Found 14 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020725
(CHEMBL3291439)Show SMILES COc1ccc(-c2nc(c(-c3ccc(Cl)cc3)n2C(=O)N2CCN(CCO)CC2)-c2ccc(Cl)cc2)c(OC(C)C)c1 Show InChI InChI=1S/C32H34Cl2N4O4/c1-21(2)42-28-20-26(41-3)12-13-27(28)31-35-29(22-4-8-24(33)9-5-22)30(23-6-10-25(34)11-7-23)38(31)32(40)37-16-14-36(15-17-37)18-19-39/h4-13,20-21,39H,14-19H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020716
(CHEMBL3286447)Show SMILES Cc1[nH]c(c(c1-c1ccnc2nc3ccccc3n12)-c1ccccc1)-c1ccccc1 |(23.91,-24.16,;22.42,-23.76,;21.24,-24.74,;19.94,-23.91,;20.33,-22.42,;21.86,-22.33,;22.7,-21.04,;21.99,-19.67,;22.82,-18.37,;24.36,-18.44,;25.07,-19.81,;26.56,-20.2,;26.64,-21.74,;27.85,-22.7,;27.62,-24.22,;26.18,-24.78,;24.98,-23.82,;25.21,-22.3,;24.24,-21.11,;19.35,-21.23,;19.89,-19.78,;18.92,-18.6,;17.4,-18.85,;16.85,-20.28,;17.83,-21.47,;18.5,-24.47,;17.3,-23.51,;15.86,-24.07,;15.63,-25.59,;16.84,-26.55,;18.27,-25.99,)| Show InChI InChI=1S/C27H20N4/c1-18-24(23-16-17-28-27-30-21-14-8-9-15-22(21)31(23)27)25(19-10-4-2-5-11-19)26(29-18)20-12-6-3-7-13-20/h2-17,29H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020717
(CHEMBL3291433)Show SMILES Cc1[nH]c(c(c1-c1ccnc2[nH]c(=S)[nH]c(=O)c12)-c1ccccc1)-c1ccccc1 |(21.9,-22.75,;20.41,-22.34,;19.21,-23.29,;17.93,-22.44,;18.34,-20.96,;19.87,-20.89,;20.72,-19.61,;19.79,-18.37,;20.44,-16.96,;21.96,-16.79,;22.88,-18.03,;24.4,-17.85,;25.32,-19.09,;26.84,-18.92,;24.69,-20.5,;23.17,-20.67,;22.8,-22.17,;22.24,-19.43,;17.38,-19.76,;17.95,-18.32,;16.99,-17.11,;15.46,-17.35,;14.9,-18.78,;15.85,-19.98,;16.48,-22.98,;15.29,-22,;13.85,-22.54,;13.6,-24.06,;14.78,-25.04,;16.22,-24.5,)| Show InChI InChI=1S/C24H18N4OS/c1-14-18(17-12-13-25-22-20(17)23(29)28-24(30)27-22)19(15-8-4-2-5-9-15)21(26-14)16-10-6-3-7-11-16/h2-13,26H,1H3,(H2,25,27,28,29,30) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020724
(CHEMBL3291438)Show SMILES CCOC(=O)c1ccc([nH]c1=O)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C25H22N2O3/c1-3-30-25(29)19-14-15-20(27-24(19)28)21-16(2)26-23(18-12-8-5-9-13-18)22(21)17-10-6-4-7-11-17/h4-15,26H,3H2,1-2H3,(H,27,28) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 550 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020723
(CHEMBL3291437)Show SMILES Cc1[nH]c(c(c1-c1ccc(C#N)c(=O)[nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C23H17N3O/c1-15-20(19-13-12-18(14-24)23(27)26-19)21(16-8-4-2-5-9-16)22(25-15)17-10-6-3-7-11-17/h2-13,25H,1H3,(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 570 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020722
(CHEMBL3291436)Show SMILES CCOC(=O)c1ccc(nc1-c1ccccc1)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C31H26N2O2/c1-3-35-31(34)25-19-20-26(33-29(25)23-15-9-5-10-16-23)27-21(2)32-30(24-17-11-6-12-18-24)28(27)22-13-7-4-8-14-22/h4-20,32H,3H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 610 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020721
(CHEMBL3291435)Show SMILES CCOC(=O)c1ccc(nc1C)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C26H24N2O2/c1-4-30-26(29)21-15-16-22(27-17(21)2)23-18(3)28-25(20-13-9-6-10-14-20)24(23)19-11-7-5-8-12-19/h5-16,28H,4H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 780 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020720
(CHEMBL3291434)Show SMILES CC(=O)c1ccc(nc1C)-c1c(C)[nH]c(c1-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C25H22N2O/c1-16-21(18(3)28)14-15-22(26-16)23-17(2)27-25(20-12-8-5-9-13-20)24(23)19-10-6-4-7-11-19/h4-15,27H,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020715
(CHEMBL3291222)Show SMILES Cc1[nH]c(c(c1-c1ccnc2nnnn12)-c1ccccc1)-c1ccccc1 |(19.28,-24.27,;17.81,-23.8,;16.55,-24.7,;15.32,-23.8,;15.79,-22.34,;17.33,-22.34,;18.29,-21.14,;17.72,-19.71,;18.69,-18.5,;20.21,-18.74,;20.77,-20.18,;22.21,-20.72,;22.14,-22.25,;20.66,-22.65,;19.81,-21.37,;14.83,-21.14,;15.4,-19.71,;14.43,-18.5,;12.91,-18.74,;12.35,-20.17,;13.31,-21.37,;13.83,-24.21,;12.73,-23.12,;11.26,-23.53,;10.87,-25.02,;11.95,-26.11,;13.44,-25.7,)| Show InChI InChI=1S/C21H16N6/c1-14-18(17-12-13-22-21-24-25-26-27(17)21)19(15-8-4-2-5-9-15)20(23-14)16-10-6-3-7-11-16/h2-13,23H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020726
(CHEMBL3291221)Show SMILES Cc1[nH]c(c(c1-c1ccnc2ncnn12)-c1ccccc1)-c1ccccc1 |(17.31,-23.85,;15.91,-23.21,;14.57,-23.98,;13.43,-22.95,;14.06,-21.54,;15.59,-21.7,;16.62,-20.57,;16.15,-19.1,;17.19,-17.96,;18.7,-18.28,;19.17,-19.75,;20.57,-20.37,;20.41,-21.91,;18.9,-22.23,;18.13,-20.89,;13.29,-20.2,;14.07,-18.87,;13.3,-17.54,;11.76,-17.54,;10.99,-18.86,;11.75,-20.2,;11.92,-23.26,;10.89,-22.12,;9.39,-22.43,;8.91,-23.9,;9.94,-25.04,;11.44,-24.72,)| Show InChI InChI=1S/C22H17N5/c1-15-19(18-12-13-23-22-24-14-25-27(18)22)20(16-8-4-2-5-9-16)21(26-15)17-10-6-3-7-11-17/h2-14,26H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 890 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020727
(CHEMBL3291220)Show SMILES Cc1[nH]c(c(c1-c1ccnc2c(cnn12)C#N)-c1ccccc1)-c1ccccc1 |(17.11,-21.51,;15.65,-21.02,;14.4,-21.91,;13.16,-20.99,;13.65,-19.53,;15.19,-19.55,;16.1,-18.31,;15.49,-16.9,;16.41,-15.66,;17.94,-15.83,;18.55,-17.25,;20.01,-17.73,;20,-19.27,;18.53,-19.74,;17.63,-18.49,;21.27,-16.84,;22.52,-15.94,;12.75,-18.28,;13.4,-16.88,;12.5,-15.63,;10.97,-15.78,;10.33,-17.17,;11.22,-18.43,;11.69,-21.46,;10.56,-20.42,;9.09,-20.88,;8.75,-22.39,;9.89,-23.42,;11.36,-22.96,)| Show InChI InChI=1S/C24H17N5/c1-16-21(20-12-13-26-24-19(14-25)15-27-29(20)24)22(17-8-4-2-5-9-17)23(28-16)18-10-6-3-7-11-18/h2-13,15,28H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020728
(CHEMBL3291219)Show InChI InChI=1S/C20H16N2O/c1-14-18(17-12-13-23-22-17)19(15-8-4-2-5-9-15)20(21-14)16-10-6-3-7-11-16/h2-13,21H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020729
(CHEMBL3291218)Show SMILES Cc1[nH]c(c(c1-c1ccnn1-c1ccccc1)-c1ccccc1)-c1ccccc1 |(19.77,-21.87,;18.32,-21.38,;17.07,-22.28,;15.82,-21.37,;16.3,-19.91,;17.84,-19.91,;18.75,-18.68,;18.29,-17.21,;19.54,-16.3,;20.77,-17.22,;20.29,-18.68,;21.2,-19.92,;20.56,-21.33,;21.47,-22.58,;23,-22.43,;23.63,-21.02,;22.73,-19.77,;15.4,-18.66,;16.03,-17.25,;15.14,-16.01,;13.61,-16.16,;12.97,-17.56,;13.87,-18.81,;14.35,-21.84,;13.21,-20.81,;11.75,-21.28,;11.42,-22.78,;12.56,-23.81,;14.03,-23.34,)| Show InChI InChI=1S/C26H21N3/c1-19-24(23-17-18-27-29(23)22-15-9-4-10-16-22)25(20-11-5-2-6-12-20)26(28-19)21-13-7-3-8-14-21/h2-18,28H,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 970 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
E3 ubiquitin-protein ligase Mdm2
(Homo sapiens (Human)) | BDBM50020714
(CHEMBL3291217)Show SMILES Cc1[nH]c(c(c1-c1ccn[nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C20H15N3/c1-14-18(17-12-13-21-23-17)19(15-8-4-2-5-9-15)20(22-14)16-10-6-3-7-11-16/h2-13H,1H3/b18-17+ | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Cairo University
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged HDM2 (unknown origin) expressed in Escherichia coli BL21 cells assessed as p53 activation by measuring inhibition of His-p53... |
Eur J Med Chem 82: 472-9 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.082
BindingDB Entry DOI: 10.7270/Q2GT5PR8 |
More data for this
Ligand-Target Pair | |
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