F)n1
Show InChI InChI=1S/C12H10FN3/c13-11-4-2-1-3-9(11)5-6-10-7-8-15-12(14)16-10/h1-8H,(H2,14,15,16)/b6-5+
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n/an/an/an/a 2.90E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323583
PNG
(4-(2-(pyridin-4-yl)vinyl)pyrimidin-2-amine | CHEMB...)
Show SMILES Nc1nccc(\C=C\c2ccncc2)n1
Show InChI InChI=1S/C11H10N4/c12-11-14-8-5-10(15-11)2-1-9-3-6-13-7-4-9/h1-8H,(H2,12,14,15)/b2-1+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50323546
PNG
(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Show SMILES Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
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n/an/an/an/a>1.00E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR5 expressed in CHO-K1 cells

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 5


(Homo sapiens (Human))		BDBM50323546
PNG
(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Show SMILES Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
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n/an/an/an/a>1.00E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Agonist activity at human mGluR5 expressed in CHO-K1 cells in absence of glutamate

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323550
PNG
(2-methyl-4-styrylpyrimidine | CHEMBL1209435)
Show SMILES Cc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C13H12N2/c1-11-14-10-9-13(15-11)8-7-12-5-3-2-4-6-12/h2-10H,1H3/b8-7+
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n/an/an/an/a 6.90E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323556
PNG
(6-styrylpyrimidine-2,4-diamine | CHEMBL1209516)
Show SMILES Nc1cc(\C=C\c2ccccc2)nc(N)n1
Show InChI InChI=1S/C12H12N4/c13-11-8-10(15-12(14)16-11)7-6-9-4-2-1-3-5-9/h1-8H,(H4,13,14,15,16)/b7-6+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323558
PNG
(4-methoxy-6-styrylpyrimidin-2-amine | CHEMBL120951...)
Show SMILES COc1cc(\C=C\c2ccccc2)nc(N)n1
Show InChI InChI=1S/C13H13N3O/c1-17-12-9-11(15-13(14)16-12)8-7-10-5-3-2-4-6-10/h2-9H,1H3,(H2,14,15,16)/b8-7+
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n/an/an/an/a 2.00E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323561
PNG
(5-bromo-4-styrylpyrimidin-2-amine | CHEMBL1209521)
Show SMILES Nc1ncc(Br)c(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H10BrN3/c13-10-8-15-12(14)16-11(10)7-6-9-4-2-1-3-5-9/h1-8H,(H2,14,15,16)/b7-6+
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n/an/an/an/a 1.30E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50263669
PNG
((1aS,7aS)-7-(hydroxyimino)-N-phenyl-1,1a,7,7a-tetr...)
Show SMILES O=NC1[C@@H]2C[C@@]2(Oc2ccccc12)C(=O)Nc1ccccc1 |r|
Show InChI InChI=1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,15H,10H2,(H,18,20)/t13-,15?,17-/m0/s1
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n/an/an/an/a 5.00E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323580
PNG
(4-(2-(furan-2-yl)vinyl)pyrimidin-2-amine | CHEMBL1...)
Show SMILES Nc1nccc(\C=C\c2ccco2)n1
Show InChI InChI=1S/C10H9N3O/c11-10-12-6-5-8(13-10)3-4-9-2-1-7-14-9/h1-7H,(H2,11,12,13)/b4-3+
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n/an/an/an/a 9.40E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323581
PNG
(4-(2-(pyridin-2-yl)vinyl)pyrimidin-2-amine | CHEMB...)
Show SMILES Nc1nccc(\C=C\c2ccccn2)n1
Show InChI InChI=1S/C11H10N4/c12-11-14-8-6-10(15-11)5-4-9-3-1-2-7-13-9/h1-8H,(H2,12,14,15)/b5-4+
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n/an/an/an/a 1.17E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323560
PNG
(5-chloro-4-styrylpyrimidin-2-amine | CHEMBL1209520)
Show SMILES Nc1ncc(Cl)c(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H10ClN3/c13-10-8-15-12(14)16-11(10)7-6-9-4-2-1-3-5-9/h1-8H,(H2,14,15,16)/b7-6+
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n/an/an/an/a 1.60E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323584
PNG
(CHEMBL1209746 | ethyl 2-oxo-2-(4-styrylpyrimidin-2...)
Show SMILES CCOC(=O)C(=O)Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C16H15N3O3/c1-2-22-15(21)14(20)19-16-17-11-10-13(18-16)9-8-12-6-4-3-5-7-12/h3-11H,2H2,1H3,(H,17,18,19,20)/b9-8+
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n/an/an/an/a 5.00E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Rattus norvegicus (Rat))		BDBM50323546
PNG
(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Show SMILES Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of rat mGluR4 expressed in CHO-K1 cells

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323565
PNG
(4-(phenylethynyl)pyrimidin-2-amine | CHEMBL1209591)
Show SMILES Nc1nccc(n1)C#Cc1ccccc1
Show InChI InChI=1S/C12H9N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-5,8-9H,(H2,13,14,15)
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n/an/an/an/a 2.00E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323567
PNG
(4-(benzofuran-2-yl)pyrimidin-2-amine | CHEMBL12095...)
Show SMILES Nc1nccc(n1)-c1cc2ccccc2o1
Show InChI InChI=1S/C12H9N3O/c13-12-14-6-5-9(15-12)11-7-8-3-1-2-4-10(8)16-11/h1-7H,(H2,13,14,15)
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n/an/an/an/a 4.90E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323573
PNG
(2-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Show SMILES Nc1nccc(\C=C\c2ccccc2C#N)n1
Show InChI InChI=1S/C13H10N4/c14-9-11-4-2-1-3-10(11)5-6-12-7-8-16-13(15)17-12/h1-8H,(H2,15,16,17)/b6-5+
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n/an/an/an/a>3.00E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323575
PNG
(4-(2-(2-aminopyrimidin-4-yl)vinyl)benzonitrile | C...)
Show SMILES Nc1nccc(\C=C\c2ccc(cc2)C#N)n1
Show InChI InChI=1S/C13H10N4/c14-9-11-3-1-10(2-4-11)5-6-12-7-8-16-13(15)17-12/h1-8H,(H2,15,16,17)/b6-5+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323576
PNG
(4-(2-methylstyryl)pyrimidin-2-amine | CHEMBL120966...)
Show SMILES Cc1ccccc1\C=C\c1ccnc(N)n1
Show InChI InChI=1S/C13H13N3/c1-10-4-2-3-5-11(10)6-7-12-8-9-15-13(14)16-12/h2-9H,1H3,(H2,14,15,16)/b7-6+
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Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323582
PNG
(4-(2-(pyridin-3-yl)vinyl)pyrimidin-2-amine | CHEMB...)
Show SMILES Nc1nccc(\C=C\c2cccnc2)n1
Show InChI InChI=1S/C11H10N4/c12-11-14-7-5-10(15-11)4-3-9-2-1-6-13-8-9/h1-8H,(H2,12,14,15)/b4-3+
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n/an/an/an/a 1.64E+4n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323555
PNG
(4,5-dimethyl-6-styrylpyrimidin-2-amine | CHEMBL120...)
Show SMILES Cc1nc(N)nc(\C=C\c2ccccc2)c1C
Show InChI InChI=1S/C14H15N3/c1-10-11(2)16-14(15)17-13(10)9-8-12-6-4-3-5-7-12/h3-9H,1-2H3,(H2,15,16,17)/b9-8+
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n/an/an/an/a 1.60E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323546
PNG
(4-((E)-styryl)-pyrimidin-2-ylamine | CHEMBL1209431)
Show SMILES Nc1nccc(\C=C\c2ccccc2)n1
Show InChI InChI=1S/C12H11N3/c13-12-14-9-8-11(15-12)7-6-10-4-2-1-3-5-10/h1-9H,(H2,13,14,15)/b7-6+
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n/an/an/an/a 1.00E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50323552
PNG
(4-styrylpyrimidine-2-thiol | CHEMBL1209437)
Show SMILES S=c1nccc(C=Cc2ccccc2)[nH]1 |w:7.7|
Show InChI InChI=1S/C12H10N2S/c15-12-13-9-8-11(14-12)7-6-10-4-2-1-3-5-10/h1-9H,(H,13,14,15)
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n/an/an/an/a 7.80E+3n/an/an/an/a



Evotec (UK) Ltd

Curated by ChEMBL


Assay Description
Positive allosteric modulation of human mGluR4 expressed in CHO-K1 cells assessed as decrease in forskolin-induced intracellular cAMP accumulation af...

Bioorg Med Chem Lett 20: 4901-5 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.078
BindingDB Entry DOI: 10.7270/Q2X34XN7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%