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PubMed code 22030028

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Homo sapiens (Human))		BDBM50358810
PNG
(CHEMBL1922938)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(OC(F)(F)F)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C34H32F6N2O5/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(46)41-16-15-30(43)44)31(45)29-19-24-18-27(47-34(38,39)40)13-14-28(24)42(29)26-8-5-7-25(20-26)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,41,46)(H,43,44)/t23-/m0/s1
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n/an/a 5.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358803
PNG
(CHEMBL1922930)
Show SMILES CCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C30H27ClF3N3O4/c1-2-4-20(15-18-7-9-19(10-8-18)29(41)35-14-13-27(38)39)28(40)24-17-21-16-22(31)11-12-23(21)37(24)26-6-3-5-25(36-26)30(32,33)34/h3,5-12,16-17,20H,2,4,13-15H2,1H3,(H,35,41)(H,38,39)/t20-/m0/s1
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n/an/a 9.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358808
PNG
(CHEMBL1922936)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(F)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32F4N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358812
PNG
(CHEMBL1922940)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(C)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C34H35F3N2O4/c1-3-4-5-7-25(19-23-11-13-24(14-12-23)33(43)38-17-16-31(40)41)32(42)30-20-26-18-22(2)10-15-29(26)39(30)28-9-6-8-27(21-28)34(35,36)37/h6,8-15,18,20-21,25H,3-5,7,16-17,19H2,1-2H3,(H,38,43)(H,40,41)/t25-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358825
PNG
(CHEMBL1922926)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C31H27Cl2F3N2O4/c1-2-3-20(14-18-4-6-19(7-5-18)30(42)37-13-12-28(39)40)29(41)27-16-21-15-22(32)8-11-26(21)38(27)23-9-10-25(33)24(17-23)31(34,35)36/h4-11,15-17,20H,2-3,12-14H2,1H3,(H,37,42)(H,39,40)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358811
PNG
(CHEMBL1922939)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(ccc2n1-c1cccc(c1)C(F)(F)F)C(F)(F)F |r|
Show InChI InChI=1S/C34H32F6N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(46)41-16-15-30(43)44)31(45)29-19-24-18-26(34(38,39)40)13-14-28(24)42(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,41,46)(H,43,44)/t23-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358805
PNG
(CHEMBL1922932)
Show SMILES CCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C32H30ClF3N2O4/c1-2-3-5-22(16-20-8-10-21(11-9-20)31(42)37-15-14-29(39)40)30(41)28-18-23-17-25(33)12-13-27(23)38(28)26-7-4-6-24(19-26)32(34,35)36/h4,6-13,17-19,22H,2-3,5,14-16H2,1H3,(H,37,42)(H,39,40)/t22-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358814
PNG
(CHEMBL1922915)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1Cc1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C35H39ClN2O4/c1-5-6-26(19-23-7-11-25(12-8-23)34(42)37-18-17-32(39)40)33(41)31-21-27-20-29(36)15-16-30(27)38(31)22-24-9-13-28(14-10-24)35(2,3)4/h7-16,20-21,26H,5-6,17-19,22H2,1-4H3,(H,37,42)(H,39,40)
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n/an/a 16n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358820
PNG
(CHEMBL1922921)
Show SMILES CCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C31H28ClF3N2O4/c1-2-4-21(15-19-7-9-20(10-8-19)30(41)36-14-13-28(38)39)29(40)27-17-22-16-24(32)11-12-26(22)37(27)25-6-3-5-23(18-25)31(33,34)35/h3,5-12,16-18,21H,2,4,13-15H2,1H3,(H,36,41)(H,38,39)/t21-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358825
PNG
(CHEMBL1922926)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C31H27Cl2F3N2O4/c1-2-3-20(14-18-4-6-19(7-5-18)30(42)37-13-12-28(39)40)29(41)27-16-21-15-22(32)8-11-26(21)38(27)23-9-10-25(33)24(17-23)31(34,35)36/h4-11,15-17,20H,2-3,12-14H2,1H3,(H,37,42)(H,39,40)
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n/an/a 17n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358810
PNG
(CHEMBL1922938)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(OC(F)(F)F)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C34H32F6N2O5/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(46)41-16-15-30(43)44)31(45)29-19-24-18-27(47-34(38,39)40)13-14-28(24)42(29)26-8-5-7-25(20-26)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,41,46)(H,43,44)/t23-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358806
PNG
(CHEMBL1922934)
Show SMILES CC(C)CC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-20(2)6-9-23(16-21-7-10-22(11-8-21)32(43)38-15-14-30(40)41)31(42)29-18-24-17-26(34)12-13-28(24)39(29)27-5-3-4-25(19-27)33(35,36)37/h3-5,7-8,10-13,17-20,23H,6,9,14-16H2,1-2H3,(H,38,43)(H,40,41)/t23-/m0/s1
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358808
PNG
(CHEMBL1922936)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(F)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32F4N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358824
PNG
(CHEMBL1922925)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(OC)c(c1)C(F)(F)F
Show InChI InChI=1S/C32H30ClF3N2O5/c1-3-4-21(15-19-5-7-20(8-6-19)31(42)37-14-13-29(39)40)30(41)27-17-22-16-23(33)9-11-26(22)38(27)24-10-12-28(43-2)25(18-24)32(34,35)36/h5-12,16-18,21H,3-4,13-15H2,1-2H3,(H,37,42)(H,39,40)
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n/an/a 23n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358812
PNG
(CHEMBL1922940)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(C)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C34H35F3N2O4/c1-3-4-5-7-25(19-23-11-13-24(14-12-23)33(43)38-17-16-31(40)41)32(42)30-20-26-18-22(2)10-15-29(26)39(30)28-9-6-8-27(21-28)34(35,36)37/h6,8-15,18,20-21,25H,3-5,7,16-17,19H2,1-2H3,(H,38,43)(H,40,41)/t25-/m0/s1
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n/an/a 24n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358819
PNG
(CHEMBL1922920)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C31H28ClF3N2O5/c1-2-4-21(15-19-7-9-20(10-8-19)30(41)36-14-13-28(38)39)29(40)27-17-22-16-23(32)11-12-26(22)37(27)24-5-3-6-25(18-24)42-31(33,34)35/h3,5-12,16-18,21H,2,4,13-15H2,1H3,(H,36,41)(H,38,39)
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n/an/a 24n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358809
PNG
(CHEMBL1922937)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(OC)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C34H35F3N2O5/c1-3-4-5-7-24(18-22-10-12-23(13-11-22)33(43)38-17-16-31(40)41)32(42)30-20-25-19-28(44-2)14-15-29(25)39(30)27-9-6-8-26(21-27)34(35,36)37/h6,8-15,19-21,24H,3-5,7,16-18H2,1-2H3,(H,38,43)(H,40,41)/t24-/m0/s1
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n/an/a 26n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358801
PNG
(CHEMBL1922928)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc2OCCOc2c1
Show InChI InChI=1S/C32H31ClN2O6/c1-2-3-22(16-20-4-6-21(7-5-20)32(39)34-13-12-30(36)37)31(38)27-18-23-17-24(33)8-10-26(23)35(27)25-9-11-28-29(19-25)41-15-14-40-28/h4-11,17-19,22H,2-3,12-16H2,1H3,(H,34,39)(H,36,37)
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n/an/a 28n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358817
PNG
(CHEMBL1922918)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C31H28ClF3N2O5/c1-2-3-21(16-19-4-6-20(7-5-19)30(41)36-15-14-28(38)39)29(40)27-18-22-17-23(32)8-13-26(22)37(27)24-9-11-25(12-10-24)42-31(33,34)35/h4-13,17-18,21H,2-3,14-16H2,1H3,(H,36,41)(H,38,39)
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n/an/a 28n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358818
PNG
(CHEMBL1922919)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C31H28ClF3N2O4/c1-2-3-21(16-19-4-6-20(7-5-19)30(41)36-15-14-28(38)39)29(40)27-18-22-17-24(32)10-13-26(22)37(27)25-11-8-23(9-12-25)31(33,34)35/h4-13,17-18,21H,2-3,14-16H2,1H3,(H,36,41)(H,38,39)
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n/an/a 30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358818
PNG
(CHEMBL1922919)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C31H28ClF3N2O4/c1-2-3-21(16-19-4-6-20(7-5-19)30(41)36-15-14-28(38)39)29(40)27-18-22-17-24(32)10-13-26(22)37(27)25-11-8-23(9-12-25)31(33,34)35/h4-13,17-18,21H,2-3,14-16H2,1H3,(H,36,41)(H,38,39)
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n/an/a 31n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358816
PNG
(CHEMBL1922917)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C30H28Cl2N2O4/c1-2-3-21(16-19-4-6-20(7-5-19)30(38)33-15-14-28(35)36)29(37)27-18-22-17-24(32)10-13-26(22)34(27)25-11-8-23(31)9-12-25/h4-13,17-18,21H,2-3,14-16H2,1H3,(H,33,38)(H,35,36)
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n/an/a 32n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358800
PNG
(CHEMBL1922927)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc2cc(OC)ccc2c1
Show InChI InChI=1S/C35H33ClN2O5/c1-3-4-26(17-22-5-7-23(8-6-22)35(42)37-16-15-33(39)40)34(41)32-21-27-18-28(36)11-14-31(27)38(32)29-12-9-25-20-30(43-2)13-10-24(25)19-29/h5-14,18-21,26H,3-4,15-17H2,1-2H3,(H,37,42)(H,39,40)
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n/an/a 34n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358803
PNG
(CHEMBL1922930)
Show SMILES CCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C30H27ClF3N3O4/c1-2-4-20(15-18-7-9-19(10-8-18)29(41)35-14-13-27(38)39)28(40)24-17-21-16-22(31)11-12-23(21)37(24)26-6-3-5-25(36-26)30(32,33)34/h3,5-12,16-17,20H,2,4,13-15H2,1H3,(H,35,41)(H,38,39)/t20-/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358809
PNG
(CHEMBL1922937)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(OC)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C34H35F3N2O5/c1-3-4-5-7-24(18-22-10-12-23(13-11-22)33(43)38-17-16-31(40)41)32(42)30-20-25-19-28(44-2)14-15-29(25)39(30)27-9-6-8-26(21-27)34(35,36)37/h6,8-15,19-21,24H,3-5,7,16-18H2,1-2H3,(H,38,43)(H,40,41)/t24-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358819
PNG
(CHEMBL1922920)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C31H28ClF3N2O5/c1-2-4-21(15-19-7-9-20(10-8-19)30(41)36-14-13-28(38)39)29(40)27-17-22-16-23(32)11-12-26(22)37(27)24-5-3-6-25(18-24)42-31(33,34)35/h3,5-12,16-18,21H,2,4,13-15H2,1H3,(H,36,41)(H,38,39)
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n/an/a 35n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358806
PNG
(CHEMBL1922934)
Show SMILES CC(C)CC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-20(2)6-9-23(16-21-7-10-22(11-8-21)32(43)38-15-14-30(40)41)31(42)29-18-24-17-26(34)12-13-28(24)39(29)27-5-3-4-25(19-27)33(35,36)37/h3-5,7-8,10-13,17-20,23H,6,9,14-16H2,1-2H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358807
PNG
(CHEMBL1922935)
Show SMILES OC(=O)CCNC(=O)c1ccc(C[C@H](CC2CC2)C(=O)c2cc3cc(Cl)ccc3n2-c2cccc(c2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C32H28ClF3N2O4/c33-25-10-11-27-22(16-25)17-28(38(27)26-3-1-2-24(18-26)32(34,35)36)30(41)23(14-19-4-5-19)15-20-6-8-21(9-7-20)31(42)37-13-12-29(39)40/h1-3,6-11,16-19,23H,4-5,12-15H2,(H,37,42)(H,39,40)/t23-/m0/s1
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n/an/a 37n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358824
PNG
(CHEMBL1922925)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(OC)c(c1)C(F)(F)F
Show InChI InChI=1S/C32H30ClF3N2O5/c1-3-4-21(15-19-5-7-20(8-6-19)31(42)37-14-13-29(39)40)30(41)27-17-22-16-23(33)9-11-26(22)38(27)24-10-12-28(43-2)25(18-24)32(34,35)36/h5-12,16-18,21H,3-4,13-15H2,1-2H3,(H,37,42)(H,39,40)
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n/an/a 39n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358805
PNG
(CHEMBL1922932)
Show SMILES CCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C32H30ClF3N2O4/c1-2-3-5-22(16-20-8-10-21(11-9-20)31(42)37-15-14-29(39)40)30(41)28-18-23-17-25(33)12-13-27(23)38(28)26-7-4-6-24(19-26)32(34,35)36/h4,6-13,17-19,22H,2-3,5,14-16H2,1H3,(H,37,42)(H,39,40)/t22-/m0/s1
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n/an/a 42n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358811
PNG
(CHEMBL1922939)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(ccc2n1-c1cccc(c1)C(F)(F)F)C(F)(F)F |r|
Show InChI InChI=1S/C34H32F6N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(46)41-16-15-30(43)44)31(45)29-19-24-18-26(34(38,39)40)13-14-28(24)42(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,41,46)(H,43,44)/t23-/m0/s1
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n/an/a 44n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358817
PNG
(CHEMBL1922918)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C31H28ClF3N2O5/c1-2-3-21(16-19-4-6-20(7-5-19)30(41)36-15-14-28(38)39)29(40)27-18-22-17-23(32)8-13-26(22)37(27)24-9-11-25(12-10-24)42-31(33,34)35/h4-13,17-18,21H,2-3,14-16H2,1H3,(H,36,41)(H,38,39)
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n/an/a 45n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358821
PNG
(CHEMBL1922922)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(F)c1
Show InChI InChI=1S/C30H28ClFN2O4/c1-2-4-21(15-19-7-9-20(10-8-19)30(38)33-14-13-28(35)36)29(37)27-17-22-16-23(31)11-12-26(22)34(27)25-6-3-5-24(32)18-25/h3,5-12,16-18,21H,2,4,13-15H2,1H3,(H,33,38)(H,35,36)
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n/an/a 47n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358801
PNG
(CHEMBL1922928)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc2OCCOc2c1
Show InChI InChI=1S/C32H31ClN2O6/c1-2-3-22(16-20-4-6-21(7-5-20)32(39)34-13-12-30(36)37)31(38)27-18-23-17-24(33)8-10-26(23)35(27)25-9-11-28-29(19-25)41-15-14-40-28/h4-11,17-19,22H,2-3,12-16H2,1H3,(H,34,39)(H,36,37)
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n/an/a 49n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358813
PNG
(CHEMBL1922914)
Show SMILES FC(F)(F)Oc1ccc(cc1)C(=O)c1cc2ccc(cc2n1Cc1ccc(cc1)C(=O)Nc1nnn[nH]1)C(F)(F)F
Show InChI InChI=1S/C26H16F6N6O3/c27-25(28,29)18-8-5-17-11-21(22(39)15-6-9-19(10-7-15)41-26(30,31)32)38(20(17)12-18)13-14-1-3-16(4-2-14)23(40)33-24-34-36-37-35-24/h1-12H,13H2,(H2,33,34,35,36,37,40)
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n/an/a 51n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358815
PNG
(CHEMBL1922916)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C34H37ClN2O4/c1-5-6-24(19-22-7-9-23(10-8-22)33(41)36-18-17-31(38)39)32(40)30-21-25-20-27(35)13-16-29(25)37(30)28-14-11-26(12-15-28)34(2,3)4/h7-16,20-21,24H,5-6,17-19H2,1-4H3,(H,36,41)(H,38,39)
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n/an/a 52n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358815
PNG
(CHEMBL1922916)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C34H37ClN2O4/c1-5-6-24(19-22-7-9-23(10-8-22)33(41)36-18-17-31(38)39)32(40)30-21-25-20-27(35)13-16-29(25)37(30)28-14-11-26(12-15-28)34(2,3)4/h7-16,20-21,24H,5-6,17-19H2,1-4H3,(H,36,41)(H,38,39)
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n/an/a 52n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358820
PNG
(CHEMBL1922921)
Show SMILES CCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C31H28ClF3N2O4/c1-2-4-21(15-19-7-9-20(10-8-19)30(41)36-14-13-28(38)39)29(40)27-17-22-16-24(32)11-12-26(22)37(27)25-6-3-5-23(18-25)31(33,34)35/h3,5-12,16-18,21H,2,4,13-15H2,1H3,(H,36,41)(H,38,39)/t21-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358807
PNG
(CHEMBL1922935)
Show SMILES OC(=O)CCNC(=O)c1ccc(C[C@H](CC2CC2)C(=O)c2cc3cc(Cl)ccc3n2-c2cccc(c2)C(F)(F)F)cc1 |r|
Show InChI InChI=1S/C32H28ClF3N2O4/c33-25-10-11-27-22(16-25)17-28(38(27)26-3-1-2-24(18-26)32(34,35)36)30(41)23(14-19-4-5-19)15-20-6-8-21(9-7-20)31(42)37-13-12-29(39)40/h1-3,6-11,16-19,23H,4-5,12-15H2,(H,37,42)(H,39,40)/t23-/m0/s1
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n/an/a 55n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358802
PNG
(CHEMBL1922929)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cnc2ccccc2c1
Show InChI InChI=1S/C33H30ClN3O4/c1-2-5-24(16-21-8-10-22(11-9-21)33(41)35-15-14-31(38)39)32(40)30-19-25-17-26(34)12-13-29(25)37(30)27-18-23-6-3-4-7-28(23)36-20-27/h3-4,6-13,17-20,24H,2,5,14-16H2,1H3,(H,35,41)(H,38,39)
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n/an/a 58n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358800
PNG
(CHEMBL1922927)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc2cc(OC)ccc2c1
Show InChI InChI=1S/C35H33ClN2O5/c1-3-4-26(17-22-5-7-23(8-6-22)35(42)37-16-15-33(39)40)34(41)32-21-27-18-28(36)11-14-31(27)38(32)29-12-9-25-20-30(43-2)13-10-24(25)19-29/h5-14,18-21,26H,3-4,15-17H2,1-2H3,(H,37,42)(H,39,40)
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n/an/a 95n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358816
PNG
(CHEMBL1922917)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C30H28Cl2N2O4/c1-2-3-21(16-19-4-6-20(7-5-19)30(38)33-15-14-28(35)36)29(37)27-18-22-17-24(32)10-13-26(22)34(27)25-11-8-23(31)9-12-25/h4-13,17-18,21H,2-3,14-16H2,1H3,(H,33,38)(H,35,36)
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n/an/a 100n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358822
PNG
(CHEMBL1922923)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C30H27Cl3N2O4/c1-2-3-20(12-18-4-6-19(7-5-18)30(39)34-11-10-28(36)37)29(38)27-14-21-13-22(31)8-9-26(21)35(27)25-16-23(32)15-24(33)17-25/h4-9,13-17,20H,2-3,10-12H2,1H3,(H,34,39)(H,36,37)
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n/an/a 110n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358823
PNG
(CHEMBL1922924)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cc(C)cc(C)c1
Show InChI InChI=1S/C32H33ClN2O4/c1-4-5-24(17-22-6-8-23(9-7-22)32(39)34-13-12-30(36)37)31(38)29-19-25-18-26(33)10-11-28(25)35(29)27-15-20(2)14-21(3)16-27/h6-11,14-16,18-19,24H,4-5,12-13,17H2,1-3H3,(H,34,39)(H,36,37)
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n/an/a 120n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358821
PNG
(CHEMBL1922922)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(F)c1
Show InChI InChI=1S/C30H28ClFN2O4/c1-2-4-21(15-19-7-9-20(10-8-19)30(38)33-14-13-28(35)36)29(37)27-17-22-16-23(31)11-12-26(22)34(27)25-6-3-5-24(32)18-25/h3,5-12,16-18,21H,2,4,13-15H2,1H3,(H,33,38)(H,35,36)
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n/an/a 150n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358826
PNG
(CHEMBL1922931)
Show SMILES CCC[C@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(n1)C(F)(F)F |r|
Show InChI InChI=1S/C30H27ClF3N3O4/c1-2-4-20(15-18-7-9-19(10-8-18)29(41)35-14-13-27(38)39)28(40)24-17-21-16-22(31)11-12-23(21)37(24)26-6-3-5-25(36-26)30(32,33)34/h3,5-12,16-17,20H,2,4,13-15H2,1H3,(H,35,41)(H,38,39)/t20-/m1/s1
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n/an/a 450n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]-glucagon from human glucagon receptor expressed in CHO cells after 4 to 12 hrs by scintillation proximity assay

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50358802
PNG
(CHEMBL1922929)
Show SMILES CCCC(Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cnc2ccccc2c1
Show InChI InChI=1S/C33H30ClN3O4/c1-2-5-24(16-21-8-10-22(11-9-21)33(41)35-15-14-31(38)39)32(40)30-19-25-17-26(34)12-13-29(25)37(30)27-18-23-6-3-4-7-28(23)36-20-27/h3-4,6-13,17-20,24H,2,5,14-16H2,1H3,(H,35,41)(H,38,39)
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n/an/a 718n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human glucagon receptor expressed in CHO cells assessed as inhibition of forskolin/glucagon-induced cAMP production preincubat...

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Gastric inhibitory polypeptide receptor


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GIP receptor assessed as inhibition of cAMP production

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a 3.70E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of [35S]-MK-499 from human ERG expressed in HEK cells

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Glucagon-like peptide 1 receptor


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at human GLP1 receptor assessed as inhibition of cAMP production

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Cytochrome P450 3A4


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a>1.10E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP3A4

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Cytochrome P450 2C9


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a>1.10E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2C9

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
Cytochrome P450 2D6


(Homo sapiens (Human))		BDBM50358804
PNG
(CHEMBL1922933)
Show SMILES CCCCC[C@@H](Cc1ccc(cc1)C(=O)NCCC(O)=O)C(=O)c1cc2cc(Cl)ccc2n1-c1cccc(c1)C(F)(F)F |r|
Show InChI InChI=1S/C33H32ClF3N2O4/c1-2-3-4-6-23(17-21-9-11-22(12-10-21)32(43)38-16-15-30(40)41)31(42)29-19-24-18-26(34)13-14-28(24)39(29)27-8-5-7-25(20-27)33(35,36)37/h5,7-14,18-20,23H,2-4,6,15-17H2,1H3,(H,38,43)(H,40,41)/t23-/m0/s1
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n/an/a>1.10E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of CYP2D6

Bioorg Med Chem Lett 21: 7124-30 (2011)


Article DOI: 10.1016/j.bmcl.2011.09.105
BindingDB Entry DOI: 10.7270/Q2HT2PRF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%