Affinity Data by PubMed id=25396320

PubMed code 25396320

Found 8 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50433561 (CHEMBL2381408) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50300121 ((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50069799 (CHEMBL3407579 \| US9187441, 7M) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50436047 (CHEMBL1233798) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	916	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human MDM2 by fluorescence polarization assay				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50069800 (CHEMBL3407578) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	8.46E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50229787 ((4S,5R)-Nutlin-3 \| (rac)-(4,5-bis(4-chlorophenyl)-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50392531 (CHEMBL407632) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to MDM2 (unknown origin)				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM50069801 (CHEMBL3407580) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a
University of Michigan Comprehensive Cancer Center and Departments of Internal Medicine Curated by ChEMBL					Assay Description Binding affinity to human MDM2 by fluorescence polarization assay				J Med Chem 58: 1038-52 (2015) Article DOI: 10.1021/jm501092z BindingDB Entry DOI: 10.7270/Q21G0NZ5
					More data for this Ligand-Target Pair

* indicates data uncertainty>20%