Found 49 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50067354
(CHEMBL3401826)Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)[C@H](Cc1ccccc1)N1C(=S)S\C(=C/c2ccc(cc2)-c2ccccc2)C1=O |r| Show InChI InChI=1S/C32H26N2O4S3/c1-22-12-18-27(19-13-22)41(37,38)33-30(35)28(20-23-8-4-2-5-9-23)34-31(36)29(40-32(34)39)21-24-14-16-26(17-15-24)25-10-6-3-7-11-25/h2-19,21,28H,20H2,1H3,(H,33,35)/b29-21-/t28-/m0/s1 | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM23223
(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)Show SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)| Show InChI InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50067354
(CHEMBL3401826)Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)[C@H](Cc1ccccc1)N1C(=S)S\C(=C/c2ccc(cc2)-c2ccccc2)C1=O |r| Show InChI InChI=1S/C32H26N2O4S3/c1-22-12-18-27(19-13-22)41(37,38)33-30(35)28(20-23-8-4-2-5-9-23)34-31(36)29(40-32(34)39)21-24-14-16-26(17-15-24)25-10-6-3-7-11-25/h2-19,21,28H,20H2,1H3,(H,33,35)/b29-21-/t28-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50067354
(CHEMBL3401826)Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)[C@H](Cc1ccccc1)N1C(=S)S\C(=C/c2ccc(cc2)-c2ccccc2)C1=O |r| Show InChI InChI=1S/C32H26N2O4S3/c1-22-12-18-27(19-13-22)41(37,38)33-30(35)28(20-23-8-4-2-5-9-23)34-31(36)29(40-32(34)39)21-24-14-16-26(17-15-24)25-10-6-3-7-11-25/h2-19,21,28H,20H2,1H3,(H,33,35)/b29-21-/t28-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 570 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127758
(CHEMBL3628077)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(Br)cc3)cc2)cc1 Show InChI InChI=1S/C24H16BrNO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM23223
(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)Show SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)| Show InChI InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 640 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50127758
(CHEMBL3628077)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(Br)cc3)cc2)cc1 Show InChI InChI=1S/C24H16BrNO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50127757
(CHEMBL3628069)Show SMILES Cc1cccc(C)c1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H21NO4S2/c1-16-4-3-5-17(2)23(16)27-24(28)22(33-26(27)32)14-18-8-12-21(13-9-18)31-15-19-6-10-20(11-7-19)25(29)30/h3-14H,15H2,1-2H3,(H,29,30)/b22-14- | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 720 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127757
(CHEMBL3628069)Show SMILES Cc1cccc(C)c1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H21NO4S2/c1-16-4-3-5-17(2)23(16)27-24(28)22(33-26(27)32)14-18-8-12-21(13-9-18)31-15-19-6-10-20(11-7-19)25(29)30/h3-14H,15H2,1-2H3,(H,29,30)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127756
(CHEMBL3629837)Show SMILES COc1ccccc1N1C(=S)S\C(=C/c2cccc(OCc3ccc(cc3)C(O)=O)c2)C1=O Show InChI InChI=1S/C25H19NO5S2/c1-30-21-8-3-2-7-20(21)26-23(27)22(33-25(26)32)14-17-5-4-6-19(13-17)31-15-16-9-11-18(12-10-16)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50127759
(CHEMBL3628078)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(I)cc3)cc2)cc1 Show InChI InChI=1S/C24H16INO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127755
(CHEMBL3629836)Show SMILES COc1ccccc1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C25H19NO5S2/c1-30-21-5-3-2-4-20(21)26-23(27)22(33-25(26)32)14-16-8-12-19(13-9-16)31-15-17-6-10-18(11-7-17)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127828
(CHEMBL3629842)Show SMILES OC(=O)c1ccc(c(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(cc3)[N+]([O-])=O)cc2)c1)[N+]([O-])=O Show InChI InChI=1S/C24H15N3O8S2/c28-22-21(37-24(36)25(22)17-4-6-18(7-5-17)26(31)32)11-14-1-8-19(9-2-14)35-13-16-12-15(23(29)30)3-10-20(16)27(33)34/h1-12H,13H2,(H,29,30)/b21-11- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127754
(CHEMBL3629834)Show SMILES Cc1ccccc1N1C(=S)S\C(=C/c2cccc(OCc3ccc(cc3)C(O)=O)c2)C1=O Show InChI InChI=1S/C25H19NO4S2/c1-16-5-2-3-8-21(16)26-23(27)22(32-25(26)31)14-18-6-4-7-20(13-18)30-15-17-9-11-19(12-10-17)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50127754
(CHEMBL3629834)Show SMILES Cc1ccccc1N1C(=S)S\C(=C/c2cccc(OCc3ccc(cc3)C(O)=O)c2)C1=O Show InChI InChI=1S/C25H19NO4S2/c1-16-5-2-3-8-21(16)26-23(27)22(32-25(26)31)14-18-6-4-7-20(13-18)30-15-17-9-11-19(12-10-17)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50127756
(CHEMBL3629837)Show SMILES COc1ccccc1N1C(=S)S\C(=C/c2cccc(OCc3ccc(cc3)C(O)=O)c2)C1=O Show InChI InChI=1S/C25H19NO5S2/c1-30-21-8-3-2-7-20(21)26-23(27)22(33-25(26)32)14-17-5-4-6-19(13-17)31-15-16-9-11-18(12-10-16)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50127757
(CHEMBL3628069)Show SMILES Cc1cccc(C)c1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H21NO4S2/c1-16-4-3-5-17(2)23(16)27-24(28)22(33-26(27)32)14-18-8-12-21(13-9-18)31-15-19-6-10-20(11-7-19)25(29)30/h3-14H,15H2,1-2H3,(H,29,30)/b22-14- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Induced myeloid leukemia cell differentiation protein Mcl-1
(Homo sapiens (Human)) | BDBM50127755
(CHEMBL3629836)Show SMILES COc1ccccc1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C25H19NO5S2/c1-30-21-5-3-2-4-20(21)26-23(27)22(33-25(26)32)14-16-8-12-19(13-9-16)31-15-17-6-10-18(11-7-17)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
MMDB
NCI pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Mcl-1 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127759
(CHEMBL3628078)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(I)cc3)cc2)cc1 Show InChI InChI=1S/C24H16INO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127852
(CHEMBL3628070)Show SMILES Cc1cccc(C)c1N1C(=S)S\C(=C/c2ccc(OCC(=O)Nc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C27H22N2O5S2/c1-16-4-3-5-17(2)24(16)29-25(31)22(36-27(29)35)14-18-6-12-21(13-7-18)34-15-23(30)28-20-10-8-19(9-11-20)26(32)33/h3-14H,15H2,1-2H3,(H,28,30)(H,32,33)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127960
(CHEMBL3627742)Show SMILES OC(=O)c1ccc(c(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccccc3)cc2)c1)[N+]([O-])=O Show InChI InChI=1S/C24H16N2O6S2/c27-22-21(34-24(33)25(22)18-4-2-1-3-5-18)12-15-6-9-19(10-7-15)32-14-17-13-16(23(28)29)8-11-20(17)26(30)31/h1-13H,14H2,(H,28,29)/b21-12- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127854
(CHEMBL3628072)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3cccc(c3)[N+]([O-])=O)cc2)cc1 Show InChI InChI=1S/C24H16N2O6S2/c27-22-21(34-24(33)25(22)18-2-1-3-19(13-18)26(30)31)12-15-6-10-20(11-7-15)32-14-16-4-8-17(9-5-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-12- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127848
(CHEMBL3629844)Show SMILES Cc1cccc(c1)N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C25H19NO4S2/c1-16-3-2-4-20(13-16)26-23(27)22(32-25(26)31)14-17-7-11-21(12-8-17)30-15-18-5-9-19(10-6-18)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127856
(CHEMBL3628074)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3cccc(c3)C(F)(F)F)cc2)cc1 Show InChI InChI=1S/C25H16F3NO4S2/c26-25(27,28)18-2-1-3-19(13-18)29-22(30)21(35-24(29)34)12-15-6-10-20(11-7-15)33-14-16-4-8-17(9-5-16)23(31)32/h1-13H,14H2,(H,31,32)/b21-12- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127857
(CHEMBL3628075)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(F)cc3)cc2)cc1 Show InChI InChI=1S/C24H16FNO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127860
(CHEMBL3628080)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(Cc4ccc(F)cc4)C3=O)cc2)cc1 Show InChI InChI=1S/C25H18FNO4S2/c26-20-9-3-17(4-10-20)14-27-23(28)22(33-25(27)32)13-16-5-11-21(12-6-16)31-15-18-1-7-19(8-2-18)24(29)30/h1-13H,14-15H2,(H,29,30)/b22-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127822
(CHEMBL3629841)Show SMILES OC(=O)c1ccc(NC(=O)COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(cc3)[N+]([O-])=O)cc2)cc1 Show InChI InChI=1S/C25H17N3O7S2/c29-22(26-17-5-3-16(4-6-17)24(31)32)14-35-20-11-1-15(2-12-20)13-21-23(30)27(25(36)37-21)18-7-9-19(10-8-18)28(33)34/h1-13H,14H2,(H,26,29)(H,31,32)/b21-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127820
(CHEMBL3629840)Show SMILES OC(=O)c1ccc(COc2cccc(\C=C3/SC(=S)N(C3=O)c3ccc(cc3)[N+]([O-])=O)c2)cc1 Show InChI InChI=1S/C24H16N2O6S2/c27-22-21(34-24(33)25(22)18-8-10-19(11-9-18)26(30)31)13-16-2-1-3-20(12-16)32-14-15-4-6-17(7-5-15)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127816
(CHEMBL3629838)Show SMILES COc1ccccc1N1C(=S)S\C(=C/c2ccc(OCC(=O)Nc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H20N2O6S2/c1-33-21-5-3-2-4-20(21)28-24(30)22(36-26(28)35)14-16-6-12-19(13-7-16)34-15-23(29)27-18-10-8-17(9-11-18)25(31)32/h2-14H,15H2,1H3,(H,27,29)(H,31,32)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127858
(CHEMBL3628076)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(Cl)cc3)cc2)cc1 Show InChI InChI=1S/C24H16ClNO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50127759
(CHEMBL3628078)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(I)cc3)cc2)cc1 Show InChI InChI=1S/C24H16INO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127963
(CHEMBL3629830)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccccc3)cc2)cc1 Show InChI InChI=1S/C24H17NO4S2/c26-22-21(31-24(30)25(22)19-4-2-1-3-5-19)14-16-8-12-20(13-9-16)29-15-17-6-10-18(11-7-17)23(27)28/h1-14H,15H2,(H,27,28)/b21-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127961
(CHEMBL3629832)Show SMILES OC(=O)c1ccc(NC(=O)COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccccc3)cc2)cc1 Show InChI InChI=1S/C25H18N2O5S2/c28-22(26-18-10-8-17(9-11-18)24(30)31)15-32-20-12-6-16(7-13-20)14-21-23(29)27(25(33)34-21)19-4-2-1-3-5-19/h1-14H,15H2,(H,26,28)(H,30,31)/b21-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127959
(CHEMBL3629833)Show SMILES OC(=O)c1cc(NC(=O)c2ccc(\C=C3/SC(=S)N(C3=O)c3ccccc3)cc2)ccc1O Show InChI InChI=1S/C24H16N2O5S2/c27-19-11-10-16(13-18(19)23(30)31)25-21(28)15-8-6-14(7-9-15)12-20-22(29)26(24(32)33-20)17-4-2-1-3-5-17/h1-13,27H,(H,25,28)(H,30,31)/b20-12- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50127756
(CHEMBL3629837)Show SMILES COc1ccccc1N1C(=S)S\C(=C/c2cccc(OCc3ccc(cc3)C(O)=O)c2)C1=O Show InChI InChI=1S/C25H19NO5S2/c1-30-21-8-3-2-7-20(21)26-23(27)22(33-25(26)32)14-17-5-4-6-19(13-17)31-15-16-9-11-18(12-10-16)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50127755
(CHEMBL3629836)Show SMILES COc1ccccc1N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C25H19NO5S2/c1-30-21-5-3-2-4-20(21)26-23(27)22(33-25(26)32)14-16-8-12-19(13-9-16)31-15-17-6-10-18(11-7-17)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50127754
(CHEMBL3629834)Show SMILES Cc1ccccc1N1C(=S)S\C(=C/c2cccc(OCc3ccc(cc3)C(O)=O)c2)C1=O Show InChI InChI=1S/C25H19NO4S2/c1-16-5-2-3-8-21(16)26-23(27)22(32-25(26)31)14-18-6-4-7-20(13-18)30-15-17-9-11-19(12-10-17)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127817
(CHEMBL3629839)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(cc3)[N+]([O-])=O)cc2)cc1 Show InChI InChI=1S/C24H16N2O6S2/c27-22-21(34-24(33)25(22)18-7-9-19(10-8-18)26(30)31)13-15-3-11-20(12-4-15)32-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127853
(CHEMBL3628071)Show SMILES COc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C25H19NO5S2/c1-30-20-12-8-19(9-13-20)26-23(27)22(33-25(26)32)14-16-4-10-21(11-5-16)31-15-17-2-6-18(7-3-17)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127851
(CHEMBL3628068)Show SMILES Cc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(OCC(=O)Nc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H20N2O5S2/c1-16-2-10-20(11-3-16)28-24(30)22(35-26(28)34)14-17-4-12-21(13-5-17)33-15-23(29)27-19-8-6-18(7-9-19)25(31)32/h2-14H,15H2,1H3,(H,27,29)(H,31,32)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127855
(CHEMBL3628073)Show SMILES CC(=O)c1ccc(cc1)N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H19NO5S2/c1-16(28)19-8-10-21(11-9-19)27-24(29)23(34-26(27)33)14-17-4-12-22(13-5-17)32-15-18-2-6-20(7-3-18)25(30)31/h2-14H,15H2,1H3,(H,30,31)/b23-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127849
(CHEMBL3629845)Show SMILES Cc1cccc(c1)N1C(=S)S\C(=C/c2ccc(OCC(=O)Nc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H20N2O5S2/c1-16-3-2-4-20(13-16)28-24(30)22(35-26(28)34)14-17-5-11-21(12-6-17)33-15-23(29)27-19-9-7-18(8-10-19)25(31)32/h2-14H,15H2,1H3,(H,27,29)(H,31,32)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127962
(CHEMBL3629831)Show SMILES OC(=O)c1ccc(COc2cccc(\C=C3/SC(=S)N(C3=O)c3ccccc3)c2)cc1 Show InChI InChI=1S/C24H17NO4S2/c26-22-21(31-24(30)25(22)19-6-2-1-3-7-19)14-17-5-4-8-20(13-17)29-15-16-9-11-18(12-10-16)23(27)28/h1-14H,15H2,(H,27,28)/b21-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127859
(CHEMBL3628079)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3c(F)cccc3F)cc2)cc1 Show InChI InChI=1S/C24H15F2NO4S2/c25-18-2-1-3-19(26)21(18)27-22(28)20(33-24(27)32)12-14-6-10-17(11-7-14)31-13-15-4-8-16(9-5-15)23(29)30/h1-12H,13H2,(H,29,30)/b20-12- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50127758
(CHEMBL3628077)Show SMILES OC(=O)c1ccc(COc2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(Br)cc3)cc2)cc1 Show InChI InChI=1S/C24H16BrNO4S2/c25-18-7-9-19(10-8-18)26-22(27)21(32-24(26)31)13-15-3-11-20(12-4-15)30-14-16-1-5-17(6-2-16)23(28)29/h1-13H,14H2,(H,28,29)/b21-13- | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-xL (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127861
(CHEMBL3629835)Show SMILES Cc1ccccc1N1C(=S)S\C(=C/c2ccc(OCC(=O)Nc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C26H20N2O5S2/c1-16-4-2-3-5-21(16)28-24(30)22(35-26(28)34)14-17-6-12-20(13-7-17)33-15-23(29)27-19-10-8-18(9-11-19)25(31)32/h2-14H,15H2,1H3,(H,27,29)(H,31,32)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127850
(CHEMBL3629846)Show SMILES Cc1ccc(cc1)N1C(=S)S\C(=C/c2ccc(OCc3ccc(cc3)C(O)=O)cc2)C1=O Show InChI InChI=1S/C25H19NO4S2/c1-16-2-10-20(11-3-16)26-23(27)22(32-25(26)31)14-17-6-12-21(13-7-17)30-15-18-4-8-19(9-5-18)24(28)29/h2-14H,15H2,1H3,(H,28,29)/b22-14- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127964
(CHEMBL2377534)Show SMILES OC(=O)c1ccc(\C=C2/SC(=S)N(C2=O)c2ccccc2)cc1 Show InChI InChI=1S/C17H11NO3S2/c19-15-14(10-11-6-8-12(9-7-11)16(20)21)23-17(22)18(15)13-4-2-1-3-5-13/h1-10H,(H,20,21)/b14-10- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50127829
(CHEMBL3629843)Show SMILES OC(=O)c1cccc(NC(=O)c2ccc(\C=C3/SC(=S)N(C3=O)c3ccc(cc3)[N+]([O-])=O)cc2)c1O Show InChI InChI=1S/C24H15N3O7S2/c28-20-17(23(31)32)2-1-3-18(20)25-21(29)14-6-4-13(5-7-14)12-19-22(30)26(24(35)36-19)15-8-10-16(11-9-15)27(33)34/h1-12,28H,(H,25,29)(H,31,32)/b19-12- | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 (unknown origin) by fluorescence polarization assay |
Bioorg Med Chem Lett 25: 5265-9 (2015)
Article DOI: 10.1016/j.bmcl.2015.09.051
BindingDB Entry DOI: 10.7270/Q2RB76DD |
More data for this
Ligand-Target Pair | |
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