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PubMed code 23320547

Compile data set for download or QSAR
Found 69 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 47n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a 51n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 84n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50427000
PNG
(CHEMBL2326265)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C32H45N7O5S/c1-21(2)17-26(15-16-45(5,43)44)35-30(40)27(18-22(3)4)36-31(41)28(19-24-11-13-25(33)14-12-24)37-32(42)29(38-39-34)20-23-9-7-6-8-10-23/h6-16,21-22,26-29H,17-20,33H2,1-5H3,(H,35,40)(H,36,41)(H,37,42)/b16-15+/t26-,27+,28+,29+/m1/s1
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n/an/a 93n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50427003
PNG
(CHEMBL2326262)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(N)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-13-15-29(38)16-14-26)41-35(46)32(21-27-9-11-28(23-37)12-10-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426998
PNG
(CHEMBL2326267)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H42N6O5S/c1-25(2)21-30(33(42)37-29(19-20-47(3,45)46)22-26-13-7-4-8-14-26)38-34(43)31(23-27-15-9-5-10-16-27)39-35(44)32(40-41-36)24-28-17-11-6-12-18-28/h4-20,25,29-32H,21-24H2,1-3H3,(H,37,42)(H,38,43)(H,39,44)/b20-19+/t29-,30+,31+,32+/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 110n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426999
PNG
(CHEMBL2326266)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C31H43N7O5S/c1-21(2)17-25(13-16-44(5,42)43)34-29(39)26(18-22(3)4)35-30(40)27(19-24-11-14-33-15-12-24)36-31(41)28(37-38-32)20-23-9-7-6-8-10-23/h6-16,21-22,25-28H,17-20H2,1-5H3,(H,34,39)(H,35,40)(H,36,41)/b16-13+/t25-,26+,27+,28+/m1/s1
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n/an/a 160n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 170n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50427001
PNG
(CHEMBL2326264)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-27(15-16-46(5,44)45)36-31(41)28(18-23(3)4)37-32(42)29(19-25-11-13-26(21-34)14-12-25)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 190n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426993
PNG
(CHEMBL2326539)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(O)c1C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C28H38N4O7S/c1-17(2)25(32-26(35)22-6-5-7-24(34)18(22)3)28(37)31-23(16-33)27(36)30-21(12-13-40(4,38)39)14-19-8-10-20(15-29)11-9-19/h5-13,17,21,23,25,33-34H,14-16,29H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)/b13-12+/t21-,23+,25+/m1/s1
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n/an/a 200n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a 270n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50427002
PNG
(CHEMBL2326263)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccncc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-27-13-16-38-17-14-27)40-34(45)31(21-26-9-11-28(23-36)12-10-26)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a 370n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 420n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50427001
PNG
(CHEMBL2326264)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-27(15-16-46(5,44)45)36-31(41)28(18-23(3)4)37-32(42)29(19-25-11-13-26(21-34)14-12-25)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 480n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 580n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50427003
PNG
(CHEMBL2326262)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(N)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-13-15-29(38)16-14-26)41-35(46)32(21-27-9-11-28(23-37)12-10-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 630n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426995
PNG
(CHEMBL2326272)
Show SMILES [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-c1cccc(-[#8])c1-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)[C@@]1([#6])[#6]-[#8]1 |r|
Show InChI InChI=1S/C25H38N6O7/c1-13(2)19(31-21(35)15-7-5-9-18(33)14(15)3)23(37)30-17(11-32)22(36)29-16(8-6-10-28-24(26)27)20(34)25(4)12-38-25/h5,7,9,13,16-17,19,32-33H,6,8,10-12H2,1-4H3,(H,29,36)(H,30,37)(H,31,35)(H4,26,27,28)/t16-,17-,19-,25+/m0/s1
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n/an/a 900n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50427005
PNG
(CHEMBL2326535)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(N)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C32H45N7O5S/c1-21(2)17-27(30(40)35-26(15-16-45(5,43)44)19-24-11-13-25(33)14-12-24)36-31(41)28(18-22(3)4)37-32(42)29(38-39-34)20-23-9-7-6-8-10-23/h6-16,21-22,26-29H,17-20,33H2,1-5H3,(H,35,40)(H,36,41)(H,37,42)/b16-15+/t26-,27+,28+,29+/m1/s1
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n/an/a 1.10E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 1.20E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50427004
PNG
(CHEMBL2326537)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccncc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C31H43N7O5S/c1-21(2)17-26(29(39)34-25(13-16-44(5,42)43)19-24-11-14-33-15-12-24)35-30(40)27(18-22(3)4)36-31(41)28(37-38-32)20-23-9-7-6-8-10-23/h6-16,21-22,25-28H,17-20H2,1-5H3,(H,34,39)(H,35,40)(H,36,41)/b16-13+/t25-,26+,27+,28+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50427005
PNG
(CHEMBL2326535)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(N)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C32H45N7O5S/c1-21(2)17-27(30(40)35-26(15-16-45(5,43)44)19-24-11-13-25(33)14-12-24)36-31(41)28(18-22(3)4)37-32(42)29(38-39-34)20-23-9-7-6-8-10-23/h6-16,21-22,26-29H,17-20,33H2,1-5H3,(H,35,40)(H,36,41)(H,37,42)/b16-15+/t26-,27+,28+,29+/m1/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human NCI-H929 cells at 200 uM after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50427002
PNG
(CHEMBL2326263)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccncc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-27-13-16-38-17-14-27)40-34(45)31(21-26-9-11-28(23-36)12-10-26)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50427004
PNG
(CHEMBL2326537)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccncc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C31H43N7O5S/c1-21(2)17-26(29(39)34-25(13-16-44(5,42)43)19-24-11-14-33-15-12-24)35-30(40)27(18-22(3)4)36-31(41)28(37-38-32)20-23-9-7-6-8-10-23/h6-16,21-22,25-28H,17-20H2,1-5H3,(H,34,39)(H,35,40)(H,36,41)/b16-13+/t25-,26+,27+,28+/m1/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426998
PNG
(CHEMBL2326267)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H42N6O5S/c1-25(2)21-30(33(42)37-29(19-20-47(3,45)46)22-26-13-7-4-8-14-26)38-34(43)31(23-27-15-9-5-10-16-27)39-35(44)32(40-41-36)24-28-17-11-6-12-18-28/h4-20,25,29-32H,21-24H2,1-3H3,(H,37,42)(H,38,43)(H,39,44)/b20-19+/t29-,30+,31+,32+/m1/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50427000
PNG
(CHEMBL2326265)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C32H45N7O5S/c1-21(2)17-26(15-16-45(5,43)44)35-30(40)27(18-22(3)4)36-31(41)28(19-24-11-13-25(33)14-12-24)37-32(42)29(38-39-34)20-23-9-7-6-8-10-23/h6-16,21-22,26-29H,17-20,33H2,1-5H3,(H,35,40)(H,36,41)(H,37,42)/b16-15+/t26-,27+,28+,29+/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426993
PNG
(CHEMBL2326539)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(O)c1C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C28H38N4O7S/c1-17(2)25(32-26(35)22-6-5-7-24(34)18(22)3)28(37)31-23(16-33)27(36)30-21(12-13-40(4,38)39)14-19-8-10-20(15-29)11-9-19/h5-13,17,21,23,25,33-34H,14-16,29H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)/b13-12+/t21-,23+,25+/m1/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 3.60E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a 5.50E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426999
PNG
(CHEMBL2326266)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C31H43N7O5S/c1-21(2)17-25(13-16-44(5,42)43)34-29(39)26(18-22(3)4)35-30(40)27(19-24-11-14-33-15-12-24)36-31(41)28(37-38-32)20-23-9-7-6-8-10-23/h6-16,21-22,25-28H,17-20H2,1-5H3,(H,34,39)(H,35,40)(H,36,41)/b16-13+/t25-,26+,27+,28+/m1/s1
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n/an/a 5.60E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr by S...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 5.80E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 7.20E+3n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a 1.05E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 1.05E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426993
PNG
(CHEMBL2326539)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(O)c1C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C28H38N4O7S/c1-17(2)25(32-26(35)22-6-5-7-24(34)18(22)3)28(37)31-23(16-33)27(36)30-21(12-13-40(4,38)39)14-19-8-10-20(15-29)11-9-19/h5-13,17,21,23,25,33-34H,14-16,29H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)/b13-12+/t21-,23+,25+/m1/s1
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n/an/a 1.30E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426993
PNG
(CHEMBL2326539)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(O)c1C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C28H38N4O7S/c1-17(2)25(32-26(35)22-6-5-7-24(34)18(22)3)28(37)31-23(16-33)27(36)30-21(12-13-40(4,38)39)14-19-8-10-20(15-29)11-9-19/h5-13,17,21,23,25,33-34H,14-16,29H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)/b13-12+/t21-,23+,25+/m1/s1
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n/an/a 1.50E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 1.74E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human NCI-H929 cells at 200 uM after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 2.10E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK-293T cell lysates using BODIPY-BODIPY-TMR-epoxomicin as probe after 1 hr...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human NCI-H929 cells at 200 uM after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426995
PNG
(CHEMBL2326272)
Show SMILES [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-c1cccc(-[#8])c1-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)[C@@]1([#6])[#6]-[#8]1 |r|
Show InChI InChI=1S/C25H38N6O7/c1-13(2)19(31-21(35)15-7-5-9-18(33)14(15)3)23(37)30-17(11-32)22(36)29-16(8-6-10-28-24(26)27)20(34)25(4)12-38-25/h5,7,9,13,16-17,19,32-33H,6,8,10-12H2,1-4H3,(H,29,36)(H,30,37)(H,31,35)(H4,26,27,28)/t16-,17-,19-,25+/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of trypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 2.70E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human NCI-H929 cells at 200 uM after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426995
PNG
(CHEMBL2326272)
Show SMILES [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-c1cccc(-[#8])c1-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)[C@@]1([#6])[#6]-[#8]1 |r|
Show InChI InChI=1S/C25H38N6O7/c1-13(2)19(31-21(35)15-7-5-9-18(33)14(15)3)23(37)30-17(11-32)22(36)29-16(8-6-10-28-24(26)27)20(34)25(4)12-38-25/h5,7,9,13,16-17,19,32-33H,6,8,10-12H2,1-4H3,(H,29,36)(H,30,37)(H,31,35)(H4,26,27,28)/t16-,17-,19-,25+/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human NCI-H929 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426995
PNG
(CHEMBL2326272)
Show SMILES [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-c1cccc(-[#8])c1-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)[C@@]1([#6])[#6]-[#8]1 |r|
Show InChI InChI=1S/C25H38N6O7/c1-13(2)19(31-21(35)15-7-5-9-18(33)14(15)3)23(37)30-17(11-32)22(36)29-16(8-6-10-28-24(26)27)20(34)25(4)12-38-25/h5,7,9,13,16-17,19,32-33H,6,8,10-12H2,1-4H3,(H,29,36)(H,30,37)(H,31,35)(H4,26,27,28)/t16-,17-,19-,25+/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of chymotrypsin-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426993
PNG
(CHEMBL2326539)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(O)c1C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C28H38N4O7S/c1-17(2)25(32-26(35)22-6-5-7-24(34)18(22)3)28(37)31-23(16-33)27(36)30-21(12-13-40(4,38)39)14-19-8-10-20(15-29)11-9-19/h5-13,17,21,23,25,33-34H,14-16,29H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)/b13-12+/t21-,23+,25+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426993
PNG
(CHEMBL2326539)
Show SMILES CC(C)[C@H](NC(=O)c1cccc(O)c1C)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C28H38N4O7S/c1-17(2)25(32-26(35)22-6-5-7-24(34)18(22)3)28(37)31-23(16-33)27(36)30-21(12-13-40(4,38)39)14-19-8-10-20(15-29)11-9-19/h5-13,17,21,23,25,33-34H,14-16,29H2,1-4H3,(H,30,36)(H,31,37)(H,32,35)/b13-12+/t21-,23+,25+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human NCI-H929 cells at 200 uM after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426995
PNG
(CHEMBL2326272)
Show SMILES [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-c1cccc(-[#8])c1-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)[C@@]1([#6])[#6]-[#8]1 |r|
Show InChI InChI=1S/C25H38N6O7/c1-13(2)19(31-21(35)15-7-5-9-18(33)14(15)3)23(37)30-17(11-32)22(36)29-16(8-6-10-28-24(26)27)20(34)25(4)12-38-25/h5,7,9,13,16-17,19,32-33H,6,8,10-12H2,1-4H3,(H,29,36)(H,30,37)(H,31,35)(H4,26,27,28)/t16-,17-,19-,25+/m0/s1
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Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426995
PNG
(CHEMBL2326272)
Show SMILES [#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-c1cccc(-[#8])c1-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)[C@@]1([#6])[#6]-[#8]1 |r|
Show InChI InChI=1S/C25H38N6O7/c1-13(2)19(31-21(35)15-7-5-9-18(33)14(15)3)23(37)30-17(11-32)22(36)29-16(8-6-10-28-24(26)27)20(34)25(4)12-38-25/h5,7,9,13,16-17,19,32-33H,6,8,10-12H2,1-4H3,(H,29,36)(H,30,37)(H,31,35)(H4,26,27,28)/t16-,17-,19-,25+/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human NCI-H929 cells at 200 uM after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Inhibition of caspase-like activity of proteasome in human RPMI-8226 cells after 6 hrs by proteasomeGlo assay

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BO...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BO...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BO...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of caspase-like activity of proteasome beta 1 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-5


(Homo sapiens (Human))		BDBM50426994
PNG
(CHEMBL2326533)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C33H47N7O5S/c1-22(2)17-28(31(41)36-27(15-16-46(5,44)45)19-25-11-13-26(21-34)14-12-25)37-32(42)29(18-23(3)4)38-33(43)30(39-40-35)20-24-9-7-6-8-10-24/h6-16,22-23,27-30H,17-21,34H2,1-5H3,(H,36,41)(H,37,42)(H,38,43)/b16-15+/t27-,28+,29+,30+/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of chymotrypsin-like activity of proteasome beta 5 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BO...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of caspase-like activity of proteasome beta 1 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-2


(Homo sapiens (Human))		BDBM50426996
PNG
(CHEMBL2326261)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1
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n/an/a 5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of trypsin-like activity of proteasome beta 2 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426992
PNG
(CHEMBL2326260)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C36H46N8O5S/c1-24(2)19-31(34(45)40-30(17-18-50(3,48)49)20-26-9-11-28(23-37)12-10-26)41-35(46)32(21-27-13-15-29(38)16-14-27)42-36(47)33(43-44-39)22-25-7-5-4-6-8-25/h4-18,24,30-33H,19-23,37-38H2,1-3H3,(H,40,45)(H,41,46)(H,42,47)/b18-17+/t30-,31+,32+,33+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of caspase-like activity of proteasome beta 1 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
Proteasome subunit beta type-1


(Homo sapiens (Human))		BDBM50426997
PNG
(CHEMBL2326541)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](Cc1ccc(CN)cc1)\C=C\S(C)(=O)=O |r|
Show InChI InChI=1S/C35H44N8O5S/c1-24(2)19-30(33(44)39-29(15-18-49(3,47)48)20-26-9-11-28(23-36)12-10-26)40-34(45)31(21-27-13-16-38-17-14-27)41-35(46)32(42-43-37)22-25-7-5-4-6-8-25/h4-18,24,29-32H,19-23,36H2,1-3H3,(H,39,44)(H,40,45)(H,41,46)/b18-15+/t29-,30+,31+,32+/m1/s1
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n/an/a>5.00E+4n/an/an/an/an/an/a



Leiden Institute of Chemistry and Netherlands Proteomics Centre

Curated by ChEMBL


Assay Description
Competitive inhibition of caspase-like activity of proteasome beta 1 subunit in HEK293T cells after 4 hrs by SDS-PAGE analysis in presence of BODIPY-...

J Med Chem 56: 1262-75 (2013)


Article DOI: 10.1021/jm3016987
BindingDB Entry DOI: 10.7270/Q2TQ62VM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%