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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM18050 (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | DrugBank MMDB PDB Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178023 (4-[2-(2,4-Diamino-5,6,7,8-tetrahydropyrido[3,2-d]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178024 (4-[2-(2,4-Diamino-5-formyl-5,6,7,8-tetrahydropyrid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 41 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178027 (4-[2-(2-Diamino-4-hydroxy-5,6,7,8-tetrahydropyrido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178029 (4-[2-(2-Amino-4-hydroxy-5-allyl-5,6,7,8-tetrahydro...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 298 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178030 (N-[4-[2-(2,4-Diamino-5-formyl-5,6,7,8-tetrahydropy...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 590 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178026 (4-[2-[2,4-Diamino-5-(2,3-dibromopropyl)-5,6,7,8-te...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 680 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178025 (4-[2-(2,4-Diamino-5-allyl-5,6,7,8-tetrahydropyrido...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 706 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydrofolate reductase (Homo sapiens (Human)) | BDBM178028 (4-[2-(2-Amino-4-hydroxy-5-formyl-5,6,7,8- tetrahyd...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.01E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Peking University | Assay Description The recombinant human (rh) DHFR was purchased from Sigma-Aldrich (Shanghai, China). All rhDHFR enzymes were assayed spectrophotometrically in a solut... | Chem Biol Drug Des 87: 444-54 (2016) Article DOI: 10.1111/cbdd.12681 BindingDB Entry DOI: 10.7270/Q2862F60 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
