Found 20 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133021
(CHEMBL3634592)Show SMILES CCOc1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)N(CC(=O)OC)S(C)(=O)=O)c1ccc(CN(Cc2ccccc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C34H39N3O9S3/c1-5-46-32-19-21-33(22-20-32)49(43,44)37(25-29-13-15-30(16-14-29)36(48(4,41)42)26-34(38)45-2)31-17-11-28(12-18-31)24-35(47(3,39)40)23-27-9-7-6-8-10-27/h6-22H,5,23-26H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 222 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133000
(CHEMBL3634591)Show SMILES COC(=O)CN(c1ccc(CN(c2ccc(CN(Cc3ccccc3)S(C)(=O)=O)cc2)S(=O)(=O)c2ccc(OC)cc2)cc1)S(C)(=O)=O Show InChI InChI=1S/C33H37N3O9S3/c1-44-31-18-20-32(21-19-31)48(42,43)36(24-28-12-14-29(15-13-28)35(47(4,40)41)25-33(37)45-2)30-16-10-27(11-17-30)23-34(46(3,38)39)22-26-8-6-5-7-9-26/h5-21H,22-25H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 346 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133031
(CHEMBL3634683)Show SMILES CCOc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)N(Cc1ccc(cc1)N(CC(=O)OC)S(=O)(=O)CC)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C33H37N3O9S3/c1-4-45-31-19-21-32(22-20-31)48(42,43)34-28-13-17-30(18-14-28)35(47(40,41)25-27-9-7-6-8-10-27)23-26-11-15-29(16-12-26)36(24-33(37)44-3)46(38,39)5-2/h6-22,34H,4-5,23-25H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133030
(CHEMBL3634681)Show SMILES COC(=O)CN(c1ccc(CN(c2ccc(cc2)N(Cc2ccccc2)S(C)(=O)=O)S(=O)(=O)Cc2ccccc2)cc1)S(C)(=O)=O Show InChI InChI=1S/C32H35N3O8S3/c1-43-32(36)24-34(45(3,39)40)29-16-14-27(15-17-29)23-35(46(41,42)25-28-12-8-5-9-13-28)31-20-18-30(19-21-31)33(44(2,37)38)22-26-10-6-4-7-11-26/h4-21H,22-25H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 492 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133028
(CHEMBL3634594)Show SMILES CCCCOc1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)N(CC(=O)OC)S(C)(=O)=O)c1ccc(CN(Cc2ccccc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C36H43N3O9S3/c1-5-6-24-48-34-20-22-35(23-21-34)51(45,46)39(27-31-14-16-32(17-15-31)38(50(4,43)44)28-36(40)47-2)33-18-12-30(13-19-33)26-37(49(3,41)42)25-29-10-8-7-9-11-29/h7-23H,5-6,24-28H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 896 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133027
(CHEMBL3634593)Show SMILES CCCOc1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)N(CC(=O)OC)S(C)(=O)=O)c1ccc(CN(Cc2ccccc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C35H41N3O9S3/c1-5-23-47-33-19-21-34(22-20-33)50(44,45)38(26-30-13-15-31(16-14-30)37(49(4,42)43)27-35(39)46-2)32-17-11-29(12-18-32)25-36(48(3,40)41)24-28-9-7-6-8-10-28/h6-22H,5,23-27H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 902 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O |r,c:10| Show InChI InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133032
(CHEMBL3634684)Show SMILES CCCCOc1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)N(CC(=O)OC)S(C)(=O)=O)c1ccc(NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C34H39N3O9S3/c1-4-5-23-46-32-19-21-33(22-20-32)49(43,44)37(24-27-11-15-30(16-12-27)36(47(3,39)40)25-34(38)45-2)31-17-13-29(14-18-31)35-48(41,42)26-28-9-7-6-8-10-28/h6-22,35H,4-5,23-26H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50133021
(CHEMBL3634592)Show SMILES CCOc1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)N(CC(=O)OC)S(C)(=O)=O)c1ccc(CN(Cc2ccccc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C34H39N3O9S3/c1-5-46-32-19-21-33(22-20-32)49(43,44)37(25-29-13-15-30(16-14-29)36(48(4,41)42)26-34(38)45-2)31-17-11-28(12-18-31)24-35(47(3,39)40)23-27-9-7-6-8-10-27/h6-22H,5,23-26H2,1-4H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.86E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50133031
(CHEMBL3634683)Show SMILES CCOc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)N(Cc1ccc(cc1)N(CC(=O)OC)S(=O)(=O)CC)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C33H37N3O9S3/c1-4-45-31-19-21-32(22-20-31)48(42,43)34-28-13-17-30(18-14-28)35(47(40,41)25-27-9-7-6-8-10-27)23-26-11-15-29(16-12-26)36(24-33(37)44-3)46(38,39)5-2/h6-22,34H,4-5,23-25H2,1-3H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 6
(Homo sapiens (Human)) | BDBM50133021
(CHEMBL3634592)Show SMILES CCOc1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)N(CC(=O)OC)S(C)(=O)=O)c1ccc(CN(Cc2ccccc2)S(C)(=O)=O)cc1 Show InChI InChI=1S/C34H39N3O9S3/c1-5-46-32-19-21-33(22-20-32)49(43,44)37(25-29-13-15-30(16-14-29)36(48(4,41)42)26-34(38)45-2)31-17-11-28(12-18-31)24-35(47(3,39)40)23-27-9-7-6-8-10-27/h6-22H,5,23-26H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of SHP1 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 2
(Homo sapiens (Human)) | BDBM50346601
(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)Show SMILES CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O |r,c:10| Show InChI InChI=1S/C30H48O3/c1-25(2)14-16-30(24(32)33)17-15-28(6)19(20(30)18-25)8-9-22-27(5)12-11-23(31)26(3,4)21(27)10-13-29(22,28)7/h8,20-23,31H,9-18H2,1-7H3,(H,32,33)/t20-,21-,22+,23-,27-,28+,29+,30-/m0/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
KEGG
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of TCPTP (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 6
(Homo sapiens (Human)) | BDBM50133030
(CHEMBL3634681)Show SMILES COC(=O)CN(c1ccc(CN(c2ccc(cc2)N(Cc2ccccc2)S(C)(=O)=O)S(=O)(=O)Cc2ccccc2)cc1)S(C)(=O)=O Show InChI InChI=1S/C32H35N3O8S3/c1-43-32(36)24-34(45(3,39)40)29-16-14-27(15-17-29)23-35(46(41,42)25-28-12-8-5-9-13-28)31-20-18-30(19-21-31)33(44(2,37)38)22-26-10-6-4-7-11-26/h4-21H,22-25H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of SHP1 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 6
(Homo sapiens (Human)) | BDBM50133031
(CHEMBL3634683)Show SMILES CCOc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)N(Cc1ccc(cc1)N(CC(=O)OC)S(=O)(=O)CC)S(=O)(=O)Cc1ccccc1 Show InChI InChI=1S/C33H37N3O9S3/c1-4-45-31-19-21-32(22-20-31)48(42,43)34-28-13-17-30(18-14-28)35(47(40,41)25-27-9-7-6-8-10-27)23-26-11-15-29(16-12-26)36(24-33(37)44-3)46(38,39)5-2/h6-22,34H,4-5,23-25H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of SHP1 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM50391109
(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of SHP2 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 11
(Homo sapiens (Human)) | BDBM50133030
(CHEMBL3634681)Show SMILES COC(=O)CN(c1ccc(CN(c2ccc(cc2)N(Cc2ccccc2)S(C)(=O)=O)S(=O)(=O)Cc2ccccc2)cc1)S(C)(=O)=O Show InChI InChI=1S/C32H35N3O8S3/c1-43-32(36)24-34(45(3,39)40)29-16-14-27(15-17-29)23-35(46(41,42)25-28-12-8-5-9-13-28)31-20-18-30(19-21-31)33(44(2,37)38)22-26-10-6-4-7-11-26/h4-21H,22-25H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of SHP2 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 6
(Homo sapiens (Human)) | BDBM50391109
(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of SHP1 (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50132983
(CHEMBL3634590)Show SMILES COC(=O)CN(c1ccc(CN(c2ccc(CN(Cc3ccccc3)S(C)(=O)=O)cc2)S(=O)(=O)c2ccccc2)cc1)S(C)(=O)=O Show InChI InChI=1S/C32H35N3O8S3/c1-43-32(36)25-34(45(3,39)40)29-18-16-28(17-19-29)24-35(46(41,42)31-12-8-5-9-13-31)30-20-14-27(15-21-30)23-33(44(2,37)38)22-26-10-6-4-7-11-26/h4-21H,22-25H2,1-3H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50133029
(CHEMBL3634679)Show SMILES COC(=O)CN(c1ccc(CN(c2ccc(CN(Cc3ccc(C)cc3)S(C)(=O)=O)cc2)S(=O)(=O)Cc2ccccc2)cc1)S(C)(=O)=O Show InChI InChI=1S/C34H39N3O8S3/c1-27-10-12-28(13-11-27)22-35(46(3,39)40)23-29-14-20-33(21-15-29)37(48(43,44)26-31-8-6-5-7-9-31)24-30-16-18-32(19-17-30)36(47(4,41)42)25-34(38)45-2/h5-21H,22-26H2,1-4H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.03E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of recombinant PTP1B (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
Receptor-type tyrosine-protein phosphatase F
(Homo sapiens (Human)) | BDBM50391109
(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Qilu University of Technology
Curated by ChEMBL
| Assay Description
Inhibition of LAR (unknown origin) assessed as hydrolysis of pNPP to pNP after 30 mins |
Bioorg Med Chem 23: 7079-88 (2015)
Article DOI: 10.1016/j.bmc.2015.09.024
BindingDB Entry DOI: 10.7270/Q2QZ2CTV |
More data for this
Ligand-Target Pair | |
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