Found 45 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348344
(CHEMBL1800313)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1Br Show InChI InChI=1S/C21H20BrN3O3S/c1-13-8-19(15-6-4-5-7-16(15)24-13)29-12-20(26)25-23-11-14-9-17(27-2)21(22)18(10-14)28-3/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348333
(CHEMBL1800236)Show SMILES COc1ccc2nc(C)cc(SCC(=O)N\N=C\c3cc(OC)c(OC)c(OC)c3)c2c1 Show InChI InChI=1S/C23H25N3O5S/c1-14-8-21(17-11-16(28-2)6-7-18(17)25-14)32-13-22(27)26-24-12-15-9-19(29-3)23(31-5)20(10-15)30-4/h6-12H,13H2,1-5H3,(H,26,27)/b24-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348350
(CHEMBL1800307)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C22H23N3O4S/c1-14-9-20(16-7-5-6-8-17(16)24-14)30-13-21(26)25-23-12-15-10-18(27-2)22(29-4)19(11-15)28-3/h5-12H,13H2,1-4H3,(H,25,26)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348349
(CHEMBL1800308)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(C#N)c1OC Show InChI InChI=1S/C22H20N4O3S/c1-14-8-20(17-6-4-5-7-18(17)25-14)30-13-21(27)26-24-12-15-9-16(11-23)22(29-3)19(10-15)28-2/h4-10,12H,13H2,1-3H3,(H,26,27)/b24-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348345
(CHEMBL1800312)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1C#N Show InChI InChI=1S/C22H20N4O3S/c1-14-8-21(16-6-4-5-7-18(16)25-14)30-13-22(27)26-24-12-15-9-19(28-2)17(11-23)20(10-15)29-3/h4-10,12H,13H2,1-3H3,(H,26,27)/b24-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348335
(CHEMBL1800234)Show SMILES COc1cc(\C=N\NC(=O)CSc2ccnc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C21H21N3O4S/c1-26-17-10-14(11-18(27-2)21(17)28-3)12-23-24-20(25)13-29-19-8-9-22-16-7-5-4-6-15(16)19/h4-12H,13H2,1-3H3,(H,24,25)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348328
(CHEMBL1800240)Show SMILES COc1cc(\C=N\N(C)C(=O)CSc2cc(C)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C23H25N3O4S/c1-15-10-21(17-8-6-7-9-18(17)25-15)31-14-22(27)26(2)24-13-16-11-19(28-3)23(30-5)20(12-16)29-4/h6-13H,14H2,1-5H3/b24-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348334
(CHEMBL1800235)Show SMILES COc1cc(\C=N\NC(=O)CSc2ccnc3cc(Cl)ccc23)cc(OC)c1OC Show InChI InChI=1S/C21H20ClN3O4S/c1-27-17-8-13(9-18(28-2)21(17)29-3)11-24-25-20(26)12-30-19-6-7-23-16-10-14(22)4-5-15(16)19/h4-11H,12H2,1-3H3,(H,25,26)/b24-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348348
(CHEMBL1800309)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(Br)c1OC Show InChI InChI=1S/C21H20BrN3O3S/c1-13-8-19(15-6-4-5-7-17(15)24-13)29-12-20(26)25-23-11-14-9-16(22)21(28-3)18(10-14)27-2/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348347
(CHEMBL1800310)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(Cl)c1OC Show InChI InChI=1S/C21H20ClN3O3S/c1-13-8-19(15-6-4-5-7-17(15)24-13)29-12-20(26)25-23-11-14-9-16(22)21(28-3)18(10-14)27-2/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348327
(CHEMBL1800817)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC Show InChI InChI=1S/C21H21N3O3S/c1-14-10-20(16-6-4-5-7-17(16)23-14)28-13-21(25)24-22-12-15-8-9-18(26-2)19(11-15)27-3/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348346
(CHEMBL1800311)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc(F)c1OC Show InChI InChI=1S/C21H20FN3O3S/c1-13-8-19(15-6-4-5-7-17(15)24-13)29-12-20(26)25-23-11-14-9-16(22)21(28-3)18(10-14)27-2/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348354
(CHEMBL1800303)Show SMILES COc1cc(Br)c(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC Show InChI InChI=1S/C21H20BrN3O3S/c1-13-8-20(15-6-4-5-7-17(15)24-13)29-12-21(26)25-23-11-14-9-18(27-2)19(28-3)10-16(14)22/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348368
(CHEMBL1800821)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1Cl Show InChI InChI=1S/C20H18ClN3O2S/c1-13-9-19(15-5-3-4-6-17(15)23-13)27-12-20(25)24-22-11-14-7-8-16(21)18(10-14)26-2/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348366
(CHEMBL1800823)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1Br Show InChI InChI=1S/C20H18BrN3O2S/c1-13-9-19(15-5-3-4-6-17(15)23-13)27-12-20(25)24-22-11-14-7-8-16(21)18(10-14)26-2/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348336
(CHEMBL1800233)Show SMILES COc1cc(\C=N\NC(=O)CSc2ccc([N+]([O-])=O)c3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C22H21N3O6S/c1-29-18-10-14(11-19(30-2)22(18)31-3)12-23-24-21(26)13-32-20-9-8-17(25(27)28)15-6-4-5-7-16(15)20/h4-12H,13H2,1-3H3,(H,24,26)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348365
(CHEMBL1800824)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1C Show InChI InChI=1S/C21H21N3O2S/c1-14-8-9-16(11-19(14)26-3)12-22-24-21(25)13-27-20-10-15(2)23-18-7-5-4-6-17(18)20/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348337
(CHEMBL1800232)Show SMILES COc1cc(\C=N\NC(=O)CSc2ccc3ccccc3n2)cc(OC)c1OC Show InChI InChI=1S/C21H21N3O4S/c1-26-17-10-14(11-18(27-2)21(17)28-3)12-22-24-19(25)13-29-20-9-8-15-6-4-5-7-16(15)23-20/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348369
(CHEMBL1800820)Show SMILES COc1cc(OC)cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)c1 Show InChI InChI=1S/C21H21N3O3S/c1-14-8-20(18-6-4-5-7-19(18)23-14)28-13-21(25)24-22-12-15-9-16(26-2)11-17(10-15)27-3/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348364
(CHEMBL1800825)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1C#N Show InChI InChI=1S/C21H18N4O2S/c1-14-9-20(17-5-3-4-6-18(17)24-14)28-13-21(26)25-23-12-15-7-8-16(11-22)19(10-15)27-2/h3-10,12H,13H2,1-2H3,(H,25,26)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348330
(CHEMBL1800238)Show SMILES COc1ccc(cc1OC)C(C)=NNC(=O)CSc1cc(C)nc2ccccc12 |w:12.13| Show InChI InChI=1S/C22H23N3O3S/c1-14-11-21(17-7-5-6-8-18(17)23-14)29-13-22(26)25-24-15(2)16-9-10-19(27-3)20(12-16)28-4/h5-12H,13H2,1-4H3,(H,25,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348338
(CHEMBL1800231)Show SMILES COc1cc(\C=N\NC(=O)CSc2cccc3cccnc23)cc(OC)c1OC Show InChI InChI=1S/C21H21N3O4S/c1-26-16-10-14(11-17(27-2)21(16)28-3)12-23-24-19(25)13-29-18-8-4-6-15-7-5-9-22-20(15)18/h4-12H,13H2,1-3H3,(H,24,25)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348353
(CHEMBL1800304)Show SMILES COc1cc(F)c(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC Show InChI InChI=1S/C21H20FN3O3S/c1-13-8-20(15-6-4-5-7-17(15)24-13)29-12-21(26)25-23-11-14-9-18(27-2)19(28-3)10-16(14)22/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348367
(CHEMBL1800822)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1F Show InChI InChI=1S/C20H18FN3O2S/c1-13-9-19(15-5-3-4-6-17(15)23-13)27-12-20(25)24-22-11-14-7-8-16(21)18(10-14)26-2/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348355
(CHEMBL1800302)Show SMILES COc1cc(Cl)c(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC Show InChI InChI=1S/C21H20ClN3O3S/c1-13-8-20(15-6-4-5-7-17(15)24-13)29-12-21(26)25-23-11-14-9-18(27-2)19(28-3)10-16(14)22/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348358
(CHEMBL1800299)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1Cl Show InChI InChI=1S/C20H18ClN3O2S/c1-13-9-19(15-5-3-4-6-17(15)23-13)27-12-20(25)24-22-11-14-7-8-18(26-2)16(21)10-14/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348363
(CHEMBL1800826)Show SMILES COc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1C(F)(F)F Show InChI InChI=1S/C21H18F3N3O2S/c1-13-9-19(15-5-3-4-6-17(15)26-13)30-12-20(28)27-25-11-14-7-8-16(21(22,23)24)18(10-14)29-2/h3-11H,12H2,1-2H3,(H,27,28)/b25-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348361
(CHEMBL1800296)Show SMILES CCOc1cc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)ccc1OC Show InChI InChI=1S/C22H23N3O3S/c1-4-28-20-12-16(9-10-19(20)27-3)13-23-25-22(26)14-29-21-11-15(2)24-18-8-6-5-7-17(18)21/h5-13H,4,14H2,1-3H3,(H,25,26)/b23-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348339
(CHEMBL1800230)Show SMILES COc1cc(\C=N\NC(=O)CSc2ccc(cc2)-c2ccccc2)cc(OC)c1OC Show InChI InChI=1S/C24H24N2O4S/c1-28-21-13-17(14-22(29-2)24(21)30-3)15-25-26-23(27)16-31-20-11-9-19(10-12-20)18-7-5-4-6-8-18/h4-15H,16H2,1-3H3,(H,26,27)/b25-15+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348362
(CHEMBL1800827)Show SMILES Cc1cc(SCC(=O)N\N=C\c2ccc(OC(F)F)c(OC(F)F)c2)c2ccccc2n1 Show InChI InChI=1S/C21H17F4N3O3S/c1-12-8-18(14-4-2-3-5-15(14)27-12)32-11-19(29)28-26-10-13-6-7-16(30-20(22)23)17(9-13)31-21(24)25/h2-10,20-21H,11H2,1H3,(H,28,29)/b26-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348329
(CHEMBL1800239)Show SMILES COc1cc(\C=N\NC(=O)CN(C)c2cc(C)nc3ccccc23)cc(OC)c1OC Show InChI InChI=1S/C23H26N4O4/c1-15-10-19(17-8-6-7-9-18(17)25-15)27(2)14-22(28)26-24-13-16-11-20(29-3)23(31-5)21(12-16)30-4/h6-13H,14H2,1-5H3,(H,26,28)/b24-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348360
(CHEMBL1800297)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1C(F)(F)F Show InChI InChI=1S/C21H18F3N3O2S/c1-13-9-19(15-5-3-4-6-17(15)26-13)30-12-20(28)27-25-11-14-7-8-18(29-2)16(10-14)21(22,23)24/h3-11H,12H2,1-2H3,(H,27,28)/b25-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348340
(CHEMBL1800229)Show InChI InChI=1S/C17H19N3O4S/c1-22-14-8-12(9-15(23-2)17(14)24-3)10-19-20-16(21)11-25-13-4-6-18-7-5-13/h4-10H,11H2,1-3H3,(H,20,21)/b19-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348359
(CHEMBL1800298)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1F Show InChI InChI=1S/C20H18FN3O2S/c1-13-9-19(15-5-3-4-6-17(15)23-13)27-12-20(25)24-22-11-14-7-8-18(26-2)16(21)10-14/h3-11H,12H2,1-2H3,(H,24,25)/b22-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348341
(CHEMBL1800316)Show SMILES COc1ccccc1SCC(=O)N\N=C\c1cc(OC)c(OC)c(OC)c1 Show InChI InChI=1S/C19H22N2O5S/c1-23-14-7-5-6-8-17(14)27-12-18(22)21-20-11-13-9-15(24-2)19(26-4)16(10-13)25-3/h5-11H,12H2,1-4H3,(H,21,22)/b20-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348356
(CHEMBL1800301)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC(C)C Show InChI InChI=1S/C23H25N3O3S/c1-15(2)29-21-12-17(9-10-20(21)28-4)13-24-26-23(27)14-30-22-11-16(3)25-19-8-6-5-7-18(19)22/h5-13,15H,14H2,1-4H3,(H,26,27)/b24-13+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348342
(CHEMBL1800315)Show SMILES COc1cc(\C=N\NC(=O)CSc2ccc(OC(F)(F)F)cc2)cc(OC)c1OC Show InChI InChI=1S/C19H19F3N2O5S/c1-26-15-8-12(9-16(27-2)18(15)28-3)10-23-24-17(25)11-30-14-6-4-13(5-7-14)29-19(20,21)22/h4-10H,11H2,1-3H3,(H,24,25)/b23-10+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348343
(CHEMBL1800314)Show InChI InChI=1S/C16H18N4O4S/c1-22-12-6-11(7-13(23-2)16(12)24-3)8-19-20-14(21)9-25-15-4-5-17-10-18-15/h4-8,10H,9H2,1-3H3,(H,20,21)/b19-8+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348371
(CHEMBL1800818)Show InChI InChI=1S/C20H19N3O2S/c1-14-10-19(17-8-3-4-9-18(17)22-14)26-13-20(24)23-21-12-15-6-5-7-16(11-15)25-2/h3-12H,13H2,1-2H3,(H,23,24)/b21-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348370
(CHEMBL1800819)Show InChI InChI=1S/C20H19N3O2S/c1-14-11-19(17-5-3-4-6-18(17)22-14)26-13-20(24)23-21-12-15-7-9-16(25-2)10-8-15/h3-12H,13H2,1-2H3,(H,23,24)/b21-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348332
(CHEMBL1800237)Show SMILES COc1ccc(\C=N\NC(=O)COc2cc(C)nc3ccccc23)cc1OC Show InChI InChI=1S/C21H21N3O4/c1-14-10-19(16-6-4-5-7-17(16)23-14)28-13-21(25)24-22-12-15-8-9-18(26-2)20(11-15)27-3/h4-12H,13H2,1-3H3,(H,24,25)/b22-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348357
(CHEMBL1800300)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)cc1OC(F)(F)F Show InChI InChI=1S/C21H18F3N3O3S/c1-13-9-19(15-5-3-4-6-16(15)26-13)31-12-20(28)27-25-11-14-7-8-17(29-2)18(10-14)30-21(22,23)24/h3-11H,12H2,1-2H3,(H,27,28)/b25-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348352
(CHEMBL1800305)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)c(Cl)c1OC Show InChI InChI=1S/C21H20ClN3O3S/c1-13-10-18(15-6-4-5-7-16(15)24-13)29-12-19(26)25-23-11-14-8-9-17(27-2)21(28-3)20(14)22/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348351
(CHEMBL1800306)Show SMILES COc1ccc(\C=N\NC(=O)CSc2cc(C)nc3ccccc23)c(Br)c1OC Show InChI InChI=1S/C21H20BrN3O3S/c1-13-10-18(15-6-4-5-7-16(15)24-13)29-12-19(26)25-23-11-14-8-9-17(27-2)21(28-3)20(14)22/h4-11H,12H2,1-3H3,(H,25,26)/b23-11+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Mus musculus) | BDBM50348331
(CHEMBL1800077)Show SMILES COc1ccc(\C=N\NC(=O)CNc2cc(C)nc3ccccc23)cc1OC Show InChI InChI=1S/C21H22N4O3/c1-14-10-18(16-6-4-5-7-17(16)24-14)22-13-21(26)25-23-12-15-8-9-19(27-2)20(11-15)28-3/h4-12H,13H2,1-3H3,(H,22,24)(H,25,26)/b23-12+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Omeros Corp.
Curated by ChEMBL
| Assay Description
Inhibition of mouse PDE10A assessed as inhibition of hydrolysis of [3H]cGMP to [3H]GMP after 20 mins by scintillation counting |
Bioorg Med Chem Lett 21: 4155-9 (2011)
Article DOI: 10.1016/j.bmcl.2011.05.100
BindingDB Entry DOI: 10.7270/Q2CJ8FRT |
More data for this
Ligand-Target Pair | |
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