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PubMed code 21788139

Compile data set for download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136451
PNG
(5-Chloro-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H16ClN3O2/c1-23-17-5-3-2-4-11(17)9-16(19(23)25)22-18(24)15-10-12-8-13(20)6-7-14(12)21-15/h2-8,10,16,21H,9H2,1H3,(H,22,24)
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n/an/a 25n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136445
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((R)-2-oxo-1,...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N[C@@H]1Cc2ccccc2NC1=O
Show InChI InChI=1S/C18H14ClN3O2/c19-12-5-6-14-11(7-12)9-15(20-14)17(23)22-16-8-10-3-1-2-4-13(10)21-18(16)24/h1-7,9,16,20H,8H2,(H,21,24)(H,22,23)/t16-/m1/s1
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n/an/a 25n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136440
PNG
(5-Bromo-1H-indole-2-carboxylic acid (1-methyl-2-ox...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Br)ccc2[nH]1
Show InChI InChI=1S/C19H16BrN3O2/c1-23-17-5-3-2-4-11(17)9-16(19(23)25)22-18(24)15-10-12-8-13(20)6-7-14(12)21-15/h2-8,10,16,21H,9H2,1H3,(H,22,24)
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n/an/a 30n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136437
PNG
(5-Chloro-1H-indole-2-carboxylic acid (2-oxo-1,2,3,...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NC1Cc2ccccc2NC1=O
Show InChI InChI=1S/C18H14ClN3O2/c19-12-5-6-14-11(7-12)9-15(20-14)17(23)22-16-8-10-3-1-2-4-13(10)21-18(16)24/h1-7,9,16,20H,8H2,(H,21,24)(H,22,23)
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n/an/a 44n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136447
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((S)-2-oxo-1,...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N[C@H]1Cc2ccccc2NC1=O
Show InChI InChI=1S/C18H14ClN3O2/c19-12-5-6-14-11(7-12)9-15(20-14)17(23)22-16-8-10-3-1-2-4-13(10)21-18(16)24/h1-7,9,16,20H,8H2,(H,21,24)(H,22,23)/t16-/m0/s1
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n/an/a 47n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136428
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((S)-1-methyl...)
Show SMILES CN1C(=O)[C@H](Cc2ccccc12)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H16ClN3O2/c1-23-17-5-3-2-4-11(17)9-16(19(23)25)22-18(24)15-10-12-8-13(20)6-7-14(12)21-15/h2-8,10,16,21H,9H2,1H3,(H,22,24)/t16-/m0/s1
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n/an/a 57n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136448
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((R)-1-methyl...)
Show SMILES CN1C(=O)[C@@H](Cc2ccccc12)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C19H16ClN3O2/c1-23-17-5-3-2-4-11(17)9-16(19(23)25)22-18(24)15-10-12-8-13(20)6-7-14(12)21-15/h2-8,10,16,21H,9H2,1H3,(H,22,24)/t16-/m1/s1
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n/an/a 61n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136424
PNG
(5-Chloro-7-fluoro-1H-indole-2-carboxylic acid (1-m...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)cc(F)c2[nH]1
Show InChI InChI=1S/C19H15ClFN3O2/c1-24-16-5-3-2-4-10(16)7-15(19(24)26)23-18(25)14-8-11-6-12(20)9-13(21)17(11)22-14/h2-6,8-9,15,22H,7H2,1H3,(H,23,25)
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n/an/a 83n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136450
PNG
(7-Chloro-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cccc(Cl)c2[nH]1
Show InChI InChI=1S/C19H16ClN3O2/c1-23-16-8-3-2-5-11(16)9-15(19(23)25)22-18(24)14-10-12-6-4-7-13(20)17(12)21-14/h2-8,10,15,21H,9H2,1H3,(H,22,24)
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n/an/a 88n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136416
PNG
(6-Chloro-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2ccc(Cl)cc2[nH]1
Show InChI InChI=1S/C19H16ClN3O2/c1-23-17-5-3-2-4-12(17)9-16(19(23)25)22-18(24)15-8-11-6-7-13(20)10-14(11)21-15/h2-8,10,16,21H,9H2,1H3,(H,22,24)
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n/an/a 99n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136430
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((R)-2-oxo-2,...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N[C@@H]1CCc2ccccc2NC1=O
Show InChI InChI=1S/C19H16ClN3O2/c20-13-6-8-15-12(9-13)10-17(21-15)19(25)23-16-7-5-11-3-1-2-4-14(11)22-18(16)24/h1-4,6,8-10,16,21H,5,7H2,(H,22,24)(H,23,25)/t16-/m1/s1
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n/an/a 99n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136435
PNG
(5-Chloro-1H-indole-2-carboxylic acid (2-oxo-2,3,4,...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NC1CCc2ccccc2NC1=O
Show InChI InChI=1S/C19H16ClN3O2/c20-13-6-8-15-12(9-13)10-17(21-15)19(25)23-16-7-5-11-3-1-2-4-14(11)22-18(16)24/h1-4,6,8-10,16,21H,5,7H2,(H,22,24)(H,23,25)
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n/an/a 105n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136425
PNG
(5-Chloro-1H-indole-2-carboxylic acid (2-oxo-1-pyri...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NC1Cc2ccccc2N(Cc2ccccn2)C1=O
Show InChI InChI=1S/C24H19ClN4O2/c25-17-8-9-19-16(11-17)13-20(27-19)23(30)28-21-12-15-5-1-2-7-22(15)29(24(21)31)14-18-6-3-4-10-26-18/h1-11,13,21,27H,12,14H2,(H,28,30)
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n/an/a 110n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136443
PNG
(5-Methyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(C)ccc2[nH]1
Show InChI InChI=1S/C20H19N3O2/c1-12-7-8-15-14(9-12)11-16(21-15)19(24)22-17-10-13-5-3-4-6-18(13)23(2)20(17)25/h3-9,11,17,21H,10H2,1-2H3,(H,22,24)
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n/an/a 120n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136414
PNG
(5-Fluoro-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(F)ccc2[nH]1
Show InChI InChI=1S/C19H16FN3O2/c1-23-17-5-3-2-4-11(17)9-16(19(23)25)22-18(24)15-10-12-8-13(20)6-7-14(12)21-15/h2-8,10,16,21H,9H2,1H3,(H,22,24)
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n/an/a 120n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136420
PNG
(5-Chloro-1H-indole-2-carboxylic acid (2-oxo-1-pyri...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NC1Cc2ccccc2N(Cc2cccnc2)C1=O
Show InChI InChI=1S/C24H19ClN4O2/c25-18-7-8-19-17(10-18)12-20(27-19)23(30)28-21-11-16-5-1-2-6-22(16)29(24(21)31)14-15-4-3-9-26-13-15/h1-10,12-13,21,27H,11,14H2,(H,28,30)
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n/an/a 130n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136429
PNG
(5-Chloro-1H-indole-2-carboxylic acid [1-(5-methyl-...)
Show SMILES Cc1nnc(CN2C(=O)C(Cc3ccccc23)NC(=O)c2cc3cc(Cl)ccc3[nH]2)[nH]1
Show InChI InChI=1S/C22H19ClN6O2/c1-12-24-20(28-27-12)11-29-19-5-3-2-4-13(19)9-18(22(29)31)26-21(30)17-10-14-8-15(23)6-7-16(14)25-17/h2-8,10,18,25H,9,11H2,1H3,(H,26,30)(H,24,27,28)
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n/an/a 140n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136418
PNG
(1H-Indole-2-carboxylic acid (1-methyl-2-oxo-1,2,3,...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H17N3O2/c1-22-17-9-5-3-7-13(17)11-16(19(22)24)21-18(23)15-10-12-6-2-4-8-14(12)20-15/h2-10,16,20H,11H2,1H3,(H,21,23)
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n/an/a 160n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136441
PNG
(5-Chloro-1H-indole-2-carboxylic acid {1-[5-(1H-imi...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)NC1Cc2ccccc2N(Cc2nnc([nH]2)-c2ncc[nH]2)C1=O
Show InChI InChI=1S/C24H19ClN8O2/c25-15-5-6-16-14(9-15)11-17(28-16)23(34)29-18-10-13-3-1-2-4-19(13)33(24(18)35)12-20-30-22(32-31-20)21-26-7-8-27-21/h1-9,11,18,28H,10,12H2,(H,26,27)(H,29,34)(H,30,31,32)
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n/an/a 160n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136417
PNG
(5-Cyano-1H-indole-2-carboxylic acid (1-methyl-2-ox...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(ccc2[nH]1)C#N
Show InChI InChI=1S/C20H16N4O2/c1-24-18-5-3-2-4-13(18)9-17(20(24)26)23-19(25)16-10-14-8-12(11-21)6-7-15(14)22-16/h2-8,10,17,22H,9H2,1H3,(H,23,25)
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n/an/a 180n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136442
PNG
(5-Chloro-1H-indole-2-carboxylic acid ((S)-2-oxo-2,...)
Show SMILES Clc1ccc2[nH]c(cc2c1)C(=O)N[C@H]1CCc2ccccc2NC1=O
Show InChI InChI=1S/C19H16ClN3O2/c20-13-6-8-15-12(9-13)10-17(21-15)19(25)23-16-7-5-11-3-1-2-4-14(11)22-18(16)24/h1-4,6,8-10,16,21H,5,7H2,(H,22,24)(H,23,25)/t16-/m0/s1
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n/an/a 240n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136434
PNG
(7-Nitro-1H-indole-2-carboxylic acid (1-methyl-2-ox...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cccc([N+]([O-])=O)c2[nH]1
Show InChI InChI=1S/C19H16N4O4/c1-22-15-7-3-2-5-11(15)9-14(19(22)25)21-18(24)13-10-12-6-4-8-16(23(26)27)17(12)20-13/h2-8,10,14,20H,9H2,1H3,(H,21,24)
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n/an/a 300n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136444
PNG
(5-Chloro-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1c2ccccc2CCC(NC(=O)c2cc3cc(Cl)ccc3[nH]2)C1=O
Show InChI InChI=1S/C20H18ClN3O2/c1-24-18-5-3-2-4-12(18)6-8-16(20(24)26)23-19(25)17-11-13-10-14(21)7-9-15(13)22-17/h2-5,7,9-11,16,22H,6,8H2,1H3,(H,23,25)
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n/an/a 305n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136433
PNG
(7-Amino-1H-indole-2-carboxylic acid (1-methyl-2-ox...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cccc(N)c2[nH]1
Show InChI InChI=1S/C19H18N4O2/c1-23-16-8-3-2-5-11(16)9-15(19(23)25)22-18(24)14-10-12-6-4-7-13(20)17(12)21-14/h2-8,10,15,21H,9,20H2,1H3,(H,22,24)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136419
PNG
(3,4-Dichloro-N-(2-oxo-1,2,3,4-tetrahydro-quinolin-...)
Show SMILES Clc1ccc(cc1Cl)C(=O)NC1Cc2ccccc2NC1=O
Show InChI InChI=1S/C16H12Cl2N2O2/c17-11-6-5-10(7-12(11)18)15(21)20-14-8-9-3-1-2-4-13(9)19-16(14)22/h1-7,14H,8H2,(H,19,22)(H,20,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136449
PNG
(5-Trifluoromethyl-1H-indole-2-carboxylic acid (1-m...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(ccc2[nH]1)C(F)(F)F
Show InChI InChI=1S/C20H16F3N3O2/c1-26-17-5-3-2-4-11(17)9-16(19(26)28)25-18(27)15-10-12-8-13(20(21,22)23)6-7-14(12)24-15/h2-8,10,16,24H,9H2,1H3,(H,25,27)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136439
PNG
(4-Chloro-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2c(Cl)cccc2[nH]1
Show InChI InChI=1S/C19H16ClN3O2/c1-23-17-8-3-2-5-11(17)9-16(19(23)25)22-18(24)15-10-12-13(20)6-4-7-14(12)21-15/h2-8,10,16,21H,9H2,1H3,(H,22,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136415
PNG
(5-Methoxy-1H-indole-2-carboxylic acid (1-methyl-2-...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)NC1Cc2ccccc2N(C)C1=O
Show InChI InChI=1S/C20H19N3O3/c1-23-18-6-4-3-5-12(18)10-17(20(23)25)22-19(24)16-11-13-9-14(26-2)7-8-15(13)21-16/h3-9,11,17,21H,10H2,1-2H3,(H,22,24)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136438
PNG
(5-Ethyl-1H-indole-2-carboxylic acid (1-methyl-2-ox...)
Show SMILES CCc1ccc2[nH]c(cc2c1)C(=O)NC1Cc2ccccc2N(C)C1=O
Show InChI InChI=1S/C21H21N3O2/c1-3-13-8-9-16-15(10-13)12-17(22-16)20(25)23-18-11-14-6-4-5-7-19(14)24(2)21(18)26/h4-10,12,18,22H,3,11H2,1-2H3,(H,23,25)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350687
PNG
(CHEMBL1814684)
Show SMILES Clc1ccccc1NC(=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C15H13ClN2O2/c16-12-8-4-5-9-13(12)18-15(20)14(19)17-10-11-6-2-1-3-7-11/h1-9H,10H2,(H,17,19)(H,18,20)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350688
PNG
(CHEMBL1814498)
Show SMILES Clc1cccc(c1)-c1nnc(o1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C18H11ClN2O/c19-16-7-3-6-14(11-16)17-20-21-18(22-17)15-9-8-12-4-1-2-5-13(12)10-15/h1-11H
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n/an/a 3.20E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350692
PNG
(CHEMBL1814507)
Show SMILES COc1ccc(cc1)C(=O)CC(=O)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C16H13NO5/c1-22-14-7-5-11(6-8-14)15(18)10-16(19)12-3-2-4-13(9-12)17(20)21/h2-9H,10H2,1H3
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n/an/a 4.10E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136432
PNG
(2-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl...)
Show SMILES COC(=O)c1ccc2[nH]c(cc2c1)C(=O)NC1Cc2ccccc2N(C)C1=O
Show InChI InChI=1S/C21H19N3O4/c1-24-18-6-4-3-5-12(18)10-17(20(24)26)23-19(25)16-11-14-9-13(21(27)28-2)7-8-15(14)22-16/h3-9,11,17,22H,10H2,1-2H3,(H,23,25)
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n/an/a 5.30E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350694
PNG
(CHEMBL1504147)
Show SMILES Cc1ccccc1NC(=O)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C16H16N2O2/c1-11-7-3-5-9-13(11)17-15(19)16(20)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H,17,19)(H,18,20)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350693
PNG
(CHEMBL128249)
Show SMILES Cc1cc(c(S)cc1Cl)S(=O)(=O)Nc1nnc2c(cc(Cl)cn12)C(F)(F)F
Show InChI InChI=1S/C14H9Cl2F3N4O2S2/c1-6-2-11(10(26)4-9(6)16)27(24,25)22-13-21-20-12-8(14(17,18)19)3-7(15)5-23(12)13/h2-5,26H,1H3,(H,21,22)
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n/an/a 5.90E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136413
PNG
(3,4-Dichloro-N-(2-oxo-2,3,4,5-tetrahydro-1H-benzo[...)
Show SMILES Clc1ccc(cc1Cl)C(=O)NC1CCc2ccccc2NC1=O
Show InChI InChI=1S/C17H14Cl2N2O2/c18-12-7-5-11(9-13(12)19)16(22)21-15-8-6-10-3-1-2-4-14(10)20-17(15)23/h1-5,7,9,15H,6,8H2,(H,20,23)(H,21,22)
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n/an/a 6.40E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350690
PNG
(CHEMBL128850)
Show SMILES Cc1cc(c(S)cc1Cl)S(=O)(=O)Nc1nc2ccccc2[nH]1
Show InChI InChI=1S/C14H12ClN3O2S2/c1-8-6-13(12(21)7-9(8)15)22(19,20)18-14-16-10-4-2-3-5-11(10)17-14/h2-7,21H,1H3,(H2,16,17,18)
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n/an/a 6.90E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350691
PNG
(CHEMBL338902)
Show SMILES Cc1cc(c(S)cc1Cl)S(=O)(=O)Nc1nnc2c3ccccc3ccn12
Show InChI InChI=1S/C17H13ClN4O2S2/c1-10-8-15(14(25)9-13(10)18)26(23,24)21-17-20-19-16-12-5-3-2-4-11(12)6-7-22(16)17/h2-9,25H,1H3,(H,20,21)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, muscle form


(Oryctolagus cuniculus (rabbit))		BDBM50350689
PNG
(CHEMBL1814500)
Show SMILES Cc1ccc(cc1)S(=O)(=O)CC1CCc2ccccc2C1=O
Show InChI InChI=1S/C18H18O3S/c1-13-6-10-16(11-7-13)22(20,21)12-15-9-8-14-4-2-3-5-17(14)18(15)19/h2-7,10-11,15H,8-9,12H2,1H3
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n/an/a 1.65E+4n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of rabbit muscle glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136427
PNG
(5-Chloro-2-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quin...)
Show SMILES COC(=O)c1cc2[nH]c(cc2cc1Cl)C(=O)NC1Cc2ccccc2N(C)C1=O
Show InChI InChI=1S/C21H18ClN3O4/c1-25-18-6-4-3-5-11(18)8-17(20(25)27)24-19(26)16-9-12-7-14(22)13(21(28)29-2)10-15(12)23-16/h3-7,9-10,17,23H,8H2,1-2H3,(H,24,26)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136426
PNG
(6-Phenyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2ccc(cc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C25H21N3O2/c1-28-23-10-6-5-9-19(23)15-22(25(28)30)27-24(29)21-14-18-12-11-17(13-20(18)26-21)16-7-3-2-4-8-16/h2-14,22,26H,15H2,1H3,(H,27,29)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136431
PNG
(5-Phenyl-1H-indole-2-carboxylic acid (1-methyl-2-o...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(ccc2[nH]1)-c1ccccc1
Show InChI InChI=1S/C25H21N3O2/c1-28-23-10-6-5-9-18(23)14-22(25(28)30)27-24(29)21-15-19-13-17(11-12-20(19)26-21)16-7-3-2-4-8-16/h2-13,15,22,26H,14H2,1H3,(H,27,29)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136422
PNG
(5-Chloro-2-(1-methyl-2-oxo-1,2,3,4-tetrahydro-quin...)
Show SMILES COC(=O)c1c(Cl)ccc2[nH]c(cc12)C(=O)NC1Cc2ccccc2N(C)C1=O
Show InChI InChI=1S/C21H18ClN3O4/c1-25-17-6-4-3-5-11(17)9-16(20(25)27)24-19(26)15-10-12-14(23-15)8-7-13(22)18(12)21(28)29-2/h3-8,10,16,23H,9H2,1-2H3,(H,24,26)
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n/an/a>2.00E+4n/an/an/an/an/an/a



Applied Science University

Curated by ChEMBL


Assay Description
Inhibition of human liver glycogen phosphorylase 1a assessed as release of phosphate from glucose-1- phosphate after 20 mins

Bioorg Med Chem 19: 4746-71 (2011)


Article DOI: 10.1016/j.bmc.2011.06.086
BindingDB Entry DOI: 10.7270/Q2028RXJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%