Found 30 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401298
(CHEMBL2204542)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnccc1C)-c1ccc(Cl)nc1 Show InChI InChI=1S/C22H23ClN6O2/c1-13(2)31-21-16-12-29(22(30)27-18-11-24-8-6-14(18)3)9-7-17(16)26-20(28-21)15-4-5-19(23)25-10-15/h4-6,8,10-11,13H,7,9,12H2,1-3H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401294
(CHEMBL2204538 | US8492392, Q-2)Show SMILES COCCOc1nc(nc2CCN(Cc12)C(=O)c1ncn2ccccc12)-c1ccc(Cl)nc1 Show InChI InChI=1S/C23H21ClN6O3/c1-32-10-11-33-22-16-13-29(23(31)20-18-4-2-3-8-30(18)14-26-20)9-7-17(16)27-21(28-22)15-5-6-19(24)25-12-15/h2-6,8,12,14H,7,9-11,13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401295
(CHEMBL2204539)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)N(C)c1cn[nH]c1)-c1ccc(Cl)nc1 Show InChI InChI=1S/C20H22ClN7O2/c1-12(2)30-19-15-11-28(20(29)27(3)14-9-23-24-10-14)7-6-16(15)25-18(26-19)13-4-5-17(21)22-8-13/h4-5,8-10,12H,6-7,11H2,1-3H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401299
(CHEMBL2204543)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnccc1C)-c1ccc(F)nc1 Show InChI InChI=1S/C22H23FN6O2/c1-13(2)31-21-16-12-29(22(30)27-18-11-24-8-6-14(18)3)9-7-17(16)26-20(28-21)15-4-5-19(23)25-10-15/h4-6,8,10-11,13H,7,9,12H2,1-3H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM98544
(CHEMBL2204537 | US8492392, 1-19)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)c1cn(C)cn1)-c1ccc(Cl)nc1 Show InChI InChI=1S/C20H21ClN6O2/c1-12(2)29-19-14-9-27(20(28)16-10-26(3)11-23-16)7-6-15(14)24-18(25-19)13-4-5-17(21)22-8-13/h4-5,8,10-12H,6-7,9H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401301
(CHEMBL2205202)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnccc1C)-c1cccnc1 Show InChI InChI=1S/C22H24N6O2/c1-14(2)30-21-17-13-28(22(29)26-19-12-24-9-6-15(19)3)10-7-18(17)25-20(27-21)16-5-4-8-23-11-16/h4-6,8-9,11-12,14H,7,10,13H2,1-3H3,(H,26,29) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401300
(CHEMBL2204544)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnccc1C)-c1ccc(C)nc1 Show InChI InChI=1S/C23H26N6O2/c1-14(2)31-22-18-13-29(23(30)27-20-12-24-9-7-15(20)3)10-8-19(18)26-21(28-22)17-6-5-16(4)25-11-17/h5-7,9,11-12,14H,8,10,13H2,1-4H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401302
(CHEMBL2205203 | US8492392, 1-7)Show SMILES CCc1cccc(NC(=O)N2CCc3nc(nc(OC4CCN(C)CC4)c3C2)-c2cccnc2)c1 Show InChI InChI=1S/C27H32N6O2/c1-3-19-6-4-8-21(16-19)29-27(34)33-15-11-24-23(18-33)26(35-22-9-13-32(2)14-10-22)31-25(30-24)20-7-5-12-28-17-20/h4-8,12,16-17,22H,3,9-11,13-15,18H2,1-2H3,(H,29,34) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401303
(CHEMBL2205204)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1cccnc1 Show InChI InChI=1S/C22H23N5O2/c1-15(2)29-21-18-14-27(22(28)24-17-8-4-3-5-9-17)12-10-19(18)25-20(26-21)16-7-6-11-23-13-16/h3-9,11,13,15H,10,12,14H2,1-2H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401297
(CHEMBL2204541)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnccc1C)-c1ccc(=O)[nH]c1 Show InChI InChI=1S/C22H24N6O3/c1-13(2)31-21-16-12-28(22(30)26-18-11-23-8-6-14(18)3)9-7-17(16)25-20(27-21)15-4-5-19(29)24-10-15/h4-6,8,10-11,13H,7,9,12H2,1-3H3,(H,24,29)(H,26,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401304
(CHEMBL2205205)Show SMILES COc1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1cccnc1 Show InChI InChI=1S/C20H19N5O2/c1-27-19-16-13-25(20(26)22-15-7-3-2-4-8-15)11-9-17(16)23-18(24-19)14-6-5-10-21-12-14/h2-8,10,12H,9,11,13H2,1H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401322
(CHEMBL2205221)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1ccncc1 Show InChI InChI=1S/C27H27N7O/c1-33(17-12-21-7-5-6-14-29-21)26-23-19-34(27(35)30-22-8-3-2-4-9-22)18-13-24(23)31-25(32-26)20-10-15-28-16-11-20/h2-11,14-16H,12-13,17-19H2,1H3,(H,30,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401305
(CHEMBL2205206)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1ccncc1 Show InChI InChI=1S/C22H23N5O2/c1-15(2)29-21-18-14-27(22(28)24-17-6-4-3-5-7-17)13-10-19(18)25-20(26-21)16-8-11-23-12-9-16/h3-9,11-12,15H,10,13-14H2,1-2H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 98 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401315
(CHEMBL2205216)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)Nc1ccncc1)-c1ccncc1 Show InChI InChI=1S/C26H26N8O/c1-33(16-9-20-4-2-3-11-29-20)25-22-18-34(26(35)30-21-7-14-28-15-8-21)17-10-23(22)31-24(32-25)19-5-12-27-13-6-19/h2-8,11-15H,9-10,16-18H2,1H3,(H,28,30,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 117 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401321
(CHEMBL2205220)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1cccnc1 Show InChI InChI=1S/C27H27N7O/c1-33(16-12-21-9-5-6-15-29-21)26-23-19-34(27(35)30-22-10-3-2-4-11-22)17-13-24(23)31-25(32-26)20-8-7-14-28-18-20/h2-11,14-15,18H,12-13,16-17,19H2,1H3,(H,30,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 121 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401314
(CHEMBL2205215)Show SMILES COc1ccc(NC(=O)N2CCc3nc(nc(N(C)CCc4ccccn4)c3C2)-c2ccncc2)cc1 Show InChI InChI=1S/C28H29N7O2/c1-34(17-12-21-5-3-4-14-30-21)27-24-19-35(28(36)31-22-6-8-23(37-2)9-7-22)18-13-25(24)32-26(33-27)20-10-15-29-16-11-20/h3-11,14-16H,12-13,17-19H2,1-2H3,(H,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 122 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401306
(CHEMBL2205207)Show SMILES COCCOc1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1ccncc1 Show InChI InChI=1S/C22H23N5O3/c1-29-13-14-30-21-18-15-27(22(28)24-17-5-3-2-4-6-17)12-9-19(18)25-20(26-21)16-7-10-23-11-8-16/h2-8,10-11H,9,12-15H2,1H3,(H,24,28) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401313
(CHEMBL2205214)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)Nc1cccc(F)c1)-c1ccncc1 Show InChI InChI=1S/C27H26FN7O/c1-34(15-10-21-6-2-3-12-30-21)26-23-18-35(27(36)31-22-7-4-5-20(28)17-22)16-11-24(23)32-25(33-26)19-8-13-29-14-9-19/h2-9,12-14,17H,10-11,15-16,18H2,1H3,(H,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 156 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401312
(CHEMBL2205213)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)OC(C)(C)C)-c1ccncc1 Show InChI InChI=1S/C25H30N6O2/c1-25(2,3)33-24(32)31-16-11-21-20(17-31)23(29-22(28-21)18-8-13-26-14-9-18)30(4)15-10-19-7-5-6-12-27-19/h5-9,12-14H,10-11,15-17H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 186 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401311
(CHEMBL2205212)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)NC(C)(C)C)-c1ccncc1 Show InChI InChI=1S/C25H31N7O/c1-25(2,3)30-24(33)32-16-11-21-20(17-32)23(29-22(28-21)18-8-13-26-14-9-18)31(4)15-10-19-7-5-6-12-27-19/h5-9,12-14H,10-11,15-17H2,1-4H3,(H,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 223 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401296
(CHEMBL2204540)Show SMILES CC(C)Oc1nc(nc2CCN(Cc12)C(=O)Nc1cnccc1C)-c1ccc(nc1)C(F)(F)F Show InChI InChI=1S/C23H23F3N6O2/c1-13(2)34-21-16-12-32(22(33)30-18-11-27-8-6-14(18)3)9-7-17(16)29-20(31-21)15-4-5-19(28-10-15)23(24,25)26/h4-6,8,10-11,13H,7,9,12H2,1-3H3,(H,30,33) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 247 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401307
(CHEMBL2205208)Show SMILES COc1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1ccncc1 Show InChI InChI=1S/C20H19N5O2/c1-27-19-16-13-25(20(26)22-15-5-3-2-4-6-15)12-9-17(16)23-18(24-19)14-7-10-21-11-8-14/h2-8,10-11H,9,12-13H2,1H3,(H,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 422 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401319
(CHEMBL2205218)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1ccccc1 Show InChI InChI=1S/C28H28N6O/c1-33(18-15-22-12-8-9-17-29-22)27-24-20-34(28(35)30-23-13-6-3-7-14-23)19-16-25(24)31-26(32-27)21-10-4-2-5-11-21/h2-14,17H,15-16,18-20H2,1H3,(H,30,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401316
(CHEMBL2205217)Show SMILES CN(C)c1nc2CCN(Cc2c(n1)N(C)CCc1ccccn1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C24H29N7O/c1-29(2)23-27-21-13-16-31(24(32)26-19-10-5-4-6-11-19)17-20(21)22(28-23)30(3)15-12-18-9-7-8-14-25-18/h4-11,14H,12-13,15-17H2,1-3H3,(H,26,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 512 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401310
(CHEMBL2205211)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)c1ccc(Cl)cc1)-c1ccncc1 Show InChI InChI=1S/C27H25ClN6O/c1-33(16-11-22-4-2-3-13-30-22)26-23-18-34(27(35)20-5-7-21(28)8-6-20)17-12-24(23)31-25(32-26)19-9-14-29-15-10-19/h2-10,13-15H,11-12,16-18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 522 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401308
(CHEMBL2205209)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)S(C)(=O)=O)-c1ccncc1 Show InChI InChI=1S/C21H24N6O2S/c1-26(13-8-17-5-3-4-10-23-17)21-18-15-27(30(2,28)29)14-9-19(18)24-20(25-21)16-6-11-22-12-7-16/h3-7,10-12H,8-9,13-15H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| 843 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401320
(CHEMBL2205219)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1ccccn1 Show InChI InChI=1S/C27H27N7O/c1-33(17-13-20-9-5-7-15-28-20)26-22-19-34(27(35)30-21-10-3-2-4-11-21)18-14-23(22)31-25(32-26)24-12-6-8-16-29-24/h2-12,15-16H,13-14,17-19H2,1H3,(H,30,35) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 864 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401309
(CHEMBL2205210)Show SMILES CC(C)CC(=O)N1CCc2nc(nc(N(C)CCc3ccccn3)c2C1)-c1ccncc1 Show InChI InChI=1S/C25H30N6O/c1-18(2)16-23(32)31-15-10-22-21(17-31)25(29-24(28-22)19-7-12-26-13-8-19)30(3)14-9-20-6-4-5-11-27-20/h4-8,11-13,18H,9-10,14-17H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 868 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401318
(CHEMBL2205223)Show SMILES CN(CCc1ccccn1)c1nc(nc2CCN(Cc12)C(=O)Nc1ccccc1)-c1cccc(Br)c1 Show InChI InChI=1S/C28H27BrN6O/c1-34(16-13-22-10-5-6-15-30-22)27-24-19-35(28(36)31-23-11-3-2-4-12-23)17-14-25(24)32-26(33-27)20-8-7-9-21(29)18-20/h2-12,15,18H,13-14,16-17,19H2,1H3,(H,31,36) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 991 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM50401317
(CHEMBL2205222)Show SMILES CN(CCc1ccccn1)c1nc(C)nc2CCN(Cc12)C(=O)Nc1ccccc1 Show InChI InChI=1S/C23H26N6O/c1-17-25-21-12-15-29(23(30)27-19-9-4-3-5-10-19)16-20(21)22(26-17)28(2)14-11-18-8-6-7-13-24-18/h3-10,13H,11-12,14-16H2,1-2H3,(H,27,30) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of PDE10A |
Bioorg Med Chem Lett 22: 5903-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.07.072
BindingDB Entry DOI: 10.7270/Q23J3F3X |
More data for this
Ligand-Target Pair | |
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