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PubMed code 22263917

Compile data set for download or QSAR
Found 77 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382659
PNG
(CHEMBL2023990)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(OC(F)(F)F)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H30F3N5O5/c1-37-21-13-19(14-22(38-2)24(21)39-3)33-26-31-11-10-23(34-26)35-12-4-5-18(16-35)25(36)32-15-17-6-8-20(9-7-17)40-27(28,29)30/h6-11,13-14,18H,4-5,12,15-16H2,1-3H3,(H,32,36)(H,31,33,34)/t18-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382660
PNG
(CHEMBL2023556)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(OC(F)(F)F)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H30F3N5O5/c1-37-21-13-19(14-22(38-2)24(21)39-3)33-26-31-10-9-23(34-26)35-11-5-7-18(16-35)25(36)32-15-17-6-4-8-20(12-17)40-27(28,29)30/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,32,36)(H,31,33,34)/t18-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382651
PNG
(CHEMBL2023998)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(c2)-c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O4/c1-39-27-18-26(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-13-25(21-37)31(38)34-20-22-9-7-12-24(17-22)23-10-5-4-6-11-23/h4-7,9-12,14-15,17-19,25H,8,13,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t25-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382648
PNG
(CHEMBL2024001)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(c2)N2CCOCC2)cc(OC)c1OC |r|
Show InChI InChI=1S/C30H38N6O5/c1-38-25-17-23(18-26(39-2)28(25)40-3)33-30-31-10-9-27(34-30)36-11-5-7-22(20-36)29(37)32-19-21-6-4-8-24(16-21)35-12-14-41-15-13-35/h4,6,8-10,16-18,22H,5,7,11-15,19-20H2,1-3H3,(H,32,37)(H,31,33,34)/t22-/m0/s1
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n/an/a 28n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of ALK phosphorylation in human Karpas-299 cells after 1 hr

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382648
PNG
(CHEMBL2024001)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(c2)N2CCOCC2)cc(OC)c1OC |r|
Show InChI InChI=1S/C30H38N6O5/c1-38-25-17-23(18-26(39-2)28(25)40-3)33-30-31-10-9-27(34-30)36-11-5-7-22(20-36)29(37)32-19-21-6-4-8-24(16-21)35-12-14-41-15-13-35/h4,6,8-10,16-18,22H,5,7,11-15,19-20H2,1-3H3,(H,32,37)(H,31,33,34)/t22-/m0/s1
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n/an/a 31n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382660
PNG
(CHEMBL2023556)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(OC(F)(F)F)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H30F3N5O5/c1-37-21-13-19(14-22(38-2)24(21)39-3)33-26-31-10-9-23(34-26)35-11-5-7-18(16-35)25(36)32-15-17-6-4-8-20(12-17)40-27(28,29)30/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,32,36)(H,31,33,34)/t18-/m0/s1
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n/an/a 59n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of ALK phosphorylation in human Karpas-299 cells after 1 hr

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382653
PNG
(CHEMBL2023996)
Show SMILES COC(=O)c1cccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)c1 |r|
Show InChI InChI=1S/C28H33N5O6/c1-36-22-14-21(15-23(37-2)25(22)38-3)31-28-29-11-10-24(32-28)33-12-6-9-20(17-33)26(34)30-16-18-7-5-8-19(13-18)27(35)39-4/h5,7-8,10-11,13-15,20H,6,9,12,16-17H2,1-4H3,(H,30,34)(H,29,31,32)/t20-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382653
PNG
(CHEMBL2023996)
Show SMILES COC(=O)c1cccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)c1 |r|
Show InChI InChI=1S/C28H33N5O6/c1-36-22-14-21(15-23(37-2)25(22)38-3)31-28-29-11-10-24(32-28)33-12-6-9-20(17-33)26(34)30-16-18-7-5-8-19(13-18)27(35)39-4/h5,7-8,10-11,13-15,20H,6,9,12,16-17H2,1-4H3,(H,30,34)(H,29,31,32)/t20-/m0/s1
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n/an/a 61n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of ALK phosphorylation in human Karpas-299 cells after 1 hr

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382655
PNG
(CHEMBL2023994)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(c2)[N+]([O-])=O)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30N6O6/c1-36-21-13-19(14-22(37-2)24(21)38-3)29-26-27-10-9-23(30-26)31-11-5-7-18(16-31)25(33)28-15-17-6-4-8-20(12-17)32(34)35/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,28,33)(H,27,29,30)/t18-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382657
PNG
(CHEMBL2023992)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Cl)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30ClN5O4/c1-34-21-13-20(14-22(35-2)24(21)36-3)30-26-28-10-9-23(31-26)32-11-5-7-18(16-32)25(33)29-15-17-6-4-8-19(27)12-17/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,29,33)(H,28,30,31)/t18-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382661
PNG
(CHEMBL2023555)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(C)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-7-5-8-19(13-18)16-29-26(33)20-9-6-12-32(17-20)24-10-11-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h5,7-8,10-11,13-15,20H,6,9,12,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m0/s1
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n/an/a 83n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382656
PNG
(CHEMBL2023993)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(Cl)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30ClN5O4/c1-34-21-13-20(14-22(35-2)24(21)36-3)30-26-28-11-10-23(31-26)32-12-4-5-18(16-32)25(33)29-15-17-6-8-19(27)9-7-17/h6-11,13-14,18H,4-5,12,15-16H2,1-3H3,(H,29,33)(H,28,30,31)/t18-/m0/s1
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n/an/a 95n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382660
PNG
(CHEMBL2023556)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(OC(F)(F)F)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H30F3N5O5/c1-37-21-13-19(14-22(38-2)24(21)39-3)33-26-31-10-9-23(34-26)35-11-5-7-18(16-35)25(36)32-15-17-6-4-8-20(12-17)40-27(28,29)30/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,32,36)(H,31,33,34)/t18-/m0/s1
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n/an/a 116n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382650
PNG
(CHEMBL2023999)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(cc2)-c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O4/c1-39-27-18-26(19-28(40-2)30(27)41-3)35-32-33-16-15-29(36-32)37-17-7-10-25(21-37)31(38)34-20-22-11-13-24(14-12-22)23-8-5-4-6-9-23/h4-6,8-9,11-16,18-19,25H,7,10,17,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t25-/m0/s1
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n/an/a 138n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382646
PNG
(CHEMBL2023534)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-7-9-19(10-8-18)16-29-26(33)20-6-5-13-32(17-20)24-11-12-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h7-12,14-15,20H,5-6,13,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m0/s1
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n/an/a 174n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382649
PNG
(CHEMBL2024000)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Oc3ccccc3)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O5/c1-39-27-18-24(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-10-23(21-37)31(38)34-20-22-9-7-13-26(17-22)42-25-11-5-4-6-12-25/h4-7,9,11-15,17-19,23H,8,10,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t23-/m0/s1
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n/an/a 192n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382651
PNG
(CHEMBL2023998)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(c2)-c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O4/c1-39-27-18-26(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-13-25(21-37)31(38)34-20-22-9-7-12-24(17-22)23-10-5-4-6-11-23/h4-7,9-12,14-15,17-19,25H,8,13,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t25-/m0/s1
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n/an/a 224n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of ALK phosphorylation in human Karpas-299 cells after 1 hr

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382657
PNG
(CHEMBL2023992)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Cl)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30ClN5O4/c1-34-21-13-20(14-22(35-2)24(21)36-3)30-26-28-10-9-23(31-26)32-11-5-7-18(16-32)25(33)29-15-17-6-4-8-19(27)12-17/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,29,33)(H,28,30,31)/t18-/m0/s1
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n/an/a 226n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of ALK phosphorylation in human Karpas-299 cells after 1 hr

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382670
PNG
(CHEMBL2023546)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc(OC)c1 |r|
Show InChI InChI=1S/C26H31N5O3/c1-18-6-8-19(9-7-18)16-28-25(32)20-5-4-12-31(17-20)24-10-11-27-26(30-24)29-21-13-22(33-2)15-23(14-21)34-3/h6-11,13-15,20H,4-5,12,16-17H2,1-3H3,(H,28,32)(H,27,29,30)/t20-/m0/s1
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n/an/a 325n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382662
PNG
(CHEMBL2023554)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccccc2C)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-8-5-6-9-19(18)16-29-26(33)20-10-7-13-32(17-20)24-11-12-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h5-6,8-9,11-12,14-15,20H,7,10,13,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m0/s1
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n/an/a 341n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382667
PNG
(CHEMBL2023549)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCCc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-34-22-16-21(17-23(35-2)25(22)36-3)30-27-29-14-12-24(31-27)32-15-7-10-20(18-32)26(33)28-13-11-19-8-5-4-6-9-19/h4-6,8-9,12,14,16-17,20H,7,10-11,13,15,18H2,1-3H3,(H,28,33)(H,29,30,31)/t20-/m0/s1
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n/an/a 358n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382657
PNG
(CHEMBL2023992)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Cl)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30ClN5O4/c1-34-21-13-20(14-22(35-2)24(21)36-3)30-26-28-10-9-23(31-26)32-11-5-7-18(16-32)25(33)29-15-17-6-4-8-19(27)12-17/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,29,33)(H,28,30,31)/t18-/m0/s1
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n/an/a 364n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382668
PNG
(CHEMBL2023548)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H31N5O4/c1-33-21-14-20(15-22(34-2)24(21)35-3)29-26-27-12-11-23(30-26)31-13-7-10-19(17-31)25(32)28-16-18-8-5-4-6-9-18/h4-6,8-9,11-12,14-15,19H,7,10,13,16-17H2,1-3H3,(H,28,32)(H,27,29,30)/t19-/m0/s1
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n/an/a 364n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382646
PNG
(CHEMBL2023534)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-7-9-19(10-8-18)16-29-26(33)20-6-5-13-32(17-20)24-11-12-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h7-12,14-15,20H,5-6,13,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m0/s1
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n/an/a 384n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of ALK phosphorylation in human Karpas-299 cells after 1 hr

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382655
PNG
(CHEMBL2023994)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(c2)[N+]([O-])=O)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30N6O6/c1-36-21-13-19(14-22(37-2)24(21)38-3)29-26-27-10-9-23(30-26)31-11-5-7-18(16-31)25(33)28-15-17-6-4-8-20(12-17)32(34)35/h4,6,8-10,12-14,18H,5,7,11,15-16H2,1-3H3,(H,28,33)(H,27,29,30)/t18-/m0/s1
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n/an/a 503n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382658
PNG
(CHEMBL2023991)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccccc2Cl)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30ClN5O4/c1-34-21-13-19(14-22(35-2)24(21)36-3)30-26-28-11-10-23(31-26)32-12-6-8-18(16-32)25(33)29-15-17-7-4-5-9-20(17)27/h4-5,7,9-11,13-14,18H,6,8,12,15-16H2,1-3H3,(H,29,33)(H,28,30,31)/t18-/m0/s1
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n/an/a 587n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382661
PNG
(CHEMBL2023555)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(C)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-7-5-8-19(13-18)16-29-26(33)20-9-6-12-32(17-20)24-10-11-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h5,7-8,10-11,13-15,20H,6,9,12,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m0/s1
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n/an/a 722n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382659
PNG
(CHEMBL2023990)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(OC(F)(F)F)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H30F3N5O5/c1-37-21-13-19(14-22(38-2)24(21)39-3)33-26-31-11-10-23(34-26)35-12-4-5-18(16-35)25(36)32-15-17-6-8-20(9-7-17)40-27(28,29)30/h6-11,13-14,18H,4-5,12,15-16H2,1-3H3,(H,32,36)(H,31,33,34)/t18-/m0/s1
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n/an/a 798n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382669
PNG
(CHEMBL2023547)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)Nc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C25H29N5O4/c1-32-20-14-19(15-21(33-2)23(20)34-3)28-25-26-12-11-22(29-25)30-13-7-8-17(16-30)24(31)27-18-9-5-4-6-10-18/h4-6,9-12,14-15,17H,7-8,13,16H2,1-3H3,(H,27,31)(H,26,28,29)/t17-/m0/s1
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n/an/a 833n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382638
PNG
(CHEMBL2023542)
Show SMILES CCc1cccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)c1 |r|
Show InChI InChI=1S/C26H31N5O/c1-3-20-6-4-8-23(16-20)29-26-27-14-13-24(30-26)31-15-5-7-22(18-31)25(32)28-17-21-11-9-19(2)10-12-21/h4,6,8-14,16,22H,3,5,7,15,17-18H2,1-2H3,(H,28,32)(H,27,29,30)/t22-/m0/s1
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n/an/a 912n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382640
PNG
(CHEMBL2023540)
Show SMILES COc1cccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)c1 |r|
Show InChI InChI=1S/C25H29N5O2/c1-18-8-10-19(11-9-18)16-27-24(31)20-5-4-14-30(17-20)23-12-13-26-25(29-23)28-21-6-3-7-22(15-21)32-2/h3,6-13,15,20H,4-5,14,16-17H2,1-2H3,(H,27,31)(H,26,28,29)/t20-/m0/s1
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n/an/a 1.02E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382671
PNG
(CHEMBL2023545)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3ccc4OCCOc4c3)n2)cc1 |r|
Show InChI InChI=1S/C26H29N5O3/c1-18-4-6-19(7-5-18)16-28-25(32)20-3-2-12-31(17-20)24-10-11-27-26(30-24)29-21-8-9-22-23(15-21)34-14-13-33-22/h4-11,15,20H,2-3,12-14,16-17H2,1H3,(H,28,32)(H,27,29,30)/t20-/m0/s1
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n/an/a 1.48E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382652
PNG
(CHEMBL2023997)
Show SMILES COC(=O)c1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)cc1 |r|
Show InChI InChI=1S/C28H33N5O6/c1-36-22-14-21(15-23(37-2)25(22)38-3)31-28-29-12-11-24(32-28)33-13-5-6-20(17-33)26(34)30-16-18-7-9-19(10-8-18)27(35)39-4/h7-12,14-15,20H,5-6,13,16-17H2,1-4H3,(H,30,34)(H,29,31,32)/t20-/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382636
PNG
(CHEMBL2023544)
Show SMILES COc1ccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc1OC |r|
Show InChI InChI=1S/C26H31N5O3/c1-18-6-8-19(9-7-18)16-28-25(32)20-5-4-14-31(17-20)24-12-13-27-26(30-24)29-21-10-11-22(33-2)23(15-21)34-3/h6-13,15,20H,4-5,14,16-17H2,1-3H3,(H,28,32)(H,27,29,30)/t20-/m0/s1
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n/an/a 1.73E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382656
PNG
(CHEMBL2023993)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(Cl)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30ClN5O4/c1-34-21-13-20(14-22(35-2)24(21)36-3)30-26-28-11-10-23(31-26)32-12-4-5-18(16-32)25(33)29-15-17-6-8-19(27)9-7-17/h6-11,13-14,18H,4-5,12,15-16H2,1-3H3,(H,29,33)(H,28,30,31)/t18-/m0/s1
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n/an/a 1.87E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382663
PNG
(CHEMBL2023553)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)N[C@H](C)c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18(19-9-6-5-7-10-19)29-26(33)20-11-8-14-32(17-20)24-12-13-28-27(31-24)30-21-15-22(34-2)25(36-4)23(16-21)35-3/h5-7,9-10,12-13,15-16,18,20H,8,11,14,17H2,1-4H3,(H,29,33)(H,28,30,31)/t18-,20+/m1/s1
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n/an/a 2.01E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382642
PNG
(CHEMBL2023538)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3cccc(Cl)c3)n2)cc1 |r|
Show InChI InChI=1S/C24H26ClN5O/c1-17-7-9-18(10-8-17)15-27-23(31)19-4-3-13-30(16-19)22-11-12-26-24(29-22)28-21-6-2-5-20(25)14-21/h2,5-12,14,19H,3-4,13,15-16H2,1H3,(H,27,31)(H,26,28,29)/t19-/m0/s1
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n/an/a 2.01E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382644
PNG
(CHEMBL2023536)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3ccccc3)n2)cc1 |r|
Show InChI InChI=1S/C24H27N5O/c1-18-9-11-19(12-10-18)16-26-23(30)20-6-5-15-29(17-20)22-13-14-25-24(28-22)27-21-7-3-2-4-8-21/h2-4,7-14,20H,5-6,15-17H2,1H3,(H,26,30)(H,25,27,28)/t20-/m0/s1
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n/an/a 2.32E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382664
PNG
(CHEMBL2023552)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)N[C@@H](C)c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18(19-9-6-5-7-10-19)29-26(33)20-11-8-14-32(17-20)24-12-13-28-27(31-24)30-21-15-22(34-2)25(36-4)23(16-21)35-3/h5-7,9-10,12-13,15-16,18,20H,8,11,14,17H2,1-4H3,(H,29,33)(H,28,30,31)/t18-,20-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382649
PNG
(CHEMBL2024000)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(Oc3ccccc3)c2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O5/c1-39-27-18-24(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-10-23(21-37)31(38)34-20-22-9-7-13-26(17-22)42-25-11-5-4-6-12-25/h4-7,9,11-15,17-19,23H,8,10,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t23-/m0/s1
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n/an/a 2.77E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382670
PNG
(CHEMBL2023546)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc(OC)c1 |r|
Show InChI InChI=1S/C26H31N5O3/c1-18-6-8-19(9-7-18)16-28-25(32)20-5-4-12-31(17-20)24-10-11-27-26(30-24)29-21-13-22(33-2)15-23(14-21)34-3/h6-11,13-15,20H,4-5,12,16-17H2,1-3H3,(H,28,32)(H,27,29,30)/t20-/m0/s1
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n/an/a 2.93E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382654
PNG
(CHEMBL2023995)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30N6O6/c1-36-21-13-19(14-22(37-2)24(21)38-3)29-26-27-11-10-23(30-26)31-12-4-5-18(16-31)25(33)28-15-17-6-8-20(9-7-17)32(34)35/h6-11,13-14,18H,4-5,12,15-16H2,1-3H3,(H,28,33)(H,27,29,30)/t18-/m0/s1
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n/an/a 2.93E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382665
PNG
(CHEMBL2023551)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCC(=O)c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H31N5O5/c1-35-22-14-20(15-23(36-2)25(22)37-3)30-27-28-12-11-24(31-27)32-13-7-10-19(17-32)26(34)29-16-21(33)18-8-5-4-6-9-18/h4-6,8-9,11-12,14-15,19H,7,10,13,16-17H2,1-3H3,(H,29,34)(H,28,30,31)/t19-/m0/s1
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n/an/a 2.94E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382639
PNG
(CHEMBL2023541)
Show SMILES COc1ccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc1 |r|
Show InChI InChI=1S/C25H29N5O2/c1-18-5-7-19(8-6-18)16-27-24(31)20-4-3-15-30(17-20)23-13-14-26-25(29-23)28-21-9-11-22(32-2)12-10-21/h5-14,20H,3-4,15-17H2,1-2H3,(H,27,31)(H,26,28,29)/t20-/m0/s1
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n/an/a 3.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382665
PNG
(CHEMBL2023551)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCC(=O)c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H31N5O5/c1-35-22-14-20(15-23(36-2)25(22)37-3)30-27-28-12-11-24(31-27)32-13-7-10-19(17-32)26(34)29-16-21(33)18-8-5-4-6-9-18/h4-6,8-9,11-12,14-15,19H,7,10,13,16-17H2,1-3H3,(H,29,34)(H,28,30,31)/t19-/m0/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382647
PNG
(CHEMBL2024002)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@H](C2)C(=O)NCc2ccc(C)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-7-9-19(10-8-18)16-29-26(33)20-6-5-13-32(17-20)24-11-12-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h7-12,14-15,20H,5-6,13,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m1/s1
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n/an/a 4.12E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382651
PNG
(CHEMBL2023998)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2cccc(c2)-c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O4/c1-39-27-18-26(19-28(40-2)30(27)41-3)35-32-33-15-14-29(36-32)37-16-8-13-25(21-37)31(38)34-20-22-9-7-12-24(17-22)23-10-5-4-6-11-23/h4-7,9-12,14-15,17-19,25H,8,13,16,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t25-/m0/s1
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n/an/a 4.23E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382646
PNG
(CHEMBL2023534)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-7-9-19(10-8-18)16-29-26(33)20-6-5-13-32(17-20)24-11-12-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h7-12,14-15,20H,5-6,13,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m0/s1
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n/an/a 4.61E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382668
PNG
(CHEMBL2023548)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H31N5O4/c1-33-21-14-20(15-22(34-2)24(21)35-3)29-26-27-12-11-23(30-26)31-13-7-10-19(17-31)25(32)28-16-18-8-5-4-6-9-18/h4-6,8-9,11-12,14-15,19H,7,10,13,16-17H2,1-3H3,(H,28,32)(H,27,29,30)/t19-/m0/s1
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n/an/a 6.12E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382641
PNG
(CHEMBL2023539)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3ccc(Cl)cc3)n2)cc1 |r|
Show InChI InChI=1S/C24H26ClN5O/c1-17-4-6-18(7-5-17)15-27-23(31)19-3-2-14-30(16-19)22-12-13-26-24(29-22)28-21-10-8-20(25)9-11-21/h4-13,19H,2-3,14-16H2,1H3,(H,27,31)(H,26,28,29)/t19-/m0/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382666
PNG
(CHEMBL2023550)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCCCc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C28H35N5O4/c1-35-23-17-22(18-24(36-2)26(23)37-3)31-28-30-15-13-25(32-28)33-16-8-12-21(19-33)27(34)29-14-7-11-20-9-5-4-6-10-20/h4-6,9-10,13,15,17-18,21H,7-8,11-12,14,16,19H2,1-3H3,(H,29,34)(H,30,31,32)/t21-/m0/s1
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n/an/a 6.39E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382669
PNG
(CHEMBL2023547)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)Nc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C25H29N5O4/c1-32-20-14-19(15-21(33-2)23(20)34-3)28-25-26-12-11-22(29-25)30-13-7-8-17(16-30)24(31)27-18-9-5-4-6-10-18/h4-6,9-12,14-15,17H,7-8,13,16H2,1-3H3,(H,27,31)(H,26,28,29)/t17-/m0/s1
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n/an/a 6.59E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382666
PNG
(CHEMBL2023550)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCCCc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C28H35N5O4/c1-35-23-17-22(18-24(36-2)26(23)37-3)31-28-30-15-13-25(32-28)33-16-8-12-21(19-33)27(34)29-14-7-11-20-9-5-4-6-10-20/h4-6,9-10,13,15,17-18,21H,7-8,11-12,14,16,19H2,1-3H3,(H,29,34)(H,30,31,32)/t21-/m0/s1
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n/an/a 6.71E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382658
PNG
(CHEMBL2023991)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccccc2Cl)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30ClN5O4/c1-34-21-13-19(14-22(35-2)24(21)36-3)30-26-28-11-10-23(31-26)32-12-6-8-18(16-32)25(33)29-15-17-7-4-5-9-20(17)27/h4-5,7,9-11,13-14,18H,6,8,12,15-16H2,1-3H3,(H,29,33)(H,28,30,31)/t18-/m0/s1
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n/an/a 7.08E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382662
PNG
(CHEMBL2023554)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccccc2C)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-8-5-6-9-19(18)16-29-26(33)20-10-7-13-32(17-20)24-11-12-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h5-6,8-9,11-12,14-15,20H,7,10,13,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m0/s1
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n/an/a 8.32E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382653
PNG
(CHEMBL2023996)
Show SMILES COC(=O)c1cccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)c1 |r|
Show InChI InChI=1S/C28H33N5O6/c1-36-22-14-21(15-23(37-2)25(22)38-3)31-28-29-11-10-24(32-28)33-12-6-9-20(17-33)26(34)30-16-18-7-5-8-19(13-18)27(35)39-4/h5,7-8,10-11,13-15,20H,6,9,12,16-17H2,1-4H3,(H,30,34)(H,29,31,32)/t20-/m0/s1
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n/an/a 8.89E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382640
PNG
(CHEMBL2023540)
Show SMILES COc1cccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)c1 |r|
Show InChI InChI=1S/C25H29N5O2/c1-18-8-10-19(11-9-18)16-27-24(31)20-5-4-14-30(17-20)23-12-13-26-25(29-23)28-21-6-3-7-22(15-21)32-2/h3,6-13,15,20H,4-5,14,16-17H2,1-2H3,(H,27,31)(H,26,28,29)/t20-/m0/s1
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n/an/a 9.02E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382664
PNG
(CHEMBL2023552)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)N[C@@H](C)c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18(19-9-6-5-7-10-19)29-26(33)20-11-8-14-32(17-20)24-12-13-28-27(31-24)30-21-15-22(34-2)25(36-4)23(16-21)35-3/h5-7,9-10,12-13,15-16,18,20H,8,11,14,17H2,1-4H3,(H,29,33)(H,28,30,31)/t18-,20-/m0/s1
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n/an/a 1.05E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382636
PNG
(CHEMBL2023544)
Show SMILES COc1ccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc1OC |r|
Show InChI InChI=1S/C26H31N5O3/c1-18-6-8-19(9-7-18)16-28-25(32)20-5-4-14-31(17-20)24-12-13-27-26(30-24)29-21-10-11-22(33-2)23(15-21)34-3/h6-13,15,20H,4-5,14,16-17H2,1-3H3,(H,28,32)(H,27,29,30)/t20-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382650
PNG
(CHEMBL2023999)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(cc2)-c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C32H35N5O4/c1-39-27-18-26(19-28(40-2)30(27)41-3)35-32-33-16-15-29(36-32)37-17-7-10-25(21-37)31(38)34-20-22-11-13-24(14-12-22)23-8-5-4-6-9-23/h4-6,8-9,11-16,18-19,25H,7,10,17,20-21H2,1-3H3,(H,34,38)(H,33,35,36)/t25-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382671
PNG
(CHEMBL2023545)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3ccc4OCCOc4c3)n2)cc1 |r|
Show InChI InChI=1S/C26H29N5O3/c1-18-4-6-19(7-5-18)16-28-25(32)20-3-2-12-31(17-20)24-10-11-27-26(30-24)29-21-8-9-22-23(15-21)34-14-13-33-22/h4-11,15,20H,2-3,12-14,16-17H2,1H3,(H,28,32)(H,27,29,30)/t20-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382637
PNG
(CHEMBL2023543)
Show SMILES CCc1ccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc1 |r|
Show InChI InChI=1S/C26H31N5O/c1-3-20-10-12-23(13-11-20)29-26-27-15-14-24(30-26)31-16-4-5-22(18-31)25(32)28-17-21-8-6-19(2)7-9-21/h6-15,22H,3-5,16-18H2,1-2H3,(H,28,32)(H,27,29,30)/t22-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382667
PNG
(CHEMBL2023549)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCCc2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-34-22-16-21(17-23(35-2)25(22)36-3)30-27-29-14-12-24(31-27)32-15-7-10-20(18-32)26(33)28-13-11-19-8-5-4-6-9-19/h4-6,8-9,12,14,16-17,20H,7,10-11,13,15,18H2,1-3H3,(H,28,33)(H,29,30,31)/t20-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382643
PNG
(CHEMBL2023537)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(NCc3ccccc3)n2)cc1 |r|
Show InChI InChI=1S/C25H29N5O/c1-19-9-11-21(12-10-19)16-27-24(31)22-8-5-15-30(18-22)23-13-14-26-25(29-23)28-17-20-6-3-2-4-7-20/h2-4,6-7,9-14,22H,5,8,15-18H2,1H3,(H,27,31)(H,26,28,29)/t22-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382643
PNG
(CHEMBL2023537)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(NCc3ccccc3)n2)cc1 |r|
Show InChI InChI=1S/C25H29N5O/c1-19-9-11-21(12-10-19)16-27-24(31)22-8-5-15-30(18-22)23-13-14-26-25(29-23)28-17-20-6-3-2-4-7-20/h2-4,6-7,9-14,22H,5,8,15-18H2,1H3,(H,27,31)(H,26,28,29)/t22-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382641
PNG
(CHEMBL2023539)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3ccc(Cl)cc3)n2)cc1 |r|
Show InChI InChI=1S/C24H26ClN5O/c1-17-4-6-18(7-5-17)15-27-23(31)19-3-2-14-30(16-19)22-12-13-26-24(29-22)28-21-10-8-20(25)9-11-21/h4-13,19H,2-3,14-16H2,1H3,(H,27,31)(H,26,28,29)/t19-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382647
PNG
(CHEMBL2024002)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@H](C2)C(=O)NCc2ccc(C)cc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18-7-9-19(10-8-18)16-29-26(33)20-6-5-13-32(17-20)24-11-12-28-27(31-24)30-21-14-22(34-2)25(36-4)23(15-21)35-3/h7-12,14-15,20H,5-6,13,16-17H2,1-4H3,(H,29,33)(H,28,30,31)/t20-/m1/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382638
PNG
(CHEMBL2023542)
Show SMILES CCc1cccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)c1 |r|
Show InChI InChI=1S/C26H31N5O/c1-3-20-6-4-8-23(16-20)29-26-27-14-13-24(30-26)31-15-5-7-22(18-31)25(32)28-17-21-11-9-19(2)10-12-21/h4,6,8-14,16,22H,3,5,7,15,17-18H2,1-2H3,(H,28,32)(H,27,29,30)/t22-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382637
PNG
(CHEMBL2023543)
Show SMILES CCc1ccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc1 |r|
Show InChI InChI=1S/C26H31N5O/c1-3-20-10-12-23(13-11-20)29-26-27-15-14-24(30-26)31-16-4-5-22(18-31)25(32)28-17-21-8-6-19(2)7-9-21/h6-15,22H,3-5,16-18H2,1-2H3,(H,28,32)(H,27,29,30)/t22-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382654
PNG
(CHEMBL2023995)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(cc2)[N+]([O-])=O)cc(OC)c1OC |r|
Show InChI InChI=1S/C26H30N6O6/c1-36-21-13-19(14-22(37-2)24(21)38-3)29-26-27-11-10-23(30-26)31-12-4-5-18(16-31)25(33)28-15-17-6-8-20(9-7-17)32(34)35/h6-11,13-14,18H,4-5,12,15-16H2,1-3H3,(H,28,33)(H,27,29,30)/t18-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382645
PNG
(CHEMBL2023535)
Show SMILES CNc1nccc(n1)N1CCC[C@@H](C1)C(=O)NCc1ccc(C)cc1 |r|
Show InChI InChI=1S/C19H25N5O/c1-14-5-7-15(8-6-14)12-22-18(25)16-4-3-11-24(13-16)17-9-10-21-19(20-2)23-17/h5-10,16H,3-4,11-13H2,1-2H3,(H,22,25)(H,20,21,23)/t16-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382644
PNG
(CHEMBL2023536)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3ccccc3)n2)cc1 |r|
Show InChI InChI=1S/C24H27N5O/c1-18-9-11-19(12-10-18)16-26-23(30)20-6-5-15-29(17-20)22-13-14-25-24(28-22)27-21-7-3-2-4-8-21/h2-4,7-14,20H,5-6,15-17H2,1H3,(H,26,30)(H,25,27,28)/t20-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382639
PNG
(CHEMBL2023541)
Show SMILES COc1ccc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)NCc2ccc(C)cc2)cc1 |r|
Show InChI InChI=1S/C25H29N5O2/c1-18-5-7-19(8-6-18)16-27-24(31)20-4-3-15-30(17-20)23-13-14-26-25(29-23)28-21-9-11-22(32-2)12-10-21/h5-14,20H,3-4,15-17H2,1-2H3,(H,27,31)(H,26,28,29)/t20-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))		BDBM50382645
PNG
(CHEMBL2023535)
Show SMILES CNc1nccc(n1)N1CCC[C@@H](C1)C(=O)NCc1ccc(C)cc1 |r|
Show InChI InChI=1S/C19H25N5O/c1-14-5-7-15(8-6-14)12-22-18(25)16-4-3-11-24(13-16)17-9-10-21-19(20-2)23-17/h5-10,16H,3-4,11-13H2,1-2H3,(H,22,25)(H,20,21,23)/t16-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused ALK cytoplasmic domain (1058 to 1620) expressed in SF9 cells using Biotin-Ahx- EQEDEPEGIYGVLF-OH as substrat...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382663
PNG
(CHEMBL2023553)
Show SMILES COc1cc(Nc2nccc(n2)N2CCC[C@@H](C2)C(=O)N[C@H](C)c2ccccc2)cc(OC)c1OC |r|
Show InChI InChI=1S/C27H33N5O4/c1-18(19-9-6-5-7-10-19)29-26(33)20-11-8-14-32(17-20)24-12-13-28-27(31-24)30-21-15-22(34-2)25(36-4)23(16-21)35-3/h5-7,9-10,12-13,15-16,18,20H,8,11,14,17H2,1-4H3,(H,29,33)(H,28,30,31)/t18-,20+/m1/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382642
PNG
(CHEMBL2023538)
Show SMILES Cc1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3cccc(Cl)c3)n2)cc1 |r|
Show InChI InChI=1S/C24H26ClN5O/c1-17-7-9-18(10-8-17)15-27-23(31)19-4-3-13-30(16-19)22-11-12-26-24(29-22)28-21-6-2-5-20(25)14-21/h2,5-12,14,19H,3-4,13,15-16H2,1H3,(H,27,31)(H,26,28,29)/t19-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor


(Homo sapiens (Human))		BDBM50382652
PNG
(CHEMBL2023997)
Show SMILES COC(=O)c1ccc(CNC(=O)[C@H]2CCCN(C2)c2ccnc(Nc3cc(OC)c(OC)c(OC)c3)n2)cc1 |r|
Show InChI InChI=1S/C28H33N5O6/c1-36-22-14-21(15-23(37-2)25(22)38-3)31-28-29-12-11-24(32-28)33-13-5-6-20(17-33)26(34)30-16-18-7-9-19(10-8-18)27(35)39-4/h7-12,14-15,20H,5-6,13,16-17H2,1-4H3,(H,30,34)(H,29,31,32)/t20-/m0/s1
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n/an/a>2.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of human N-terminal GST-fused IGF1R cytoplasmic domain (960 to 1367) expressed in Hi5 cells using Biotin- Ahx- EEEEAYGWLDF-OH as substrate...

J Med Chem 55: 1698-705 (2012)


Article DOI: 10.1021/jm201565s
BindingDB Entry DOI: 10.7270/Q20P111R
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%