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PubMed code 25882525

Compile data set for download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069326
PNG
(CHEMBL3403541 | US9688661, 1-(5-Chloro-2-methylphe...)
Show SMILES Cc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H14ClN5O/c1-10-2-3-12(19)7-14(10)24-8-11(6-15(24)17(20)25)16-13-4-5-21-18(13)23-9-22-16/h2-9H,1H3,(H2,20,25)(H,21,22,23)
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n/an/a 1n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069316
PNG
(CHEMBL3403549 | US9688661, 1-[2-Chloro-5-(trifluor...)
Show SMILES NC(=O)c1cc(cn1-c1cc(ccc1Cl)C(F)(F)F)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H11ClF3N5O/c19-12-2-1-10(18(20,21)22)6-13(12)27-7-9(5-14(27)16(23)28)15-11-3-4-24-17(11)26-8-25-15/h1-8H,(H2,23,28)(H,24,25,26)
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n/an/a 1n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069322
PNG
(CHEMBL3403545)
Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H16ClN5O/c1-2-11-3-4-13(20)8-15(11)25-9-12(7-16(25)18(21)26)17-14-5-6-22-19(14)24-10-23-17/h3-10H,2H2,1H3,(H2,21,26)(H,22,23,24)
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n/an/a 1n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069366
PNG
(CHEMBL3403553)
Show SMILES CCc1ccc(Cl)cc1-c1cc([nH]c1C(N)=O)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C19H16ClN5O/c1-2-10-3-4-11(20)7-13(10)14-8-15(25-17(14)18(21)26)16-12-5-6-22-19(12)24-9-23-16/h3-9,25H,2H2,1H3,(H2,21,26)(H,22,23,24)
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n/an/a 3n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069324
PNG
(CHEMBL3403543)
Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1cc(N)ncn1
Show InChI InChI=1S/C17H16ClN5O/c1-2-10-3-4-12(18)6-14(10)23-8-11(5-15(23)17(20)24)13-7-16(19)22-9-21-13/h3-9H,2H2,1H3,(H2,20,24)(H2,19,21,22)
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n/an/a 8n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069310
PNG
(CHEMBL3403552)
Show SMILES Cc1ccc(Cl)cc1-c1cc([nH]c1C(N)=O)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H14ClN5O/c1-9-2-3-10(19)6-12(9)13-7-14(24-16(13)17(20)25)15-11-4-5-21-18(11)23-8-22-15/h2-8,24H,1H3,(H2,20,25)(H,21,22,23)
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n/an/a 9n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069323
PNG
(CHEMBL3403544)
Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1cc(NC)ncn1
Show InChI InChI=1S/C18H18ClN5O/c1-3-11-4-5-13(19)7-15(11)24-9-12(6-16(24)18(20)25)14-8-17(21-2)23-10-22-14/h4-10H,3H2,1-2H3,(H2,20,25)(H,21,22,23)
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n/an/a 12n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069344
PNG
(CHEMBL3403537 | US9688661, 4-(5-Chloro-2-methylphe...)
Show SMILES Cc1ccc(Cl)cc1-c1cn(cc1C(N)=O)-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C18H14ClN5O/c1-10-2-3-11(19)6-13(10)14-7-24(8-15(14)16(20)25)18-12-4-5-21-17(12)22-9-23-18/h2-9H,1H3,(H2,20,25)(H,21,22,23)
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n/an/a 16n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069365
PNG
(CHEMBL3330104 | US9670191, F25)
Show SMILES Cc1ccc(Cl)cc1-c1[nH]c(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H14ClN5O/c1-8-2-3-9(17)6-10(8)14-11(15(18)23)7-13(21-14)12-4-5-20-16(19)22-12/h2-7,21H,1H3,(H2,18,23)(H2,19,20,22)
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n/an/a 20n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069321
PNG
(CHEMBL3403546 | US9688661, 1-(5-Chloro-2-ethylphen...)
Show SMILES CCc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1ncnn2cccc12
Show InChI InChI=1S/C19H16ClN5O/c1-2-12-5-6-14(20)9-16(12)24-10-13(8-17(24)19(21)26)18-15-4-3-7-25(15)23-11-22-18/h3-11H,2H2,1H3,(H2,21,26)
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n/an/a 20n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069325
PNG
(CHEMBL3403542 | US9688661, 1-(5-chloro-2-methylphe...)
Show SMILES Cc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1ncnn2cccc12
Show InChI InChI=1S/C18H14ClN5O/c1-11-4-5-13(19)8-15(11)23-9-12(7-16(23)18(20)25)17-14-3-2-6-24(14)22-10-21-17/h2-10H,1H3,(H2,20,25)
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n/an/a 68n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069318
PNG
(CHEMBL3403547 | US9688661, 4-(6-Aminopyrimidin-4-y...)
Show SMILES NC(=O)c1cc(cn1-c1cc(ccc1Cl)C(F)(F)F)-c1cc(N)ncn1
Show InChI InChI=1S/C16H11ClF3N5O/c17-10-2-1-9(16(18,19)20)4-12(10)25-6-8(3-13(25)15(22)26)11-5-14(21)24-7-23-11/h1-7H,(H2,22,26)(H2,21,23,24)
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n/an/a 71n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069328
PNG
(CHEMBL3403539 | US9688661, 4-(6-aminopyrimidin-4-y...)
Show SMILES Cc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1cc(N)ncn1
Show InChI InChI=1S/C16H14ClN5O/c1-9-2-3-11(17)5-13(9)22-7-10(4-14(22)16(19)23)12-6-15(18)21-8-20-12/h2-8H,1H3,(H2,19,23)(H2,18,20,21)
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n/an/a 73n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069312
PNG
(CHEMBL3403550 | US9688661, 1-[2-chloro-5-(trifluor...)
Show SMILES NC(=O)c1cc(cn1-c1cc(ccc1Cl)C(F)(F)F)-c1ncnn2cccc12
Show InChI InChI=1S/C18H11ClF3N5O/c19-12-4-3-11(18(20,21)22)7-14(12)26-8-10(6-15(26)17(23)28)16-13-2-1-5-27(13)25-9-24-16/h1-9H,(H2,23,28)
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n/an/a 85n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069327
PNG
(CHEMBL3403540)
Show SMILES CNc1cc(ncn1)-c1cc(C(N)=O)n(c1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C17H16ClN5O/c1-10-3-4-12(18)6-14(10)23-8-11(5-15(23)17(19)24)13-7-16(20-2)22-9-21-13/h3-9H,1-2H3,(H2,19,24)(H,20,21,22)
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n/an/a 131n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069347
PNG
(CHEMBL3403534)
Show SMILES Cc1ccc(Cl)cc1-n1cc(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H14ClN5O/c1-9-2-3-11(17)7-13(9)22-8-10(6-14(22)15(18)23)12-4-5-20-16(19)21-12/h2-8H,1H3,(H2,18,23)(H2,19,20,21)
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n/an/a 216n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069351
PNG
(CHEMBL3402480)
Show SMILES Cc1ccc(Cl)cc1-c1cn(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C16H14ClN5O/c1-9-2-3-10(17)6-11(9)12-7-22(8-13(12)15(18)23)14-4-5-20-16(19)21-14/h2-8H,1H3,(H2,18,23)(H2,19,20,21)
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n/an/a 220n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069317
PNG
(CHEMBL3403548)
Show SMILES CNc1cc(ncn1)-c1cc(C(N)=O)n(c1)-c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C17H13ClF3N5O/c1-23-15-6-12(24-8-25-15)9-4-14(16(22)27)26(7-9)13-5-10(17(19,20)21)2-3-11(13)18/h2-8H,1H3,(H2,22,27)(H,23,24,25)
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n/an/a 331n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069346
PNG
(CHEMBL3403535)
Show SMILES Cc1ccc(Cl)cc1-c1cn(cc1C(N)=O)-c1cc(N)ncn1
Show InChI InChI=1S/C16H14ClN5O/c1-9-2-3-10(17)4-11(9)12-6-22(7-13(12)16(19)23)15-5-14(18)20-8-21-15/h2-8H,1H3,(H2,19,23)(H2,18,20,21)
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n/an/a 369n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069345
PNG
(CHEMBL3403536)
Show SMILES CNc1cc(ncn1)-n1cc(C(N)=O)c(c1)-c1cc(Cl)ccc1C
Show InChI InChI=1S/C17H16ClN5O/c1-10-3-4-11(18)5-12(10)13-7-23(8-14(13)17(19)24)16-6-15(20-2)21-9-22-16/h3-9H,1-2H3,(H2,19,24)(H,20,21,22)
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n/an/a 620n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069311
PNG
(CHEMBL3403551)
Show SMILES Cc1ccc(Cl)cc1-c1cc([nH]c1C(N)=O)-c1cc(N)ncn1
Show InChI InChI=1S/C16H14ClN5O/c1-8-2-3-9(17)4-10(8)11-5-13(22-15(11)16(19)23)12-6-14(18)21-7-20-12/h2-7,22H,1H3,(H2,19,23)(H2,18,20,21)
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n/an/a 690n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069358
PNG
(CHEMBL3402478)
Show SMILES Cc1ccc(Cl)cc1-n1cc(cn1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H12ClN5/c1-9-2-3-11(15)6-13(9)20-8-10(7-18-20)12-4-5-17-14(16)19-12/h2-8H,1H3,(H2,16,17,19)
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n/an/a 950n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069360
PNG
(CHEMBL3402476)
Show SMILES Cc1ccc(Cl)cc1-c1ccc([nH]1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13ClN4/c1-9-2-3-10(16)8-11(9)12-4-5-13(19-12)14-6-7-18-15(17)20-14/h2-8,19H,1H3,(H2,17,18,20)
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n/an/a 972n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069359
PNG
(CHEMBL3402477)
Show SMILES Cc1ccc(Cl)cc1-c1ncc([nH]1)-c1ccnc(N)n1
Show InChI InChI=1S/C14H12ClN5/c1-8-2-3-9(15)6-10(8)13-18-7-12(19-13)11-4-5-17-14(16)20-11/h2-7H,1H3,(H,18,19)(H2,16,17,20)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069329
PNG
(CHEMBL3403538)
Show SMILES Cc1ccc(Cl)cc1-c1cn(cc1C(N)=O)-c1ncnn2cccc12
Show InChI InChI=1S/C18H14ClN5O/c1-11-4-5-12(19)7-13(11)14-8-23(9-15(14)17(20)25)18-16-3-2-6-24(16)22-10-21-18/h2-10H,1H3,(H2,20,25)
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n/an/a 2.91E+3n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50069353
PNG
(CHEMBL3402479)
Show SMILES Cc1ccc(Cl)cc1-n1nc(cc1C(N)=O)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13ClN6O/c1-8-2-3-9(16)6-12(8)22-13(14(17)23)7-11(21-22)10-4-5-19-15(18)20-10/h2-7H,1H3,(H2,17,23)(H2,18,19,20)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Nerviano Medical Sciences S.r.l.

Curated by ChEMBL


Assay Description
Inhibition of recombinant epitope-tagged JAK2 (808 to 1132) (unknown origin) using LPLDKDYYVVREPGQ as substrate by beta-countiing analysis in presenc...

Bioorg Med Chem 23: 2387-407 (2015)


Article DOI: 10.1016/j.bmc.2015.03.059
BindingDB Entry DOI: 10.7270/Q2Q52RB6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%