Affinity Data by PubMed id=2299645

PubMed code 2299645

Found 27 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014970 (4-(3,5-Difluoro-4-hydroxy-benzyl)-2,4-dihydro-[1,2...) Show SMILES Oc1c(F)cc(Cn2cn[nH]c2=S)cc1F Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014978 (1-(3,5-Difluoro-4-hydroxy-benzyl)-1,3-dihydro-imid...) Show SMILES Oc1c(F)cc(Cn2cc[nH]c2=S)cc1F Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014963 (1-(3,5-Difluoro-4-hydroxy-benzyl)-1,3-dihydro-benz...) Show SMILES Oc1c(F)cc(Cn2c3ccccc3[nH]c2=S)cc1F Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014984 (4-(3,5-Difluoro-benzyl)-2,4-dihydro-[1,2,4]triazol...) Show SMILES Fc1cc(F)cc(Cn2cn[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014983 (1-(3,5-Difluoro-benzyl)-1,3-dihydro-imidazole-2-th...) Show SMILES Fc1cc(F)cc(Cn2cc[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014971 (1-(3,5-Difluoro-benzyl)-imidazolidine-2-thione \| C...) Show SMILES Fc1cc(F)cc(CN2CCNC2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014967 (1-(3,5-Difluoro-benzyl)-1H-tetrazole-5-thiol \| CHE...) Show SMILES Fc1cc(F)cc(Cn2nn[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014979 (4-(3-Fluoro-benzyl)-2,4-dihydro-[1,2,4]triazole-3-...) Show SMILES Fc1cccc(Cn2cn[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014962 (1-[3-(4-Hydroxy-phenyl)-propyl]-1,3-dihydro-imidaz...) Show SMILES Oc1ccc(CCCn2cc[nH]c2=S)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014968 (1-(4-Hydroxy-benzyl)-1,3-dihydro-imidazole-2-thion...) Show SMILES Oc1ccc(Cn2cc[nH]c2=S)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014976 (1-(3,5-Difluoro-benzyl)-1H-pyrimidine-2-thione \| C...) Show SMILES Fc1cc(F)cc(Cn2cccnc2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014982 (1-(3-Fluoro-benzyl)-imidazolidine-2-thione \| CHEMB...) Show SMILES Fc1cccc(CN2CCNC2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014969 (1-(3-Fluoro-benzyl)-1,3-dihydro-imidazole-2-thione...) Show SMILES Fc1cccc(Cn2cc[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014973 (2-(3,5-Difluoro-benzyl)-2,4-dihydro-[1,2,4]triazol...) Show SMILES Fc1cc(F)cc(Cn2nc[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014959 (1-(3,5-Difluoro-benzyl)-1,3-dihydro-benzoimidazole...) Show SMILES Fc1cc(F)cc(Cn2c3ccccc3[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014980 (3-(3,5-Difluoro-benzyl)-1H-pyridine-2-thione \| CHE...) Show SMILES Fc1cc(F)cc(Cc2ccc[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014965 (2-(3-Fluoro-benzyl)-2,4-dihydro-[1,2,4]triazole-3-...) Show SMILES Fc1cccc(Cn2nc[nH]c2=S)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014981 (1-Benzyl-1H-tetrazole-5-thiol \| CHEMBL349152) Show SMILES S=c1[nH]nnn1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014975 (4-Benzyl-2,4-dihydro-[1,2,4]triazole-3-thione \| CH...) Show SMILES S=c1[nH]ncn1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014960 (1-Benzyl-1,3-dihydro-imidazole-2-thione \| 1-Benzyl...) Show SMILES S=c1[nH]ccn1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014961 (1-Benzyl-1H-imidazole-2-carboxylic acid \| CHEMBL35...) Show SMILES OC(=O)c1nccn1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	5.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM80308 (1-Benzyl-1,3-dihydro-benzoimidazole-2-thione \| 1-B...) Show SMILES S=c1[nH]c2ccccc2n1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014972 (2-Benzyl-2,4-dihydro-[1,2,4]triazole-3-thione \| CH...) Show SMILES S=c1[nH]cnn1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014966 (4-[3-(2-Methylsulfanyl-imidazol-1-yl)-propyl]-phen...) Show SMILES CSc1nccn1CCCc1ccc(O)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014964 (1-(4-Hydroxy-benzyl)-1H-imidazole-2-carboxylic aci...) Show SMILES OC(=O)c1nccn1Cc1ccc(O)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	1.12E+5	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014974 (4-(2-Aminomethyl-imidazol-1-ylmethyl)-phenol \| CHE...) Show SMILES NCc1nccn1Cc1ccc(O)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.65E+5	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Dopamine beta-hydroxylase (Bos taurus)	BDBM50014985 (C-(1-Benzyl-1H-imidazol-2-yl)-methylamine \| CHEMBL...) Show SMILES NCc1nccn1Cc1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Smith Kline & French Laboratories Curated by ChEMBL					Assay Description Inhibitory activity was determined against bovine dopamine beta-hydroxylase(DBH)				J Med Chem 33: 781-9 (1990) BindingDB Entry DOI: 10.7270/Q2DZ078G
Smith Kline & French Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%