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PubMed code 23914285

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437283
PNG
(CHEMBL449442)
Show SMILES Clc1ccc(cc1)-c1nnn[nH]1
Show InChI InChI=1S/C7H5ClN4/c8-6-3-1-5(2-4-6)7-9-11-12-10-7/h1-4H,(H,9,10,11,12)
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n/an/an/a 1.85E+6n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437307
PNG
(CHEMBL2407463)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H9Cl2N3O2S2/c18-9-3-1-8(2-4-9)15-20-21-17(25)22(15)10-5-6-11-12(7-10)26-14(13(11)19)16(23)24/h1-7H,(H,21,25)(H,23,24)
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n/an/an/a 5.20E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437304
PNG
(CHEMBL2407460)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H14ClN3O3S2/c24-19-17-10-9-14(12-18(17)32-20(19)22(28)29)27-21(25-26-23(27)31)13-5-4-8-16(11-13)30-15-6-2-1-3-7-15/h1-12H,(H,26,31)(H,28,29)
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n/an/an/a 6.30E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437312
PNG
(CHEMBL2407593)
Show SMILES OC(=O)CSc1nnc(-c2sc3ccccc3c2Cl)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H10Cl3N3O2S2/c19-11-6-5-9(7-12(11)20)24-17(22-23-18(24)27-8-14(25)26)16-15(21)10-3-1-2-4-13(10)28-16/h1-7H,8H2,(H,25,26)
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n/an/an/a 4.60E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437313
PNG
(CHEMBL2407465)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc2ccccc2c1
Show InChI InChI=1S/C21H12ClN3O2S2/c22-17-15-8-7-14(10-16(15)29-18(17)20(26)27)25-19(23-24-21(25)28)13-6-5-11-3-1-2-4-12(11)9-13/h1-10H,(H,24,28)(H,26,27)
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n/an/an/a 4.30E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437317
PNG
(CHEMBL2407467)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)C1CCCCC1
Show InChI InChI=1S/C17H16ClN3O2S2/c18-13-11-7-6-10(8-12(11)25-14(13)16(22)23)21-15(19-20-17(21)24)9-4-2-1-3-5-9/h6-9H,1-5H2,(H,20,24)(H,22,23)
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n/an/an/a 2.50E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437319
PNG
(CHEMBL2407442)
Show SMILES CC(C)C1=C[C@]23CC[C@@H]4[C@](C)(CCC[C@@]4(C)C(O)=O)[C@H]2C[C@@H]1[C@H]([C@@H]3C(O)=O)C(O)=O |r,t:3,THB:1:3:19.20:22.23|
Show InChI InChI=1S/C24H34O6/c1-12(2)14-11-24-9-6-15-22(3,7-5-8-23(15,4)21(29)30)16(24)10-13(14)17(19(25)26)18(24)20(27)28/h11-13,15-18H,5-10H2,1-4H3,(H,25,26)(H,27,28)(H,29,30)/t13-,15+,16+,17+,18+,22-,23+,24+/m0/s1
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n/an/an/a 1.83E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N expressed in Escherichia coli BL21 (DE3) assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 aft...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437275
PNG
(CHEMBL2407473)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H8Cl3N3O2S2/c18-10-4-1-7(5-11(10)19)15-21-22-17(26)23(15)8-2-3-9-12(6-8)27-14(13(9)20)16(24)25/h1-6H,(H,22,26)(H,24,25)
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n/an/an/a 1.10E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437284
PNG
(CHEMBL2407482)
Show SMILES OC(=O)CSc1nnc(-c2ccc(F)cc2)n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H11ClFN3O2S/c17-11-3-7-13(8-4-11)21-15(10-1-5-12(18)6-2-10)19-20-16(21)24-9-14(22)23/h1-8H,9H2,(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437285
PNG
(CHEMBL2407481)
Show SMILES COc1ccc(cc1)-c1nnc(SCC(O)=O)n1-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H14ClN3O3S/c1-24-14-8-2-11(3-9-14)16-19-20-17(25-10-15(22)23)21(16)13-6-4-12(18)5-7-13/h2-9H,10H2,1H3,(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437300
PNG
(CHEMBL2407458)
Show SMILES Cc1cccc(c1)-c1n[nH]c(=S)n1-c1ccc2c(Cl)c(sc2c1)C(O)=O
Show InChI InChI=1S/C18H12ClN3O2S2/c1-9-3-2-4-10(7-9)16-20-21-18(25)22(16)11-5-6-12-13(8-11)26-15(14(12)19)17(23)24/h2-8H,1H3,(H,21,25)(H,23,24)
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n/an/an/a 8.30E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437308
PNG
(CHEMBL2407450)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1cccc(Br)c1
Show InChI InChI=1S/C17H10BrN3O2S2/c18-11-3-1-2-10(6-11)15-19-20-17(24)21(15)12-5-4-9-7-14(16(22)23)25-13(9)8-12/h1-8H,(H,20,24)(H,22,23)
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n/an/an/a 4.90E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437318
PNG
(CHEMBL2407456)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H9Cl2N3O2S2/c18-11-4-2-9(5-12(11)19)15-20-21-17(25)22(15)10-3-1-8-6-14(16(23)24)26-13(8)7-10/h1-7H,(H,21,25)(H,23,24)
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n/an/an/a 2.20E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437321
PNG
(CHEMBL2407471)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(Cl)c(Br)c1
Show InChI InChI=1S/C17H8BrCl2N3O2S2/c18-10-5-7(1-4-11(10)19)15-21-22-17(26)23(15)8-2-3-9-12(6-8)27-14(13(9)20)16(24)25/h1-6H,(H,22,26)(H,24,25)
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n/an/an/a 1.60E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437276
PNG
(CHEMBL2407470)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(Br)c(Cl)c1
Show InChI InChI=1S/C17H8BrCl2N3O2S2/c18-10-4-1-7(5-11(10)19)15-21-22-17(26)23(15)8-2-3-9-12(6-8)27-14(13(9)20)16(24)25/h1-6H,(H,22,26)(H,24,25)
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Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437281
PNG
(CHEMBL2407446)
Show SMILES Cc1ccccc1-c1n[nH]c(=S)n1-c1ccc2cc(sc2c1)C(O)=O
Show InChI InChI=1S/C18H13N3O2S2/c1-10-4-2-3-5-13(10)16-19-20-18(24)21(16)12-7-6-11-8-15(17(22)23)25-14(11)9-12/h2-9H,1H3,(H,20,24)(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437290
PNG
(CHEMBL2407476)
Show SMILES OC(=O)CSc1nnc(-c2ccccc2Cl)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C16H11Cl2N3O2S/c17-10-4-3-5-11(8-10)21-15(12-6-1-2-7-13(12)18)19-20-16(21)24-9-14(22)23/h1-8H,9H2,(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437294
PNG
(CHEMBL2407483)
Show SMILES COc1ccc(cc1)-c1nnc(SCC(O)=O)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H13Cl2N3O3S/c1-25-12-5-2-10(3-6-12)16-20-21-17(26-9-15(23)24)22(16)11-4-7-13(18)14(19)8-11/h2-8H,9H2,1H3,(H,23,24)
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n/an/an/a 1.64E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437301
PNG
(CHEMBL2407452)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H10ClN3O2S2/c18-11-4-1-9(2-5-11)15-19-20-17(24)21(15)12-6-3-10-7-14(16(22)23)25-13(10)8-12/h1-8H,(H,20,24)(H,22,23)
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n/an/an/a 7.80E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437314
PNG
(CHEMBL2407462)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(Br)cc1
Show InChI InChI=1S/C17H9BrClN3O2S2/c18-9-3-1-8(2-4-9)15-20-21-17(25)22(15)10-5-6-11-12(7-10)26-14(13(11)19)16(23)24/h1-7H,(H,21,25)(H,23,24)
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n/an/an/a 4.20E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437316
PNG
(CHEMBL2407469)
Show SMILES Cc1cc(ccc1Br)-c1n[nH]c(=S)n1-c1ccc2c(Cl)c(sc2c1)C(O)=O
Show InChI InChI=1S/C18H11BrClN3O2S2/c1-8-6-9(2-5-12(8)19)16-21-22-18(26)23(16)10-3-4-11-13(7-10)27-15(14(11)20)17(24)25/h2-7H,1H3,(H,22,26)(H,24,25)
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n/an/an/a 3.10E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437323
PNG
(CHEMBL2407454)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1ccc(Br)c(Cl)c1
Show InChI InChI=1S/C17H9BrClN3O2S2/c18-11-4-2-9(5-12(11)19)15-20-21-17(25)22(15)10-3-1-8-6-14(16(23)24)26-13(8)7-10/h1-7H,(H,21,25)(H,23,24)
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n/an/an/a 1.20E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437280
PNG
(CHEMBL2407447)
Show SMILES Cc1cccc(c1)-c1n[nH]c(=S)n1-c1ccc2cc(sc2c1)C(O)=O
Show InChI InChI=1S/C18H13N3O2S2/c1-10-3-2-4-12(7-10)16-19-20-18(24)21(16)13-6-5-11-8-15(17(22)23)25-14(11)9-13/h2-9H,1H3,(H,20,24)(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437287
PNG
(CHEMBL2407479)
Show SMILES COc1ccc(cc1)-c1nnc(SCC(O)=O)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C17H14ClN3O3S/c1-24-14-7-5-11(6-8-14)16-19-20-17(25-10-15(22)23)21(16)13-4-2-3-12(18)9-13/h2-9H,10H2,1H3,(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437293
PNG
(CHEMBL2407486)
Show SMILES OC(=O)CSc1nnc(-c2ccc(cc2)[N+]([O-])=O)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H10Cl2N4O4S/c17-12-6-5-11(7-13(12)18)21-15(19-20-16(21)27-8-14(23)24)9-1-3-10(4-2-9)22(25)26/h1-7H,8H2,(H,23,24)
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n/an/an/a 1.78E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437297
PNG
(CHEMBL2407485)
Show SMILES Nc1ccc(cc1)-c1nnc(SCC(O)=O)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H12Cl2N4O2S/c17-12-6-5-11(7-13(12)18)22-15(9-1-3-10(19)4-2-9)20-21-16(22)25-8-14(23)24/h1-7H,8,19H2,(H,23,24)
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n/an/an/a 1.09E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437298
PNG
(CHEMBL2407449)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H15N3O3S2/c27-22(28)20-12-14-9-10-16(13-19(14)31-20)26-21(24-25-23(26)30)15-5-4-8-18(11-15)29-17-6-2-1-3-7-17/h1-13H,(H,25,30)(H,27,28)
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n/an/an/a 1.04E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437302
PNG
(CHEMBL2407451)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1ccc(Br)cc1
Show InChI InChI=1S/C17H10BrN3O2S2/c18-11-4-1-9(2-5-11)15-19-20-17(24)21(15)12-6-3-10-7-14(16(22)23)25-13(10)8-12/h1-8H,(H,20,24)(H,22,23)
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n/an/an/a 7.10E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437305
PNG
(CHEMBL2407592)
Show SMILES OC(=O)CSc1nnc(-c2cc3ccccc3s2)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C18H11Cl2N3O2S2/c19-12-6-5-11(8-13(12)20)23-17(21-22-18(23)26-9-16(24)25)15-7-10-3-1-2-4-14(10)27-15/h1-8H,9H2,(H,24,25)
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n/an/an/a 5.80E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437306
PNG
(CHEMBL2407461)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1cccc(Br)c1
Show InChI InChI=1S/C17H9BrClN3O2S2/c18-9-3-1-2-8(6-9)15-20-21-17(25)22(15)10-4-5-11-12(7-10)26-14(13(11)19)16(23)24/h1-7H,(H,21,25)(H,23,24)
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n/an/an/a 5.80E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437309
PNG
(CHEMBL2407468)
Show SMILES Cc1cccc(-c2n[nH]c(=S)n2-c2ccc3c(Cl)c(sc3c2)C(O)=O)c1Br
Show InChI InChI=1S/C18H11BrClN3O2S2/c1-8-3-2-4-11(13(8)19)16-21-22-18(26)23(16)9-5-6-10-12(7-9)27-15(14(10)20)17(24)25/h2-7H,1H3,(H,22,26)(H,24,25)
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n/an/an/a 4.80E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437310
PNG
(CHEMBL2407591)
Show SMILES OC(=O)CSc1nnc(-c2ccc3ccccc3c2)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C20H13Cl2N3O2S/c21-16-8-7-15(10-17(16)22)25-19(23-24-20(25)28-11-18(26)27)14-6-5-12-3-1-2-4-13(12)9-14/h1-10H,11H2,(H,26,27)
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n/an/an/a 4.70E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437282
PNG
(CHEMBL2407445)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1ccccc1
Show InChI InChI=1S/C17H11N3O2S2/c21-16(22)14-8-11-6-7-12(9-13(11)24-14)20-15(18-19-17(20)23)10-4-2-1-3-5-10/h1-9H,(H,19,23)(H,21,22)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437288
PNG
(CHEMBL2407478)
Show SMILES OC(=O)CSc1nnc(-c2ccc(F)cc2)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C16H11ClFN3O2S/c17-11-2-1-3-13(8-11)21-15(10-4-6-12(18)7-5-10)19-20-16(21)24-9-14(22)23/h1-8H,9H2,(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437289
PNG
(CHEMBL2407477)
Show SMILES OC(=O)CSc1nnc(-c2ccccc2Br)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C16H11BrClN3O2S/c17-13-7-2-1-6-12(13)15-19-20-16(24-9-14(22)23)21(15)11-5-3-4-10(18)8-11/h1-8H,9H2,(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50424782
PNG
(CHEMBL1448105)
Show SMILES OC(=O)c1sc2cc(Cl)ccc2c1Cl
Show InChI InChI=1S/C9H4Cl2O2S/c10-4-1-2-5-6(3-4)14-8(7(5)11)9(12)13/h1-3H,(H,12,13)
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n/an/an/a 6.27E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437311
PNG
(CHEMBL2407464)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(F)cc1
Show InChI InChI=1S/C17H9ClFN3O2S2/c18-13-11-6-5-10(7-12(11)26-14(13)16(23)24)22-15(20-21-17(22)25)8-1-3-9(19)4-2-8/h1-7H,(H,21,25)(H,23,24)
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n/an/an/a 4.70E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437315
PNG
(CHEMBL2407455)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C17H9Cl2N3O2S2/c18-10-3-9(4-11(19)6-10)15-20-21-17(25)22(15)12-2-1-8-5-14(16(23)24)26-13(8)7-12/h1-7H,(H,21,25)(H,23,24)
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n/an/an/a 3.50E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437276
PNG
(CHEMBL2407470)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(Br)c(Cl)c1
Show InChI InChI=1S/C17H8BrCl2N3O2S2/c18-10-4-1-7(5-11(10)19)15-21-22-17(26)23(15)8-2-3-9-12(6-8)27-14(13(9)20)16(24)25/h1-6H,(H,22,26)(H,24,25)
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n/an/an/a 1.00E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA (1 to 422) containing RPA70N and RPA70NAB assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437277
PNG
(CHEMBL2407466)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1c[nH]c2ccccc12
Show InChI InChI=1S/C19H11ClN4O2S2/c20-15-11-6-5-9(7-14(11)28-16(15)18(25)26)24-17(22-23-19(24)27)12-8-21-13-4-2-1-3-10(12)13/h1-8,21H,(H,23,27)(H,25,26)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437278
PNG
(CHEMBL2407453)
Show SMILES OC(=O)c1cc2ccc(cc2s1)-n1c(n[nH]c1=S)-c1ccc(F)cc1
Show InChI InChI=1S/C17H10FN3O2S2/c18-11-4-1-9(2-5-11)15-19-20-17(24)21(15)12-6-3-10-7-14(16(22)23)25-13(10)8-12/h1-8H,(H,20,24)(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437291
PNG
(CHEMBL2407475)
Show SMILES Cc1ccccc1-c1nnc(SCC(O)=O)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C17H14ClN3O2S/c1-11-5-2-3-8-14(11)16-19-20-17(24-10-15(22)23)21(16)13-7-4-6-12(18)9-13/h2-9H,10H2,1H3,(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437295
PNG
(CHEMBL2407474)
Show SMILES OC(=O)CSc1nnc(-c2sc3ccccc3c2Cl)n1-c1ccccc1
Show InChI InChI=1S/C18H12ClN3O2S2/c19-15-12-8-4-5-9-13(12)26-16(15)17-20-21-18(25-10-14(23)24)22(17)11-6-2-1-3-7-11/h1-9H,10H2,(H,23,24)
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n/an/an/a 1.35E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437296
PNG
(CHEMBL2407444)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccccc1
Show InChI InChI=1S/C17H10ClN3O2S2/c18-13-11-7-6-10(8-12(11)25-14(13)16(22)23)21-15(19-20-17(21)24)9-4-2-1-3-5-9/h1-8H,(H,20,24)(H,22,23)
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n/an/an/a 1.30E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437320
PNG
(CHEMBL2407594)
Show SMILES Cc1ccc2c(Cl)c(sc2c1)-c1nnc(SCC(O)=O)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C19H12Cl3N3O2S2/c1-9-2-4-11-14(6-9)29-17(16(11)22)18-23-24-19(28-8-15(26)27)25(18)10-3-5-12(20)13(21)7-10/h2-7H,8H2,1H3,(H,26,27)
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n/an/an/a 1.80E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437275
PNG
(CHEMBL2407473)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H8Cl3N3O2S2/c18-10-4-1-7(5-11(10)19)15-21-22-17(26)23(15)8-2-3-9-12(6-8)27-14(13(9)20)16(24)25/h1-6H,(H,22,26)(H,24,25)
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n/an/an/a 1.70E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA (1 to 422) containing RPA70N and RPA70NAB assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437322
PNG
(CHEMBL2407472)
Show SMILES OC(=O)c1sc2cc(ccc2c1Cl)-n1c(n[nH]c1=S)-c1cc(Cl)cc(Cl)c1
Show InChI InChI=1S/C17H8Cl3N3O2S2/c18-8-3-7(4-9(19)5-8)15-21-22-17(26)23(15)10-1-2-11-12(6-10)27-14(13(11)20)16(24)25/h1-6H,(H,22,26)(H,24,25)
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n/an/an/a 1.50E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437279
PNG
(CHEMBL2407448)
Show SMILES Cc1ccc(cc1)-c1n[nH]c(=S)n1-c1ccc2cc(sc2c1)C(O)=O
Show InChI InChI=1S/C18H13N3O2S2/c1-10-2-4-11(5-3-10)16-19-20-18(24)21(16)13-7-6-12-8-15(17(22)23)25-14(12)9-13/h2-9H,1H3,(H,20,24)(H,22,23)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437292
PNG
(CHEMBL2407484)
Show SMILES OC(=O)CSc1nnc(-c2ccc(O)cc2)n1-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H11Cl2N3O3S/c17-12-6-3-10(7-13(12)18)21-15(9-1-4-11(22)5-2-9)19-20-16(21)25-8-14(23)24/h1-7,22H,8H2,(H,23,24)
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n/an/an/a 2.33E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437299
PNG
(CHEMBL2407459)
Show SMILES Cc1ccc(cc1)-c1n[nH]c(=S)n1-c1ccc2c(Cl)c(sc2c1)C(O)=O
Show InChI InChI=1S/C18H12ClN3O2S2/c1-9-2-4-10(5-3-9)16-20-21-18(25)22(16)11-6-7-12-13(8-11)26-15(14(12)19)17(23)24/h2-8H,1H3,(H,21,25)(H,23,24)
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n/an/an/a 9.20E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437303
PNG
(CHEMBL2407457)
Show SMILES Cc1ccccc1-c1n[nH]c(=S)n1-c1ccc2c(Cl)c(sc2c1)C(O)=O
Show InChI InChI=1S/C18H12ClN3O2S2/c1-9-4-2-3-5-11(9)16-20-21-18(25)22(16)10-6-7-12-13(8-10)26-15(14(12)19)17(23)24/h2-8H,1H3,(H,21,25)(H,23,24)
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n/an/an/a 6.60E+4n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
Replication protein A 70 kDa DNA-binding subunit


(Homo sapiens (Human))		BDBM50437286
PNG
(CHEMBL2407480)
Show SMILES OC(=O)CSc1nnc(-c2ccc3ccccc3c2)n1-c1cccc(Cl)c1
Show InChI InChI=1S/C20H14ClN3O2S/c21-16-6-3-7-17(11-16)24-19(22-23-20(24)27-12-18(25)26)15-9-8-13-4-1-2-5-14(13)10-15/h1-11H,12H2,(H,25,26)
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n/an/an/a>2.50E+5n/an/an/an/an/a



Vanderbilt University School of Medicine

Curated by ChEMBL


Assay Description
Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anis...

ACS Med Chem Lett 4: 601-605 (2013)


Article DOI: 10.1021/ml400032y
BindingDB Entry DOI: 10.7270/Q22N53PW
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%