Found 50 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384561
(CHEMBL2036458)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccncc1 |t:14| Show InChI InChI=1S/C27H24ClN5O2/c28-21-3-1-19(2-4-21)24-9-10-25(34-24)26-31-35-27(20-11-13-29-14-12-20)33(26)23-7-5-22(6-8-23)32-17-15-30-16-18-32/h1-14,27,30H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384559
(CHEMBL2036456)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccn1 |t:14| Show InChI InChI=1S/C27H24ClN5O2/c28-20-6-4-19(5-7-20)24-12-13-25(34-24)26-31-35-27(23-3-1-2-14-30-23)33(26)22-10-8-21(9-11-22)32-17-15-29-16-18-32/h1-14,27,29H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384572
(CHEMBL2036606)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-24-7-5-22(6-8-24)29-13-14-30(40-29)31-37-41-32(28-4-2-1-3-27(28)23-19-35-21-36-20-23)39(31)26-11-9-25(10-12-26)38-17-15-34-16-18-38/h1-14,19-21,32,34H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384555
(CHEMBL2036452)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1 |t:14| Show InChI InChI=1S/C28H25ClN4O2/c29-22-8-6-20(7-9-22)25-14-15-26(34-25)27-31-35-28(21-4-2-1-3-5-21)33(27)24-12-10-23(11-13-24)32-18-16-30-17-19-32/h1-15,28,30H,16-19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384544
(CHEMBL2036610)Show SMILES Fc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27FN6O2/c33-24-7-5-22(6-8-24)29-13-14-30(40-29)31-37-41-32(28-4-2-1-3-27(28)23-19-35-21-36-20-23)39(31)26-11-9-25(10-12-26)38-17-15-34-16-18-38/h1-14,19-21,32,34H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384560
(CHEMBL2036457)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1cccnc1 |t:14| Show InChI InChI=1S/C27H24ClN5O2/c28-21-5-3-19(4-6-21)24-11-12-25(34-24)26-31-35-27(20-2-1-13-30-18-20)33(26)23-9-7-22(8-10-23)32-16-14-29-15-17-32/h1-13,18,27,29H,14-17H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384575
(CHEMBL2036460)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccncn1 |t:14| Show InChI InChI=1S/C26H23ClN6O2/c27-19-3-1-18(2-4-19)23-9-10-24(34-23)25-31-35-26(22-11-12-29-17-30-22)33(25)21-7-5-20(6-8-21)32-15-13-28-14-16-32/h1-12,17,26,28H,13-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384562
(CHEMBL2036459)Show SMILES Fc1ccc(nc1)C1ON=C(N1c1ccc(cc1)N1CCNCC1)c1ccc(o1)-c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C27H23ClFN5O2/c28-19-3-1-18(2-4-19)24-11-12-25(35-24)26-32-36-27(23-10-5-20(29)17-31-23)34(26)22-8-6-21(7-9-22)33-15-13-30-14-16-33/h1-12,17,27,30H,13-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384563
(CHEMBL2036461)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1cncnc1 |t:14| Show InChI InChI=1S/C26H23ClN6O2/c27-20-3-1-18(2-4-20)23-9-10-24(34-23)25-31-35-26(19-15-29-17-30-16-19)33(25)22-7-5-21(6-8-22)32-13-11-28-12-14-32/h1-10,15-17,26,28H,11-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384567
(CHEMBL2036601)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1cnc[nH]1 |t:14| Show InChI InChI=1S/C25H23ClN6O2/c26-18-3-1-17(2-4-18)22-9-10-23(33-22)24-30-34-25(21-15-28-16-29-21)32(24)20-7-5-19(6-8-20)31-13-11-27-12-14-31/h1-10,15-16,25,27H,11-14H2,(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384565
(CHEMBL2036599)Show SMILES Fc1ccc(C2ON=C(N2c2ccc(cc2)N2CCNCC2)c2ccc(o2)-c2ccc(Cl)cc2)c(F)c1 |c:7| Show InChI InChI=1S/C28H23ClF2N4O2/c29-19-3-1-18(2-4-19)25-11-12-26(36-25)27-33-37-28(23-10-5-20(30)17-24(23)31)35(27)22-8-6-21(7-9-22)34-15-13-32-14-16-34/h1-12,17,28,32H,13-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384570
(CHEMBL2036604)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccc(cc1)-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-26-7-5-23(6-8-26)29-13-14-30(40-29)31-37-41-32(24-3-1-22(2-4-24)25-19-35-21-36-20-25)39(31)28-11-9-27(10-12-28)38-17-15-34-16-18-38/h1-14,19-21,32,34H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384557
(CHEMBL2036454)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOCCN1c1ccc(cc1)N1CCNCC1 |t:15| Show InChI InChI=1S/C24H23N5O2/c25-17-18-1-3-19(4-2-18)22-9-10-23(31-22)24-27-30-16-15-29(24)21-7-5-20(6-8-21)28-13-11-26-12-14-28/h1-10,26H,11-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50362106
(CHEMBL1938681)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N(Cc1ccccn1)c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C27H25ClN4O2/c28-21-6-4-20(5-7-21)25-12-13-26(34-25)27(33)32(19-22-3-1-2-14-30-22)24-10-8-23(9-11-24)31-17-15-29-16-18-31/h1-14,29H,15-19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384564
(CHEMBL2036598)Show SMILES Fc1ccc(cc1)C1ON=C(N1c1ccc(cc1)N1CCNCC1)c1ccc(o1)-c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C28H24ClFN4O2/c29-21-5-1-19(2-6-21)25-13-14-26(35-25)27-32-36-28(20-3-7-22(30)8-4-20)34(27)24-11-9-23(10-12-24)33-17-15-31-16-18-33/h1-14,28,31H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384573
(CHEMBL2036607)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cccnc1 |t:14| Show InChI InChI=1S/C33H28ClN5O2/c34-25-9-7-23(8-10-25)30-15-16-31(40-30)32-37-41-33(29-6-2-1-5-28(29)24-4-3-17-36-22-24)39(32)27-13-11-26(12-14-27)38-20-18-35-19-21-38/h1-17,22,33,35H,18-21H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384566
(CHEMBL2036600)Show SMILES Fc1cc(F)cc(c1)C1ON=C(N1c1ccc(cc1)N1CCNCC1)c1ccc(o1)-c1ccc(Cl)cc1 |c:11| Show InChI InChI=1S/C28H23ClF2N4O2/c29-20-3-1-18(2-4-20)25-9-10-26(36-25)27-33-37-28(19-15-21(30)17-22(31)16-19)35(27)24-7-5-23(6-8-24)34-13-11-32-12-14-34/h1-10,15-17,28,32H,11-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384551
(CHEMBL2036618)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)C1CCNCC1)c1ccncc1 |t:14| Show InChI InChI=1S/C28H25ClN4O2/c29-23-5-1-21(2-6-23)25-9-10-26(34-25)27-32-35-28(22-13-17-31-18-14-22)33(27)24-7-3-19(4-8-24)20-11-15-30-16-12-20/h1-10,13-14,17-18,20,28,30H,11-12,15-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384546
(CHEMBL2036612)Show SMILES Fc1cc(ccc1Cl)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C32H26ClFN6O2/c33-27-10-5-21(17-28(27)34)29-11-12-30(41-29)31-38-42-32(26-4-2-1-3-25(26)22-18-36-20-37-19-22)40(31)24-8-6-23(7-9-24)39-15-13-35-14-16-39/h1-12,17-20,32,35H,13-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384548
(CHEMBL2036614)Show SMILES COc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H30N6O3/c1-40-27-12-6-23(7-13-27)30-14-15-31(41-30)32-37-42-33(29-5-3-2-4-28(29)24-20-35-22-36-21-24)39(32)26-10-8-25(9-11-26)38-18-16-34-17-19-38/h2-15,20-22,33-34H,16-19H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384569
(CHEMBL2036603)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccc(cc1)-c1ncccn1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-25-8-6-22(7-9-25)28-14-15-29(40-28)31-37-41-32(24-4-2-23(3-5-24)30-35-16-1-17-36-30)39(31)27-12-10-26(11-13-27)38-20-18-34-19-21-38/h1-17,32,34H,18-21H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384571
(CHEMBL2036605)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1cccc(c1)-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-26-6-4-22(5-7-26)29-12-13-30(40-29)31-37-41-32(24-3-1-2-23(18-24)25-19-35-21-36-20-25)39(31)28-10-8-27(9-11-28)38-16-14-34-15-17-38/h1-13,18-21,32,34H,14-17H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384574
(CHEMBL2036608)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1ccccc1 |t:14| Show InChI InChI=1S/C34H29ClN4O2/c35-26-12-10-25(11-13-26)31-18-19-32(40-31)33-37-41-34(30-9-5-4-8-29(30)24-6-2-1-3-7-24)39(33)28-16-14-27(15-17-28)38-22-20-36-21-23-38/h1-19,34,36H,20-23H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384547
(CHEMBL2036613)Show SMILES C1CN(CCN1)c1ccc(cc1)N1C(ON=C1c1ccc(o1)-c1ccncc1)c1ccccc1-c1cncnc1 |c:17| Show InChI InChI=1S/C31H27N7O2/c1-2-4-27(26(3-1)23-19-34-21-35-20-23)31-38(25-7-5-24(6-8-25)37-17-15-33-16-18-37)30(36-40-31)29-10-9-28(39-29)22-11-13-32-14-12-22/h1-14,19-21,31,33H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384545
(CHEMBL2036611)Show SMILES Clc1ccc(cc1Cl)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C32H26Cl2N6O2/c33-27-10-5-21(17-28(27)34)29-11-12-30(41-29)31-38-42-32(26-4-2-1-3-25(26)22-18-36-20-37-19-22)40(31)24-8-6-23(7-9-24)39-15-13-35-14-16-39/h1-12,17-20,32,35H,13-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384568
(CHEMBL2036602)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1cnc(nc1)-c1ccccc1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-25-8-6-22(7-9-25)28-14-15-29(40-28)31-37-41-32(24-20-35-30(36-21-24)23-4-2-1-3-5-23)39(31)27-12-10-26(11-13-27)38-18-16-34-17-19-38/h1-15,20-21,32,34H,16-19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384543
(CHEMBL2036609)Show SMILES Clc1cccc(c1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-24-5-3-4-22(18-24)29-12-13-30(40-29)31-37-41-32(28-7-2-1-6-27(28)23-19-35-21-36-20-23)39(31)26-10-8-25(9-11-26)38-16-14-34-15-17-38/h1-13,18-21,32,34H,14-17H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384558
(CHEMBL2036455)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOCCCN1c1ccc(cc1)N1CCNCC1 |t:14| Show InChI InChI=1S/C24H25ClN4O2/c25-19-4-2-18(3-5-19)22-10-11-23(31-22)24-27-30-17-1-14-29(24)21-8-6-20(7-9-21)28-15-12-26-13-16-28/h2-11,26H,1,12-17H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384552
(CHEMBL2036449)Show SMILES Clc1ccc(cc1)-c1ccc(o1)-c1nocc1-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C23H20ClN3O2/c24-18-5-1-17(2-6-18)21-9-10-22(29-21)23-20(15-28-26-23)16-3-7-19(8-4-16)27-13-11-25-12-14-27/h1-10,15,25H,11-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384556
(CHEMBL2036453)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1ON=C(N1c1ccc(cc1)N1CCNCC1)c1ccccc1 |c:16| Show InChI InChI=1S/C28H25ClN4O2/c29-22-8-6-20(7-9-22)25-14-15-26(34-25)28-33(27(31-35-28)21-4-2-1-3-5-21)24-12-10-23(11-13-24)32-18-16-30-17-19-32/h1-15,28,30H,16-19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384550
(CHEMBL2036617)Show SMILES N#Cc1cccc(c1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-4-3-5-24(18-23)30-12-13-31(41-30)32-38-42-33(29-7-2-1-6-28(29)25-20-36-22-37-21-25)40(32)27-10-8-26(9-11-27)39-16-14-35-15-17-39/h1-13,18,20-22,33,35H,14-17H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384554
(CHEMBL2036451)Show SMILES Clc1ccc(cc1)-c1ccc(o1)-c1noc(=O)n1-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C22H19ClN4O3/c23-16-3-1-15(2-4-16)19-9-10-20(29-19)21-25-30-22(28)27(21)18-7-5-17(6-8-18)26-13-11-24-12-14-26/h1-10,24H,11-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384541
(CHEMBL2036620)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1Cc1ccc(cc1)N1CCNCC1)c1ccncc1 |t:14| Show InChI InChI=1S/C28H26ClN5O2/c29-23-5-3-21(4-6-23)25-9-10-26(35-25)27-32-36-28(22-11-13-30-14-12-22)34(27)19-20-1-7-24(8-2-20)33-17-15-31-16-18-33/h1-14,28,31H,15-19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384549
(CHEMBL2036615)Show SMILES CNC(=O)c1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:17| Show InChI InChI=1S/C34H31N7O3/c1-35-33(42)24-8-6-23(7-9-24)30-14-15-31(43-30)32-39-44-34(29-5-3-2-4-28(29)25-20-37-22-38-21-25)41(32)27-12-10-26(11-13-27)40-18-16-36-17-19-40/h2-15,20-22,34,36H,16-19H2,1H3,(H,35,42) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384540
(CHEMBL2036619)Show SMILES FC1(F)CCN(CC1)c1ccc(cc1)N1C(ON=C1c1ccc(o1)-c1ccc(Cl)cc1)c1ccncc1 |c:19| Show InChI InChI=1S/C28H23ClF2N4O2/c29-21-3-1-19(2-4-21)24-9-10-25(36-24)26-33-37-27(20-11-15-32-16-12-20)35(26)23-7-5-22(6-8-23)34-17-13-28(30,31)14-18-34/h1-12,15-16,27H,13-14,17-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384553
(CHEMBL2036450)Show SMILES Clc1ccc(cc1)-c1ccc(o1)-c1cc(on1)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C23H20ClN3O2/c24-18-5-1-16(2-6-18)21-9-10-22(28-21)20-15-23(29-26-20)17-3-7-19(8-4-17)27-13-11-25-12-14-27/h1-10,15,25H,11-14H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 using 5TAMRA-KKLNRTLSVA-COOH as substrate incubated for 30 mins prior to substrate addition measured after 30 mins by immobilized m... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384570
(CHEMBL2036604)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccc(cc1)-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-26-7-5-23(6-8-26)29-13-14-30(40-29)31-37-41-32(24-3-1-22(2-4-24)25-19-35-21-36-20-25)39(31)28-11-9-27(10-12-28)38-17-15-34-16-18-38/h1-14,19-21,32,34H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 820 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384561
(CHEMBL2036458)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccncc1 |t:14| Show InChI InChI=1S/C27H24ClN5O2/c28-21-3-1-19(2-4-21)24-9-10-25(34-24)26-31-35-27(20-11-13-29-14-12-20)33(26)23-7-5-22(6-8-23)32-17-15-30-16-18-32/h1-14,27,30H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384544
(CHEMBL2036610)Show SMILES Fc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27FN6O2/c33-24-7-5-22(6-8-24)29-13-14-30(40-29)31-37-41-32(28-4-2-1-3-27(28)23-19-35-21-36-20-23)39(31)26-11-9-25(10-12-26)38-17-15-34-16-18-38/h1-14,19-21,32,34H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 760 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384555
(CHEMBL2036452)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1 |t:14| Show InChI InChI=1S/C28H25ClN4O2/c29-22-8-6-20(7-9-22)25-14-15-26(34-25)27-31-35-28(21-4-2-1-3-5-21)33(27)24-12-10-23(11-13-24)32-18-16-30-17-19-32/h1-15,28,30H,16-19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 6.70E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384572
(CHEMBL2036606)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:14| Show InChI InChI=1S/C32H27ClN6O2/c33-24-7-5-22(6-8-24)29-13-14-30(40-29)31-37-41-32(28-4-2-1-3-27(28)23-19-35-21-36-20-23)39(31)26-11-9-25(10-12-26)38-17-15-34-16-18-38/h1-14,19-21,32,34H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 730 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384542
(CHEMBL2036616)Show SMILES N#Cc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccc1-c1cncnc1 |t:15| Show InChI InChI=1S/C33H27N7O2/c34-19-23-5-7-24(8-6-23)30-13-14-31(41-30)32-38-42-33(29-4-2-1-3-28(29)25-20-36-22-37-21-25)40(32)27-11-9-26(10-12-27)39-17-15-35-16-18-39/h1-14,20-22,33,35H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384562
(CHEMBL2036459)Show SMILES Fc1ccc(nc1)C1ON=C(N1c1ccc(cc1)N1CCNCC1)c1ccc(o1)-c1ccc(Cl)cc1 |c:10| Show InChI InChI=1S/C27H23ClFN5O2/c28-19-3-1-18(2-4-19)24-11-12-25(35-24)26-32-36-27(23-10-5-20(29)17-31-23)34(26)22-8-6-21(7-9-22)33-15-13-30-14-16-33/h1-12,17,27,30H,13-16H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384559
(CHEMBL2036456)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1ccccn1 |t:14| Show InChI InChI=1S/C27H24ClN5O2/c28-20-6-4-19(5-7-20)24-12-13-25(34-24)26-31-35-27(23-3-1-2-14-30-23)33(26)22-10-8-21(9-11-22)32-17-15-29-16-18-32/h1-14,27,29H,15-18H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50384567
(CHEMBL2036601)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C1=NOC(N1c1ccc(cc1)N1CCNCC1)c1cnc[nH]1 |t:14| Show InChI InChI=1S/C25H23ClN6O2/c26-18-3-1-17(2-4-18)22-9-10-23(33-22)24-30-34-25(21-15-28-16-29-21)32(24)20-7-5-19(6-8-20)31-13-11-27-12-14-31/h1-10,15-16,25,27H,11-14H2,(H,28,29) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
MAP kinase-activated protein kinase 2
(Homo sapiens (Human)) | BDBM50362106
(CHEMBL1938681)Show SMILES Clc1ccc(cc1)-c1ccc(o1)C(=O)N(Cc1ccccn1)c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C27H25ClN4O2/c28-21-6-4-20(5-7-21)25-12-13-26(34-25)27(33)32(19-22-3-1-2-14-30-22)24-10-8-23(9-11-24)31-17-15-29-16-18-31/h1-14,29H,15-19H2 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 350 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of MK2 in human THP1 cells assessed as inhibition of LPS-induced HSP27 Ser78 phosphorylation incubated for 60 mins prior to LPS-induction ... |
ACS Med Chem Lett 3: 100-105 (2012)
Article DOI: 10.1021/ml200238g
BindingDB Entry DOI: 10.7270/Q2K0759N |
More data for this
Ligand-Target Pair | |
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