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PubMed code 27156565

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181060
PNG
(CHEMBL3817940)
Show SMILES [H][C@]12C[C@H](O)[C@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24+/m1/s1
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 0.5n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181054
PNG
(CHEMBL3819146)
Show SMILES [H][C@]12CN(CC3CCCCC3)[C@]([H])(CN1Cc1ccccc1)[C@H](O)CC2 |r,TLB:15:14:3.2:22.25.24,23:22:3.2:13.14,4:3:13.14:22.25.24|
Show InChI InChI=1S/C21H32N2O/c24-21-12-11-19-15-23(14-18-9-5-2-6-10-18)20(21)16-22(19)13-17-7-3-1-4-8-17/h1,3-4,7-8,18-21,24H,2,5-6,9-16H2/t19-,20+,21+/m0/s1
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 1.60n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181297
PNG
(CHEMBL3819489)
Show SMILES [H][C@]12C[C@H](O)[C@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20+/m1/s1
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 1.60n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181054
PNG
(CHEMBL3819146)
Show SMILES [H][C@]12CN(CC3CCCCC3)[C@]([H])(CN1Cc1ccccc1)[C@H](O)CC2 |r,TLB:15:14:3.2:22.25.24,23:22:3.2:13.14,4:3:13.14:22.25.24|
Show InChI InChI=1S/C21H32N2O/c24-21-12-11-19-15-23(14-18-9-5-2-6-10-18)20(21)16-22(19)13-17-7-3-1-4-8-17/h1,3-4,7-8,18-21,24H,2,5-6,9-16H2/t19-,20+,21+/m0/s1
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 2.20n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181300
PNG
(CHEMBL3819437)
Show SMILES [H][C@@]12C[C@@H](O)[C@@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20+/m0/s1
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 2.40n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181299
PNG
(CHEMBL3819331)
Show SMILES [H][C@]12C[C@@H](O)[C@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20-/m1/s1
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 2.80n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181301
PNG
(CHEMBL3819395)
Show SMILES [H][C@@]12C[C@H](O)[C@@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20-/m0/s1
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 3.20n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181301
PNG
(CHEMBL3819395)
Show SMILES [H][C@@]12C[C@H](O)[C@@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20-/m0/s1
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 4.80n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50001028
PNG
((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Show SMILES [#6]-[#6@H]1-[#6@H]-2-[#6]-c3ccc(-[#8])cc3[C@]1([#6])[#6]-[#6]-[#7]-2-[#6]\[#6]=[#6](\[#6])-[#6] |r,TLB:16:15:1:3.4.10|
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m0/s1
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 5.40n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181297
PNG
(CHEMBL3819489)
Show SMILES [H][C@]12C[C@H](O)[C@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20+/m1/s1
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 5.70n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181055
PNG
(CHEMBL3819463)
Show SMILES [H][C@]12CN(CC3CCCCC3)[C@]([H])(CN1Cc1ccccc1)[C@@H](O)CC2 |r,TLB:15:14:3.2:22.25.24,23:22:3.2:13.14,4:3:13.14:22.25.24|
Show InChI InChI=1S/C21H32N2O/c24-21-12-11-19-15-23(14-18-9-5-2-6-10-18)20(21)16-22(19)13-17-7-3-1-4-8-17/h1,3-4,7-8,18-21,24H,2,5-6,9-16H2/t19-,20+,21-/m0/s1
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 6n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181060
PNG
(CHEMBL3817940)
Show SMILES [H][C@]12C[C@H](O)[C@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24+/m1/s1
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 6n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181055
PNG
(CHEMBL3819463)
Show SMILES [H][C@]12CN(CC3CCCCC3)[C@]([H])(CN1Cc1ccccc1)[C@@H](O)CC2 |r,TLB:15:14:3.2:22.25.24,23:22:3.2:13.14,4:3:13.14:22.25.24|
Show InChI InChI=1S/C21H32N2O/c24-21-12-11-19-15-23(14-18-9-5-2-6-10-18)20(21)16-22(19)13-17-7-3-1-4-8-17/h1,3-4,7-8,18-21,24H,2,5-6,9-16H2/t19-,20+,21-/m0/s1
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 6.40n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 6.60n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181300
PNG
(CHEMBL3819437)
Show SMILES [H][C@@]12C[C@@H](O)[C@@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20+/m0/s1
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 6.90n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181113
PNG
(CHEMBL3818112)
Show SMILES [H][C@@]12C[C@@H](O)[C@@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24+/m0/s1
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 7.10n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181113
PNG
(CHEMBL3818112)
Show SMILES [H][C@@]12C[C@@H](O)[C@@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24+/m0/s1
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 7.20n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181130
PNG
(CHEMBL3818532)
Show SMILES [H][C@@]12C[C@H](O)[C@@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24-/m0/s1
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 8n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181059
PNG
(CHEMBL3819588)
Show SMILES [H][C@@]12C[C@H](O)[C@@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26-/m0/s1
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 8.70n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181056
PNG
(CHEMBL3818546)
Show SMILES [H][C@]12C[C@H](O)[C@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26+/m1/s1
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 11n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181057
PNG
(CHEMBL3819457)
Show SMILES [H][C@]12C[C@@H](O)[C@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26-/m1/s1
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 11n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181130
PNG
(CHEMBL3818532)
Show SMILES [H][C@@]12C[C@H](O)[C@@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24-/m0/s1
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 13n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181061
PNG
(CHEMBL3819557)
Show SMILES [H][C@]12C[C@@H](O)[C@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24-/m1/s1
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 14n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181299
PNG
(CHEMBL3819331)
Show SMILES [H][C@]12C[C@@H](O)[C@]([H])(CN1Cc1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:16.24:7.8|
Show InChI InChI=1S/C20H30N2O/c23-20-11-18-14-22(13-17-9-5-2-6-10-17)19(20)15-21(18)12-16-7-3-1-4-8-16/h1,3-4,7-8,17-20,23H,2,5-6,9-15H2/t18-,19+,20-/m1/s1
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 23n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50181058
PNG
(CHEMBL3818045)
Show SMILES [H][C@@]12C[C@@H](O)[C@@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26+/m0/s1
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 23n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181056
PNG
(CHEMBL3818546)
Show SMILES [H][C@]12C[C@H](O)[C@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26+/m1/s1
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 24n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181057
PNG
(CHEMBL3819457)
Show SMILES [H][C@]12C[C@@H](O)[C@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26-/m1/s1
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 27n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181059
PNG
(CHEMBL3819588)
Show SMILES [H][C@@]12C[C@H](O)[C@@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26-/m0/s1
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 27n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50001028
PNG
((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Show SMILES [#6]-[#6@H]1-[#6@H]-2-[#6]-c3ccc(-[#8])cc3[C@]1([#6])[#6]-[#6]-[#7]-2-[#6]\[#6]=[#6](\[#6])-[#6] |r,TLB:16:15:1:3.4.10|
Show InChI InChI=1S/C19H27NO/c1-13(2)7-9-20-10-8-19(4)14(3)18(20)11-15-5-6-16(21)12-17(15)19/h5-7,12,14,18,21H,8-11H2,1-4H3/t14-,18+,19+/m0/s1
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 36n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181061
PNG
(CHEMBL3819557)
Show SMILES [H][C@]12C[C@@H](O)[C@]([H])(CN1Cc1cccc3ccccc13)N(CC1CCCCC1)C2 |r,THB:4:3:20.28:7.8|
Show InChI InChI=1S/C24H32N2O/c27-24-13-21-16-26(14-18-7-2-1-3-8-18)23(24)17-25(21)15-20-11-6-10-19-9-4-5-12-22(19)20/h4-6,9-12,18,21,23-24,27H,1-3,7-8,13-17H2/t21-,23+,24-/m1/s1
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 38n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM21398
PNG
(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
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 40n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Sigma non-opioid intracellular receptor 1


(Cavia porcellus (Guinea pig))		BDBM50009307
PNG
(DITOLYLGUANIDINE | Di-o-tolylguanidine)
Show SMILES Cc1ccccc1NC(=N)Nc1ccccc1C
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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 71n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in guinea pig brain membranes after 120 mins by scintillation counting analysis

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50181058
PNG
(CHEMBL3818045)
Show SMILES [H][C@@]12C[C@@H](O)[C@@]([H])(CN1Cc1ccc(cc1)-c1ccccc1)N(CC1CCCCC1)C2 |r,THB:4:3:22.30:7.8|
Show InChI InChI=1S/C26H34N2O/c29-26-15-24-18-28(17-20-7-3-1-4-8-20)25(26)19-27(24)16-21-11-13-23(14-12-21)22-9-5-2-6-10-22/h2,5-6,9-14,20,24-26,29H,1,3-4,7-8,15-19H2/t24-,25+,26+/m0/s1
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 73n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50009307
PNG
(DITOLYLGUANIDINE | Di-o-tolylguanidine)
Show SMILES Cc1ccccc1NC(=N)Nc1ccccc1C
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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 208n/an/an/an/an/an/an/an/a



University of M£nster

Curated by ChEMBL


Assay Description
Displacement of [3H](+)-Pentazocine from sigma 1 receptor in human RPMI8226 cell membranes

J Med Chem 59: 5505-19 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00585
BindingDB Entry DOI: 10.7270/Q2CC12KN
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%