Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 125 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341312 ((1R,5R,8R)-Isopropyl 8-(5-Methyl-6-(2-methylpyridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341311 ((+/-)-isopropyl 8-(5-methyl-6-(2-methylpyridin-3-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341313 ((1S,5S,8S)-Isopropyl 8-(5-Methyl-6-(2-methylpyridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]isopropyl 4-(1-(4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)piperidine-1-carboxylate/tert-butyl 4-(1-(4-(methyl... | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341313 ((1S,5S,8S)-Isopropyl 8-(5-Methyl-6-(2-methylpyridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 2.07E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 84 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341312 ((1R,5R,8R)-Isopropyl 8-(5-Methyl-6-(2-methylpyridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 740 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 227 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 65 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Rattus norvegicus) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 228 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at rat GPR119 expressed in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341310 (CHEMBL1766082 | Isopropyl 9-anti-({5-Methyl-6-[(2-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341311 ((+/-)-isopropyl 8-(5-methyl-6-(2-methylpyridin-3-y...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.24E+3 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glucose-dependent insulinotropic receptor (Homo sapiens (Human)) | BDBM50341309 (CHEMBL1766081 | isopropyl 4-(5-methyl-6-(2-methylp...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 14 | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Agonist activity at GPR119 in human HEK293 cells assessed as increase in cAMP level after 16 hrs by beta-lactamase reporter gene assay | J Med Chem 54: 1948-52 (2011) Article DOI: 10.1021/jm200003p BindingDB Entry DOI: 10.7270/Q2CZ37G0 | |||||||||||
More data for this Ligand-Target Pair |