| Reaction Details |
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 | Report a problem with these data |
| Target | Dopamine beta-hydroxylase |
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| Ligand | BDBM50014970 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_59422 |
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| IC50 | 35±n/a nM |
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| Citation |  Kruse, LI; Kaiser, C; DeWolf, WE; Finkelstein, JA; Frazee, JS; Hilbert, EL; Ross, ST; Flaim, KE; Sawyer, JL Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine beta-hydroxylase. 4. Structure-activity relationships at the copper binding site. J Med Chem33:781-9 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Dopamine beta-hydroxylase |
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| Name: | Dopamine beta-hydroxylase |
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| Synonyms: | DBH | DOPO_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 68136.39 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_50738 |
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| Residue: | 610 |
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| Sequence: | MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISY
AQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDS
QQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSG
LHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIV
MYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAK
AFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMEL
GLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARD
GRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEM
CVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSF
NREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGP
TVLNISGGKG
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|
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| BDBM50014970 |
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| n/a |
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| Name | BDBM50014970 |
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| Synonyms: | 4-(3,5-Difluoro-4-hydroxy-benzyl)-2,4-dihydro-[1,2,4]triazole-3-thione | CHEMBL351873 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H7F2N3OS |
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| Mol. Mass. | 243.233 |
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| SMILES | Oc1c(F)cc(Cn2cn[nH]c2=S)cc1F |
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| Structure | 
|
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